Click here to switch to the map view.

The map label for this gene is dnaA [H]

Identifier: 91785914

GI number: 91785914

Start: 40

End: 1434

Strand: Direct

Name: dnaA [H]

Synonym: Bpro_0001

Alternate gene names: 91785914

Gene position: 40-1434 (Clockwise)

Preceding gene: NA

Following gene: 91785915

Centisome position: 0.0

GC content: 58.92

Gene sequence:

>1395_bases
ATGAGTGAGGTCTCCATCCCTAGCCTGAGTCACGATCTGTGGCAAAACTGTGTCGACCATCTGGCACAGGAATTACCCGA
GCAGCAGTTCAACACCTGGATCCGTCCGCTGGTCGTTCACGTGGCTGCGGACCTCTCCAAAGTCACCATCCAGGTCGGCA
ACCGCTTCAAGCTGGACTGGATACGCGCCCAGTATGCGGCCCGCATTTCTGCCTTGCTCGAAAAAATCTCGGGCCACCGG
ATTTCTCTTGAGTTAGCGCTCGCTCCTCGTGAACCCGCCGCAAAATCAGCGTCATTGACCCGAAGCTTTGAAGGTGTTGG
CGTTGCCGAGCCGGCCGGTTTGGGTGTGCCCGAAGAAGCGGCAGGCGCCCCGTTCAAGAACCGCCTCAACAGCGCGCTGA
CCTTTGACACGCTCATTGAAGGCACGGCCAACCGCATGGGCCGGGCCGCGGCACTGCATGTCTCGAGCAGCCTGGGGCAG
CTTTACAACCCCCTCTTTATCTACGGCGGTGTCGGTCTCGGCAAAACGCACTTGATGCACGCCATCGGCAACAAGCTGCT
GGCGGACAACCCGGCGGCGAAAGTTCTCTACATCCATGCCGAGCAATTTGTCTCGGATGTGGTTAAAGCGTACCAGCGCA
AGACTTTTGACGAGTTCAAGGAACGCTACCACTCACTCGATTTGCTGCTGATCGACGACGTGCAGTTTTTTGCCAACAAG
GACCGCACGCAGGAAGAGTTCTTCAACGCCTTCGAAGCCTTGCTGACCAAAAAGTCGCACATCGTGATGACCAGCGACAC
CTACCCCAAGGGTCTGACGGATATCCATGAGCGCCTGGTGTCACGTTTTGACTCCGGCCTGACGGTGGCGATCGAGCCGC
CCGAGCTCGAGATGCGCGTGGCCATCCTGATCCGCAAAGCCGAGGCCGAAGGCACGGTCATGCCGGAGGAGGTCGCGTTC
TTCGTGGCCAAGAACGTGCGCTCCAACGTGCGCGAACTCGAAGGCGCGCTGCGCAAGATCCTGGCCTATTCGCGCTTCAA
CCTCAAGGAAATCTCCATCCAGCTGGCCCGCGAAGCCCTGCGCGATCTGCTGTCGATTCAAAACCGGCAGATTTCCGTAG
AGAACATCCAGAAGACAGTCGCCGACTATTACAAGATCAAGGTCGCCGACATGTACTCCAAGAAGCGGCCTGCCAGCATT
GCCAGGCCGCGCCAGATTGCCATGTACCTGGCCAAGGAGCTCACGCAAAAAAGCCTGCCCGAGATCGGCGAGCTGTTTGG
CGGCCGCGACCACACCACCGTGCTGCACGCCGTGCGCAAGATGTCTGCCGAGCGCCAGCAGATGACCGAACTCAACCAGC
AACTGCATGTGCTGGAACAAACCCTGAAAGGCTGA

Upstream 100 bases:

>100_bases
ATAACTTGCCACGCGGACTACAATTGCAGGTGCTAAAAATAAACAATATCCACAAGCAGCCGCTGACTGCTTTGCACCTG
CAGCCCAGCCAAATCCCGTC

Downstream 100 bases:

>100_bases
AATGAATGCTTTATGACTCAGTTTTCAGGGCATAAGTCGATGAATAACACGTTCACAACAACCATGGGGACAACTTTTGA
ACAACCCATGACTTATCCAC

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSEVSIPSLSHDLWQNCVDHLAQELPEQQFNTWIRPLVVHVAADLSKVTIQVGNRFKLDWIRAQYAARISALLEKISGHR
ISLELALAPREPAAKSASLTRSFEGVGVAEPAGLGVPEEAAGAPFKNRLNSALTFDTLIEGTANRMGRAAALHVSSSLGQ
LYNPLFIYGGVGLGKTHLMHAIGNKLLADNPAAKVLYIHAEQFVSDVVKAYQRKTFDEFKERYHSLDLLLIDDVQFFANK
DRTQEEFFNAFEALLTKKSHIVMTSDTYPKGLTDIHERLVSRFDSGLTVAIEPPELEMRVAILIRKAEAEGTVMPEEVAF
FVAKNVRSNVRELEGALRKILAYSRFNLKEISIQLAREALRDLLSIQNRQISVENIQKTVADYYKIKVADMYSKKRPASI
ARPRQIAMYLAKELTQKSLPEIGELFGGRDHTTVLHAVRKMSAERQQMTELNQQLHVLEQTLKG

Sequences:

>Translated_464_residues
MSEVSIPSLSHDLWQNCVDHLAQELPEQQFNTWIRPLVVHVAADLSKVTIQVGNRFKLDWIRAQYAARISALLEKISGHR
ISLELALAPREPAAKSASLTRSFEGVGVAEPAGLGVPEEAAGAPFKNRLNSALTFDTLIEGTANRMGRAAALHVSSSLGQ
LYNPLFIYGGVGLGKTHLMHAIGNKLLADNPAAKVLYIHAEQFVSDVVKAYQRKTFDEFKERYHSLDLLLIDDVQFFANK
DRTQEEFFNAFEALLTKKSHIVMTSDTYPKGLTDIHERLVSRFDSGLTVAIEPPELEMRVAILIRKAEAEGTVMPEEVAF
FVAKNVRSNVRELEGALRKILAYSRFNLKEISIQLAREALRDLLSIQNRQISVENIQKTVADYYKIKVADMYSKKRPASI
ARPRQIAMYLAKELTQKSLPEIGELFGGRDHTTVLHAVRKMSAERQQMTELNQQLHVLEQTLKG
>Mature_463_residues
SEVSIPSLSHDLWQNCVDHLAQELPEQQFNTWIRPLVVHVAADLSKVTIQVGNRFKLDWIRAQYAARISALLEKISGHRI
SLELALAPREPAAKSASLTRSFEGVGVAEPAGLGVPEEAAGAPFKNRLNSALTFDTLIEGTANRMGRAAALHVSSSLGQL
YNPLFIYGGVGLGKTHLMHAIGNKLLADNPAAKVLYIHAEQFVSDVVKAYQRKTFDEFKERYHSLDLLLIDDVQFFANKD
RTQEEFFNAFEALLTKKSHIVMTSDTYPKGLTDIHERLVSRFDSGLTVAIEPPELEMRVAILIRKAEAEGTVMPEEVAFF
VAKNVRSNVRELEGALRKILAYSRFNLKEISIQLAREALRDLLSIQNRQISVENIQKTVADYYKIKVADMYSKKRPASIA
RPRQIAMYLAKELTQKSLPEIGELFGGRDHTTVLHAVRKMSAERQQMTELNQQLHVLEQTLKG

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=475, Percent_Identity=49.0526315789474, Blast_Score=458, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 52055; Mature: 51923

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVSIPSLSHDLWQNCVDHLAQELPEQQFNTWIRPLVVHVAADLSKVTIQVGNRFKLDW
CCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEHHH
IRAQYAARISALLEKISGHRISLELALAPREPAAKSASLTRSFEGVGVAEPAGLGVPEEA
HHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHH
AGAPFKNRLNSALTFDTLIEGTANRMGRAAALHVSSSLGQLYNPLFIYGGVGLGKTHLMH
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHH
AIGNKLLADNPAAKVLYIHAEQFVSDVVKAYQRKTFDEFKERYHSLDLLLIDDVQFFANK
HHCCHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHCC
DRTQEEFFNAFEALLTKKSHIVMTSDTYPKGLTDIHERLVSRFDSGLTVAIEPPELEMRV
CCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEECCCCHHEEE
AILIRKAEAEGTVMPEEVAFFVAKNVRSNVRELEGALRKILAYSRFNLKEISIQLAREAL
EHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
RDLLSIQNRQISVENIQKTVADYYKIKVADMYSKKRPASIARPRQIAMYLAKELTQKSLP
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCH
EIGELFGGRDHTTVLHAVRKMSAERQQMTELNQQLHVLEQTLKG
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEVSIPSLSHDLWQNCVDHLAQELPEQQFNTWIRPLVVHVAADLSKVTIQVGNRFKLDW
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEHHH
IRAQYAARISALLEKISGHRISLELALAPREPAAKSASLTRSFEGVGVAEPAGLGVPEEA
HHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHH
AGAPFKNRLNSALTFDTLIEGTANRMGRAAALHVSSSLGQLYNPLFIYGGVGLGKTHLMH
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHH
AIGNKLLADNPAAKVLYIHAEQFVSDVVKAYQRKTFDEFKERYHSLDLLLIDDVQFFANK
HHCCHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHCC
DRTQEEFFNAFEALLTKKSHIVMTSDTYPKGLTDIHERLVSRFDSGLTVAIEPPELEMRV
CCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEECCCCHHEEE
AILIRKAEAEGTVMPEEVAFFVAKNVRSNVRELEGALRKILAYSRFNLKEISIQLAREAL
EHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
RDLLSIQNRQISVENIQKTVADYYKIKVADMYSKKRPASIARPRQIAMYLAKELTQKSLP
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCH
EIGELFGGRDHTTVLHAVRKMSAERQQMTELNQQLHVLEQTLKG
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA