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The map label for this gene is lspA

Identifier: 91784687

GI number: 91784687

Start: 3672857

End: 3673369

Strand: Reverse

Name: lspA

Synonym: Bxe_A1105

Alternate gene names: 91784687

Gene position: 3673369-3672857 (Counterclockwise)

Preceding gene: 91784688

Following gene: 91784686

Centisome position: 75.03

GC content: 50.49

Gene sequence:

>513_bases
ATGCTCATTATTGGCAAAAAGCTCTCGCCGTATGCCCTATTGTCCATATCGGGCCTGCTGGCAGCGTCTGATCAGGCTGT
AAAGTGGCTGGTGCAGCAATCAATGGCCTATGGCGAGTATGTTTCGGTGACCCCGTTCTTTAACTGGGTGCACCTATGGA
ACACCGGTGCCGCATTCAGTCTTTTTGCGAATGGTGGAGGCTGGCAGCGCTACTTTTTTATCGGAATCGCGGTAGTGGTC
TCGATTTTTCTGATCAAGCTGATCCTTGAAAATCGTCATAAAGGAGAAGCCATCGCTTACAGTCTTATCCTCGGTGGCGC
CATGGGCAACCTGATTGACCGGGTCTTTCGCGGCTATGTTGTGGATTCCTTTGATTTCTATTGGCGAGACTGGCATTGGC
CGGCCTTCAACCTGGCTGATATTGCAATTGTCCTCGGTGCCTTACTTTTCGTTTCCAGCAGCTTGTTGGGTAAAAAAGCA
AACACCAATGCCGAGCCGGATGGATCTGACTGA

Upstream 100 bases:

>100_bases
GTGGACCGGTTCCAATTATCCGGATCTGATTATCGGCACCATCGCGGGGGGCATTGTACTTAACGGTGCCAGACGCATTT
TGGCGTTGAAGGGTTAAATA

Downstream 100 bases:

>100_bases
CACCTACGCCTATACAACACCATGACCGAACTTCCCGACAACATCCTTCACCTGCCGCAATACCAAGTACTGGGCTGCAA
ATCAACCGACGACGAAATGC

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MLIIGKKLSPYALLSISGLLAASDQAVKWLVQQSMAYGEYVSVTPFFNWVHLWNTGAAFSLFANGGGWQRYFFIGIAVVV
SIFLIKLILENRHKGEAIAYSLILGGAMGNLIDRVFRGYVVDSFDFYWRDWHWPAFNLADIAIVLGALLFVSSSLLGKKA
NTNAEPDGSD

Sequences:

>Translated_170_residues
MLIIGKKLSPYALLSISGLLAASDQAVKWLVQQSMAYGEYVSVTPFFNWVHLWNTGAAFSLFANGGGWQRYFFIGIAVVV
SIFLIKLILENRHKGEAIAYSLILGGAMGNLIDRVFRGYVVDSFDFYWRDWHWPAFNLADIAIVLGALLFVSSSLLGKKA
NTNAEPDGSD
>Mature_170_residues
MLIIGKKLSPYALLSISGLLAASDQAVKWLVQQSMAYGEYVSVTPFFNWVHLWNTGAAFSLFANGGGWQRYFFIGIAVVV
SIFLIKLILENRHKGEAIAYSLILGGAMGNLIDRVFRGYVVDSFDFYWRDWHWPAFNLADIAIVLGALLFVSSSLLGKKA
NTNAEPDGSD

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=142, Percent_Identity=45.7746478873239, Blast_Score=121, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_SERMA (O52213)

Other databases:

- EMBL:   AF027768
- MEROPS:   A08.001
- BRENDA:   3.4.23.36
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18815; Mature: 18815

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 113-113 ACT_SITE 140-140

Signals:

None

Transmembrane regions:

HASH(0x15a9c0d8)-; HASH(0x1ab199a4)-; HASH(0x1873ea0c)-; HASH(0x1ab36f0c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIIGKKLSPYALLSISGLLAASDQAVKWLVQQSMAYGEYVSVTPFFNWVHLWNTGAAFS
CEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEECCHHHEEEEECCCCEEE
LFANGGGWQRYFFIGIAVVVSIFLIKLILENRHKGEAIAYSLILGGAMGNLIDRVFRGYV
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCHH
VDSFDFYWRDWHWPAFNLADIAIVLGALLFVSSSLLGKKANTNAEPDGSD
CCCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
>Mature Secondary Structure
MLIIGKKLSPYALLSISGLLAASDQAVKWLVQQSMAYGEYVSVTPFFNWVHLWNTGAAFS
CEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEECCHHHEEEEECCCCEEE
LFANGGGWQRYFFIGIAVVVSIFLIKLILENRHKGEAIAYSLILGGAMGNLIDRVFRGYV
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCHH
VDSFDFYWRDWHWPAFNLADIAIVLGALLFVSSSLLGKKANTNAEPDGSD
CCCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA