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The map label for this gene is clcR [H]

Identifier: 91784661

GI number: 91784661

Start: 3649227

End: 3650111

Strand: Reverse

Name: clcR [H]

Synonym: Bxe_A1131

Alternate gene names: 91784661

Gene position: 3650111-3649227 (Counterclockwise)

Preceding gene: 91784668

Following gene: 91784659

Centisome position: 74.56

GC content: 55.37

Gene sequence:

>885_bases
ATGGAATTTCGGCAGCTTCGCTATTTCATCGCGGTCGCAGAAGAGGGAAATATCGGTGCTGCGGCAAGACGCCTGCATAT
TTCCCAGCCGCCCATTACCCGCCAAATACAGGCCCTGGAACAGGATCTCGGCGTGGTGCTGTTTGAACGCACGCACCGCG
GCGTCGAATTGACGGCAGCGGGTACAACATTTTTAGAGGATGCCAGGCGCCTACTGCACGTTACCGAGATCTCAAGGGTG
AGATCACGTGCAGCATCGCGCGGTGAAATCGGGGAATTGCGCATCGCCTATTTCGGAACCGTCGTTTTGCATACGCTACC
GCTACTGCTGCGGCAACTCTTGTCGGTTGCTCCCTCGGCAACTGTGTCCTTGACGCAGATGAGCAAGAACCGCCAGATTG
AAGCGCTGGACGCTGGCACCATCGATATCGGGTTCGGGCGTTTCTACCCCTATCAGGAGGGTGTAGTTGTCCGAAACGTA
ACCAATGAGAGGCTATTTCTGGGTGCGCAAAAGTCGCGCGCTCGCTCGTTTGGTGAGCAAGTTCATTGCAGCGCGCTTCG
TAACGAGCCCTTGATCCTGTTCCCGCGAGAAGGACGCCCCAGTTTCGCAGACGAAGTCATCGGCGTATTCAAAAACGCGC
GAGTGGAGCCAAAGGTTGTCGCCATAGTTGAAGACGTCAATGCAGCCATGGCTCTGGCGTTGGCCGGCGTCGGCGTGACA
ATTGTTCCCGAGACAGTAGCCATGATTTCGTGGCCTGACTTCGGCTTCACTGAACTCGTGGGCTCCAAGGCCACTGTACC
GGTCAGTTGTATCTACCGTCACGATCACATTGCGCCGATTCTGAAAACATTCTTGAACTTGCTACCTATTCGAGAATCGC
AATAG

Upstream 100 bases:

>100_bases
ATTCGCGTGTCATGCGGTCCAATACCTTTTTTTAGCCTTTGCAATACGGGATCGGTATGGCTTAGCGGTGTCCACCCCTA
GGGAAAACCAGAGGTCTTAA

Downstream 100 bases:

>100_bases
ATGCCAATCGTTAGGTTGTCGAGCCCGCAATTCGGCATAACACTGGCCGTAAAGCGGGCATCAATCGCTGTACTCCAACT
CTTACTGCGACATGGCTCAC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: ClcABD operon transcriptional activator [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MEFRQLRYFIAVAEEGNIGAAARRLHISQPPITRQIQALEQDLGVVLFERTHRGVELTAAGTTFLEDARRLLHVTEISRV
RSRAASRGEIGELRIAYFGTVVLHTLPLLLRQLLSVAPSATVSLTQMSKNRQIEALDAGTIDIGFGRFYPYQEGVVVRNV
TNERLFLGAQKSRARSFGEQVHCSALRNEPLILFPREGRPSFADEVIGVFKNARVEPKVVAIVEDVNAAMALALAGVGVT
IVPETVAMISWPDFGFTELVGSKATVPVSCIYRHDHIAPILKTFLNLLPIRESQ

Sequences:

>Translated_294_residues
MEFRQLRYFIAVAEEGNIGAAARRLHISQPPITRQIQALEQDLGVVLFERTHRGVELTAAGTTFLEDARRLLHVTEISRV
RSRAASRGEIGELRIAYFGTVVLHTLPLLLRQLLSVAPSATVSLTQMSKNRQIEALDAGTIDIGFGRFYPYQEGVVVRNV
TNERLFLGAQKSRARSFGEQVHCSALRNEPLILFPREGRPSFADEVIGVFKNARVEPKVVAIVEDVNAAMALALAGVGVT
IVPETVAMISWPDFGFTELVGSKATVPVSCIYRHDHIAPILKTFLNLLPIRESQ
>Mature_294_residues
MEFRQLRYFIAVAEEGNIGAAARRLHISQPPITRQIQALEQDLGVVLFERTHRGVELTAAGTTFLEDARRLLHVTEISRV
RSRAASRGEIGELRIAYFGTVVLHTLPLLLRQLLSVAPSATVSLTQMSKNRQIEALDAGTIDIGFGRFYPYQEGVVVRNV
TNERLFLGAQKSRARSFGEQVHCSALRNEPLILFPREGRPSFADEVIGVFKNARVEPKVVAIVEDVNAAMALALAGVGVT
IVPETVAMISWPDFGFTELVGSKATVPVSCIYRHDHIAPILKTFLNLLPIRESQ

Specific function: Involved in regulation of chlorinated catechol metabolism. Transcriptional activator of the clcABD chlorocatechol oxidative operon [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=290, Percent_Identity=31.3793103448276, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1788887, Length=285, Percent_Identity=27.0175438596491, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI2367136, Length=293, Percent_Identity=29.3515358361775, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI157672245, Length=250, Percent_Identity=30, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1790399, Length=245, Percent_Identity=27.3469387755102, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI145693105, Length=199, Percent_Identity=28.643216080402, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87081904, Length=205, Percent_Identity=30.7317073170732, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788297, Length=249, Percent_Identity=27.710843373494, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787601, Length=253, Percent_Identity=22.5296442687747, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787949, Length=86, Percent_Identity=41.8604651162791, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790208, Length=146, Percent_Identity=32.1917808219178, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787530, Length=263, Percent_Identity=23.574144486692, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789639, Length=122, Percent_Identity=31.9672131147541, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87082132, Length=203, Percent_Identity=29.064039408867, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32508; Mature: 32508

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFRQLRYFIAVAEEGNIGAAARRLHISQPPITRQIQALEQDLGVVLFERTHRGVELTAA
CCHHHEEEEEEEECCCCCCHHHHEEECCCCCHHHHHHHHHHHHCEEEEECCCCCEEEEEC
GTTFLEDARRLLHVTEISRVRSRAASRGEIGELRIAYFGTVVLHTLPLLLRQLLSVAPSA
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCC
TVSLTQMSKNRQIEALDAGTIDIGFGRFYPYQEGVVVRNVTNERLFLGAQKSRARSFGEQ
EEEEEECCCCCCEEEECCCEEEECCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHH
VHCSALRNEPLILFPREGRPSFADEVIGVFKNARVEPKVVAIVEDVNAAMALALAGVGVT
HHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHCCCEE
IVPETVAMISWPDFGFTELVGSKATVPVSCIYRHDHIAPILKTFLNLLPIRESQ
EECCCEEEEECCCCCHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEFRQLRYFIAVAEEGNIGAAARRLHISQPPITRQIQALEQDLGVVLFERTHRGVELTAA
CCHHHEEEEEEEECCCCCCHHHHEEECCCCCHHHHHHHHHHHHCEEEEECCCCCEEEEEC
GTTFLEDARRLLHVTEISRVRSRAASRGEIGELRIAYFGTVVLHTLPLLLRQLLSVAPSA
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCC
TVSLTQMSKNRQIEALDAGTIDIGFGRFYPYQEGVVVRNVTNERLFLGAQKSRARSFGEQ
EEEEEECCCCCCEEEECCCEEEECCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHH
VHCSALRNEPLILFPREGRPSFADEVIGVFKNARVEPKVVAIVEDVNAAMALALAGVGVT
HHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHCCCEE
IVPETVAMISWPDFGFTELVGSKATVPVSCIYRHDHIAPILKTFLNLLPIRESQ
EECCCEEEEECCCCCHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8419291 [H]