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The map label for this gene is fadA [H]

Identifier: 91783542

GI number: 91783542

Start: 2404538

End: 2405716

Strand: Direct

Name: fadA [H]

Synonym: Bxe_A2273

Alternate gene names: 91783542

Gene position: 2404538-2405716 (Clockwise)

Preceding gene: 91783541

Following gene: 91783544

Centisome position: 49.11

GC content: 65.22

Gene sequence:

>1179_bases
ATGACTGACGCCGTAATCGTATCGACCGCTCGCACAGGCCTCGCCAAATCGTGGCGCGGCGGTTTCAACATGACGCACGG
CGCGACGCTCGGCGGCCATGTGACGCAGGCCGCCGTCGAACGCGCGAAGCTCGACCCGGCGCGCGTCGAGGACGTGATCA
TGGGCTGCGCCAATCCGGAAGGCGCGACGGGCATGAACATCGCGCGGCAGATCGCGCTGCGCGCCGGTTTGCCGGTCAGC
GTGCCGGGCATGACGGTGAACCGTTTCTGTTCGTCGGGATTGCAAACTATCGCGCTGGCCGCGCAACGCGTGATCGCCGG
TGAAGGCGACGTGTATGTGGCAGGCGGCGTGGAATCGATCTCGTGCGTGCAGAACGAGATGAACCACCACATGCTGACGG
AAGGCTGGCTCAGCGAAAACAAACCGGAAATCTACTGGTCGATGCTGCAGACCGCGGAGAACGTCGCGAAACGCTATTCG
ATCTCGAAGGAGCGTCAGGACGAGTACGGCGTGCGTTCGCAACAGCGCGCGGCCGCCGCGCTCGAAGCCGGCAGGTTCAA
GGACGAGATCGTGCCGCTGACGGTGCTCGCGGGCGTCACCGATAAAGCGGGCGGGCGTCTTTTCACGAAGGAAGTGACCG
TCAGCGGCGACGAAGGCATTCGCGCCGACACGACGCTCGAAGGCGTCTCGAAGATTCGTACCGCATTGCCAGGCGGCGTG
ATCACCGCGGGCAATGCGAGCCAGTTCTCGGACGGCGCGTCGGCGTGCGTGGTGATGAACGCGAAGGTGGCGGAGCGCGA
AGGCCTGCAGCCGCTCGGTATTTTCCGCGGCTTCGCGGTGGCAGGTTGCGAGCCGGACGAAATGGGGATCGGCCCGGTGT
TCGCGGTGCCGAAGCTGCTCAGGCAGGCAGGTCTGAAAGTCGAGGACATCGACCTGTGGGAGTTGAACGAAGCGTTCGCG
GTGCAGGTGCTGTATTGCGCCGACAAGCTCGGTATTCCCCAGGATCGTCTGAACGTGAACGGCGGCGCGATCGCGGTCGG
GCATCCGTATGGCGTGTCGGGCGCGCGGCTGACCGGGCATGCGCTGATCGAAGGCAAGCGGCGCGGCGCGAAGCTGGTTG
TCGTGACGATGTGTATTGGCGGCGGGCAGGGCGCGGCGGGGTTGTTCGAAGTGGTGTGA

Upstream 100 bases:

>100_bases
GGTGATCGATTCGCCAGCGCGCCCCCATCGACATCTGCAAGTATCGATCAACTCGTATGGGATCAGAGCGCGCCACCTCT
GATCGACACAGGAGACACGC

Downstream 100 bases:

>100_bases
GCCATGCCGAACGCCATCAGGGCAACGCCATGCCGGACGACGGCAGGCTCAACGTCCCCTGATCGACGAATCGCGTCGTG
CCGGTGAGTCCACCCGCGAG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTDAVIVSTARTGLAKSWRGGFNMTHGATLGGHVTQAAVERAKLDPARVEDVIMGCANPEGATGMNIARQIALRAGLPVS
VPGMTVNRFCSSGLQTIALAAQRVIAGEGDVYVAGGVESISCVQNEMNHHMLTEGWLSENKPEIYWSMLQTAENVAKRYS
ISKERQDEYGVRSQQRAAAALEAGRFKDEIVPLTVLAGVTDKAGGRLFTKEVTVSGDEGIRADTTLEGVSKIRTALPGGV
ITAGNASQFSDGASACVVMNAKVAEREGLQPLGIFRGFAVAGCEPDEMGIGPVFAVPKLLRQAGLKVEDIDLWELNEAFA
VQVLYCADKLGIPQDRLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGAKLVVVTMCIGGGQGAAGLFEVV

Sequences:

>Translated_392_residues
MTDAVIVSTARTGLAKSWRGGFNMTHGATLGGHVTQAAVERAKLDPARVEDVIMGCANPEGATGMNIARQIALRAGLPVS
VPGMTVNRFCSSGLQTIALAAQRVIAGEGDVYVAGGVESISCVQNEMNHHMLTEGWLSENKPEIYWSMLQTAENVAKRYS
ISKERQDEYGVRSQQRAAAALEAGRFKDEIVPLTVLAGVTDKAGGRLFTKEVTVSGDEGIRADTTLEGVSKIRTALPGGV
ITAGNASQFSDGASACVVMNAKVAEREGLQPLGIFRGFAVAGCEPDEMGIGPVFAVPKLLRQAGLKVEDIDLWELNEAFA
VQVLYCADKLGIPQDRLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGAKLVVVTMCIGGGQGAAGLFEVV
>Mature_391_residues
TDAVIVSTARTGLAKSWRGGFNMTHGATLGGHVTQAAVERAKLDPARVEDVIMGCANPEGATGMNIARQIALRAGLPVSV
PGMTVNRFCSSGLQTIALAAQRVIAGEGDVYVAGGVESISCVQNEMNHHMLTEGWLSENKPEIYWSMLQTAENVAKRYSI
SKERQDEYGVRSQQRAAAALEAGRFKDEIVPLTVLAGVTDKAGGRLFTKEVTVSGDEGIRADTTLEGVSKIRTALPGGVI
TAGNASQFSDGASACVVMNAKVAEREGLQPLGIFRGFAVAGCEPDEMGIGPVFAVPKLLRQAGLKVEDIDLWELNEAFAV
QVLYCADKLGIPQDRLNVNGGAIAVGHPYGVSGARLTGHALIEGKRRGAKLVVVTMCIGGGQGAAGLFEVV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=390, Percent_Identity=42.8205128205128, Blast_Score=278, Evalue=5e-75,
Organism=Homo sapiens, GI167614485, Length=367, Percent_Identity=39.5095367847411, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI4557237, Length=403, Percent_Identity=36.9727047146402, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI148539872, Length=395, Percent_Identity=35.9493670886076, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=32.3907455012853, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI4504327, Length=399, Percent_Identity=30.8270676691729, Blast_Score=159, Evalue=4e-39,
Organism=Escherichia coli, GI1787663, Length=412, Percent_Identity=40.5339805825243, Blast_Score=256, Evalue=1e-69,
Organism=Escherichia coli, GI1788554, Length=405, Percent_Identity=42.7160493827161, Blast_Score=255, Evalue=4e-69,
Organism=Escherichia coli, GI48994986, Length=398, Percent_Identity=39.4472361809045, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI87082165, Length=402, Percent_Identity=38.3084577114428, Blast_Score=242, Evalue=2e-65,
Organism=Escherichia coli, GI1788683, Length=421, Percent_Identity=29.2161520190024, Blast_Score=151, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI133906874, Length=399, Percent_Identity=38.0952380952381, Blast_Score=244, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI17535921, Length=406, Percent_Identity=35.4679802955665, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI25147385, Length=399, Percent_Identity=33.8345864661654, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=437, Percent_Identity=29.9771167048055, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17535917, Length=390, Percent_Identity=30, Blast_Score=142, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=37.3737373737374, Blast_Score=229, Evalue=8e-61,
Organism=Saccharomyces cerevisiae, GI6325229, Length=402, Percent_Identity=32.5870646766169, Blast_Score=186, Evalue=7e-48,
Organism=Drosophila melanogaster, GI24655093, Length=400, Percent_Identity=41.25, Blast_Score=268, Evalue=5e-72,
Organism=Drosophila melanogaster, GI17648125, Length=360, Percent_Identity=39.4444444444444, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24640423, Length=401, Percent_Identity=35.6608478802993, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI17137578, Length=408, Percent_Identity=32.3529411764706, Blast_Score=185, Evalue=4e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41118; Mature: 40986

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAVIVSTARTGLAKSWRGGFNMTHGATLGGHVTQAAVERAKLDPARVEDVIMGCANPE
CCCEEEEECHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCC
GATGMNIARQIALRAGLPVSVPGMTVNRFCSSGLQTIALAAQRVIAGEGDVYVAGGVESI
CCCHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQNEMNHHMLTEGWLSENKPEIYWSMLQTAENVAKRYSISKERQDEYGVRSQQRAAAA
HHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHH
LEAGRFKDEIVPLTVLAGVTDKAGGRLFTKEVTVSGDEGIRADTTLEGVSKIRTALPGGV
HHHCCCCCCCEEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCE
ITAGNASQFSDGASACVVMNAKVAEREGLQPLGIFRGFAVAGCEPDEMGIGPVFAVPKLL
EECCCCCCCCCCCCEEEEEECHHHHHCCCCHHHHHHCCEEECCCCCCCCCCHHHHHHHHH
RQAGLKVEDIDLWELNEAFAVQVLYCADKLGIPQDRLNVNGGAIAVGHPYGVSGARLTGH
HHHCCCEEECCCEECCHHHEEEEEEEHHHCCCCHHHEECCCCEEEECCCCCCCCCEEECH
ALIEGKRRGAKLVVVTMCIGGGQGAAGLFEVV
HEEECCCCCCEEEEEEEEECCCCCCCCCEECC
>Mature Secondary Structure 
TDAVIVSTARTGLAKSWRGGFNMTHGATLGGHVTQAAVERAKLDPARVEDVIMGCANPE
CCEEEEECHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCC
GATGMNIARQIALRAGLPVSVPGMTVNRFCSSGLQTIALAAQRVIAGEGDVYVAGGVESI
CCCHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQNEMNHHMLTEGWLSENKPEIYWSMLQTAENVAKRYSISKERQDEYGVRSQQRAAAA
HHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHH
LEAGRFKDEIVPLTVLAGVTDKAGGRLFTKEVTVSGDEGIRADTTLEGVSKIRTALPGGV
HHHCCCCCCCEEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCE
ITAGNASQFSDGASACVVMNAKVAEREGLQPLGIFRGFAVAGCEPDEMGIGPVFAVPKLL
EECCCCCCCCCCCCEEEEEECHHHHHCCCCHHHHHHCCEEECCCCCCCCCCHHHHHHHHH
RQAGLKVEDIDLWELNEAFAVQVLYCADKLGIPQDRLNVNGGAIAVGHPYGVSGARLTGH
HHHCCCEEECCCEECCHHHEEEEEEEHHHCCCCHHHEECCCCEEEECCCCCCCCCEEECH
ALIEGKRRGAKLVVVTMCIGGGQGAAGLFEVV
HEEECCCCCCEEEEEEEEECCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]