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The map label for this gene is gyaR [H]

Identifier: 91784738

GI number: 91784738

Start: 3725155

End: 3726144

Strand: Reverse

Name: gyaR [H]

Synonym: Bxe_A1055

Alternate gene names: 91784738

Gene position: 3726144-3725155 (Counterclockwise)

Preceding gene: 91784739

Following gene: 91784737

Centisome position: 76.11

GC content: 64.75

Gene sequence:

>990_bases
ATGCAGAAGATCCTCGTCGCCCGTCCGATCTTTCCCGATGTGATCGAACGGCTCAAACAGTATTTCGACGTCGACTGGAA
TCAGGGCGACGTATTGTCCGCTGACGAACTGACACGCCGTCTCGCGGACAAAGACGGCGCGCTGACCGCGGGCGAGCCGA
TTGGCGCTGCCGTGCTCGCGGCGGCGCCGCGCCTGCGCGTGGTGTCGAATATGGCGGTGGGCTACAACAACTTCGACATG
ACCGCCTTCAACGCGGCTAACGTGCTCGGCACCAACACGCCGGACGTGCTGAACGAATCGACGGCGGATTTCGGCTGGGC
GCTGATGATGGCGGCGGCGCGCCGCATCGCCGAATCGGAGCACTGGCTGCGCGCGGGCAAGTGGCAGAAGTGGACGTATG
ACGGTTTCCTCGGCAGCGATCTGTACGGCTCGACGCTCGGCGTGATCGGCATGGGCCGGATCGGCCAGGCGCTGGCGCGC
CGTGCGAAGGGCTTCAACATGCAGGTGATTTATCACAATCGTTCGCGCGTCGCGCCGGAGATCGAGGCCGAGCTGAACGC
CGGATATGTGTCGAAGCAGGATCTGTTGCGGCGCGCCGATCACGTCGTGCTCGTCCTTCCGTACACGAAGGAAAACCATC
ACACGATCGGCGCGGCCGAACTCGCGCTGATGAAGCCGAGCGCGACGCTTACCAACATCGCACGCGGCGGCATTGTCGAC
GACGCGGCGCTCGTCGAGGCATTGCGCTCGAAGCAGATCGCAGCAGCCGGTCTCGATGTGTTCGAAGGCGAGCCGAATCT
GAATCGGGACCTCCTGAGCGTGCCGAATGTCGTGCTGACGCCGCACATTGCCAGCGCGACCGAAGCCACGCGCCGCGCTA
TGGCGAATCTTGCCGCGGACAATCTGATCGCGGGGCTGGGTGAAGGCCCGCGCGCGGGCCGGCCGCCGAATCCGGTCAAT
CCCGGGGTTATCGGCAAGGCGCGTTCATGA

Upstream 100 bases:

>100_bases
CTGGTCCGCCGCGGTGTTGTTGCCGCTTTTCCTCGTCACCGGCTGGCTCTTTTTCTGACGTCGAGGCAATCGAACTCGAC
GCGCTACACGGAGAATTGCA

Downstream 100 bases:

>100_bases
CCATGATTCTGGTGGCGGCCGTCGCGGTGCTGGCGGTCGCATTGGTCATCGCGCTGGCTTTGCTGATGCGCGGTCATAGC
GCCGGGAACCGCGAACACTT

Product: putative 2-ketogluconate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MQKILVARPIFPDVIERLKQYFDVDWNQGDVLSADELTRRLADKDGALTAGEPIGAAVLAAAPRLRVVSNMAVGYNNFDM
TAFNAANVLGTNTPDVLNESTADFGWALMMAAARRIAESEHWLRAGKWQKWTYDGFLGSDLYGSTLGVIGMGRIGQALAR
RAKGFNMQVIYHNRSRVAPEIEAELNAGYVSKQDLLRRADHVVLVLPYTKENHHTIGAAELALMKPSATLTNIARGGIVD
DAALVEALRSKQIAAAGLDVFEGEPNLNRDLLSVPNVVLTPHIASATEATRRAMANLAADNLIAGLGEGPRAGRPPNPVN
PGVIGKARS

Sequences:

>Translated_329_residues
MQKILVARPIFPDVIERLKQYFDVDWNQGDVLSADELTRRLADKDGALTAGEPIGAAVLAAAPRLRVVSNMAVGYNNFDM
TAFNAANVLGTNTPDVLNESTADFGWALMMAAARRIAESEHWLRAGKWQKWTYDGFLGSDLYGSTLGVIGMGRIGQALAR
RAKGFNMQVIYHNRSRVAPEIEAELNAGYVSKQDLLRRADHVVLVLPYTKENHHTIGAAELALMKPSATLTNIARGGIVD
DAALVEALRSKQIAAAGLDVFEGEPNLNRDLLSVPNVVLTPHIASATEATRRAMANLAADNLIAGLGEGPRAGRPPNPVN
PGVIGKARS
>Mature_329_residues
MQKILVARPIFPDVIERLKQYFDVDWNQGDVLSADELTRRLADKDGALTAGEPIGAAVLAAAPRLRVVSNMAVGYNNFDM
TAFNAANVLGTNTPDVLNESTADFGWALMMAAARRIAESEHWLRAGKWQKWTYDGFLGSDLYGSTLGVIGMGRIGQALAR
RAKGFNMQVIYHNRSRVAPEIEAELNAGYVSKQDLLRRADHVVLVLPYTKENHHTIGAAELALMKPSATLTNIARGGIVD
DAALVEALRSKQIAAAGLDVFEGEPNLNRDLLSVPNVVLTPHIASATEATRRAMANLAADNLIAGLGEGPRAGRPPNPVN
PGVIGKARS

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=312, Percent_Identity=35.5769230769231, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI23308577, Length=300, Percent_Identity=31, Blast_Score=148, Evalue=6e-36,
Organism=Homo sapiens, GI145580578, Length=245, Percent_Identity=35.5102040816327, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI4557499, Length=245, Percent_Identity=35.5102040816327, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI61743967, Length=245, Percent_Identity=33.8775510204082, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI4557497, Length=242, Percent_Identity=34.297520661157, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI145580575, Length=245, Percent_Identity=34.6938775510204, Blast_Score=115, Evalue=6e-26,
Organism=Escherichia coli, GI87082289, Length=325, Percent_Identity=42.1538461538462, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1789279, Length=313, Percent_Identity=29.073482428115, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1787645, Length=252, Percent_Identity=28.968253968254, Blast_Score=107, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17532191, Length=305, Percent_Identity=31.8032786885246, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI25147481, Length=237, Percent_Identity=26.1603375527426, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324055, Length=246, Percent_Identity=33.739837398374, Blast_Score=152, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6320925, Length=310, Percent_Identity=28.3870967741935, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6322116, Length=322, Percent_Identity=28.2608695652174, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6325144, Length=144, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6321253, Length=334, Percent_Identity=23.9520958083832, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45551003, Length=313, Percent_Identity=39.297124600639, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI28574284, Length=313, Percent_Identity=39.297124600639, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI45552429, Length=313, Percent_Identity=39.297124600639, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24585514, Length=313, Percent_Identity=39.297124600639, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI28574282, Length=313, Percent_Identity=39.297124600639, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI28574286, Length=301, Percent_Identity=36.8770764119601, Blast_Score=180, Evalue=9e-46,
Organism=Drosophila melanogaster, GI28571528, Length=310, Percent_Identity=36.4516129032258, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24585516, Length=287, Percent_Identity=33.7979094076655, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI19921140, Length=320, Percent_Identity=30.9375, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI62472511, Length=245, Percent_Identity=33.469387755102, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646446, Length=245, Percent_Identity=33.469387755102, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646448, Length=245, Percent_Identity=33.469387755102, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646452, Length=245, Percent_Identity=33.469387755102, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646450, Length=245, Percent_Identity=33.469387755102, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35410; Mature: 35410

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: PS00018 EF_HAND_1 ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKILVARPIFPDVIERLKQYFDVDWNQGDVLSADELTRRLADKDGALTAGEPIGAAVLA
CCCEEECCCCCHHHHHHHHHHHCCCCCCCCEECHHHHHHHHHCCCCCEECCCCHHHHHHH
AAPRLRVVSNMAVGYNNFDMTAFNAANVLGTNTPDVLNESTADFGWALMMAAARRIAESE
HCCHHHHHHHHHCCCCCCCCEEECCCHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHH
HWLRAGKWQKWTYDGFLGSDLYGSTLGVIGMGRIGQALARRAKGFNMQVIYHNRSRVAPE
HHHHCCCCCEEEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCCH
IEAELNAGYVSKQDLLRRADHVVLVLPYTKENHHTIGAAELALMKPSATLTNIARGGIVD
HHHHCCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCHHHEEEECCCHHHHHHHCCCCCC
DAALVEALRSKQIAAAGLDVFEGEPNLNRDLLSVPNVVLTPHIASATEATRRAMANLAAD
HHHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
NLIAGLGEGPRAGRPPNPVNPGVIGKARS
HHHHCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQKILVARPIFPDVIERLKQYFDVDWNQGDVLSADELTRRLADKDGALTAGEPIGAAVLA
CCCEEECCCCCHHHHHHHHHHHCCCCCCCCEECHHHHHHHHHCCCCCEECCCCHHHHHHH
AAPRLRVVSNMAVGYNNFDMTAFNAANVLGTNTPDVLNESTADFGWALMMAAARRIAESE
HCCHHHHHHHHHCCCCCCCCEEECCCHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHH
HWLRAGKWQKWTYDGFLGSDLYGSTLGVIGMGRIGQALARRAKGFNMQVIYHNRSRVAPE
HHHHCCCCCEEEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCCH
IEAELNAGYVSKQDLLRRADHVVLVLPYTKENHHTIGAAELALMKPSATLTNIARGGIVD
HHHHCCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCHHHEEEECCCHHHHHHHCCCCCC
DAALVEALRSKQIAAAGLDVFEGEPNLNRDLLSVPNVVLTPHIASATEATRRAMANLAAD
HHHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
NLIAGLGEGPRAGRPPNPVNPGVIGKARS
HHHHCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA