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The map label for this gene is ptpA [H]

Identifier: 91784250

GI number: 91784250

Start: 3196885

End: 3197382

Strand: Reverse

Name: ptpA [H]

Synonym: Bxe_A1551

Alternate gene names: 91784250

Gene position: 3197382-3196885 (Counterclockwise)

Preceding gene: 91784251

Following gene: 91784249

Centisome position: 65.31

GC content: 65.46

Gene sequence:

>498_bases
ATGAAAACCGTGTCCATCTGCTTTGTCTGCCTCGGCAACATCTGCCGCTCTCCGACGGCGGAAGGTGTGATGCGCCGTCT
GGTGGGCGAAGCAAGGCTCGCGGAGCACATCCTGATCGATTCCGCCGGCACAGGCGACTGGCACATCGGCCAACCGCCGG
ACGAACGCGCGCAATATGCGGCTGGCCGGCGGGGGTATGAACTGGCCGCCTTGCGCGGCCGCCAGATTGCCGCAGCGGAT
TTCGAGCGCTTCGATCTGCTGATCGCGATGGACGACAAAAACGTCGCCGCGTTGCGCCAGGTCTGCGCACCGGAACAACG
CGACAAGATTCGTCTGCTGATGGAGTTTGTTCCGGAAACGGAGGCCCGCTGGGGCGGCGCCCGTGAAGTCGTCGATCCGT
ATTTCGGCGGCGCGGACGGTTTCGAGCAGGTGCTGGACCAGTGCGAGGCGGCCTGCCGCGGCCTGATTGCGGCGTTGCGC
CCCCGCTTGCAGGCGTAA

Upstream 100 bases:

>100_bases
CCCGGCGAGATTCCGGCGAGCTTTGTATAATCCCGGCACCTATCTTGATAAACATCGGCCGACGCGCCTCGCGTGCCTGT
GCGTGCCTGAAAAGCCCCTG

Downstream 100 bases:

>100_bases
GGTTTGACCGGGGTTCGACGATAGCGCGCGGAGCGCATCCGGTAATTAAGCAAATGACCCAAATCGCAATAGGGATACTT
GACTAAATCGGTCATGTATT

Product: protein tyrosine phosphatase

Products: NA

Alternate protein names: PTPase; Small, acidic phosphotyrosine protein phosphatase; PY protein phosphatase [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MKTVSICFVCLGNICRSPTAEGVMRRLVGEARLAEHILIDSAGTGDWHIGQPPDERAQYAAGRRGYELAALRGRQIAAAD
FERFDLLIAMDDKNVAALRQVCAPEQRDKIRLLMEFVPETEARWGGAREVVDPYFGGADGFEQVLDQCEAACRGLIAALR
PRLQA

Sequences:

>Translated_165_residues
MKTVSICFVCLGNICRSPTAEGVMRRLVGEARLAEHILIDSAGTGDWHIGQPPDERAQYAAGRRGYELAALRGRQIAAAD
FERFDLLIAMDDKNVAALRQVCAPEQRDKIRLLMEFVPETEARWGGAREVVDPYFGGADGFEQVLDQCEAACRGLIAALR
PRLQA
>Mature_165_residues
MKTVSICFVCLGNICRSPTAEGVMRRLVGEARLAEHILIDSAGTGDWHIGQPPDERAQYAAGRRGYELAALRGRQIAAAD
FERFDLLIAMDDKNVAALRQVCAPEQRDKIRLLMEFVPETEARWGGAREVVDPYFGGADGFEQVLDQCEAACRGLIAALR
PRLQA

Specific function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. May be involved in the regulation of sulfur amino acid metabolism [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI4757714, Length=156, Percent_Identity=38.4615384615385, Blast_Score=113, Evalue=9e-26,
Organism=Homo sapiens, GI6005988, Length=156, Percent_Identity=37.8205128205128, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI96304457, Length=80, Percent_Identity=45, Blast_Score=76, Evalue=1e-14,
Organism=Escherichia coli, GI87081812, Length=154, Percent_Identity=33.1168831168831, Blast_Score=68, Evalue=3e-13,
Organism=Escherichia coli, GI1788375, Length=155, Percent_Identity=30.9677419354839, Blast_Score=65, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6325330, Length=146, Percent_Identity=30.8219178082192, Blast_Score=92, Evalue=6e-20,
Organism=Drosophila melanogaster, GI78706770, Length=157, Percent_Identity=39.4904458598726, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI78706772, Length=157, Percent_Identity=39.4904458598726, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI78706766, Length=161, Percent_Identity=35.4037267080745, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI78706768, Length=161, Percent_Identity=35.4037267080745, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI78711846, Length=155, Percent_Identity=36.7741935483871, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI78706764, Length=131, Percent_Identity=33.587786259542, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 18189; Mature: 18189

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVSICFVCLGNICRSPTAEGVMRRLVGEARLAEHILIDSAGTGDWHIGQPPDERAQYA
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
AGRRGYELAALRGRQIAAADFERFDLLIAMDDKNVAALRQVCAPEQRDKIRLLMEFVPET
CCCCCCCHHHHCCCCHHHHHHHHHEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHCCCH
EARWGGAREVVDPYFGGADGFEQVLDQCEAACRGLIAALRPRLQA
HHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTVSICFVCLGNICRSPTAEGVMRRLVGEARLAEHILIDSAGTGDWHIGQPPDERAQYA
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
AGRRGYELAALRGRQIAAADFERFDLLIAMDDKNVAALRQVCAPEQRDKIRLLMEFVPET
CCCCCCCHHHHCCCCHHHHHHHHHEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHCCCH
EARWGGAREVVDPYFGGADGFEQVLDQCEAACRGLIAALRPRLQA
HHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550407; 12000953 [H]