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The map label for this gene is hemE [H]

Identifier: 91785729

GI number: 91785729

Start: 4799885

End: 4800985

Strand: Reverse

Name: hemE [H]

Synonym: Bxe_A0044

Alternate gene names: 91785729

Gene position: 4800985-4799885 (Counterclockwise)

Preceding gene: 91785731

Following gene: 91785728

Centisome position: 98.06

GC content: 65.03

Gene sequence:

>1101_bases
GTGGCCCATAAACTTCTGAACGATACTTTCCTGCGCGCGCTGCTGCGCCAGCCGACCGACTACACGCCGATCTGGCTGAT
GCGGCAAGCTGGCCGCTACCTGCCGGAATACAACGCCACGCGCGCTCGCGCGGGCAGCTTCCTGGGTCTGGCAAAAAACC
CGGCGTTCGCAACGGAAGTCACGCTGCAACCGCTGGAGCGCTATCCGCTCGACGCCGCGATCCTGTTCTCCGACATCCTG
ACCGTGCCCGACGCAATGGGTCTGGGCCTCGAGTTCGTGACTGGCGAGGGCCCCAAATTCGCGCGCCCGGTGCGCACGGA
AGACGACGTCGCGCGCCTCGCGGTGCCGGACATCGACGCCACGCTGCGCTACGTGACCGACGCCGTGCGCGAAATTCGCA
CCGCGCTTACCGACGCGCAGGGCCGCCAGCGCGTGCCGCTGATCGGTTTTTCGGGCAGTCCGTGGACGCTCGCGTGCTAC
ATGGTCGAAGGCGGCGGTTCGGCGGACTTCCGCACGGTCAAGTCGATGTTGTATGCGCGTCCGGACCTCATGCATCGCAT
TCTCGACGTCAACGCGCGCGCGGTTGCGGCCTACCTGAACGCGCAGATCGAAGCCGGCGCGCAAGCTGTGATGATTTTCG
ACACATGGGGTGGGGCGCTGGCGGACGGCGTCTATCAACGCTTTTCGTTGCACTACATCCAGCAGGTGGTGAGTCAGCTA
AAGCGCGACCATGACGGCGAAAAAGTGCCGGTGATCACTTTCACCAAAGGCGGCGGCCTGTGGCTCGACGAGATCGCCGA
AACCGGCGTGGATGCGGTCGGCCTCGACTGGACCGTGAACCTGAGCAAGGCCCGGGAGCGCGTGGGCGGCAAGGTGGCGC
TGCAAGGCAATATCGATCCGTCGGTCCTGTTTGCCCCGCCGGCTGCGATCCGCATGGAAGCGCGCGCCGTACTGGACAGT
TTCGGTAACCATCCGGGCCATGTGTTCAACCTCGGCCACGGCATTTCGCAGTTCACGCCGCCGGAGCACGTCGCCGAACT
GGTGGACGAAGTGCATCGTCATAGCCGGGCAATTCGCAGCGGCGCACATGCACCGGCATGA

Upstream 100 bases:

>100_bases
GCCGCCTTGAGCAAAGCACGCAAGAGTTATTGGCCGCATCGGGCACGATGCGGCGAGCCTGGTCCGGTAAAATGCCCCTT
TGCCCTGAGTCGTACGCAAC

Downstream 100 bases:

>100_bases
GGCCGTAATCGTTACCATTTTTGTTGCGACGCAGCGAACTGGGCTCTCGGTCTAAGGGAAAATATGCAGTCAACGGGCCG
TCAGATGGCGGTCCTGAGAA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MAHKLLNDTFLRALLRQPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKNPAFATEVTLQPLERYPLDAAILFSDIL
TVPDAMGLGLEFVTGEGPKFARPVRTEDDVARLAVPDIDATLRYVTDAVREIRTALTDAQGRQRVPLIGFSGSPWTLACY
MVEGGGSADFRTVKSMLYARPDLMHRILDVNARAVAAYLNAQIEAGAQAVMIFDTWGGALADGVYQRFSLHYIQQVVSQL
KRDHDGEKVPVITFTKGGGLWLDEIAETGVDAVGLDWTVNLSKARERVGGKVALQGNIDPSVLFAPPAAIRMEARAVLDS
FGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRSGAHAPA

Sequences:

>Translated_366_residues
MAHKLLNDTFLRALLRQPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKNPAFATEVTLQPLERYPLDAAILFSDIL
TVPDAMGLGLEFVTGEGPKFARPVRTEDDVARLAVPDIDATLRYVTDAVREIRTALTDAQGRQRVPLIGFSGSPWTLACY
MVEGGGSADFRTVKSMLYARPDLMHRILDVNARAVAAYLNAQIEAGAQAVMIFDTWGGALADGVYQRFSLHYIQQVVSQL
KRDHDGEKVPVITFTKGGGLWLDEIAETGVDAVGLDWTVNLSKARERVGGKVALQGNIDPSVLFAPPAAIRMEARAVLDS
FGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRSGAHAPA
>Mature_365_residues
AHKLLNDTFLRALLRQPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKNPAFATEVTLQPLERYPLDAAILFSDILT
VPDAMGLGLEFVTGEGPKFARPVRTEDDVARLAVPDIDATLRYVTDAVREIRTALTDAQGRQRVPLIGFSGSPWTLACYM
VEGGGSADFRTVKSMLYARPDLMHRILDVNARAVAAYLNAQIEAGAQAVMIFDTWGGALADGVYQRFSLHYIQQVVSQLK
RDHDGEKVPVITFTKGGGLWLDEIAETGVDAVGLDWTVNLSKARERVGGKVALQGNIDPSVLFAPPAAIRMEARAVLDSF
GNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRSGAHAPA

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=361, Percent_Identity=47.9224376731302, Blast_Score=324, Evalue=9e-89,
Organism=Escherichia coli, GI2367337, Length=352, Percent_Identity=62.7840909090909, Blast_Score=452, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6320252, Length=359, Percent_Identity=36.2116991643454, Blast_Score=246, Evalue=4e-66,
Organism=Drosophila melanogaster, GI19921920, Length=352, Percent_Identity=38.6363636363636, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI221330099, Length=352, Percent_Identity=38.6363636363636, Blast_Score=250, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 40018; Mature: 39887

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHKLLNDTFLRALLRQPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKNPAFATEV
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCEEEECCCCCCEEHH
TLQPLERYPLDAAILFSDILTVPDAMGLGLEFVTGEGPKFARPVRTEDDVARLAVPDIDA
HHHHHHHCCCHHHHHHHHHHHCCHHHCCCEEEEECCCCCCCCCCCCCCCHHHHCCCCCHH
TLRYVTDAVREIRTALTDAQGRQRVPLIGFSGSPWTLACYMVEGGGSADFRTVKSMLYAR
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHC
PDLMHRILDVNARAVAAYLNAQIEAGAQAVMIFDTWGGALADGVYQRFSLHYIQQVVSQL
HHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
KRDHDGEKVPVITFTKGGGLWLDEIAETGVDAVGLDWTVNLSKARERVGGKVALQGNIDP
HHCCCCCEEEEEEEECCCCCCHHHHHHCCCCEECCEEEEEHHHHHHHHCCEEEEECCCCC
SVLFAPPAAIRMEARAVLDSFGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRS
CEEECCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GAHAPA
CCCCCC
>Mature Secondary Structure 
AHKLLNDTFLRALLRQPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKNPAFATEV
CCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCEEEECCCCCCEEHH
TLQPLERYPLDAAILFSDILTVPDAMGLGLEFVTGEGPKFARPVRTEDDVARLAVPDIDA
HHHHHHHCCCHHHHHHHHHHHCCHHHCCCEEEEECCCCCCCCCCCCCCCHHHHCCCCCHH
TLRYVTDAVREIRTALTDAQGRQRVPLIGFSGSPWTLACYMVEGGGSADFRTVKSMLYAR
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHC
PDLMHRILDVNARAVAAYLNAQIEAGAQAVMIFDTWGGALADGVYQRFSLHYIQQVVSQL
HHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
KRDHDGEKVPVITFTKGGGLWLDEIAETGVDAVGLDWTVNLSKARERVGGKVALQGNIDP
HHCCCCCEEEEEEEECCCCCCHHHHHHCCCCEECCEEEEEHHHHHHHHCCEEEEECCCCC
SVLFAPPAAIRMEARAVLDSFGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRS
CEEECCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GAHAPA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA