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The map label for this gene is maeB [H]

Identifier: 91785222

GI number: 91785222

Start: 4268106

End: 4270445

Strand: Reverse

Name: maeB [H]

Synonym: Bxe_A0557

Alternate gene names: 91785222

Gene position: 4270445-4268106 (Counterclockwise)

Preceding gene: 91785227

Following gene: 91785221

Centisome position: 87.23

GC content: 64.87

Gene sequence:

>2340_bases
ATGCCGTCGAACGTCTATTCTAATCTGCCCTTCGAAGCCCGCCTTATGTCGACTCCCGTCAATAGCAAACTCCGCGAAGC
CGCCCTCGATTACCACGAGTTCCCCACCCCCGGGAAGATCGCGATCGCCCCGACCAAGCAGATGATCAACCAGCGCGACC
TGGCGCTGGCGTACTCGCCGGGCGTGGCGTTCGCGTGCGAGGAAATCGTCGAAAACCCGCTGAACGCCGCGCGTTTCACC
GCGCGCAGCAACCTGGTCGGCGTGGTCACCAACGGCACCGCGGTGCTGGGTCTGGGCAACATCGGGCCGCTCGCCTCGAA
GCCGGTCATGGAAGGCAAGGCCGTGCTGTTCAAGAAGTTCGCCGGCATCGACGTGTTCGATATCGAGCTGAACGAGTCCG
ACCCGCACAAGCTGGTCGACGTGATCGCGGCGCTGGAGCCGACCTTCGGCGGCATCAACCTCGAAGACATCAAGGCGCCG
GACTGTTTCATCGTCGAGCGCGAATGCCGCAAGCGCATGAAGATTCCGGTCTTCCACGACGACCAGCACGGCACCGCGAT
CGTCGTCGCGGCGGCCATCACCAATGGTCTGAAGGTGGTCGGCAAGGACATCAGGGAGGTCAAGCTGGTGTCCTCCGGCG
CGGGCGCGGCGGCGCTGGCCTGTCTGGACCTGCTGGTCGACATCGGCCTGCCGCTGGAGAACATCACCGTCACCGATCTG
GCCGGCGTGGTCTACAAGGGCCGTGTCGAACTGATGGACCCGGACAAGGAGCGCTTCGCGCGTGAAACCGACGCCCGCAC
GCTTGCCGAAGCCATCGGCGGCGCGGACGTTTTTCTCGGCCTCTCCGCCGGCGGCGTGCTCAAGCAGGACATGGTCAAAC
AGATGGCGGACAAGCCGCTGATTCTGGCGCTGGCCAACCCGACACCGGAAATCCTGCCGGAACTGGCGCTCGAAGTGCGC
CCGGATGCGGTGCTGTGCACGGGCCGCACCGACTATCCGAACCAGGTGAACAACGTGCTGGTGTTCCCGTTCCTGTTCCG
CGGCGCGCTGGACGCGGGCGCGACCACGGTGACGCGGGAAATGGAAATCGCGGCGGTCAATGCGATCGCCGAACTGGCGC
GCCAGGAACAGAGCGATATCGTCGCGACGGCGTATGGCATTCAGGATCTCTCGTTCGGCCCGGAGTATCTGATTCCGAAG
CCGTTCGATCCGCGCCTGATCGTCAAGGTCGCGCCGGCGGTGGCGCAGGCCGCGATGGATTCGGGCGTCGCCGAGCGGCC
GATCGAGGACATGGACGCGTACGAACAGCATCTGCAGCAGTTCGTGTATCACAGCGGCACGACCATGAAGCCGATTTTCC
AGCTGGCGCGCAGCGTCGAGCCGGAGAAGAAGCGCATCGTGTTCGCGGAAGGCGAGGAGGAGCGCGTGCTGCGCGCCATG
CAGATCATCGTCGACGAGAAGCTGGCCAAACCGATCCTGATCGGCCGCCCGGCGGTGATCGAGCAGCGCATTGCGCGCTA
CGGTCTGCGGCTGGTCGCGGGGCAGGACTACACGGTGGTGAACACCGACCACGACGAGCGTTACCGCGACTTCTGGCAGG
AGTATCACCGGATGATGTCGCGCAAGGGCATCAGCGCGCAGATGGCGAAGCTCGAAATGCGCCGCCGCACCACGCTGATC
GGCGCGATGCTGGTGGAAAAGGGCGAGGCGGACGGCATGATCTGCGGCACGGTGTCGACCACGCACCGGCATCTGCACTT
CATCGATCAGGTGATCGGCAGGAAGGCGGGCGCGAAAGTGTACGCGGCGATGAACGCGCTGGTGTTGCCGAACCGCCAGA
TCTTCCTGGTGGACACGCACGTGAACGTGGATCCGACGCCGGAGCAACTGGCGGAAATCACGATCATGGCGGCCGAAGAA
GTGCGCCGTTTCGGGATCGAGCCGAAGGTGGCGCTGCTGTCGCATTCGAACTTCGGCACGAGCAACGCGCCGACCGCGCA
GAAGATGCGCGACACGCTGGCGATTTTGCGCGAGCGCGCGCCGGACCTGCAGGTGGACGGCGAAATGCACGGTGACATCG
CACTCGACGCGAACCTGCGCCGCGAAGTGATGCCCGACTCGACGCTCGAAGGCGATGCGAACCTGCTGGTGCTGCCGAAC
ATCGACGCGGCGAACATCTCGTACAACCTGCTGAAGACCGCCGCGGGCAACAACATCGCGATCGGTCCGATACTGCTGGG
CGCAGCCAGGCCGGTGCACGTGCTGACGGCTTCGGCGACGGTGCGCCGGATCGTCAATATGACGGCGTTGCTGGTGGCGG
ATGTGATCGCGGCGCGTTAA

