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The map label for this gene is adh [H]

Identifier: 91783951

GI number: 91783951

Start: 2864847

End: 2865887

Strand: Reverse

Name: adh [H]

Synonym: Bxe_A1860

Alternate gene names: 91783951

Gene position: 2865887-2864847 (Counterclockwise)

Preceding gene: 91783952

Following gene: 91783946

Centisome position: 58.54

GC content: 62.73

Gene sequence:

>1041_bases
ATGAAAGCACTCGTGTATCACGGTCCCGGAAAGAAGTCGCTCGACGAGCGGCCCATGCCGCAACTCGCCAGCGCCACCGA
CGCCATCGTCAAGGTGACGCGCACGACGATCTGCGGTACCGATCTTCACATTCTGAAGGGCGACGTGCCCACGTGCCAGC
CCGGCCGCATTCTGGGTCACGAAGGAGTGGGCATCGTGCAGCAGGTCGGCGCCGCGGTCAGTTCGTTGAAAGAGGGCGAT
CACGTGCTGATCTCGTGCATCTCCGCATGCGGCAAGTGCGATTATTGCCGGCGCGGCATGTATTCGCACTGCACGACCGG
CGGCTGGATTCTCGGCAACCGTATCGACGGCACGCAAGCCGAATATGTGCGCATTCCGCATGCGGAGACGAGTCTTTATC
CGATTCCCGCCGGTGCCGACGAAGAAGCGCTGGTGATGCTGTCCGACATCCTGCCGACCGGCTTCGAATGCGGCGTCCTC
AACGGCAAGGTGCAGCCGGGCAGCGCCGTGGCGATTGTCGGCGCCGGGCCGATCGGACTGGCTTCGCTGCTCACCGCGCA
GTTCTATTCGCCGGCCCAGATCATCATGATCGATCGCGACGAGCGCCGGCTCGAAGTGGCGAGCCGTTTCGGCGCGACCG
CGTGTATCGACAGCCGGGTGGCCGAACCGGTCGTGGAGGTGATGAAGCTTACCGGGCACGTCGGTGTGGATTGCGCGATC
GAGGCCGTGGGCGTGCCCGACACCTTCGAGTTGTGCCAGGCGCTGGTTGCGCCCGGTGGTGTGATCGCCAATATCGGCGT
GCATGGGGTGAAGGCGGATCTGCATCTGGAATCGCTGTGGGATCGCAACATTTCCATTACGACGCGCCTCGTCGATACCG
TCAGTACACCGATGTTGCTGAAGACGGTGCAATCCGGCCGGATCGATCCGGCCAGACTCATCACCCATCATTTCCAGCTG
GACGACGTGTTGAACGCCTACGATACCTTCGGCCGCGCGGCGGATTCGCATGCGTTGAAGGTGATCATCGAGATGTCGTG
A

Upstream 100 bases:

>100_bases
GGTACTGCTGATCCGTGAAGAGGCGAAGACGGAGCATGACACCCCGGCCTGAGCGTGATGCCTGTCTCGCTGCGGCCTTG
ACTGACCAATGAGGTAATCC

Downstream 100 bases:

>100_bases
CGTAACAGCGGGCGGCGCCGCGTCGAGCGCCTGGCGGCGCGATGCAAACGCAGTAAAGCCCGCCGCAAAGCCCGCTAAAT
TCGTGTGCCGCAGCGCCGCC

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKALVYHGPGKKSLDERPMPQLASATDAIVKVTRTTICGTDLHILKGDVPTCQPGRILGHEGVGIVQQVGAAVSSLKEGD
HVLISCISACGKCDYCRRGMYSHCTTGGWILGNRIDGTQAEYVRIPHAETSLYPIPAGADEEALVMLSDILPTGFECGVL
NGKVQPGSAVAIVGAGPIGLASLLTAQFYSPAQIIMIDRDERRLEVASRFGATACIDSRVAEPVVEVMKLTGHVGVDCAI
EAVGVPDTFELCQALVAPGGVIANIGVHGVKADLHLESLWDRNISITTRLVDTVSTPMLLKTVQSGRIDPARLITHHFQL
DDVLNAYDTFGRAADSHALKVIIEMS

Sequences:

>Translated_346_residues
MKALVYHGPGKKSLDERPMPQLASATDAIVKVTRTTICGTDLHILKGDVPTCQPGRILGHEGVGIVQQVGAAVSSLKEGD
HVLISCISACGKCDYCRRGMYSHCTTGGWILGNRIDGTQAEYVRIPHAETSLYPIPAGADEEALVMLSDILPTGFECGVL
NGKVQPGSAVAIVGAGPIGLASLLTAQFYSPAQIIMIDRDERRLEVASRFGATACIDSRVAEPVVEVMKLTGHVGVDCAI
EAVGVPDTFELCQALVAPGGVIANIGVHGVKADLHLESLWDRNISITTRLVDTVSTPMLLKTVQSGRIDPARLITHHFQL
DDVLNAYDTFGRAADSHALKVIIEMS
>Mature_346_residues
MKALVYHGPGKKSLDERPMPQLASATDAIVKVTRTTICGTDLHILKGDVPTCQPGRILGHEGVGIVQQVGAAVSSLKEGD
HVLISCISACGKCDYCRRGMYSHCTTGGWILGNRIDGTQAEYVRIPHAETSLYPIPAGADEEALVMLSDILPTGFECGVL
NGKVQPGSAVAIVGAGPIGLASLLTAQFYSPAQIIMIDRDERRLEVASRFGATACIDSRVAEPVVEVMKLTGHVGVDCAI
EAVGVPDTFELCQALVAPGGVIANIGVHGVKADLHLESLWDRNISITTRLVDTVSTPMLLKTVQSGRIDPARLITHHFQL
DDVLNAYDTFGRAADSHALKVIIEMS

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=348, Percent_Identity=25.2873563218391, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI4501929, Length=245, Percent_Identity=31.8367346938775, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI4501939, Length=357, Percent_Identity=27.7310924369748, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI156523966, Length=357, Percent_Identity=27.7310924369748, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI34577061, Length=245, Percent_Identity=31.4285714285714, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI71565154, Length=333, Percent_Identity=27.3273273273273, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4501933, Length=246, Percent_Identity=30.0813008130081, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI71743840, Length=236, Percent_Identity=30.5084745762712, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI262073058, Length=236, Percent_Identity=30.5084745762712, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI71565152, Length=332, Percent_Identity=24.3975903614458, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI1786825, Length=377, Percent_Identity=30.2387267904509, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1787863, Length=347, Percent_Identity=28.2420749279539, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1788073, Length=325, Percent_Identity=29.8461538461538, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786552, Length=336, Percent_Identity=30.0595238095238, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788075, Length=358, Percent_Identity=25.6983240223464, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87082125, Length=334, Percent_Identity=27.8443113772455, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1790045, Length=322, Percent_Identity=28.8819875776398, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI226510992, Length=333, Percent_Identity=25.2252252252252, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1790718, Length=324, Percent_Identity=25.6172839506173, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788407, Length=279, Percent_Identity=27.5985663082437, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87081918, Length=207, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562876, Length=347, Percent_Identity=25.9365994236311, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17562878, Length=348, Percent_Identity=27.0114942528736, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25146526, Length=341, Percent_Identity=29.0322580645161, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71997431, Length=346, Percent_Identity=28.3236994219653, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17565904, Length=338, Percent_Identity=28.4023668639053, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319258, Length=302, Percent_Identity=28.8079470198675, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322619, Length=352, Percent_Identity=26.1363636363636, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319955, Length=352, Percent_Identity=26.1363636363636, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=338, Percent_Identity=26.3313609467456, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323099, Length=340, Percent_Identity=25.2941176470588, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=373, Percent_Identity=23.8605898123324, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=236, Percent_Identity=29.6610169491525, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=263, Percent_Identity=27.7566539923954, Blast_Score=66, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=271, Percent_Identity=25.4612546125461, Blast_Score=63, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17137530, Length=350, Percent_Identity=30.2857142857143, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17737897, Length=351, Percent_Identity=30.7692307692308, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI17737895, Length=333, Percent_Identity=27.027027027027, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45550770, Length=325, Percent_Identity=23.3846153846154, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221457811, Length=325, Percent_Identity=23.3846153846154, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45551930, Length=325, Percent_Identity=23.3846153846154, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36754; Mature: 36754

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALVYHGPGKKSLDERPMPQLASATDAIVKVTRTTICGTDLHILKGDVPTCQPGRILGH
CCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCEEEEECCCCCCCCCCEECC
EGVGIVQQVGAAVSSLKEGDHVLISCISACGKCDYCRRGMYSHCTTGGWILGNRIDGTQA
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHCCCHHHCCCCCEEECCCCCCCCC
EYVRIPHAETSLYPIPAGADEEALVMLSDILPTGFECGVLNGKVQPGSAVAIVGAGPIGL
EEEECCCCCCCEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCHHH
ASLLTAQFYSPAQIIMIDRDERRLEVASRFGATACIDSRVAEPVVEVMKLTGHVGVDCAI
HHHHHHHCCCCEEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEE
EAVGVPDTFELCQALVAPGGVIANIGVHGVKADLHLESLWDRNISITTRLVDTVSTPMLL
EECCCCCHHHHHHHHHCCCCEEEECCCEEEEEEEEHHHHHCCCCEEEHHHHHHHCCHHHH
KTVQSGRIDPARLITHHFQLDDVLNAYDTFGRAADSHALKVIIEMS
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEC
>Mature Secondary Structure
MKALVYHGPGKKSLDERPMPQLASATDAIVKVTRTTICGTDLHILKGDVPTCQPGRILGH
CCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCEEEEECCCCCCCCCCEECC
EGVGIVQQVGAAVSSLKEGDHVLISCISACGKCDYCRRGMYSHCTTGGWILGNRIDGTQA
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHCCCHHHCCCCCEEECCCCCCCCC
EYVRIPHAETSLYPIPAGADEEALVMLSDILPTGFECGVLNGKVQPGSAVAIVGAGPIGL
EEEECCCCCCCEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCHHH
ASLLTAQFYSPAQIIMIDRDERRLEVASRFGATACIDSRVAEPVVEVMKLTGHVGVDCAI
HHHHHHHCCCCEEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEE
EAVGVPDTFELCQALVAPGGVIANIGVHGVKADLHLESLWDRNISITTRLVDTVSTPMLL
EECCCCCHHHHHHHHHCCCCEEEECCCEEEEEEEEHHHHHCCCCEEEHHHHHHHCCHHHH
KTVQSGRIDPARLITHHFQLDDVLNAYDTFGRAADSHALKVIIEMS
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]