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The map label for this gene is tcmR [H]

Identifier: 91783135

GI number: 91783135

Start: 1981587

End: 1982240

Strand: Direct

Name: tcmR [H]

Synonym: Bxe_A2672

Alternate gene names: 91783135

Gene position: 1981587-1982240 (Clockwise)

Preceding gene: 91783134

Following gene: 91783136

Centisome position: 40.47

GC content: 57.8

Gene sequence:

>654_bases
TTGGGACTGCGCGAACTAAAGAAAGATCGGACCAGGACTCAGCTCCTTGAGGCGGCGCTGGAACTCATTGCGCGCCAGGG
GTTCGAGCAGACAACCATCAGCGAGATTGCCGATGCTGTTCAGGTTTCACCGAGGACGCTGCTGAGATACTTTCCAACGA
AAGAGGATGTAATCGTCAGTTGGGTCGATCAGGGGATGTCCATCCTCCGGGAGAGTCTCGGAGCGCGCCCGCCGGGCGAA
ACCGATGCTGAAGCGCTGGTAGCTGCCGCGCGTGAAATGCTGACTGCCTATGAGGCCCGATCGACGTTCTTCCTTGTGAT
CGAACGCACTATTGCAGCCTCGCCGGGTATTTCCGCTCGCAAGCAGCAGATGATGGAGGGTCTGGCGCGCGACATCTGCG
CGCTTTTGGTTAAACGCCCAGCGGCTAGCATCTCATCGGCCCTCATTCGTGATGTCTATGTAGGAACCGTATTTGCCGCC
ATCCACGCAGCCATACAGGCGTGGGTTGCAACGAACGGTAGCCAGTCGTTGATCGGTCTCTTTGACGAAGCCACCGCCGT
TGTGAAATTTGTCGAGCCATCCGGTGCTGACCGTAGAAAACAAGGCGCCAATGCTCGTAACCAGACTGGTCGTGTCCGCC
CTGTTGGACGCTAG

Upstream 100 bases:

>100_bases
TAGACTATAAACGACATTTGTCATACGAAGACATTTTGGCTAGAATCCATATAGCCATCATTAATCGGCCGTGGCGGGTA
AAGCTTGGGGAGTTAATTCG

Downstream 100 bases:

>100_bases
TTACAAGGAGTCGTGCCATGTTCTATGCCAGTATCGCTCGCGACAAGCCGGATGCGCTTGAGCAGCGCATCGCATTGCGT
AATCTTCATTTCGACTATCT

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Tetracenomycin C transcriptional repressor [H]

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MGLRELKKDRTRTQLLEAALELIARQGFEQTTISEIADAVQVSPRTLLRYFPTKEDVIVSWVDQGMSILRESLGARPPGE
TDAEALVAAAREMLTAYEARSTFFLVIERTIAASPGISARKQQMMEGLARDICALLVKRPAASISSALIRDVYVGTVFAA
IHAAIQAWVATNGSQSLIGLFDEATAVVKFVEPSGADRRKQGANARNQTGRVRPVGR

Sequences:

>Translated_217_residues
MGLRELKKDRTRTQLLEAALELIARQGFEQTTISEIADAVQVSPRTLLRYFPTKEDVIVSWVDQGMSILRESLGARPPGE
TDAEALVAAAREMLTAYEARSTFFLVIERTIAASPGISARKQQMMEGLARDICALLVKRPAASISSALIRDVYVGTVFAA
IHAAIQAWVATNGSQSLIGLFDEATAVVKFVEPSGADRRKQGANARNQTGRVRPVGR
>Mature_216_residues
GLRELKKDRTRTQLLEAALELIARQGFEQTTISEIADAVQVSPRTLLRYFPTKEDVIVSWVDQGMSILRESLGARPPGET
DAEALVAAAREMLTAYEARSTFFLVIERTIAASPGISARKQQMMEGLARDICALLVKRPAASISSALIRDVYVGTVFAAI
HAAIQAWVATNGSQSLIGLFDEATAVVKFVEPSGADRRKQGANARNQTGRVRPVGR

Specific function: Represses transcription of the divergently oriented tcmR and tcmA (tetracenomycin C resistance and export) genes by binding to an intergenic operator region. This binding is inhibited by tetracenomycin C [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23612; Mature: 23481

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLRELKKDRTRTQLLEAALELIARQGFEQTTISEIADAVQVSPRTLLRYFPTKEDVIVS
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHH
WVDQGMSILRESLGARPPGETDAEALVAAAREMLTAYEARSTFFLVIERTIAASPGISAR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHCCCCCHHH
KQQMMEGLARDICALLVKRPAASISSALIRDVYVGTVFAAIHAAIQAWVATNGSQSLIGL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
FDEATAVVKFVEPSGADRRKQGANARNQTGRVRPVGR
HHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GLRELKKDRTRTQLLEAALELIARQGFEQTTISEIADAVQVSPRTLLRYFPTKEDVIVS
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHH
WVDQGMSILRESLGARPPGETDAEALVAAAREMLTAYEARSTFFLVIERTIAASPGISAR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHCCCCCHHH
KQQMMEGLARDICALLVKRPAASISSALIRDVYVGTVFAAIHAAIQAWVATNGSQSLIGL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
FDEATAVVKFVEPSGADRRKQGANARNQTGRVRPVGR
HHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1592819; 1592820 [H]