Upstream 100 bases:

>100_bases
CCGCGTTCGGTCCCACGCGCGCCGCGTCAAGCTTTCGCTATGTTTAAGTCGCGGCAGTTGTACCCGTATTGAAGGAATCG
GGCTGGCAATTGGGGCTACA

Downstream 100 bases:

>100_bases
TCCGCGATCCACACGAAGCATGGCGCGGGAACGACCGCGCCATGCAAAAAAAAGCGCGCCCGCAACGGGCACGCCTCAGG
GTGAACAGGGGATCCCTCAC

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 779; Mature: 778

Protein sequence:

>779_residues
MPSNVYSNLPFEARLMSTPVNSKLREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSPGVAFACEEIVENPLNAARFT
ARSNLVGVVTNGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDPHKLVDVIAALEPTFGGINLEDIKAP
DCFIVERECRKRMKIPVFHDDQHGTAIVVAAAITNGLKVVGKDIREVKLVSSGAGAAALACLDLLVDIGLPLENITVTDL
AGVVYKGRVELMDPDKERFARETDARTLAEAIGGADVFLGLSAGGVLKQDMVKQMADKPLILALANPTPEILPELALEVR
PDAVLCTGRTDYPNQVNNVLVFPFLFRGALDAGATTVTREMEIAAVNAIAELARQEQSDIVATAYGIQDLSFGPEYLIPK
PFDPRLIVKVAPAVAQAAMDSGVAERPIEDMDAYEQHLQQFVYHSGTTMKPIFQLARSVEPEKKRIVFAEGEEERVLRAM
QIIVDEKLAKPILIGRPAVIEQRIARYGLRLVAGQDYTVVNTDHDERYRDFWQEYHRMMSRKGISAQMAKLEMRRRTTLI
GAMLVEKGEADGMICGTVSTTHRHLHFIDQVIGRKAGAKVYAAMNALVLPNRQIFLVDTHVNVDPTPEQLAEITIMAAEE
VRRFGIEPKVALLSHSNFGTSNAPTAQKMRDTLAILRERAPDLQVDGEMHGDIALDANLRREVMPDSTLEGDANLLVLPN
IDAANISYNLLKTAAGNNIAIGPILLGAARPVHVLTASATVRRIVNMTALLVADVIAAR

Sequences:

