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The map label for this gene is relA [H]

Identifier: 91784429

GI number: 91784429

Start: 3403174

End: 3405417

Strand: Reverse

Name: relA [H]

Synonym: Bxe_A1370

Alternate gene names: 91784429

Gene position: 3405417-3403174 (Counterclockwise)

Preceding gene: 91784430

Following gene: 91784428

Centisome position: 69.56

GC content: 64.04

Gene sequence:

>2244_bases
ATGAATACCGAAATCGTTACGAGCACGCCGAAGCCCCTGCCTTCTTTCGAAGAAGCAATGGCGTTCGTGCGTGAACATGC
GGGCGAGGTGCGGCTCTCATCGGGCGAAATGCTGGCGGATCATGCGGCGGGTACGGCGTCGATCATGCGCACGCTCAACG
TCGATCCGCCGGCGGTGCTGGCGGCGGCATTGTTTGCACTGACGCCGCATCTGCAGGACCCGGAGCGCGTGATCGCCGAC
AACTTCGGCGAAGAAGTCGCGCAACTGGTCGGCGACGTGCGCAAGTTGCTGCGTCTTGGCACCGTGAGCTTGCGTGCCGC
GCAGAATGCCATGCCCGAGGCCGGGCGCGACGCCCAGGCTGCGCGCCGCGCGCAGGTCGAGGCGCTGCGCAAGATGCTGC
TCGCGTTTGCGCAGGATATTCGCGTCGTGCTGATCCGGCTCGCGTCGCGCCTGCAATCGCTGCGCTATTACGCGGCGGCG
AAAATCACGCCCTCGCCGGACGTGGCGCGCGAGACGCTCGATATCTATGCGCCTCTCGCCAACCGTCTGGGTATCTGGCA
ATTGAAGTGGGAGCTCGAAGATCTCGCGTTGCGCTTCGAAGAGCCGGTCACTTACAAGCGCATCGCCAAACTGCTCGACG
AGAAACGCGTCGAGCGCGAGAGCTATGTCGCGCAGGCTATCGAACGCCTGCAAAAGGAACTGGCTGCGGCGCATATTCGC
GCAGAGGTGAGCGGCAGGCCGAAACATATCTACAGCATCTGGCGCAAGATGCGCGGCAAGGAGCTGGACTTCGCCGAGCT
GTACGACGTGCGCGCTTTTCGTGTGATCGTGCCGGACATCAAGGATTGCTACACCGTGCTCGGCATCGTGCACAACCTGT
GGCAACCGGTGCCGAAAGAGTTCGACGACTATATCTCGCGGCCGAAACCGAACGGCTATAAATCGCTGCACACAGTCGTG
ATCGGCGACGACGGCCGCGCGTTCGAAGTGCAGATCCGTACGCAGGAAATGCATCAGTTCGCCGAATACGGCGTGGCGGC
ACATTGGCGCTACAAGGAAGCGGGCACGCGCGGGTACGCCGGTCAGTTCGCCGCGAACGGGAAGTACGACGAGAAGATCG
CGTGGCTGCGTCAATTGCTCGCGTGGAAAGACGAAGTCTCCGAGGGCGAGCACGGCGAGAAGCGCGCGGCGCAGCCGTGG
GAGCAACTGCGCCAGGCTACGCTCGACGACGACCATATCTACGTGCTGACGCCGCAGGCGCGGGTGATTCCGCTGCCGCA
CGGCGCAACGCCCGTCGATTTCGCGTATCACCTGCATAGCGAGTTGGGGCATCGCTGCCGCGGCGCTCGTGTGGATGGCG
CGATGGTGCCGCTCAACACGCCGCTGCAGAACGGTCAGACTGTTGAGATCGTCGCGGTCAAGGAGGGCGGTCCGTCGCGC
GACTGGCTGAACCCGCAACTCGGCTATCTGCAAAGTCCGCGCGCGCGGCAAAAAGTGCGCGCGTGGTTCAACGCGGTCGA
AGTGCAGGAACACATCGCGAGCGGCCGCGCGATGGTCGAAAAGACCTTGCAGCGCGAGGGCAAGACGTCGGTCAATCTGG
ACCAGCTCGCGGCCAAGCTCGGCTTCAAGACCACGGACGATCTGTTCTCCGTGGTGGGCAAGGAAGAATTCAGTTTGCGG
CTCGTCGAGCAGGCGCTGCACGACGCGCCGCCGCCGGAGCCGGTGGTCGATGCGCCTGAGCAATTCGAAAAGCGCAGTAG
TGGCGCGAGCGTGGCGCGCGGCGCGTCCACCGGCGTGCTGGTGGTCGGTGTCGACGCGTTGCTCACGCAACTCGCGCGCT
GCTGCCGGCCCGCGCCGCCCGACGATATCTGCGGTTTTGTCACGCGCGGCAAAGGCATGTCGATTCACCGCAGCGATTGC
GCGACGTTCCTGCGCATGGCCGAACGGGCGCCCGAGCGCGTGTTGCAAACGGCATGGTCGGCGGAGGTGATGAGCGGCCG
CGGCCAGTCGGTCTATCCGGTCGATCTCTCGATCGAAGCAACGGACCGGCAGGGTTTGCTGCGCGATATTTCCGAAGTGT
TCGCGCGCGAAAAGATGAACGTGATCGGCGTGAAGACGCAGACGCGCCGCAACGCTGCGTTCATGCAATTTACCGTCGAG
GTGTCGAACGCCGCGCAGATTCAGCGCGCGTGTACGCTGCTCGGTGAAGTGACAGGCGTGATGCGTGCGTCGCGCAAGAG
TTGA

Upstream 100 bases:

>100_bases
CCTCGTCGAAGTCGTCGTGGTCGCGGCGCAGCGCAGCTAAGCCAGCCACATGGGTTGTTGAAATTCCGTTGATTCGTCCG
GCCCGGTGGGCCACCGCACC

Downstream 100 bases:

>100_bases
TGCGTGCGCGGGTCGGTGGGCGCACGCCGCGGACACGTTTGGGTCCGCGAGTAGATATTTAAAGTCGGTGCATAAAAGTA
CTTGCCAAGCGGTGTGGGGC

Product: (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 747; Mature: 747

Protein sequence:

>747_residues
MNTEIVTSTPKPLPSFEEAMAFVREHAGEVRLSSGEMLADHAAGTASIMRTLNVDPPAVLAAALFALTPHLQDPERVIAD
NFGEEVAQLVGDVRKLLRLGTVSLRAAQNAMPEAGRDAQAARRAQVEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAA
KITPSPDVARETLDIYAPLANRLGIWQLKWELEDLALRFEEPVTYKRIAKLLDEKRVERESYVAQAIERLQKELAAAHIR
AEVSGRPKHIYSIWRKMRGKELDFAELYDVRAFRVIVPDIKDCYTVLGIVHNLWQPVPKEFDDYISRPKPNGYKSLHTVV
IGDDGRAFEVQIRTQEMHQFAEYGVAAHWRYKEAGTRGYAGQFAANGKYDEKIAWLRQLLAWKDEVSEGEHGEKRAAQPW
EQLRQATLDDDHIYVLTPQARVIPLPHGATPVDFAYHLHSELGHRCRGARVDGAMVPLNTPLQNGQTVEIVAVKEGGPSR
DWLNPQLGYLQSPRARQKVRAWFNAVEVQEHIASGRAMVEKTLQREGKTSVNLDQLAAKLGFKTTDDLFSVVGKEEFSLR
LVEQALHDAPPPEPVVDAPEQFEKRSSGASVARGASTGVLVVGVDALLTQLARCCRPAPPDDICGFVTRGKGMSIHRSDC
ATFLRMAERAPERVLQTAWSAEVMSGRGQSVYPVDLSIEATDRQGLLRDISEVFAREKMNVIGVKTQTRRNAAFMQFTVE
VSNAAQIQRACTLLGEVTGVMRASRKS

Sequences:

>Translated_747_residues
MNTEIVTSTPKPLPSFEEAMAFVREHAGEVRLSSGEMLADHAAGTASIMRTLNVDPPAVLAAALFALTPHLQDPERVIAD
NFGEEVAQLVGDVRKLLRLGTVSLRAAQNAMPEAGRDAQAARRAQVEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAA
KITPSPDVARETLDIYAPLANRLGIWQLKWELEDLALRFEEPVTYKRIAKLLDEKRVERESYVAQAIERLQKELAAAHIR
AEVSGRPKHIYSIWRKMRGKELDFAELYDVRAFRVIVPDIKDCYTVLGIVHNLWQPVPKEFDDYISRPKPNGYKSLHTVV
IGDDGRAFEVQIRTQEMHQFAEYGVAAHWRYKEAGTRGYAGQFAANGKYDEKIAWLRQLLAWKDEVSEGEHGEKRAAQPW
EQLRQATLDDDHIYVLTPQARVIPLPHGATPVDFAYHLHSELGHRCRGARVDGAMVPLNTPLQNGQTVEIVAVKEGGPSR
DWLNPQLGYLQSPRARQKVRAWFNAVEVQEHIASGRAMVEKTLQREGKTSVNLDQLAAKLGFKTTDDLFSVVGKEEFSLR
LVEQALHDAPPPEPVVDAPEQFEKRSSGASVARGASTGVLVVGVDALLTQLARCCRPAPPDDICGFVTRGKGMSIHRSDC
ATFLRMAERAPERVLQTAWSAEVMSGRGQSVYPVDLSIEATDRQGLLRDISEVFAREKMNVIGVKTQTRRNAAFMQFTVE
VSNAAQIQRACTLLGEVTGVMRASRKS
>Mature_747_residues
MNTEIVTSTPKPLPSFEEAMAFVREHAGEVRLSSGEMLADHAAGTASIMRTLNVDPPAVLAAALFALTPHLQDPERVIAD
NFGEEVAQLVGDVRKLLRLGTVSLRAAQNAMPEAGRDAQAARRAQVEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAA
KITPSPDVARETLDIYAPLANRLGIWQLKWELEDLALRFEEPVTYKRIAKLLDEKRVERESYVAQAIERLQKELAAAHIR
AEVSGRPKHIYSIWRKMRGKELDFAELYDVRAFRVIVPDIKDCYTVLGIVHNLWQPVPKEFDDYISRPKPNGYKSLHTVV
IGDDGRAFEVQIRTQEMHQFAEYGVAAHWRYKEAGTRGYAGQFAANGKYDEKIAWLRQLLAWKDEVSEGEHGEKRAAQPW
EQLRQATLDDDHIYVLTPQARVIPLPHGATPVDFAYHLHSELGHRCRGARVDGAMVPLNTPLQNGQTVEIVAVKEGGPSR
DWLNPQLGYLQSPRARQKVRAWFNAVEVQEHIASGRAMVEKTLQREGKTSVNLDQLAAKLGFKTTDDLFSVVGKEEFSLR
LVEQALHDAPPPEPVVDAPEQFEKRSSGASVARGASTGVLVVGVDALLTQLARCCRPAPPDDICGFVTRGKGMSIHRSDC
ATFLRMAERAPERVLQTAWSAEVMSGRGQSVYPVDLSIEATDRQGLLRDISEVFAREKMNVIGVKTQTRRNAAFMQFTVE
VSNAAQIQRACTLLGEVTGVMRASRKS

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=705, Percent_Identity=39.7163120567376, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI1790082, Length=731, Percent_Identity=34.4733242134063, Blast_Score=379, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83306; Mature: 83306

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTEIVTSTPKPLPSFEEAMAFVREHAGEVRLSSGEMLADHAAGTASIMRTLNVDPPAVL
CCCCEECCCCCCCCCHHHHHHHHHHCCCCEEECCCCCHHHHCCCHHHHHHHCCCCCHHHH
AAALFALTPHLQDPERVIADNFGEEVAQLVGDVRKLLRLGTVSLRAAQNAMPEAGRDAQA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
ARRAQVEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAAKITPSPDVARETLDIYAPLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHH
NRLGIWQLKWELEDLALRFEEPVTYKRIAKLLDEKRVERESYVAQAIERLQKELAAAHIR
HCCCEEEEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEVSGRPKHIYSIWRKMRGKELDFAELYDVRAFRVIVPDIKDCYTVLGIVHNLWQPVPKE
HHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHCCCCHH
FDDYISRPKPNGYKSLHTVVIGDDGRAFEVQIRTQEMHQFAEYGVAAHWRYKEAGTRGYA
HHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEEHHHHHHHHHCCCCEEEEEHHCCCCCCC
GQFAANGKYDEKIAWLRQLLAWKDEVSEGEHGEKRAAQPWEQLRQATLDDDHIYVLTPQA
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHCCCCCCEEEEECCCC
RVIPLPHGATPVDFAYHLHSELGHRCRGARVDGAMVPLNTPLQNGQTVEIVAVKEGGPSR
EEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEEEEECCCCCC
DWLNPQLGYLQSPRARQKVRAWFNAVEVQEHIASGRAMVEKTLQREGKTSVNLDQLAAKL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
GFKTTDDLFSVVGKEEFSLRLVEQALHDAPPPEPVVDAPEQFEKRSSGASVARGASTGVL
CCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCHHCCCCCCEE
VVGVDALLTQLARCCRPAPPDDICGFVTRGKGMSIHRSDCATFLRMAERAPERVLQTAWS
EEEHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
AEVMSGRGQSVYPVDLSIEATDRQGLLRDISEVFAREKMNVIGVKTQTRRNAAFMQFTVE
HHHHCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEEEE
VSNAAQIQRACTLLGEVTGVMRASRKS
HHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNTEIVTSTPKPLPSFEEAMAFVREHAGEVRLSSGEMLADHAAGTASIMRTLNVDPPAVL
CCCCEECCCCCCCCCHHHHHHHHHHCCCCEEECCCCCHHHHCCCHHHHHHHCCCCCHHHH
AAALFALTPHLQDPERVIADNFGEEVAQLVGDVRKLLRLGTVSLRAAQNAMPEAGRDAQA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
ARRAQVEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAAKITPSPDVARETLDIYAPLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHH
NRLGIWQLKWELEDLALRFEEPVTYKRIAKLLDEKRVERESYVAQAIERLQKELAAAHIR
HCCCEEEEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEVSGRPKHIYSIWRKMRGKELDFAELYDVRAFRVIVPDIKDCYTVLGIVHNLWQPVPKE
HHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHCCCCHH
FDDYISRPKPNGYKSLHTVVIGDDGRAFEVQIRTQEMHQFAEYGVAAHWRYKEAGTRGYA
HHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEEHHHHHHHHHCCCCEEEEEHHCCCCCCC
GQFAANGKYDEKIAWLRQLLAWKDEVSEGEHGEKRAAQPWEQLRQATLDDDHIYVLTPQA
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHCCCCCCEEEEECCCC
RVIPLPHGATPVDFAYHLHSELGHRCRGARVDGAMVPLNTPLQNGQTVEIVAVKEGGPSR
EEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEEEEECCCCCC
DWLNPQLGYLQSPRARQKVRAWFNAVEVQEHIASGRAMVEKTLQREGKTSVNLDQLAAKL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
GFKTTDDLFSVVGKEEFSLRLVEQALHDAPPPEPVVDAPEQFEKRSSGASVARGASTGVL
CCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCHHCCCCCCEE
VVGVDALLTQLARCCRPAPPDDICGFVTRGKGMSIHRSDCATFLRMAERAPERVLQTAWS
EEEHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
AEVMSGRGQSVYPVDLSIEATDRQGLLRDISEVFAREKMNVIGVKTQTRRNAAFMQFTVE
HHHHCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEEEE
VSNAAQIQRACTLLGEVTGVMRASRKS
HHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7928955 [H]