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The map label for this gene is serA [H]

Identifier: 91783386

GI number: 91783386

Start: 2232601

End: 2233665

Strand: Direct

Name: serA [H]

Synonym: Bxe_A2430

Alternate gene names: 91783386

Gene position: 2232601-2233665 (Clockwise)

Preceding gene: 91783385

Following gene: 91783387

Centisome position: 45.6

GC content: 64.23

Gene sequence:

>1065_bases
ATGACGAAGAGCGTTCAAGGCGGAGGACATGTGCCGAACAAACTGAAGGTGCTGGTGCCGGATGCGCATCTGCGCGATCT
CGATGTCGAGCGGGGCGTGACGGGCGAACTGATCGATTATCAGGTCTACGACGAAATCGACGCCGCCGCGATTCCCGACG
AAGAATGGACCTCGTGCGACGCGATTCTCGTCTGGCACCGCATGAAGATCACGCGCGAAGTGGTGAGCCGTTTGAGCCGC
TGCCGGATGATCGTGCGCGTCGGCGTGGGCTTCGATAACGTCGATACGGCGGCGTGCAGCGAGCGCGGCATTCCGGTGTC
GAACGTGCCGAACTACGGCACCACCGAAGTCGCCGATCACGCGATCGCGATGATGCTGTACCTGGCGCGCGGCCTTGGCA
CCTATCAGGCGCGCATCAAGGCCGATCCGGCGCATGGCTTCGTTGCGGAAAACGTGCCGGTGGTGCGGCGGCTGCGCGGC
GGTACGTTCGGCGCGATCGGTATGGGCCGTATCGGCACGGCGATCGCTCGGCGCGCGGCAGCGCACGACATGCACGTGAT
CTATCACGATCCGTTCTTGCCCGAGGGCCACGAACTCGGGCTCGGCTACGAGCGCGTCGGCTCGCTGGACGAACTGCTCG
CGCGCGCCGATGTGGTGAGCCTGCACGTGCCGCTCTCCGACGCCACGCGCTTCATGATGAGCGACGCGCAGTTTCAGGCG
ATGAAGCCCAATAGCATCTTCATCAATATCGCACGCGGCAAACTGGTGGACGTCGACGCGGTGTATCGCACGCTGCTCTC
TGGACATATCGCCGCAGCAGGGCTCGACGTGCTGCCCAACGAACCGCCCATGCCGCTGCCGCCGCTGCTCGAAGCGTGGC
GCAACGGCGAAGAATGGCTGGCGGGCCGTTTCATCGTCACGCCGCACGCCGCCTTCTATTCGGAAGCCGGCTATCTCGAC
ATGCGCACGTTCTCCGCGCAGATGCTGGTCGATTATCTGGTGCACGGACGCCTGCGCAACAACGTCAATCCGGCCTGGCA
GCACGCCACCCCTTCAACCCGATAA

Upstream 100 bases:

>100_bases
GCCTGCGGAGATGTTTCACACGCCGCGCGATCCGCGTCTGGCGAGTTTCCTGGGCAAGGTGCTGTCGCGTACGGCGGCCT
GATTTATACGGTTATTGACT

Downstream 100 bases:

>100_bases
AGCGAACGTCATGGCCTATCAACAGCTTTATGTGAGTTTCACTCTTCTCTCCGACGACGTGCTCGCGCAATGGCGTCTGA
TTCCGCCCGCCGTCGCCTCC

Product: putative dehydrogenase, D-3- phosphoglycerate dehydrogenase-like

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTKSVQGGGHVPNKLKVLVPDAHLRDLDVERGVTGELIDYQVYDEIDAAAIPDEEWTSCDAILVWHRMKITREVVSRLSR
CRMIVRVGVGFDNVDTAACSERGIPVSNVPNYGTTEVADHAIAMMLYLARGLGTYQARIKADPAHGFVAENVPVVRRLRG
GTFGAIGMGRIGTAIARRAAAHDMHVIYHDPFLPEGHELGLGYERVGSLDELLARADVVSLHVPLSDATRFMMSDAQFQA
MKPNSIFINIARGKLVDVDAVYRTLLSGHIAAAGLDVLPNEPPMPLPPLLEAWRNGEEWLAGRFIVTPHAAFYSEAGYLD
MRTFSAQMLVDYLVHGRLRNNVNPAWQHATPSTR

Sequences:

>Translated_354_residues
MTKSVQGGGHVPNKLKVLVPDAHLRDLDVERGVTGELIDYQVYDEIDAAAIPDEEWTSCDAILVWHRMKITREVVSRLSR
CRMIVRVGVGFDNVDTAACSERGIPVSNVPNYGTTEVADHAIAMMLYLARGLGTYQARIKADPAHGFVAENVPVVRRLRG
GTFGAIGMGRIGTAIARRAAAHDMHVIYHDPFLPEGHELGLGYERVGSLDELLARADVVSLHVPLSDATRFMMSDAQFQA
MKPNSIFINIARGKLVDVDAVYRTLLSGHIAAAGLDVLPNEPPMPLPPLLEAWRNGEEWLAGRFIVTPHAAFYSEAGYLD
MRTFSAQMLVDYLVHGRLRNNVNPAWQHATPSTR
>Mature_353_residues
TKSVQGGGHVPNKLKVLVPDAHLRDLDVERGVTGELIDYQVYDEIDAAAIPDEEWTSCDAILVWHRMKITREVVSRLSRC
RMIVRVGVGFDNVDTAACSERGIPVSNVPNYGTTEVADHAIAMMLYLARGLGTYQARIKADPAHGFVAENVPVVRRLRGG
TFGAIGMGRIGTAIARRAAAHDMHVIYHDPFLPEGHELGLGYERVGSLDELLARADVVSLHVPLSDATRFMMSDAQFQAM
KPNSIFINIARGKLVDVDAVYRTLLSGHIAAAGLDVLPNEPPMPLPPLLEAWRNGEEWLAGRFIVTPHAAFYSEAGYLDM
RTFSAQMLVDYLVHGRLRNNVNPAWQHATPSTR

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI145580578, Length=334, Percent_Identity=34.7305389221557, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI4557499, Length=334, Percent_Identity=34.7305389221557, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI145580575, Length=331, Percent_Identity=35.0453172205438, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI61743967, Length=340, Percent_Identity=32.6470588235294, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI4557497, Length=340, Percent_Identity=32.6470588235294, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI23308577, Length=229, Percent_Identity=31.8777292576419, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI6912396, Length=215, Percent_Identity=33.953488372093, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1787645, Length=266, Percent_Identity=30.4511278195489, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1789279, Length=305, Percent_Identity=31.1475409836066, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI87082289, Length=281, Percent_Identity=30.6049822064057, Blast_Score=112, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI25147481, Length=347, Percent_Identity=29.6829971181556, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17532191, Length=274, Percent_Identity=29.1970802919708, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=313, Percent_Identity=31.3099041533546, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322116, Length=316, Percent_Identity=30.6962025316456, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6324055, Length=209, Percent_Identity=33.4928229665072, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324964, Length=313, Percent_Identity=26.517571884984, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24646446, Length=335, Percent_Identity=34.9253731343284, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24646448, Length=335, Percent_Identity=34.9253731343284, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24646452, Length=335, Percent_Identity=34.9253731343284, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24646450, Length=335, Percent_Identity=34.9253731343284, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI62472511, Length=335, Percent_Identity=34.9253731343284, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI19921140, Length=231, Percent_Identity=31.1688311688312, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45552429, Length=248, Percent_Identity=28.6290322580645, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24585514, Length=248, Percent_Identity=28.6290322580645, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28574282, Length=248, Percent_Identity=28.6290322580645, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45551003, Length=248, Percent_Identity=28.6290322580645, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574284, Length=248, Percent_Identity=28.6290322580645, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585516, Length=257, Percent_Identity=28.7937743190661, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28574286, Length=259, Percent_Identity=27.027027027027, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28571528, Length=239, Percent_Identity=30.9623430962343, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 38980; Mature: 38849

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSVQGGGHVPNKLKVLVPDAHLRDLDVERGVTGELIDYQVYDEIDAAAIPDEEWTSCD
CCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEHHHCCCCCCCCCCCCCCCH
AILVWHRMKITREVVSRLSRCRMIVRVGVGFDNVDTAACSERGIPVSNVPNYGTTEVADH
HHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHH
AIAMMLYLARGLGTYQARIKADPAHGFVAENVPVVRRLRGGTFGAIGMGRIGTAIARRAA
HHHHHHHHHHCCCCEEEEEECCCCCCEECCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHH
AHDMHVIYHDPFLPEGHELGLGYERVGSLDELLARADVVSLHVPLSDATRFMMSDAQFQA
HCCEEEEEECCCCCCCCCCCCCHHHHCCHHHHHHHHCEEEEEECHHHHHHHHHCCCHHEE
MKPNSIFINIARGKLVDVDAVYRTLLSGHIAAAGLDVLPNEPPMPLPPLLEAWRNGEEWL
ECCCEEEEEECCCCEEEHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCHHHHHHCCCCHHH
AGRFIVTPHAAFYSEAGYLDMRTFSAQMLVDYLVHGRLRNNVNPAWQHATPSTR
HCEEEECCCHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TKSVQGGGHVPNKLKVLVPDAHLRDLDVERGVTGELIDYQVYDEIDAAAIPDEEWTSCD
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEHHHCCCCCCCCCCCCCCCH
AILVWHRMKITREVVSRLSRCRMIVRVGVGFDNVDTAACSERGIPVSNVPNYGTTEVADH
HHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHH
AIAMMLYLARGLGTYQARIKADPAHGFVAENVPVVRRLRGGTFGAIGMGRIGTAIARRAA
HHHHHHHHHHCCCCEEEEEECCCCCCEECCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHH
AHDMHVIYHDPFLPEGHELGLGYERVGSLDELLARADVVSLHVPLSDATRFMMSDAQFQA
HCCEEEEEECCCCCCCCCCCCCHHHHCCHHHHHHHHCEEEEEECHHHHHHHHHCCCHHEE
MKPNSIFINIARGKLVDVDAVYRTLLSGHIAAAGLDVLPNEPPMPLPPLLEAWRNGEEWL
ECCCEEEEEECCCCEEEHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCHHHHHHCCCCHHH
AGRFIVTPHAAFYSEAGYLDMRTFSAQMLVDYLVHGRLRNNVNPAWQHATPSTR
HCEEEECCCHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]