>Translated_779_residues
MPSNVYSNLPFEARLMSTPVNSKLREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSPGVAFACEEIVENPLNAARFT
ARSNLVGVVTNGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDPHKLVDVIAALEPTFGGINLEDIKAP
DCFIVERECRKRMKIPVFHDDQHGTAIVVAAAITNGLKVVGKDIREVKLVSSGAGAAALACLDLLVDIGLPLENITVTDL
AGVVYKGRVELMDPDKERFARETDARTLAEAIGGADVFLGLSAGGVLKQDMVKQMADKPLILALANPTPEILPELALEVR
PDAVLCTGRTDYPNQVNNVLVFPFLFRGALDAGATTVTREMEIAAVNAIAELARQEQSDIVATAYGIQDLSFGPEYLIPK
PFDPRLIVKVAPAVAQAAMDSGVAERPIEDMDAYEQHLQQFVYHSGTTMKPIFQLARSVEPEKKRIVFAEGEEERVLRAM
QIIVDEKLAKPILIGRPAVIEQRIARYGLRLVAGQDYTVVNTDHDERYRDFWQEYHRMMSRKGISAQMAKLEMRRRTTLI
GAMLVEKGEADGMICGTVSTTHRHLHFIDQVIGRKAGAKVYAAMNALVLPNRQIFLVDTHVNVDPTPEQLAEITIMAAEE
VRRFGIEPKVALLSHSNFGTSNAPTAQKMRDTLAILRERAPDLQVDGEMHGDIALDANLRREVMPDSTLEGDANLLVLPN
IDAANISYNLLKTAAGNNIAIGPILLGAARPVHVLTASATVRRIVNMTALLVADVIAAR
>Mature_778_residues
PSNVYSNLPFEARLMSTPVNSKLREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSPGVAFACEEIVENPLNAARFTA
RSNLVGVVTNGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIELNESDPHKLVDVIAALEPTFGGINLEDIKAPD
CFIVERECRKRMKIPVFHDDQHGTAIVVAAAITNGLKVVGKDIREVKLVSSGAGAAALACLDLLVDIGLPLENITVTDLA
GVVYKGRVELMDPDKERFARETDARTLAEAIGGADVFLGLSAGGVLKQDMVKQMADKPLILALANPTPEILPELALEVRP
DAVLCTGRTDYPNQVNNVLVFPFLFRGALDAGATTVTREMEIAAVNAIAELARQEQSDIVATAYGIQDLSFGPEYLIPKP
FDPRLIVKVAPAVAQAAMDSGVAERPIEDMDAYEQHLQQFVYHSGTTMKPIFQLARSVEPEKKRIVFAEGEEERVLRAMQ
IIVDEKLAKPILIGRPAVIEQRIARYGLRLVAGQDYTVVNTDHDERYRDFWQEYHRMMSRKGISAQMAKLEMRRRTTLIG
AMLVEKGEADGMICGTVSTTHRHLHFIDQVIGRKAGAKVYAAMNALVLPNRQIFLVDTHVNVDPTPEQLAEITIMAAEEV
RRFGIEPKVALLSHSNFGTSNAPTAQKMRDTLAILRERAPDLQVDGEMHGDIALDANLRREVMPDSTLEGDANLLVLPNI
DAANISYNLLKTAAGNNIAIGPILLGAARPVHVLTASATVRRIVNMTALLVADVIAAR

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=343, Percent_Identity=26.530612244898, Blast_Score=84, Evalue=7e-16,
Organism=Homo sapiens, GI62420882, Length=352, Percent_Identity=27.5568181818182, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI62420880, Length=352, Percent_Identity=27.5568181818182, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI239049447, Length=352, Percent_Identity=27.5568181818182, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI4505145, Length=368, Percent_Identity=28.2608695652174, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI270265879, Length=368, Percent_Identity=28.2608695652174, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1788806, Length=756, Percent_Identity=61.1111111111111, Blast_Score=958, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=319, Percent_Identity=32.2884012539185, Blast_Score=161, Evalue=2e-40,
Organism=Escherichia coli, GI1788800, Length=315, Percent_Identity=33.015873015873, Blast_Score=149, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17537199, Length=411, Percent_Identity=24.330900243309, Blast_Score=70, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322823, Length=239, Percent_Identity=27.6150627615063, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281362672, Length=474, Percent_Identity=26.1603375527426, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21356279, Length=474, Percent_Identity=26.1603375527426, Blast_Score=87, Evalue=6e-17,
Organism=Drosophila melanogaster, GI281362674, Length=474, Percent_Identity=26.1603375527426, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24646388, Length=349, Percent_Identity=28.080229226361, Blast_Score=76, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646386, Length=349, Percent_Identity=28.080229226361, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI78707242, Length=415, Percent_Identity=24.8192771084337, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI78707238, Length=415, Percent_Identity=24.8192771084337, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI78707240, Length=349, Percent_Identity=25.7879656160458, Blast_Score=71, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 84844; Mature: 84713

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSNVYSNLPFEARLMSTPVNSKLREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSP
CCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCHHHHCCCCCEEEEECC
GVAFACEEIVENPLNAARFTARSNLVGVVTNGTAVLGLGNIGPLASKPVMEGKAVLFKKF
CHHHHHHHHHHCCCHHHHHHHCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHH
AGIDVFDIELNESDPHKLVDVIAALEPTFGGINLEDIKAPDCFIVERECRKRMKIPVFHD
CCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEHHHHHCCCCCEEEC
DQHGTAIVVAAAITNGLKVVGKDIREVKLVSSGAGAAALACLDLLVDIGLPLENITVTDL
CCCCCEEEEEEHHHCCHHHHCCCHHHEEEECCCCCHHHHHHHHHHHHCCCCCCCEEHHHH
AGVVYKGRVELMDPDKERFARETDARTLAEAIGGADVFLGLSAGGVLKQDMVKQMADKPL
HHHHEECEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCE
ILALANPTPEILPELALEVRPDAVLCTGRTDYPNQVNNVLVFPFLFRGALDAGATTVTRE
EEEECCCCHHHHHHHHHEECCCEEEEECCCCCCCHHCCEEEEHHHHHHHHCCCCHHEHHH
MEIAAVNAIAELARQEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVKVAPAVAQAAMD
HHHHHHHHHHHHHHHHHCCEEEEEECCEECCCCCCCCCCCCCCCEEEEEECHHHHHHHHH
SGVAERPIEDMDAYEQHLQQFVYHSGTTMKPIFQLARSVEPEKKRIVFAEGEEERVLRAM
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHEEEEECCCHHHHHHHH
QIIVDEKLAKPILIGRPAVIEQRIARYGLRLVAGQDYTVVNTDHDERYRDFWQEYHRMMS
HHHHHHHHCCCEEECCCHHHHHHHHHCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHH
RKGISAQMAKLEMRRRTTLIGAMLVEKGEADGMICGTVSTTHRHLHFIDQVIGRKAGAKV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCC
YAAMNALVLPNRQIFLVDTHVNVDPTPEQLAEITIMAAEEVRRFGIEPKVALLSHSNFGT
EEHHHEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
SNAPTAQKMRDTLAILRERAPDLQVDGEMHGDIALDANLRREVMPDSTLEGDANLLVLPN
CCCCHHHHHHHHHHHHHHCCCCCEECCCCCCCEEECCCCHHHCCCCCCCCCCCCEEEECC
IDAANISYNLLKTAAGNNIAIGPILLGAARPVHVLTASATVRRIVNMTALLVADVIAAR
CCCCCCCHHHHHHCCCCCEEECCEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PSNVYSNLPFEARLMSTPVNSKLREAALDYHEFPTPGKIAIAPTKQMINQRDLALAYSP
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCHHHHCCCCCEEEEECC
GVAFACEEIVENPLNAARFTARSNLVGVVTNGTAVLGLGNIGPLASKPVMEGKAVLFKKF
CHHHHHHHHHHCCCHHHHHHHCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHH
AGIDVFDIELNESDPHKLVDVIAALEPTFGGINLEDIKAPDCFIVERECRKRMKIPVFHD
CCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEHHHHHCCCCCEEEC
DQHGTAIVVAAAITNGLKVVGKDIREVKLVSSGAGAAALACLDLLVDIGLPLENITVTDL
CCCCCEEEEEEHHHCCHHHHCCCHHHEEEECCCCCHHHHHHHHHHHHCCCCCCCEEHHHH
AGVVYKGRVELMDPDKERFARETDARTLAEAIGGADVFLGLSAGGVLKQDMVKQMADKPL
HHHHEECEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCE
ILALANPTPEILPELALEVRPDAVLCTGRTDYPNQVNNVLVFPFLFRGALDAGATTVTRE
EEEECCCCHHHHHHHHHEECCCEEEEECCCCCCCHHCCEEEEHHHHHHHHCCCCHHEHHH
MEIAAVNAIAELARQEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVKVAPAVAQAAMD
HHHHHHHHHHHHHHHHHCCEEEEEECCEECCCCCCCCCCCCCCCEEEEEECHHHHHHHHH
SGVAERPIEDMDAYEQHLQQFVYHSGTTMKPIFQLARSVEPEKKRIVFAEGEEERVLRAM
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHEEEEECCCHHHHHHHH
QIIVDEKLAKPILIGRPAVIEQRIARYGLRLVAGQDYTVVNTDHDERYRDFWQEYHRMMS
HHHHHHHHCCCEEECCCHHHHHHHHHCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHH
RKGISAQMAKLEMRRRTTLIGAMLVEKGEADGMICGTVSTTHRHLHFIDQVIGRKAGAKV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCC
YAAMNALVLPNRQIFLVDTHVNVDPTPEQLAEITIMAAEEVRRFGIEPKVALLSHSNFGT
EEHHHEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
SNAPTAQKMRDTLAILRERAPDLQVDGEMHGDIALDANLRREVMPDSTLEGDANLLVLPN
CCCCHHHHHHHHHHHHHHCCCCCEECCCCCCCEEECCCCHHHCCCCCCCCCCCCEEEECC
IDAANISYNLLKTAAGNNIAIGPILLGAARPVHVLTASATVRRIVNMTALLVADVIAAR
CCCCCCCHHHHHHCCCCCEEECCEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]