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The map label for this gene is cusS [H]

Identifier: 91784076

GI number: 91784076

Start: 3000190

End: 3001545

Strand: Reverse

Name: cusS [H]

Synonym: Bxe_A1726

Alternate gene names: 91784076

Gene position: 3001545-3000190 (Counterclockwise)

Preceding gene: 91784077

Following gene: 91784072

Centisome position: 61.31

GC content: 57.01

Gene sequence:

>1356_bases
ATGTTCAATCACTGGATTCGAAGTCTGTCGGCCCGGTTATGGGTGACGACCGTCGTCGCGCTCGCAGCCAGCCTGACCGT
GCTTGCCGGGATGGTTATCCATGTTCTCGATCACTACCCGGAGCAGACTCTGGGTCGACGTGAAGAGATGGAGAGTCTCG
CCAGGGTAATTGATTCAATCAGGTTCGACGACTCCGGCTTTCCCCGCGATGTGGAGCTTCCCGATCGGCAGGCTTGGCTG
TTTCAGGTTGCGCCCACCGAGCTCAAATATCGTGTGCTGGACGCGCAGGGTCACGTCCTGCTCGCATCCGCGGGAGCAGA
AAAAGACGGTCCGTGGCTGATGGGCGACCTTTCTGCCGACGTTGGCAAGATAGCCCACGCGGATGTCGACGGCCGGCGGT
TTTCGATCGCGACGCGCAGGGTATTGCGGGGACAATCCGAGTTCTATGTGCAGACCGCGACGAGCGCCAGGTTCATAGAC
ATACTGGTCAGTTCAAAGGTCAAGCCCATTCCGTCGACGGTCAGGGTCATTTTCTTTATTACAATCGCTATATTCGGCGT
TGTGCTGTTGTTTACGATCCGCCGCATGCTCAAGCCGTTGCGGGACGCGTCCGACGCGGCGGCGCAGATAACTCCGCGTC
ATCTGAAAACGCGCCTTTCGACCCATGGTGTTCCAAGTGAGCTCAAGCCGTTGATCAATGCCTTCAACGAGGCGCTCGGA
CGGCTCGAGAACGGCTTCCTGGTTCAGCAGCAATTTCTTGCGGCTGCTGCGCATGAGTTTCAAACGCCGCTGACGTTGAT
CCGCGGGCAGATCGAGTTGCAGCCGGAGATCAAGGAAAGAGATCTTTTGTTCCGCGAAATCGACCTGATGTCGAGGCAGG
TGCGACAGCTGCTACATCTGGCCGAAGTCAGCGAAGCACAGAATTTCGACTTCGGCGAAGCCAACATTGTCGACGTGGCG
CAGGATGTCGTTGCCTATCTGGCTCGCAAGGCCGATGCAAAGCAGGTGAAGTTACGTGTGGATGAGCGCGACGCGGCACC
GTCGATCTGGGCGGACAAAAGCGCGTTGTTCATCCTCCTCAAGAATATCGTCGAAAACGCGATCAACGCGTCCCCTGCTT
ACGGCATCGTGTTGTTGACGATTGATGGGATATCGATCGAGATTTCTGACGAAGGGCCTGGTATCCGGAAGGATCATCTT
CCGTTTCTGTTCAAGCGATTCTGGCGCGCGCCCGATGCAAGGCACGATGGCGCGGGCCTGGGATTGGCAATATGCAAGGA
AATTGCAGCGGTGCATGATTGGCGCCTGACAGTGAGCTCACTTTCGATTGGAACGCGCTTCACTGTCTGGCTATGA

Upstream 100 bases:

>100_bases
CGGACCGCAAGAGCGACCGATTCGTGTCGCCCGCGGATCCACCCGATATGAGTATTCCGACGCCCAGCAATTCCGCTCCC
GTTTTAACCTGAGAGCCGCC

Downstream 100 bases:

>100_bases
CCTTCCTCTTTGTCGAACCGCTGACTCGTCGCGCGATTCTCGTCATATGCACGGGCGGAACGTCGATGCGCATCTCGTCG
TTGAGGAAACCGCGAGACTG

Product: Signal transduction histidine Kinases (STHK)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MFNHWIRSLSARLWVTTVVALAASLTVLAGMVIHVLDHYPEQTLGRREEMESLARVIDSIRFDDSGFPRDVELPDRQAWL
FQVAPTELKYRVLDAQGHVLLASAGAEKDGPWLMGDLSADVGKIAHADVDGRRFSIATRRVLRGQSEFYVQTATSARFID
ILVSSKVKPIPSTVRVIFFITIAIFGVVLLFTIRRMLKPLRDASDAAAQITPRHLKTRLSTHGVPSELKPLINAFNEALG
RLENGFLVQQQFLAAAAHEFQTPLTLIRGQIELQPEIKERDLLFREIDLMSRQVRQLLHLAEVSEAQNFDFGEANIVDVA
QDVVAYLARKADAKQVKLRVDERDAAPSIWADKSALFILLKNIVENAINASPAYGIVLLTIDGISIEISDEGPGIRKDHL
PFLFKRFWRAPDARHDGAGLGLAICKEIAAVHDWRLTVSSLSIGTRFTVWL

Sequences:

>Translated_451_residues
MFNHWIRSLSARLWVTTVVALAASLTVLAGMVIHVLDHYPEQTLGRREEMESLARVIDSIRFDDSGFPRDVELPDRQAWL
FQVAPTELKYRVLDAQGHVLLASAGAEKDGPWLMGDLSADVGKIAHADVDGRRFSIATRRVLRGQSEFYVQTATSARFID
ILVSSKVKPIPSTVRVIFFITIAIFGVVLLFTIRRMLKPLRDASDAAAQITPRHLKTRLSTHGVPSELKPLINAFNEALG
RLENGFLVQQQFLAAAAHEFQTPLTLIRGQIELQPEIKERDLLFREIDLMSRQVRQLLHLAEVSEAQNFDFGEANIVDVA
QDVVAYLARKADAKQVKLRVDERDAAPSIWADKSALFILLKNIVENAINASPAYGIVLLTIDGISIEISDEGPGIRKDHL
PFLFKRFWRAPDARHDGAGLGLAICKEIAAVHDWRLTVSSLSIGTRFTVWL
>Mature_451_residues
MFNHWIRSLSARLWVTTVVALAASLTVLAGMVIHVLDHYPEQTLGRREEMESLARVIDSIRFDDSGFPRDVELPDRQAWL
FQVAPTELKYRVLDAQGHVLLASAGAEKDGPWLMGDLSADVGKIAHADVDGRRFSIATRRVLRGQSEFYVQTATSARFID
ILVSSKVKPIPSTVRVIFFITIAIFGVVLLFTIRRMLKPLRDASDAAAQITPRHLKTRLSTHGVPSELKPLINAFNEALG
RLENGFLVQQQFLAAAAHEFQTPLTLIRGQIELQPEIKERDLLFREIDLMSRQVRQLLHLAEVSEAQNFDFGEANIVDVA
QDVVAYLARKADAKQVKLRVDERDAAPSIWADKSALFILLKNIVENAINASPAYGIVLLTIDGISIEISDEGPGIRKDHL
PFLFKRFWRAPDARHDGAGLGLAICKEIAAVHDWRLTVSSLSIGTRFTVWL

Specific function: Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Probably activates CusR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=291, Percent_Identity=31.2714776632302, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1790551, Length=265, Percent_Identity=30.9433962264151, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789403, Length=266, Percent_Identity=27.8195488721804, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788279, Length=292, Percent_Identity=27.0547945205479, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786600, Length=216, Percent_Identity=30.0925925925926, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788393, Length=267, Percent_Identity=24.7191011235955, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790436, Length=214, Percent_Identity=27.5700934579439, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790346, Length=264, Percent_Identity=26.5151515151515, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790861, Length=271, Percent_Identity=25.830258302583, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50390; Mature: 50390

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNHWIRSLSARLWVTTVVALAASLTVLAGMVIHVLDHYPEQTLGRREEMESLARVIDSI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHH
RFDDSGFPRDVELPDRQAWLFQVAPTELKYRVLDAQGHVLLASAGAEKDGPWLMGDLSAD
CCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCEEEEECCCCCCCCEEEECCCHH
VGKIAHADVDGRRFSIATRRVLRGQSEFYVQTATSARFIDILVSSKVKPIPSTVRVIFFI
HHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHH
TIAIFGVVLLFTIRRMLKPLRDASDAAAQITPRHLKTRLSTHGVPSELKPLINAFNEALG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
RLENGFLVQQQFLAAAAHEFQTPLTLIRGQIELQPEIKERDLLFREIDLMSRQVRQLLHL
HHCCCHHHHHHHHHHHHHHHCCCHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
AEVSEAQNFDFGEANIVDVAQDVVAYLARKADAKQVKLRVDERDAAPSIWADKSALFILL
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHH
KNIVENAINASPAYGIVLLTIDGISIEISDEGPGIRKDHLPFLFKRFWRAPDARHDGAGL
HHHHHHHCCCCCCCEEEEEEECCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCH
GLAICKEIAAVHDWRLTVSSLSIGTRFTVWL
HHHHHHHHHHHHHHEEEEEHCCCCCEEEEEC
>Mature Secondary Structure
MFNHWIRSLSARLWVTTVVALAASLTVLAGMVIHVLDHYPEQTLGRREEMESLARVIDSI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCHHHHHHHHHHHHHHH
RFDDSGFPRDVELPDRQAWLFQVAPTELKYRVLDAQGHVLLASAGAEKDGPWLMGDLSAD
CCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCEEEEECCCCCCCCEEEECCCHH
VGKIAHADVDGRRFSIATRRVLRGQSEFYVQTATSARFIDILVSSKVKPIPSTVRVIFFI
HHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHH
TIAIFGVVLLFTIRRMLKPLRDASDAAAQITPRHLKTRLSTHGVPSELKPLINAFNEALG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
RLENGFLVQQQFLAAAAHEFQTPLTLIRGQIELQPEIKERDLLFREIDLMSRQVRQLLHL
HHCCCHHHHHHHHHHHHHHHCCCHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
AEVSEAQNFDFGEANIVDVAQDVVAYLARKADAKQVKLRVDERDAAPSIWADKSALFILL
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHH
KNIVENAINASPAYGIVLLTIDGISIEISDEGPGIRKDHLPFLFKRFWRAPDARHDGAGL
HHHHHHHCCCCCCCEEEEEEECCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCH
GLAICKEIAAVHDWRLTVSSLSIGTRFTVWL
HHHHHHHHHHHHHHEEEEEHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]