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The map label for this gene is gyrA [H]

Identifier: 91784819

GI number: 91784819

Start: 3809766

End: 3812414

Strand: Reverse

Name: gyrA [H]

Synonym: Bxe_A0974

Alternate gene names: 91784819

Gene position: 3812414-3809766 (Counterclockwise)

Preceding gene: 91784824

Following gene: 91784818

Centisome position: 77.87

GC content: 60.74

Gene sequence:

>2649_bases
ATGGATCAATTCGCCAAAGAGACTCTGCCAATCTCCCTAGAGGAGGAAATGCGCCGTTCGTATCTCGATTACGCGATGAG
CGTGATCGTAGGGCGTGCGCTTCCCGATGTTCGCGACGGCCTGAAGCCGGTGCACCGGCGCGTGCTGTACGCGATGCACG
AACTGAACAACGACTGGAACCGGGCTTACAAGAAGTCGGCGCGTATTGTCGGCGACGTTATCGGTAAGTATCACCCGCAC
GGCGACACGGCTGTTTACGACACCATCGTCCGGATGGCGCAAGACTTCTCGCTGCGCTACATGCTGGTGGACGGCCAGGG
CAACTTCGGCTCGGTCGACGGCGACAATGCCGCGGCCATGCGGTACACCGAAATCCGCATGGCGAAGATCGGCCATGAGT
TGCTGGCCGACATCGACAAGGAAACGGTCGACTTCACGCCGAACTACGACGGCAGCGAAAACGAACCGGCCATCCTGCCG
GCGCGCATTCCCAATCTGCTGATCAATGGTTCGTCCGGTATCGCGGTCGGCATGGCAACCAACATTCCGCCGCACAACCT
CAATGAAGTTGTCGACGCCTGCCAGCATCTGCTCAAGAACCCGGAAGCCACGATCGACGAACTGATCGAGATCGTTCCGG
CGCCCGACTTCCCGACCGCCGGCATCATCTACGGCGTGGCGGGCGTGCGCGACGGCTATCGCACGGGCCGCGGCCGCGTG
GTGATGCGCGCGCTCACGCACTTTGAGGAAATCGACCGCGGCCAGCGCATGGCGATCATCGTCGACGAACTGCCGTACCA
GGTGAACAAGCGCTCACTTCTGGAGCGCATCGCCGAACTGGTCAACGAAAAGAAGCTCGAAGGCATCTCCGACATCCGCG
ACGAGTCCGACAAGAGCGGCATGCGGGTCGTGATCGAACTGAAGCGCGGCGAAGTGCCGGAAGTCGTGCTCAACAATCTG
TACAAGGCAACCCAGCTTCAGGACACCTTCGGCATGAACATGGTCGCGCTGGTCGACGGCCAGCCGAAGCTGCTGAACCT
GAAGGAAATGCTGTCGTGCTTCCTGTCGCATCGCCGGGAAGTGCTGACGCGGCGCACCGTATACGAACTGCGCAAGGCGC
GCGAACGCGGCCACGTGCTCGAAGGTCTGGCGGTCGCGCTCGCCAATATCGACGAGTTCATCGCCATCATCAAAGCCGCG
CCGACTCCGCCGATCGCCAAGCAGGAATTGATGGCGCGTGCGTGGGATTCGTCGCTGGTGCGCGAAATGTTGTCGCGCGC
CGAGACGGAAAACGCAACGGCGGGTGGTCGCGAAGCCTACCGTCCTGACGGATTGAATCCGTCGTTCGGTATGCAGTCCG
ACGGCCTTTACCGTCTGTCCGACACCCAGGCTCAGGAAATTCTGCAGATGCGTCTGCAGCGCCTGACCGGTCTGGAGCAG
GACAAGATCATCGGCGAGTACCGCGAAGTCATGGCGCAGATCGCCGACCTGCTGGACATTCTGGCTCGCCCGGAACGCAT
TACGGCGATCATCGTCGAGGAACTCACGTCGATCAAAGCCGAATTCGGCGACGCGCGCCGCTCGAAAATCGAGCTGAACG
CAACCGAGCTGAACACGGAAGATCTGATCACGCCGCAAGAGATGGTCGTGACCATGTCGCACGCGGGCTATGTGAAATCG
CAGCCGCTGTCCGAGTACAGCGCGCAGAAGCGCGGCGGTCGCGGCAAGCAGGCCACGGCCATGAAAGAAGACGATTGGAT
CGACACGCTGTTCATCGCGAACACGCACGATCACATTCTGTGCTTCTCCAATCGCGGCCGCGTTTACAGCGTGAAGGTCT
ATGAAGTGCCGCAAGGTTCGCGGAACTCGCGCGGCCGTCCGATCATCAATATCTTCCCGCTTCAGGAAGGCGAAAAGATT
ACGGTTGTCCTGCCGGTCAAGGAATTCTCGGCTGACAAATTCGTCTTCATGGGCACCGCGTTAGGAACCGTAAAAAAGAC
GCCGCTGGAAGCCTTCGGCCGCGTGTTGCGCAAGGGTATTATTGCGGTCGGTCTGGATGACGGAGACTACCTGATCGGCG
CCGCCATTACCGACGGTCAGCACGACGTGATGCTGTTCTCGGATTCGGGCAAGGCGGTCCGCTTCGACGAAAACGACGTG
CGTCCAATGGGCCGCGAGGCGCGCGGTGTACGCGGCATGCAACTCGAAGACGGCCAGAACGTGATCGCGTTGCTGGTAGC
CGGCGACGAGCAGCAGTCGGTGCTCACCGCCACGGAAAACGGTTTTGGCAAGCGTACGCCGATCATCGAGTACACCCGTC
ATGGCCGCGGTACGAAGGGCATGATCGCGATCCAGACCTCGGAGCGTAACGGCAAGGTCGTTGCCGCCACGCTGGTGGAT
CAGGAAGCGCAGATCATGCTGATCACCAATACCGGCGTGCTGATCCGTACGCGGGTGTCGGAAATTCGGGAAATGGGACG
TGCAACCCAAGGTGTTACACTCATCAGCCTTGACGAAGGGACCAAGCTTTCAGGTCTGCAACAGGTTGCTGAGGCGGAAG
CGGAAGGTGATGCGGAAAGCGACGCCGAAGGTCCCGCTGAAGGTAACAACGCGGGTGACAACGGCGGCGAAGAGGGCGGT
GCGGCCTGA

Upstream 100 bases:

>100_bases
GCATGTTAGAATCGCGTGATGCGTTGCGCCTGCAATGCTTACGCGAAGACGCGGCGAAATGTAGCCAAGCCGTCGTCTTG
GCACGTAAAAGATACGGATA

Downstream 100 bases:

>100_bases
TTCGTGTCAGCGTCTTACAGACTCAGTGACTGGTTGAAAGCTGTGCCGGGAATAATGGCGTGTCGGGCTGATACGTATCT
CGCGCAGCTTGCTGTTCAAG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 882; Mature: 882

Protein sequence:

>882_residues
MDQFAKETLPISLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELNNDWNRAYKKSARIVGDVIGKYHPH
GDTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFTPNYDGSENEPAILP
ARIPNLLINGSSGIAVGMATNIPPHNLNEVVDACQHLLKNPEATIDELIEIVPAPDFPTAGIIYGVAGVRDGYRTGRGRV
VMRALTHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL
YKATQLQDTFGMNMVALVDGQPKLLNLKEMLSCFLSHRREVLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAA
PTPPIAKQELMARAWDSSLVREMLSRAETENATAGGREAYRPDGLNPSFGMQSDGLYRLSDTQAQEILQMRLQRLTGLEQ
DKIIGEYREVMAQIADLLDILARPERITAIIVEELTSIKAEFGDARRSKIELNATELNTEDLITPQEMVVTMSHAGYVKS
QPLSEYSAQKRGGRGKQATAMKEDDWIDTLFIANTHDHILCFSNRGRVYSVKVYEVPQGSRNSRGRPIINIFPLQEGEKI
TVVLPVKEFSADKFVFMGTALGTVKKTPLEAFGRVLRKGIIAVGLDDGDYLIGAAITDGQHDVMLFSDSGKAVRFDENDV
RPMGREARGVRGMQLEDGQNVIALLVAGDEQQSVLTATENGFGKRTPIIEYTRHGRGTKGMIAIQTSERNGKVVAATLVD
QEAQIMLITNTGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQVAEAEAEGDAESDAEGPAEGNNAGDNGGEEGG
AA

Sequences:

>Translated_882_residues
MDQFAKETLPISLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELNNDWNRAYKKSARIVGDVIGKYHPH
GDTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFTPNYDGSENEPAILP
ARIPNLLINGSSGIAVGMATNIPPHNLNEVVDACQHLLKNPEATIDELIEIVPAPDFPTAGIIYGVAGVRDGYRTGRGRV
VMRALTHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL
YKATQLQDTFGMNMVALVDGQPKLLNLKEMLSCFLSHRREVLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAA
PTPPIAKQELMARAWDSSLVREMLSRAETENATAGGREAYRPDGLNPSFGMQSDGLYRLSDTQAQEILQMRLQRLTGLEQ
DKIIGEYREVMAQIADLLDILARPERITAIIVEELTSIKAEFGDARRSKIELNATELNTEDLITPQEMVVTMSHAGYVKS
QPLSEYSAQKRGGRGKQATAMKEDDWIDTLFIANTHDHILCFSNRGRVYSVKVYEVPQGSRNSRGRPIINIFPLQEGEKI
TVVLPVKEFSADKFVFMGTALGTVKKTPLEAFGRVLRKGIIAVGLDDGDYLIGAAITDGQHDVMLFSDSGKAVRFDENDV
RPMGREARGVRGMQLEDGQNVIALLVAGDEQQSVLTATENGFGKRTPIIEYTRHGRGTKGMIAIQTSERNGKVVAATLVD
QEAQIMLITNTGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQVAEAEAEGDAESDAEGPAEGNNAGDNGGEEGG
AA
>Mature_882_residues
MDQFAKETLPISLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELNNDWNRAYKKSARIVGDVIGKYHPH
GDTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFTPNYDGSENEPAILP
ARIPNLLINGSSGIAVGMATNIPPHNLNEVVDACQHLLKNPEATIDELIEIVPAPDFPTAGIIYGVAGVRDGYRTGRGRV
VMRALTHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL
YKATQLQDTFGMNMVALVDGQPKLLNLKEMLSCFLSHRREVLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAA
PTPPIAKQELMARAWDSSLVREMLSRAETENATAGGREAYRPDGLNPSFGMQSDGLYRLSDTQAQEILQMRLQRLTGLEQ
DKIIGEYREVMAQIADLLDILARPERITAIIVEELTSIKAEFGDARRSKIELNATELNTEDLITPQEMVVTMSHAGYVKS
QPLSEYSAQKRGGRGKQATAMKEDDWIDTLFIANTHDHILCFSNRGRVYSVKVYEVPQGSRNSRGRPIINIFPLQEGEKI
TVVLPVKEFSADKFVFMGTALGTVKKTPLEAFGRVLRKGIIAVGLDDGDYLIGAAITDGQHDVMLFSDSGKAVRFDENDV
RPMGREARGVRGMQLEDGQNVIALLVAGDEQQSVLTATENGFGKRTPIIEYTRHGRGTKGMIAIQTSERNGKVVAATLVD
QEAQIMLITNTGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQVAEAEAEGDAESDAEGPAEGNNAGDNGGEEGG
AA

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=410, Percent_Identity=26.0975609756098, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI19913408, Length=507, Percent_Identity=24.0631163708087, Blast_Score=91, Evalue=4e-18,
Organism=Escherichia coli, GI1788562, Length=871, Percent_Identity=59.8163030998852, Blast_Score=1055, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=719, Percent_Identity=35.6050069541029, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17535065, Length=493, Percent_Identity=24.1379310344828, Blast_Score=81, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI212645657, Length=544, Percent_Identity=23.5294117647059, Blast_Score=77, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI212645845, Length=188, Percent_Identity=31.3829787234043, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=347, Percent_Identity=27.0893371757925, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI17136538, Length=349, Percent_Identity=26.0744985673352, Blast_Score=87, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 97372; Mature: 97372

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQFAKETLPISLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELNNDWN
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHH
RAYKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAM
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEE
RYTEIRMAKIGHELLADIDKETVDFTPNYDGSENEPAILPARIPNLLINGSSGIAVGMAT
EHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCEECCCCCEEEEECCCCEEEEEEC
NIPPHNLNEVVDACQHLLKNPEATIDELIEIVPAPDFPTAGIIYGVAGVRDGYRTGRGRV
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCHH
VMRALTHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSG
HHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
MRVVIELKRGEVPEVVLNNLYKATQLQDTFGMNMVALVDGQPKLLNLKEMLSCFLSHRRE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHHHHHH
VLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAAPTPPIAKQELMARAWDSSLV
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
REMLSRAETENATAGGREAYRPDGLNPSFGMQSDGLYRLSDTQAQEILQMRLQRLTGLEQ
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCH
DKIIGEYREVMAQIADLLDILARPERITAIIVEELTSIKAEFGDARRSKIELNATELNTE
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHEECCHH
DLITPQEMVVTMSHAGYVKSQPLSEYSAQKRGGRGKQATAMKEDDWIDTLFIANTHDHIL
HCCCHHHHEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEE
CFSNRGRVYSVKVYEVPQGSRNSRGRPIINIFPLQEGEKITVVLPVKEFSADKFVFMGTA
EECCCCEEEEEEEEECCCCCCCCCCCEEEEEEECCCCCEEEEEEEHHHCCCCCEEEEECH
LGTVKKTPLEAFGRVLRKGIIAVGLDDGDYLIGAAITDGQHDVMLFSDSGKAVRFDENDV
HHHHCCCHHHHHHHHHHCCEEEEEECCCCEEEEEEEECCCCEEEEECCCCCEEEECCCCC
RPMGREARGVRGMQLEDGQNVIALLVAGDEQQSVLTATENGFGKRTPIIEYTRHGRGTKG
CCCCHHHCCCCCCEECCCCCEEEEEEECCCCCCEEEECCCCCCCCCCCHHHHCCCCCCCC
MIAIQTSERNGKVVAATLVDQEAQIMLITNTGVLIRTRVSEIREMGRATQGVTLISLDEG
EEEEEECCCCCCEEEEEEECCCCEEEEEECCCEEEEHHHHHHHHHCCHHCCEEEEEECCC
TKLSGLQQVAEAEAEGDAESDAEGPAEGNNAGDNGGEEGGAA
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDQFAKETLPISLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELNNDWN
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHH
RAYKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAM
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEE
RYTEIRMAKIGHELLADIDKETVDFTPNYDGSENEPAILPARIPNLLINGSSGIAVGMAT
EHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCEECCCCCEEEEECCCCEEEEEEC
NIPPHNLNEVVDACQHLLKNPEATIDELIEIVPAPDFPTAGIIYGVAGVRDGYRTGRGRV
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCHH
VMRALTHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSG
HHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
MRVVIELKRGEVPEVVLNNLYKATQLQDTFGMNMVALVDGQPKLLNLKEMLSCFLSHRRE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHHHHHH
VLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAAPTPPIAKQELMARAWDSSLV
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
REMLSRAETENATAGGREAYRPDGLNPSFGMQSDGLYRLSDTQAQEILQMRLQRLTGLEQ
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCH
DKIIGEYREVMAQIADLLDILARPERITAIIVEELTSIKAEFGDARRSKIELNATELNTE
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHEECCHH
DLITPQEMVVTMSHAGYVKSQPLSEYSAQKRGGRGKQATAMKEDDWIDTLFIANTHDHIL
HCCCHHHHEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEE
CFSNRGRVYSVKVYEVPQGSRNSRGRPIINIFPLQEGEKITVVLPVKEFSADKFVFMGTA
EECCCCEEEEEEEEECCCCCCCCCCCEEEEEEECCCCCEEEEEEEHHHCCCCCEEEEECH
LGTVKKTPLEAFGRVLRKGIIAVGLDDGDYLIGAAITDGQHDVMLFSDSGKAVRFDENDV
HHHHCCCHHHHHHHHHHCCEEEEEECCCCEEEEEEEECCCCEEEEECCCCCEEEECCCCC
RPMGREARGVRGMQLEDGQNVIALLVAGDEQQSVLTATENGFGKRTPIIEYTRHGRGTKG
CCCCHHHCCCCCCEECCCCCEEEEEEECCCCCCEEEECCCCCCCCCCCHHHHCCCCCCCC
MIAIQTSERNGKVVAATLVDQEAQIMLITNTGVLIRTRVSEIREMGRATQGVTLISLDEG
EEEEEECCCCCCEEEEEEECCCCEEEEEECCCEEEEHHHHHHHHHCCHHCCEEEEEECCC
TKLSGLQQVAEAEAEGDAESDAEGPAEGNNAGDNGGEEGGAA
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7811002; 10984043 [H]