Click here to switch to the map view.

The map label for this gene is livM [H]

Identifier: 91784480

GI number: 91784480

Start: 3468449

End: 3469735

Strand: Reverse

Name: livM [H]

Synonym: Bxe_A1319

Alternate gene names: 91784480

Gene position: 3469735-3468449 (Counterclockwise)

Preceding gene: 91784481

Following gene: 91784479

Centisome position: 70.87

GC content: 69.62

Gene sequence:

>1287_bases
ATGCGTGACGCGCCCGACTCGTCGGCTTTGTCCGCGACCGCACCGCGTGCGCTCTGGCGCGTGCTCGCGCCGTGGCTGGC
GCTCATCCTGTTCCTTGGCGTGCCGCCATTCGTCTGGCCGCAAAGCTGGCTGCTCGCCTATCTCGCGCAGACCGCGGCGA
TGATCGTGTTCGCGCTTTCCTACAATCTGCTGCTCGGCGAGACGGGGCTGTTGTCGTTCGGCCATGCCGCTTACTCCGGC
CTCGGCGCGCTCGTGGCCGCGCAACTGTTCAACCGGATCGGCGTGCCGCTCGTGCTGCTGCCGCTGGTTGGCGGTATCGG
CGGCGCGCTGTGCGGCGTGCTGTTCGGTTTCATTTCCACCCGGCGCGCCGGCACGGCCTTCGCGATGATCACACTCGGTC
TGGGCGAACTCGTGGCGGCCGCCGCGTGGACGCTGCCCGACTGGTTCGGCGGCGAGGCGGGCGTGGCGATCGATCGCGCG
AGCGGCGCGCAGTGGGCAGGCTGGAGCTTCGGCCCGGCGCGCGAGGCCTATGCGCTGATCGCCGTGTGGTGCCTGCTCGC
GTGCGCGGCGCTGTTCGCGCTCTCGCGTACGCCTTTCATGCGCCTTGCCAACGCCGTGCGGGACAATCCGGTGCGGGCGG
CGGCAATAGGCTGCTACCCGCGCCGCATCCGCTATGGCGTGGTGGTGGTGTCGGCATTTTTCGCGGGTATCTCGGGGACG
CTGGCGCTGATCAACGTGGAACTGGTGTCGACGGAAAGCGTCGGCATGATGCGCTCGGGCGCGGTGTTGATCGCCACGGT
GATCGGCGGCACGGCGGCGTTTTTCGGGCCGGTCGCGGGCGCGGTCGTGCTGACGTTTTTCAGTGTCGCGGTGGCGAGCG
TCACGCGGGCCTGGTTGTTCTATCTGGGACTCTTCTTCATCGTGGTCGTGGTGATGTCACCGGATGGCCTCGCGGGCTTC
GTGCAGCGTCATACGGCGCGTGTGGCCGCATATGGCTGGCGCCGGTGCCGCGTGGCTTATCTGTGGGGCGCGGCCGCCGC
GCTGCTGTGGACGGCGGCCGTCGTGCTCGCGATGCAATGGGCCTACGCCGCGCAATTCGGCGCGGACGACGGCGCGGCTT
GGGTCGGCATGGGCGCGCTGACGGGGATGGGCGCGTCGCCGCTCGCACTCGCAATCCTGTTGCTGGCCGCGCTCGGAGGA
CTCTCGGCGCATTACGCGATTCGAGCGCAAGCGCACCTCGCAGCCATGCGCTCAAGCGCCACGCACAGCGCCGGAGACGC
GCGATGA

Upstream 100 bases:

>100_bases
GCGCTGACGCTCGCGCAACTCGCACCGCTGCTCCCGTATCTGCTGCTGGTTGCAATGCTGGCACTGCGCCCGCGCGGACT
TTTCGGGCGGCGTGACGAAC

Downstream 100 bases:

>100_bases
TCCCGGCACTCGCACTCTATGGCATCAAAAAACGCTTCGGCTCGACGCAGGTTCTGCGCGGCGTCGATCTCGCGGTCCAG
CCCGGCGAACGTCACGCGCT

Product: branched chain amino acid ABC transporter inner membrane protein

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MRDAPDSSALSATAPRALWRVLAPWLALILFLGVPPFVWPQSWLLAYLAQTAAMIVFALSYNLLLGETGLLSFGHAAYSG
LGALVAAQLFNRIGVPLVLLPLVGGIGGALCGVLFGFISTRRAGTAFAMITLGLGELVAAAAWTLPDWFGGEAGVAIDRA
SGAQWAGWSFGPAREAYALIAVWCLLACAALFALSRTPFMRLANAVRDNPVRAAAIGCYPRRIRYGVVVVSAFFAGISGT
LALINVELVSTESVGMMRSGAVLIATVIGGTAAFFGPVAGAVVLTFFSVAVASVTRAWLFYLGLFFIVVVVMSPDGLAGF
VQRHTARVAAYGWRRCRVAYLWGAAAALLWTAAVVLAMQWAYAAQFGADDGAAWVGMGALTGMGASPLALAILLLAALGG
LSAHYAIRAQAHLAAMRSSATHSAGDAR

Sequences:

>Translated_428_residues
MRDAPDSSALSATAPRALWRVLAPWLALILFLGVPPFVWPQSWLLAYLAQTAAMIVFALSYNLLLGETGLLSFGHAAYSG
LGALVAAQLFNRIGVPLVLLPLVGGIGGALCGVLFGFISTRRAGTAFAMITLGLGELVAAAAWTLPDWFGGEAGVAIDRA
SGAQWAGWSFGPAREAYALIAVWCLLACAALFALSRTPFMRLANAVRDNPVRAAAIGCYPRRIRYGVVVVSAFFAGISGT
LALINVELVSTESVGMMRSGAVLIATVIGGTAAFFGPVAGAVVLTFFSVAVASVTRAWLFYLGLFFIVVVVMSPDGLAGF
VQRHTARVAAYGWRRCRVAYLWGAAAALLWTAAVVLAMQWAYAAQFGADDGAAWVGMGALTGMGASPLALAILLLAALGG
LSAHYAIRAQAHLAAMRSSATHSAGDAR
>Mature_428_residues
MRDAPDSSALSATAPRALWRVLAPWLALILFLGVPPFVWPQSWLLAYLAQTAAMIVFALSYNLLLGETGLLSFGHAAYSG
LGALVAAQLFNRIGVPLVLLPLVGGIGGALCGVLFGFISTRRAGTAFAMITLGLGELVAAAAWTLPDWFGGEAGVAIDRA
SGAQWAGWSFGPAREAYALIAVWCLLACAALFALSRTPFMRLANAVRDNPVRAAAIGCYPRRIRYGVVVVSAFFAGISGT
LALINVELVSTESVGMMRSGAVLIATVIGGTAAFFGPVAGAVVLTFFSVAVASVTRAWLFYLGLFFIVVVVMSPDGLAGF
VQRHTARVAAYGWRRCRVAYLWGAAAALLWTAAVVLAMQWAYAAQFGADDGAAWVGMGALTGMGASPLALAILLLAALGG
LSAHYAIRAQAHLAAMRSSATHSAGDAR

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=289, Percent_Identity=26.643598615917, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 44530; Mature: 44530

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDAPDSSALSATAPRALWRVLAPWLALILFLGVPPFVWPQSWLLAYLAQTAAMIVFALS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
YNLLLGETGLLSFGHAAYSGLGALVAAQLFNRIGVPLVLLPLVGGIGGALCGVLFGFIST
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHH
RRAGTAFAMITLGLGELVAAAAWTLPDWFGGEAGVAIDRASGAQWAGWSFGPAREAYALI
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHH
AVWCLLACAALFALSRTPFMRLANAVRDNPVRAAAIGCYPRRIRYGVVVVSAFFAGISGT
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCE
LALINVELVSTESVGMMRSGAVLIATVIGGTAAFFGPVAGAVVLTFFSVAVASVTRAWLF
EEEEEEEEECCCCCCHHHCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLGLFFIVVVVMSPDGLAGFVQRHTARVAAYGWRRCRVAYLWGAAAALLWTAAVVLAMQW
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYAAQFGADDGAAWVGMGALTGMGASPLALAILLLAALGGLSAHYAIRAQAHLAAMRSSA
HHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
THSAGDAR
CCCCCCCC
>Mature Secondary Structure
MRDAPDSSALSATAPRALWRVLAPWLALILFLGVPPFVWPQSWLLAYLAQTAAMIVFALS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
YNLLLGETGLLSFGHAAYSGLGALVAAQLFNRIGVPLVLLPLVGGIGGALCGVLFGFIST
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHH
RRAGTAFAMITLGLGELVAAAAWTLPDWFGGEAGVAIDRASGAQWAGWSFGPAREAYALI
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHH
AVWCLLACAALFALSRTPFMRLANAVRDNPVRAAAIGCYPRRIRYGVVVVSAFFAGISGT
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCE
LALINVELVSTESVGMMRSGAVLIATVIGGTAAFFGPVAGAVVLTFFSVAVASVTRAWLF
EEEEEEEEECCCCCCHHHCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLGLFFIVVVVMSPDGLAGFVQRHTARVAAYGWRRCRVAYLWGAAAALLWTAAVVLAMQW
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYAAQFGADDGAAWVGMGALTGMGASPLALAILLLAALGGLSAHYAIRAQAHLAAMRSSA
HHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
THSAGDAR
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]