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The map label for this gene is nadC [H]

Identifier: 91784966

GI number: 91784966

Start: 3976384

End: 3977283

Strand: Reverse

Name: nadC [H]

Synonym: Bxe_A0814

Alternate gene names: 91784966

Gene position: 3977283-3976384 (Counterclockwise)

Preceding gene: 91784967

Following gene: 91784961

Centisome position: 81.24

GC content: 65.11

Gene sequence:

>900_bases
ATGGGGGCGGTTGAGCGCAGTCAGGTCGAGGCGGTGTCGCCGCTGTTCGCTGAAATTCAGGCACAGTACGGCGCGGCATT
CGAAGCCGCGTTGGCGCGCAACGTCGCCGACGCACTGGCCGAAGACGTCGGCACCGGTGACCAGACGGGCCGCCTGGTTC
CAGCGGATGACGTACGCGGCGCGCGCATCATCGTGCGTGAGGATGCGGTGCTGTGCGGGGTGCCGTGGTTCAACGCGGTG
ATGCGCCAGGTCGATCCGCGTATCGAGGTCCAGTGGCGCTATCGTGAAGGCGACCGGATGAAGGCCGACACAACGGTCTG
CGAACTGCGCGGACCGGTGCGCGCCTTGTTGACGGCGGAACGCAACGCGCTGAACTTCCTGCAATTGCTGTCGGGCGTGG
CGAGCGCGACGCGCCATTATGTCGATGCCGTCGCTCATACGCGAACGCGCATTCTCGATACGCGCAAAACCTTGCCAGGT
CTGCGGCTCGCGCAGAAGTACGCGGTGCGCGTGGGCGGTGGGGCGAACCAGCGTCTCGCGCTGTACGACGGTATTCTCAT
CAAGGAAAACCACATCGCCGCGGCTGGCGGGGTGGGCGCGGCTATGAACGCGGCGCTGGCGCTGAATGCGGGCGTGCCGA
TCCAGGTCGAAGTCGAGACGCTCGAGGAACTGGAAATTGCGCTGGCTCATCGCGCGCAATCCGTTCTGCTCGACAATTTT
TCGTTCGAGGCCATGCGCGAAGCGGTGCGCATCACAGCGGGGCGGGCGGTGCTGGAGGTGTCGGGCGGTGTGAACTTCGA
TACGGTGCGCACGATCGCCGAAACCGGCGTCGATCGTGTGTCGATCGGCGCGCTGACCAAAGACGTGCGCGCAACAGATT
ACTCGATGCGGATCGTCTGA

Upstream 100 bases:

>100_bases
ACCGGATGCTGGATTTCGCGGCGCGTCACAAGAAGCGCGTGCAGGCGAGCGGCGATCTGGCGCGCGACGCGCAACTGTAT
TCGAACGTGGGAGCAGCGTG

Downstream 100 bases:

>100_bases
CGTTCGAGCGCAACCGGTCGCGGTCGATAGGAAAAGGGCTGTCGCCGGGATGATCCGGCGATGGCCCTTTTCGTTTCAGC
TCGTCCCGATCACACGTTGC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MGAVERSQVEAVSPLFAEIQAQYGAAFEAALARNVADALAEDVGTGDQTGRLVPADDVRGARIIVREDAVLCGVPWFNAV
MRQVDPRIEVQWRYREGDRMKADTTVCELRGPVRALLTAERNALNFLQLLSGVASATRHYVDAVAHTRTRILDTRKTLPG
LRLAQKYAVRVGGGANQRLALYDGILIKENHIAAAGGVGAAMNAALALNAGVPIQVEVETLEELEIALAHRAQSVLLDNF
SFEAMREAVRITAGRAVLEVSGGVNFDTVRTIAETGVDRVSIGALTKDVRATDYSMRIV

Sequences:

>Translated_299_residues
MGAVERSQVEAVSPLFAEIQAQYGAAFEAALARNVADALAEDVGTGDQTGRLVPADDVRGARIIVREDAVLCGVPWFNAV
MRQVDPRIEVQWRYREGDRMKADTTVCELRGPVRALLTAERNALNFLQLLSGVASATRHYVDAVAHTRTRILDTRKTLPG
LRLAQKYAVRVGGGANQRLALYDGILIKENHIAAAGGVGAAMNAALALNAGVPIQVEVETLEELEIALAHRAQSVLLDNF
SFEAMREAVRITAGRAVLEVSGGVNFDTVRTIAETGVDRVSIGALTKDVRATDYSMRIV
>Mature_298_residues
GAVERSQVEAVSPLFAEIQAQYGAAFEAALARNVADALAEDVGTGDQTGRLVPADDVRGARIIVREDAVLCGVPWFNAVM
RQVDPRIEVQWRYREGDRMKADTTVCELRGPVRALLTAERNALNFLQLLSGVASATRHYVDAVAHTRTRILDTRKTLPGL
RLAQKYAVRVGGGANQRLALYDGILIKENHIAAAGGVGAAMNAALALNAGVPIQVEVETLEELEIALAHRAQSVLLDNFS
FEAMREAVRITAGRAVLEVSGGVNFDTVRTIAETGVDRVSIGALTKDVRATDYSMRIV

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=244, Percent_Identity=35.2459016393443, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1786299, Length=270, Percent_Identity=52.2222222222222, Blast_Score=236, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6321162, Length=286, Percent_Identity=31.4685314685315, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 32217; Mature: 32086

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAVERSQVEAVSPLFAEIQAQYGAAFEAALARNVADALAEDVGTGDQTGRLVPADDVRG
CCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCC
ARIIVREDAVLCGVPWFNAVMRQVDPRIEVQWRYREGDRMKADTTVCELRGPVRALLTAE
CEEEEECCCEEECCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHCCHHHHHHHHH
RNALNFLQLLSGVASATRHYVDAVAHTRTRILDTRKTLPGLRLAQKYAVRVGGGANQRLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEECCCCCCEEE
LYDGILIKENHIAAAGGVGAAMNAALALNAGVPIQVEVETLEELEIALAHRAQSVLLDNF
EECCEEEECCCEEECCCCHHHHHHHEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCC
SFEAMREAVRITAGRAVLEVSGGVNFDTVRTIAETGVDRVSIGALTKDVRATDYSMRIV
CHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure 
GAVERSQVEAVSPLFAEIQAQYGAAFEAALARNVADALAEDVGTGDQTGRLVPADDVRG
CCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCC
ARIIVREDAVLCGVPWFNAVMRQVDPRIEVQWRYREGDRMKADTTVCELRGPVRALLTAE
CEEEEECCCEEECCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHCCHHHHHHHHH
RNALNFLQLLSGVASATRHYVDAVAHTRTRILDTRKTLPGLRLAQKYAVRVGGGANQRLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEECCCCCCEEE
LYDGILIKENHIAAAGGVGAAMNAALALNAGVPIQVEVETLEELEIALAHRAQSVLLDNF
EECCEEEECCCEEECCCCHHHHHHHEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCC
SFEAMREAVRITAGRAVLEVSGGVNFDTVRTIAETGVDRVSIGALTKDVRATDYSMRIV
CHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]