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The map label for this gene is folP [H]

Identifier: 91784536

GI number: 91784536

Start: 3523659

End: 3524471

Strand: Reverse

Name: folP [H]

Synonym: Bxe_A1263

Alternate gene names: 91784536

Gene position: 3524471-3523659 (Counterclockwise)

Preceding gene: 91784537

Following gene: 91784535

Centisome position: 71.99

GC content: 65.44

Gene sequence:

>813_bases
ATGGGCATTCTGAACGTCACACCTGATTCTTTTTCCGACGGCGGCCAATACGCGATGCGCGGCGATGCGTTGCGCCAGGC
CGAGCGTATGATGCTCGACGGCGCGGACATCATCGACATCGGCGGCGAATCGACGCGGCCGGGCGCGCCGCCGGTGCCGC
TCAACGAAGAACTGGAGCGGGTGATTCCGCTCGTCGAGCAATTGCGCGGCGCGAATGTGCCGCTGTCGGTCGACACCTAC
AAGCCCGAAGTGATGCGCCACGCATTGGCCGCCGGCGCCGATCTGATCAACGACATCTGGGGCTTCCGGATGCCCGGCGC
AATCGACGCCGTGCGCGACAGCGAATGTGGTCTGTGCGTCATGCATATGCTTGGCGAGCCGCAAACCATGCAGCTCGGCG
AGCCTGTCTATGACGACGTGGTGAGCGCGGTGCGGGATTTTCTCGAGGAGCGGGTCGCCGCGCTTCAGCAGGCGGGCGTC
GCGCGCGCCCGTATTAGCGTGGATCCGGGTTTCGGCTTCGGCAAGGCCGTGGTCGAACATAATTACGCGCTGCTTGCGAA
CCTGCCGGATACGGCACCGCGAGCCGAGCCGCCGTATCCGATTCTTGCTGGCATGTCGCGCAAGTCGATGATCGGCGCAG
TGGTGGGACGCGCGGCGCCGGAACGCGTTGCGGGCAGTATTGCGGCGGCGGTGTGCGCCGCTGAACGGGGCGCTGCGATT
CTGCGCGTGCACGATGTCGCGCAAACAGTAGATGCATTGAAAGTCTGGGCAGCCATGCGCGAAGCGGCGAATCACAGCCG
CGCGCGCGGTTGA

Upstream 100 bases:

>100_bases
GAAACACCGCCACGTGTCGAAAGTCGAATTCCCTTCTCTGCCTATTCCCCAACCGTTACAGTGCGGTCGATTCAAACTGA
GCTTTGAACGCCCGTTGGTT

Downstream 100 bases:

>100_bases
GCCTATAAGCCAAGGAGGAATATAAAACATGGCACGTCGTTATTTCGGAACGGACGGCATTCGCGGCAAAGTCGGCGAAG
GGCCTATCACGCCGGAATTT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MGILNVTPDSFSDGGQYAMRGDALRQAERMMLDGADIIDIGGESTRPGAPPVPLNEELERVIPLVEQLRGANVPLSVDTY
KPEVMRHALAAGADLINDIWGFRMPGAIDAVRDSECGLCVMHMLGEPQTMQLGEPVYDDVVSAVRDFLEERVAALQQAGV
ARARISVDPGFGFGKAVVEHNYALLANLPDTAPRAEPPYPILAGMSRKSMIGAVVGRAAPERVAGSIAAAVCAAERGAAI
LRVHDVAQTVDALKVWAAMREAANHSRARG

Sequences:

>Translated_270_residues
MGILNVTPDSFSDGGQYAMRGDALRQAERMMLDGADIIDIGGESTRPGAPPVPLNEELERVIPLVEQLRGANVPLSVDTY
KPEVMRHALAAGADLINDIWGFRMPGAIDAVRDSECGLCVMHMLGEPQTMQLGEPVYDDVVSAVRDFLEERVAALQQAGV
ARARISVDPGFGFGKAVVEHNYALLANLPDTAPRAEPPYPILAGMSRKSMIGAVVGRAAPERVAGSIAAAVCAAERGAAI
LRVHDVAQTVDALKVWAAMREAANHSRARG
>Mature_269_residues
GILNVTPDSFSDGGQYAMRGDALRQAERMMLDGADIIDIGGESTRPGAPPVPLNEELERVIPLVEQLRGANVPLSVDTYK
PEVMRHALAAGADLINDIWGFRMPGAIDAVRDSECGLCVMHMLGEPQTMQLGEPVYDDVVSAVRDFLEERVAALQQAGVA
RARISVDPGFGFGKAVVEHNYALLANLPDTAPRAEPPYPILAGMSRKSMIGAVVGRAAPERVAGSIAAAVCAAERGAAIL
RVHDVAQTVDALKVWAAMREAANHSRARG

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=268, Percent_Identity=50.3731343283582, Blast_Score=249, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6324073, Length=313, Percent_Identity=29.3929712460064, Blast_Score=105, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 28700; Mature: 28569

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGILNVTPDSFSDGGQYAMRGDALRQAERMMLDGADIIDIGGESTRPGAPPVPLNEELER
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHH
VIPLVEQLRGANVPLSVDTYKPEVMRHALAAGADLINDIWGFRMPGAIDAVRDSECGLCV
HHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHH
MHMLGEPQTMQLGEPVYDDVVSAVRDFLEERVAALQQAGVARARISVDPGFGFGKAVVEH
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEECCCCCHHHHHHHC
NYALLANLPDTAPRAEPPYPILAGMSRKSMIGAVVGRAAPERVAGSIAAAVCAAERGAAI
CCEEEECCCCCCCCCCCCCHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEE
LRVHDVAQTVDALKVWAAMREAANHSRARG
EHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GILNVTPDSFSDGGQYAMRGDALRQAERMMLDGADIIDIGGESTRPGAPPVPLNEELER
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHH
VIPLVEQLRGANVPLSVDTYKPEVMRHALAAGADLINDIWGFRMPGAIDAVRDSECGLCV
HHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHH
MHMLGEPQTMQLGEPVYDDVVSAVRDFLEERVAALQQAGVARARISVDPGFGFGKAVVEH
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEECCCCCHHHHHHHC
NYALLANLPDTAPRAEPPYPILAGMSRKSMIGAVVGRAAPERVAGSIAAAVCAAERGAAI
CCEEEECCCCCCCCCCCCCHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEE
LRVHDVAQTVDALKVWAAMREAANHSRARG
EHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]