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The map label for this gene is gmk

Identifier: 91784886

GI number: 91784886

Start: 3888233

End: 3888910

Strand: Reverse

Name: gmk

Synonym: Bxe_A0905

Alternate gene names: 91784886

Gene position: 3888910-3888233 (Counterclockwise)

Preceding gene: 91784887

Following gene: 91784885

Centisome position: 79.43

GC content: 63.13

Gene sequence:

>678_bases
ATGACCGACCACCACACACGCGAAACGCCGCGCAATCCGTACGCCGGTGCTTACCCCGGCAACCTGTTCATGGTCGTCGC
GCCTTCGGGCGCGGGCAAGTCGACGCTCGTGAACGCGCTGCTCGCCGGCGACGACGCGATCCGTCTGTCGATTTCGTACA
CGACGCGCCCGCCGCGTCCGAAGGAGCTGGACGGCGAGCACTACCACTTCACCACCGTCGACGATTTCATGAAGCGTCAC
GATGCCGGCGAGTTTCTGGAAAGCGCGGAAGTGCACGGCAACTACTACGGCACCTCGCGCGTGTGGATCGAGGACCAGAT
GAAAAGCGGCCATGACGTGCTGCTCGAAATCGACTGGCAGGGTGCGCAGCAGGTGAAAAAGCAGTTTCACAACGCGGTCG
AAATCTTCATTTTGCCGCCGTCGCTCGAAGCGCTCGAAGAGCGTCTGAAGAAGCGCGGCCAGGACGAGCCGAACGTGATC
ACACGCCGGCTGCTCGCGGCCGGCAGCGAGATGGCGCACGCGGCGGAAGCGGAGTACGTGGTGATCAACGAGAACTTCGA
TCGCGCGCTCAGCGAACTGCAATGCCTGGTGGCGGCGACGCGTTCGCGCTTCGCCTCGCAATACGCGCGCCACACGCAGC
TTTTCGTGCAACTCGGCATTCATCTGCCACACGCGTAA

Upstream 100 bases:

>100_bases
CGCGAAGGAACTGGCGGATTCGTCGATGACCCTGAAGCTGCTCATCGAACAGATGCGCGAACAGGTACAGAATCTGGAAT
AAGGCTGGAGCACCACAAAA

Downstream 100 bases:

>100_bases
GCGCGGCGGTGTATCGAGCACATAAGGTAGAATAAGCAACATACTGAGAAGGAACCCAACATGGCCCGCATTACCGTCGA
AGACTGCCTCAAACAGATCC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MTDHHTRETPRNPYAGAYPGNLFMVVAPSGAGKSTLVNALLAGDDAIRLSISYTTRPPRPKELDGEHYHFTTVDDFMKRH
DAGEFLESAEVHGNYYGTSRVWIEDQMKSGHDVLLEIDWQGAQQVKKQFHNAVEIFILPPSLEALEERLKKRGQDEPNVI
TRRLLAAGSEMAHAAEAEYVVINENFDRALSELQCLVAATRSRFASQYARHTQLFVQLGIHLPHA

Sequences:

>Translated_225_residues
MTDHHTRETPRNPYAGAYPGNLFMVVAPSGAGKSTLVNALLAGDDAIRLSISYTTRPPRPKELDGEHYHFTTVDDFMKRH
DAGEFLESAEVHGNYYGTSRVWIEDQMKSGHDVLLEIDWQGAQQVKKQFHNAVEIFILPPSLEALEERLKKRGQDEPNVI
TRRLLAAGSEMAHAAEAEYVVINENFDRALSELQCLVAATRSRFASQYARHTQLFVQLGIHLPHA
>Mature_224_residues
TDHHTRETPRNPYAGAYPGNLFMVVAPSGAGKSTLVNALLAGDDAIRLSISYTTRPPRPKELDGEHYHFTTVDDFMKRHD
AGEFLESAEVHGNYYGTSRVWIEDQMKSGHDVLLEIDWQGAQQVKKQFHNAVEIFILPPSLEALEERLKKRGQDEPNVIT
RRLLAAGSEMAHAAEAEYVVINENFDRALSELQCLVAATRSRFASQYARHTQLFVQLGIHLPHA

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=175, Percent_Identity=37.7142857142857, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=37.7142857142857, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=37.7142857142857, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4505237, Length=179, Percent_Identity=28.4916201117318, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI262118259, Length=179, Percent_Identity=28.4916201117318, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI262118255, Length=179, Percent_Identity=28.4916201117318, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI262118263, Length=179, Percent_Identity=28.4916201117318, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI38570142, Length=178, Percent_Identity=28.0898876404494, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI21361598, Length=190, Percent_Identity=24.2105263157895, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI52630447, Length=191, Percent_Identity=24.6073298429319, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1790080, Length=201, Percent_Identity=48.7562189054726, Blast_Score=196, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI193203132, Length=189, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17508835, Length=180, Percent_Identity=33.8888888888889, Blast_Score=104, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71990720, Length=77, Percent_Identity=45.4545454545455, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71988041, Length=183, Percent_Identity=25.1366120218579, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71988048, Length=183, Percent_Identity=25.1366120218579, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=39.5604395604396, Blast_Score=132, Evalue=4e-32,
Organism=Drosophila melanogaster, GI21356141, Length=180, Percent_Identity=35, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_BURXL (Q13V49)

Other databases:

- EMBL:   CP000270
- RefSeq:   YP_560092.1
- ProteinModelPortal:   Q13V49
- SMR:   Q13V49
- GeneID:   4002827
- GenomeReviews:   CP000270_GR
- KEGG:   bxe:Bxe_A0905
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   PRK00300
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 25307; Mature: 25176

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDHHTRETPRNPYAGAYPGNLFMVVAPSGAGKSTLVNALLAGDDAIRLSISYTTRPPRP
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCC
KELDGEHYHFTTVDDFMKRHDAGEFLESAEVHGNYYGTSRVWIEDQMKSGHDVLLEIDWQ
CCCCCCEEEEECHHHHHHHCCHHHHHHHHHHCCCEECCEEEEEECCCCCCCEEEEEECCC
GAQQVKKQFHNAVEIFILPPSLEALEERLKKRGQDEPNVITRRLLAAGSEMAHAAEAEYV
CHHHHHHHHCCEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHCCCCEE
VINENFDRALSELQCLVAATRSRFASQYARHTQLFVQLGIHLPHA
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TDHHTRETPRNPYAGAYPGNLFMVVAPSGAGKSTLVNALLAGDDAIRLSISYTTRPPRP
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCC
KELDGEHYHFTTVDDFMKRHDAGEFLESAEVHGNYYGTSRVWIEDQMKSGHDVLLEIDWQ
CCCCCCEEEEECHHHHHHHCCHHHHHHHHHHCCCEECCEEEEEECCCCCCCEEEEEECCC
GAQQVKKQFHNAVEIFILPPSLEALEERLKKRGQDEPNVITRRLLAAGSEMAHAAEAEYV
CHHHHHHHHCCEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHCCCCEE
VINENFDRALSELQCLVAATRSRFASQYARHTQLFVQLGIHLPHA
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA