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The map label for this gene is dht [H]

Identifier: 91784369

GI number: 91784369

Start: 3334971

End: 3336422

Strand: Reverse

Name: dht [H]

Synonym: Bxe_A1431

Alternate gene names: 91784369

Gene position: 3336422-3334971 (Counterclockwise)

Preceding gene: 91784370

Following gene: 91784368

Centisome position: 68.15

GC content: 64.88

Gene sequence:

>1452_bases
ATGACGACCCTGATTCGCGGCGGCACGATTATCGACGCGGAGAACACCTATCGTGCGGACGTGTTGTGTGCGGACCCGCA
GGACGGCGGCACGATCCTGCAGATCGGCGAGGATCTGGAGGCGCCGGCGGGTGCCACGATCGTCGACGCGGGCGGGCAGT
ATGTGATGCCCGGCGGCATCGACCCGCACACGCATATGGAATTGCCGTTCATGGGCACCACGGCGAGCGACGATTTCTAC
ACCGGTACGGCCGCGGGTTTATCGGGCGGCACCACGAGCATCATCGACTTCGTGATTCCGAGCCCGAAGCAGCCGCTGAT
GGAGGCCTTCGAGGAATGGCGCGGCTGGGCCGGGAAAGCGTCTTCGGACTACGGCTTTCATGTCGCGGTGACGTGGTGGG
ACGATTCGGTCTATCGCGACATGGGCACGCTGGTGCACGAACACGGCGTGTCGAGTTTCAAGCACTTCATGGCCTATAAA
AACGCGATCATGGCCGACGACGAAGTACTGGTGAACAGCTTCTCCCGTTCGCTCGAACTCGGCGCGCTGCCCACCGTGCA
TGCGGAAAACGGTGAGCTGGTGTTCCAGTTGCAGCGTCAGTTGCTGGCGAAAGGCTTTACCGGTCCGGAGGCGCATCCGC
TGTCGCGGCCGCCCGAAGTGGAGGGCGAAGCGGCCAATCGCGCGATCCGGATCGCGCAGGTGCTGGGCGTGCCGGTGTAT
ATCGTGCACGTGTCCGCAAAAGACGCGGTGGATGCCATTGCGCGCGCGCGCAGCGAAGGTCTGCGCGTATTCGGCGAGGT
GCTGCCGGGCCATCTGGTGATCGACGAAGCGGTGTATCGCGATCCCGACTGGACCCGCGCGGCGGCCCACGTAATGAGCC
CGCCGTTCCGCTCGGCCGAGCATCGCGAGGCGTTGTGGCGCGGTTTGCAAGCCGGCCAGCTGCATACCACGGCGACCGAT
CACTGCGTCTTCTGCGCGTCGCAAAAGGCGATGGGCCGCGAGGACTTCACGAAGATCCCGAACGGCTGCGGCGGCGTGGA
AGACCGGATGGCGGTGCTCTGGCATCACGGCGTGAATTCCGGGCGTCTCACGCCGAACGAGTTCGTGCGTATCACTTCGA
CGAACGCCGCGCAGATTTTCAACCTGTATCCCCGCAAAGGCGCGGTGCGGGTTGGCGCGGATGCCGACCTGGTAGTGTGG
GACCCGAACGCGAGCAGGACGATTTCGGTGAAGACGCATCATCAGAAAGTGGACTTCAACGTGTTCGAAGGCATGACGGT
GCAAGGCGTGGCGATGCACACGCTCACGCGCGGCGCGCTCGCGTGGACCGACGGCGAGTTGCGCGCGGTGCGAGGTGCGG
GCCGTTATCTGAAGCGCCCGCCCAACGGCGCTTACTTCGACGCGATCCGGGTCGCCAACAGGCGCAAGGAGCCGCATCCG
GTGGAGCGGTAG

Upstream 100 bases:

>100_bases
GGATGAAGCTGAGCAAGGGACCCAGCGCGCGCGTGGCGAGTGCATGAGCAGGAACGAAGTACGTAGTACCGAAACCAGCA
GTTCATAAGGAGGCGGCAAC

Downstream 100 bases:

>100_bases
GCTACTGGCAGTCCCACGGGTGGCGCCGCCATCGCATGCGGCGCCACCCGTTTTTCCATGCCGGGCGTTCGCTCCGGCAG
CACTCCTCTCGCGTTTTCCC

Product: phenylhydantoinase

Products: NA

Alternate protein names: DHPase [H]

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MTTLIRGGTIIDAENTYRADVLCADPQDGGTILQIGEDLEAPAGATIVDAGGQYVMPGGIDPHTHMELPFMGTTASDDFY
TGTAAGLSGGTTSIIDFVIPSPKQPLMEAFEEWRGWAGKASSDYGFHVAVTWWDDSVYRDMGTLVHEHGVSSFKHFMAYK
NAIMADDEVLVNSFSRSLELGALPTVHAENGELVFQLQRQLLAKGFTGPEAHPLSRPPEVEGEAANRAIRIAQVLGVPVY
IVHVSAKDAVDAIARARSEGLRVFGEVLPGHLVIDEAVYRDPDWTRAAAHVMSPPFRSAEHREALWRGLQAGQLHTTATD
HCVFCASQKAMGREDFTKIPNGCGGVEDRMAVLWHHGVNSGRLTPNEFVRITSTNAAQIFNLYPRKGAVRVGADADLVVW
DPNASRTISVKTHHQKVDFNVFEGMTVQGVAMHTLTRGALAWTDGELRAVRGAGRYLKRPPNGAYFDAIRVANRRKEPHP
VER

Sequences:

>Translated_483_residues
MTTLIRGGTIIDAENTYRADVLCADPQDGGTILQIGEDLEAPAGATIVDAGGQYVMPGGIDPHTHMELPFMGTTASDDFY
TGTAAGLSGGTTSIIDFVIPSPKQPLMEAFEEWRGWAGKASSDYGFHVAVTWWDDSVYRDMGTLVHEHGVSSFKHFMAYK
NAIMADDEVLVNSFSRSLELGALPTVHAENGELVFQLQRQLLAKGFTGPEAHPLSRPPEVEGEAANRAIRIAQVLGVPVY
IVHVSAKDAVDAIARARSEGLRVFGEVLPGHLVIDEAVYRDPDWTRAAAHVMSPPFRSAEHREALWRGLQAGQLHTTATD
HCVFCASQKAMGREDFTKIPNGCGGVEDRMAVLWHHGVNSGRLTPNEFVRITSTNAAQIFNLYPRKGAVRVGADADLVVW
DPNASRTISVKTHHQKVDFNVFEGMTVQGVAMHTLTRGALAWTDGELRAVRGAGRYLKRPPNGAYFDAIRVANRRKEPHP
VER
>Mature_482_residues
TTLIRGGTIIDAENTYRADVLCADPQDGGTILQIGEDLEAPAGATIVDAGGQYVMPGGIDPHTHMELPFMGTTASDDFYT
GTAAGLSGGTTSIIDFVIPSPKQPLMEAFEEWRGWAGKASSDYGFHVAVTWWDDSVYRDMGTLVHEHGVSSFKHFMAYKN
AIMADDEVLVNSFSRSLELGALPTVHAENGELVFQLQRQLLAKGFTGPEAHPLSRPPEVEGEAANRAIRIAQVLGVPVYI
VHVSAKDAVDAIARARSEGLRVFGEVLPGHLVIDEAVYRDPDWTRAAAHVMSPPFRSAEHREALWRGLQAGQLHTTATDH
CVFCASQKAMGREDFTKIPNGCGGVEDRMAVLWHHGVNSGRLTPNEFVRITSTNAAQIFNLYPRKGAVRVGADADLVVWD
PNASRTISVKTHHQKVDFNVFEGMTVQGVAMHTLTRGALAWTDGELRAVRGAGRYLKRPPNGAYFDAIRVANRRKEPHPV
ER

Specific function: Catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins, to produce N-carbamoyl-D-amino acids [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=487, Percent_Identity=50.3080082135524, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI4503379, Length=486, Percent_Identity=43.4156378600823, Blast_Score=431, Evalue=1e-120,
Organism=Homo sapiens, GI4503377, Length=483, Percent_Identity=42.6501035196687, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI190194363, Length=487, Percent_Identity=44.7638603696099, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI4503051, Length=458, Percent_Identity=44.7598253275109, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI62422571, Length=458, Percent_Identity=44.7598253275109, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI19923821, Length=466, Percent_Identity=44.206008583691, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI18105007, Length=413, Percent_Identity=25.90799031477, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI87082175, Length=465, Percent_Identity=37.8494623655914, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI1786722, Length=449, Percent_Identity=26.9487750556793, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17539558, Length=486, Percent_Identity=46.7078189300411, Blast_Score=448, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI71989490, Length=486, Percent_Identity=44.238683127572, Blast_Score=428, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI86575075, Length=472, Percent_Identity=31.3559322033898, Blast_Score=245, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI193204318, Length=409, Percent_Identity=26.6503667481663, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322218, Length=407, Percent_Identity=27.2727272727273, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI221377917, Length=484, Percent_Identity=45.6611570247934, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI17137462, Length=482, Percent_Identity=45.0207468879668, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24644287, Length=298, Percent_Identity=44.6308724832215, Blast_Score=259, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24644289, Length=239, Percent_Identity=46.4435146443515, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24642586, Length=404, Percent_Identity=26.980198019802, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI18859883, Length=455, Percent_Identity=25.7142857142857, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.2 [H]

Molecular weight: Translated: 52696; Mature: 52565

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLIRGGTIIDAENTYRADVLCADPQDGGTILQIGEDLEAPAGATIVDAGGQYVMPGGI
CCEEEECCEEEECCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCEEEECCCCEEECCCC
DPHTHMELPFMGTTASDDFYTGTAAGLSGGTTSIIDFVIPSPKQPLMEAFEEWRGWAGKA
CCCCEEECCEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCC
SSDYGFHVAVTWWDDSVYRDMGTLVHEHGVSSFKHFMAYKNAIMADDEVLVNSFSRSLEL
CCCCCEEEEEEEECCHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHCEEC
GALPTVHAENGELVFQLQRQLLAKGFTGPEAHPLSRPPEVEGEAANRAIRIAQVLGVPVY
CCCCEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEE
IVHVSAKDAVDAIARARSEGLRVFGEVLPGHLVIDEAVYRDPDWTRAAAHVMSPPFRSAE
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHCCCCHHHHHHHHCCCCCCCHH
HREALWRGLQAGQLHTTATDHCVFCASQKAMGREDFTKIPNGCGGVEDRMAVLWHHGVNS
HHHHHHCCCCCCEEEECCCCCEEEECCCHHCCCHHHHHCCCCCCCHHHHEEEEEECCCCC
GRLTPNEFVRITSTNAAQIFNLYPRKGAVRVGADADLVVWDPNASRTISVKTHHQKVDFN
CCCCHHHEEEEECCCCEEEEEECCCCCCEEECCCCEEEEECCCCCCEEEEEECCEEECEE
VFEGMTVQGVAMHTLTRGALAWTDGELRAVRGAGRYLKRPPNGAYFDAIRVANRRKEPHP
HHCCCEECHHHHHHHHCCEEEECCCCCEEEHHCCHHHCCCCCCCHHHHHHHHHCCCCCCC
VER
CCC
>Mature Secondary Structure 
TTLIRGGTIIDAENTYRADVLCADPQDGGTILQIGEDLEAPAGATIVDAGGQYVMPGGI
CEEEECCEEEECCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCEEEECCCCEEECCCC
DPHTHMELPFMGTTASDDFYTGTAAGLSGGTTSIIDFVIPSPKQPLMEAFEEWRGWAGKA
CCCCEEECCEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCC
SSDYGFHVAVTWWDDSVYRDMGTLVHEHGVSSFKHFMAYKNAIMADDEVLVNSFSRSLEL
CCCCCEEEEEEEECCHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHCEEC
GALPTVHAENGELVFQLQRQLLAKGFTGPEAHPLSRPPEVEGEAANRAIRIAQVLGVPVY
CCCCEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEE
IVHVSAKDAVDAIARARSEGLRVFGEVLPGHLVIDEAVYRDPDWTRAAAHVMSPPFRSAE
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHCCCCHHHHHHHHCCCCCCCHH
HREALWRGLQAGQLHTTATDHCVFCASQKAMGREDFTKIPNGCGGVEDRMAVLWHHGVNS
HHHHHHCCCCCCEEEECCCCCEEEECCCHHCCCHHHHHCCCCCCCHHHHEEEEEECCCCC
GRLTPNEFVRITSTNAAQIFNLYPRKGAVRVGADADLVVWDPNASRTISVKTHHQKVDFN
CCCCHHHEEEEECCCCEEEEEECCCCCCEEECCCCEEEEECCCCCCEEEEEECCEEECEE
VFEGMTVQGVAMHTLTRGALAWTDGELRAVRGAGRYLKRPPNGAYFDAIRVANRRKEPHP
HHCCCEECHHHHHHHHCCEEEECCCCCEEEHHCCHHHCCCCCCCHHHHHHHHHCCCCCCC
VER
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]