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The map label for this gene is mutT [H]

Identifier: 91785281

GI number: 91785281

Start: 4327734

End: 4328162

Strand: Reverse

Name: mutT [H]

Synonym: Bxe_A0498

Alternate gene names: 91785281

Gene position: 4328162-4327734 (Counterclockwise)

Preceding gene: 91785282

Following gene: 91785280

Centisome position: 88.4

GC content: 64.34

Gene sequence:

>429_bases
ATGAGCGACGACACGCAGAAGAACGCCGCCGGCCGCAAGGTGACGGAAGTTGCCGTCGGCGTGCTGGTTCAGCCCGATGG
GCGCTATCTGCTCGCGCAGCGCCCCTCCGGCAAGCCGTACGAAGGGTACTGGGAGTTTCCGGGCGGCAAGCTGGAAGCGG
GCGAGTCGGTCGAGGCCGCGCTCGCTCGTGAACTGCACGAGGAACTGGGTATCGACGTTAAGGTGAGCCACCTCTGGCAT
ACGCTCGAACACGACTACCCGCACGCCTATGTGCGGCTTTTTTTCTGCAAGGTGACGCAGTGGTCCGGCGAGCCGCACGG
CCGCGAAGGTCAGGCTTTTGTCTGGCAGACGCTGCCCGCGAATGTCGAGCCGCTGTTGCCGGCGACCATTCCAGTGCTGG
AATGGCTCGCGGCCGAGAAGAAGAACTGA

Upstream 100 bases:

>100_bases
CGCTGGTGTGGGCGCTGGAGCGCGGCTCGCGTTCAGGACGTGTCGCGTGGCAGTTCGCGCGCGACTGGTCCGGCCGCAAG
ACCTCAGCGTGAGCCTCGGC

Downstream 100 bases:

>100_bases
AACGAAAGAAGACGGGCGCGCGGCAACGGGCGCTGCGTTAGCAGCACCAGCCCGCGCGACCCGGACAGCGGGCCGCGCTC
AGTGCGGCGTGTAATCCCCG

Product: putative mutator protein(7,8-dihydro-8- oxoguanine-triphosphatase), MutT

Products: 8-Oxo-Dgmp; Pyrophosphate. [C]

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 142; Mature: 141

Protein sequence:

>142_residues
MSDDTQKNAAGRKVTEVAVGVLVQPDGRYLLAQRPSGKPYEGYWEFPGGKLEAGESVEAALARELHEELGIDVKVSHLWH
TLEHDYPHAYVRLFFCKVTQWSGEPHGREGQAFVWQTLPANVEPLLPATIPVLEWLAAEKKN

Sequences:

>Translated_142_residues
MSDDTQKNAAGRKVTEVAVGVLVQPDGRYLLAQRPSGKPYEGYWEFPGGKLEAGESVEAALARELHEELGIDVKVSHLWH
TLEHDYPHAYVRLFFCKVTQWSGEPHGREGQAFVWQTLPANVEPLLPATIPVLEWLAAEKKN
>Mature_141_residues
SDDTQKNAAGRKVTEVAVGVLVQPDGRYLLAQRPSGKPYEGYWEFPGGKLEAGESVEAALARELHEELGIDVKVSHLWHT
LEHDYPHAYVRLFFCKVTQWSGEPHGREGQAFVWQTLPANVEPLLPATIPVLEWLAAEKKN

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1786288, Length=122, Percent_Identity=36.8852459016393, Blast_Score=85, Evalue=2e-18,
Organism=Escherichia coli, GI1788056, Length=127, Percent_Identity=39.3700787401575, Blast_Score=78, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 15902; Mature: 15771

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDTQKNAAGRKVTEVAVGVLVQPDGRYLLAQRPSGKPYEGYWEFPGGKLEAGESVEAA
CCCCCCCCCCCCCCEEEEEEEEECCCCCEEEEECCCCCCCCCEEECCCCCCCCCCHHHHH
LARELHEELGIDVKVSHLWHTLEHDYPHAYVRLFFCKVTQWSGEPHGREGQAFVWQTLPA
HHHHHHHHHCCCEEHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCC
NVEPLLPATIPVLEWLAAEKKN
CCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDDTQKNAAGRKVTEVAVGVLVQPDGRYLLAQRPSGKPYEGYWEFPGGKLEAGESVEAA
CCCCCCCCCCCCCEEEEEEEEECCCCCEEEEECCCCCCCCCEEECCCCCCCCCCHHHHH
LARELHEELGIDVKVSHLWHTLEHDYPHAYVRLFFCKVTQWSGEPHGREGQAFVWQTLPA
HHHHHHHHHCCCEEHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCC
NVEPLLPATIPVLEWLAAEKKN
CCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 8-Oxo-Dgtp; H2O [C]

Specific reaction: 8-Oxo-Dgtp + H2O = 8-Oxo-Dgmp + Pyrophosphate. [C]

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]