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The map label for this gene is clpP

Identifier: 91783520

GI number: 91783520

Start: 2373404

End: 2374057

Strand: Direct

Name: clpP

Synonym: Bxe_A2295

Alternate gene names: 91783520

Gene position: 2373404-2374057 (Clockwise)

Preceding gene: 91783519

Following gene: 91783521

Centisome position: 48.48

GC content: 60.86

Gene sequence:

>654_bases
ATGACCTTTCGCGCTCAAATGCTGGACACGTTGACCTCCCAGTCGTCGCGGGATCTCGAAGCGCAGGCGCTCGGACTTGT
GCCGATCGTCGTGGAAACGAGCGGCCGGGGTGAGCGCTCGTATGACATCTATTCGCGTCTGCTGAAGGAGCGCATCGTGT
TCCTGGTCGGCGAAGTGAACGACCAGACGGCCAATCTCGTTGTCGCGCAGATGCTGTTTCTCGAAAGCGAGAATCCGGAC
AAGGACATCAGCTTCTACATCAACAGCCCGGGCGGCTCGGTGTCCGCCGGCATGGCGATTTACGATACGATGCAGTTCAT
CAAGCCGGACGTTTCCACGCTGTGCATGGGCCTCGCGGCCAGCATGGGCGCGTTCCTGCTGGCAGCCGGCGCGAAGGGCA
AGCGTTTTGCTCTGCCGAACTCGCGGGTGATGATTCATCAGCCGCTCGGCGGCGCGCGTGGTCAGGCGTCGGACATCGAA
ATTCAGGCGCGCGAAATCCTGTATTTGAAGGAACGGCTGAATCATCTGCTCGCGCATCACACGGGTCAACCGGTCGAGCG
TATCGCGCGCGACACAGACCGCGACAATTTCATGTCCGGCGACGACGCGCAAGCTTACGGTCTGGTTGACCAGGTGGCGC
ACAAGCGTCCTTGA

Upstream 100 bases:

>100_bases
TGCGCACACGCCCGCACTGGTCGCGCACTTGAATACGGGGCCGTCGACCATACCTGTCTAGCATGTAATATTTAGAATAT
TTCAGACAAGGATCCATTGC

Downstream 100 bases:

>100_bases
TCTGGTGCGGTTTTGCCCCGAATTGGGGCGAAGCCGTCAACAGATCGATTGTGAAACAATCAAGACTCGTCCGAGCGCCT
GCGGCAAACGCCGTCACCCT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MTFRAQMLDTLTSQSSRDLEAQALGLVPIVVETSGRGERSYDIYSRLLKERIVFLVGEVNDQTANLVVAQMLFLESENPD
KDISFYINSPGGSVSAGMAIYDTMQFIKPDVSTLCMGLAASMGAFLLAAGAKGKRFALPNSRVMIHQPLGGARGQASDIE
IQAREILYLKERLNHLLAHHTGQPVERIARDTDRDNFMSGDDAQAYGLVDQVAHKRP

Sequences:

>Translated_217_residues
MTFRAQMLDTLTSQSSRDLEAQALGLVPIVVETSGRGERSYDIYSRLLKERIVFLVGEVNDQTANLVVAQMLFLESENPD
KDISFYINSPGGSVSAGMAIYDTMQFIKPDVSTLCMGLAASMGAFLLAAGAKGKRFALPNSRVMIHQPLGGARGQASDIE
IQAREILYLKERLNHLLAHHTGQPVERIARDTDRDNFMSGDDAQAYGLVDQVAHKRP
>Mature_216_residues
TFRAQMLDTLTSQSSRDLEAQALGLVPIVVETSGRGERSYDIYSRLLKERIVFLVGEVNDQTANLVVAQMLFLESENPDK
DISFYINSPGGSVSAGMAIYDTMQFIKPDVSTLCMGLAASMGAFLLAAGAKGKRFALPNSRVMIHQPLGGARGQASDIEI
QAREILYLKERLNHLLAHHTGQPVERIARDTDRDNFMSGDDAQAYGLVDQVAHKRP

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=191, Percent_Identity=59.1623036649215, Blast_Score=239, Evalue=2e-63,
Organism=Escherichia coli, GI1786641, Length=206, Percent_Identity=67.9611650485437, Blast_Score=299, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=56.989247311828, Blast_Score=223, Evalue=6e-59,
Organism=Drosophila melanogaster, GI20129427, Length=194, Percent_Identity=53.6082474226804, Blast_Score=234, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP2_BURXL (Q13Z15)

Other databases:

- EMBL:   CP000270
- RefSeq:   YP_558726.1
- ProteinModelPortal:   Q13Z15
- SMR:   Q13Z15
- MEROPS:   S14.001
- GeneID:   4005027
- GenomeReviews:   CP000270_GR
- KEGG:   bxe:Bxe_A2295
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- ProtClustDB:   PRK00277
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23830; Mature: 23698

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 121-121 ACT_SITE 146-146

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFRAQMLDTLTSQSSRDLEAQALGLVPIVVETSGRGERSYDIYSRLLKERIVFLVGEVN
CCHHHHHHHHHHCCCCCCCHHHHHCEEEEEEECCCCCCCCHHHHHHHHHHHHEEEEECCC
DQTANLVVAQMLFLESENPDKDISFYINSPGGSVSAGMAIYDTMQFIKPDVSTLCMGLAA
CHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
SMGAFLLAAGAKGKRFALPNSRVMIHQPLGGARGQASDIEIQAREILYLKERLNHLLAHH
HHHHHHHHCCCCCCEEECCCCEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHC
TGQPVERIARDTDRDNFMSGDDAQAYGLVDQVAHKRP
CCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
TFRAQMLDTLTSQSSRDLEAQALGLVPIVVETSGRGERSYDIYSRLLKERIVFLVGEVN
CHHHHHHHHHHCCCCCCCHHHHHCEEEEEEECCCCCCCCHHHHHHHHHHHHEEEEECCC
DQTANLVVAQMLFLESENPDKDISFYINSPGGSVSAGMAIYDTMQFIKPDVSTLCMGLAA
CHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
SMGAFLLAAGAKGKRFALPNSRVMIHQPLGGARGQASDIEIQAREILYLKERLNHLLAHH
HHHHHHHHCCCCCCEEECCCCEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHC
TGQPVERIARDTDRDNFMSGDDAQAYGLVDQVAHKRP
CCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA