Click here to switch to the map view.

The map label for this gene is acsA [H]

Identifier: 91782712

GI number: 91782712

Start: 1494105

End: 1496087

Strand: Direct

Name: acsA [H]

Synonym: Bxe_A3113

Alternate gene names: 91782712

Gene position: 1494105-1496087 (Clockwise)

Preceding gene: 91782711

Following gene: 91782713

Centisome position: 30.52

GC content: 64.75

Gene sequence:

>1983_bases
ATGTCTGCGATTGAATCGGTTCTTCAGGAACGCCGTGTTTTCCCGCCCTCCGCTGAAACAGTAGCGGCCGCGACGATCTC
CGGCATGGACGCGTACCGGGCGCTCGCCGCCGAAGCGGAACGCGATTACGAAGGTTTCTGGGGGCGCCTCGCTCGCGAGA
CGCTAAGCTGGAATACGCCCTTCACCAAGGTACTCGACGAATCGAAGGCGCCGTTCTACACGTGGTTCGAAGACGGCCGG
CTGAACGCGTCGTATAACAGCATCGACCGTCACGTCGAAGCCGGCAACGGCGCGCGCGTCGCGATCATTTTCGAAGCCGA
CGACGGCACCGTCACCAACGTCACCTACCAGGATCTGCTGCAACGCGTGTCGCGCTTTGCGAACGCGTTGAAGAAGCGCG
GCGTGAAAAAGGGCGACCGCGTGGTGATCTATATGCCAATGTCGATCGAAGGCATTGTCGCGATGCAGGCTTGCGCGCGG
ATCGGCGCCACGCACTCGGTCGTGTTCGGCGGCTTCTCGTCGAAGTCGCTCAACGAGCGGCTGGTGGACGTGGGCGCGGT
CGCGCTCATCACGTCGGACGAACAGATGCGCGGCGGCAAGGCGCTGCCGCTGAAGAACATCGCCGACGAAGCGCTCGCGA
TGGGCGGCTGCGAAGCGGTCAGGAGCGTGATTGTGTTCCAGCGCACCGGCGGCAAGATCGCCTGGAACGCAGACCGCGAT
CTGTGGATGCACGAACTCACGCAGGCCGAACCGGATCAATGCGCGCCGGAGTGGGTCGGCGCCGAGCATCCTCTGTTCAT
TCTGTACACGTCCGGGTCGACCGGCAAGCCGAAGGGCGTGCAGCACAGTACCGGCGGCTATCTGCTGTGGGCCGCGCAGA
CCATGAAGTGGACCTTCGACTGGAAGCCCACCGACGTGTTCTGGTGTACCGCCGACATCGGCTGGATCACCGGCCATAGC
TACATCACGTATGGTCCGCTGACGCTCGGCGGCACCCAGGTCGTGTTCGAAGGCGTGCCGACCTATCCGAACGCCGGCCG
CTTCTGGGACATGATCGCGCGGCACAAGGTGTCGCTGTTCTATACCGCGCCCACTGCGATCCGCTCGCTGATCAAGGCCG
CCGACGCGGACGCGAAGGTGCATCCGAAGAGCTACGACCTGTCCACGCTGCGCATCATCGGCACGGTCGGCGAGCCGATC
AATCCGGAAGCGTGGGTCTGGTATTACGAGAACGTCGGCGGCAGCCATTGCCCGATCGTCGATACGTGGTGGCAGACCGA
AACCGGCGGTCACATGATCACGCCGCTGCCGGGCGCCACGCCGCTCGTGCCGGGTTCGTGCACGTTGCCGCTGCCGGGCA
TCATGGCGGCGGTGGTCGATGAAACCGGCCAGGACGTGCCGAACGGGCAGGGCGGCATTCTGGTGGTGAAGCGCCCGTGG
CCGTCCATGCTGCGCAACGTGTGGGGCGATCCGGACCGCTACAGGAAGAGCTACTTTCCCGAAGAACTCGGCGGCAAGCT
GTATCTCGCCGGCGACGGCGCGGTGCGCGACAAGGAGACCGGCTACTTCACGATCATGGGCCGTATCGACGACGTGCTCA
ACGTGTCGGGCCACCGCCTCGGCACGATGGAGATCGAGTCGGCGCTGGTGTCGAACCCGCTGGTTGCCGAAGCGGCCGTG
GTGGGGCGCCCCGATGCGACCACCGGCGAAGCCGTGTGCGCGTTCGTGGTGCTCAAGCGTTCGCGTCCGGAAGGCGAGGA
AGCGGTGAAGCTCGCCAACGAACTGCGCAACTGGGTCGGCAAGGAGATCGGTCCGATTGCCAAGCCGAAGGACATCCGTT
TCGGCGAAAATCTGCCCAAGACGCGTTCGGGCAAGATCATGCGCCGCCTGCTGCGCTCGCTGGCGAAAGGCGAGGAAATC
ACCCAGGACGTGTCCACGCTGGAGAACCCCGCGATTCTCGACCAGCTCGGCGAGTCGCTCTGA

Upstream 100 bases:

>100_bases
ATTGGAGACACCCGCCGCAGCTTTCGGGCGCCATACGATACGACGCGTCCCACGCGCGTCGGCACAGGTTTTACGTTTCA
TCTTCACCAAGGGGTTGTCG

Downstream 100 bases:

>100_bases
GCCCGGGTTTGCCGGTGCAAGTGGCAAGGGCGTATCGAACGGTGCGCTCTTGACCTGAGGCAAACATCGGCCACGGAAGC
CGGCTCTTCATGGCCACCGC

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MSAIESVLQERRVFPPSAETVAAATISGMDAYRALAAEAERDYEGFWGRLARETLSWNTPFTKVLDESKAPFYTWFEDGR
LNASYNSIDRHVEAGNGARVAIIFEADDGTVTNVTYQDLLQRVSRFANALKKRGVKKGDRVVIYMPMSIEGIVAMQACAR
IGATHSVVFGGFSSKSLNERLVDVGAVALITSDEQMRGGKALPLKNIADEALAMGGCEAVRSVIVFQRTGGKIAWNADRD
LWMHELTQAEPDQCAPEWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFDWKPTDVFWCTADIGWITGHS
YITYGPLTLGGTQVVFEGVPTYPNAGRFWDMIARHKVSLFYTAPTAIRSLIKAADADAKVHPKSYDLSTLRIIGTVGEPI
NPEAWVWYYENVGGSHCPIVDTWWQTETGGHMITPLPGATPLVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPW
PSMLRNVWGDPDRYRKSYFPEELGGKLYLAGDGAVRDKETGYFTIMGRIDDVLNVSGHRLGTMEIESALVSNPLVAEAAV
VGRPDATTGEAVCAFVVLKRSRPEGEEAVKLANELRNWVGKEIGPIAKPKDIRFGENLPKTRSGKIMRRLLRSLAKGEEI
TQDVSTLENPAILDQLGESL

Sequences:

>Translated_660_residues
MSAIESVLQERRVFPPSAETVAAATISGMDAYRALAAEAERDYEGFWGRLARETLSWNTPFTKVLDESKAPFYTWFEDGR
LNASYNSIDRHVEAGNGARVAIIFEADDGTVTNVTYQDLLQRVSRFANALKKRGVKKGDRVVIYMPMSIEGIVAMQACAR
IGATHSVVFGGFSSKSLNERLVDVGAVALITSDEQMRGGKALPLKNIADEALAMGGCEAVRSVIVFQRTGGKIAWNADRD
LWMHELTQAEPDQCAPEWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFDWKPTDVFWCTADIGWITGHS
YITYGPLTLGGTQVVFEGVPTYPNAGRFWDMIARHKVSLFYTAPTAIRSLIKAADADAKVHPKSYDLSTLRIIGTVGEPI
NPEAWVWYYENVGGSHCPIVDTWWQTETGGHMITPLPGATPLVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPW
PSMLRNVWGDPDRYRKSYFPEELGGKLYLAGDGAVRDKETGYFTIMGRIDDVLNVSGHRLGTMEIESALVSNPLVAEAAV
VGRPDATTGEAVCAFVVLKRSRPEGEEAVKLANELRNWVGKEIGPIAKPKDIRFGENLPKTRSGKIMRRLLRSLAKGEEI
TQDVSTLENPAILDQLGESL
>Mature_659_residues
SAIESVLQERRVFPPSAETVAAATISGMDAYRALAAEAERDYEGFWGRLARETLSWNTPFTKVLDESKAPFYTWFEDGRL
NASYNSIDRHVEAGNGARVAIIFEADDGTVTNVTYQDLLQRVSRFANALKKRGVKKGDRVVIYMPMSIEGIVAMQACARI
GATHSVVFGGFSSKSLNERLVDVGAVALITSDEQMRGGKALPLKNIADEALAMGGCEAVRSVIVFQRTGGKIAWNADRDL
WMHELTQAEPDQCAPEWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFDWKPTDVFWCTADIGWITGHSY
ITYGPLTLGGTQVVFEGVPTYPNAGRFWDMIARHKVSLFYTAPTAIRSLIKAADADAKVHPKSYDLSTLRIIGTVGEPIN
PEAWVWYYENVGGSHCPIVDTWWQTETGGHMITPLPGATPLVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPWP
SMLRNVWGDPDRYRKSYFPEELGGKLYLAGDGAVRDKETGYFTIMGRIDDVLNVSGHRLGTMEIESALVSNPLVAEAAVV
GRPDATTGEAVCAFVVLKRSRPEGEEAVKLANELRNWVGKEIGPIAKPKDIRFGENLPKTRSGKIMRRLLRSLAKGEEIT
QDVSTLENPAILDQLGESL

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=679, Percent_Identity=48.0117820324006, Blast_Score=608, Evalue=1e-174,
Organism=Homo sapiens, GI253970489, Length=692, Percent_Identity=47.3988439306358, Blast_Score=603, Evalue=1e-172,
Organism=Homo sapiens, GI28416953, Length=635, Percent_Identity=47.0866141732283, Blast_Score=552, Evalue=1e-157,
Organism=Homo sapiens, GI13375727, Length=640, Percent_Identity=38.4375, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI31982927, Length=651, Percent_Identity=25.652841781874, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI42544132, Length=525, Percent_Identity=28.1904761904762, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI122937307, Length=529, Percent_Identity=28.3553875236295, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI38505220, Length=525, Percent_Identity=29.3333333333333, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI115511026, Length=557, Percent_Identity=27.4685816876122, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI58082049, Length=523, Percent_Identity=27.5334608030593, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI157311624, Length=524, Percent_Identity=27.2900763358779, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI157311622, Length=524, Percent_Identity=27.2900763358779, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI187761345, Length=396, Percent_Identity=26.2626262626263, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI187761343, Length=396, Percent_Identity=26.2626262626263, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI195947378, Length=436, Percent_Identity=24.7706422018349, Blast_Score=93, Evalue=9e-19,
Organism=Homo sapiens, GI42544134, Length=358, Percent_Identity=23.463687150838, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1790505, Length=632, Percent_Identity=50.7911392405063, Blast_Score=631, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=624, Percent_Identity=38.4615384615385, Blast_Score=408, Evalue=1e-115,
Organism=Escherichia coli, GI1788107, Length=576, Percent_Identity=25.6944444444444, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI145693145, Length=380, Percent_Identity=25.2631578947368, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1786810, Length=530, Percent_Identity=21.5094339622642, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71983001, Length=669, Percent_Identity=43.1988041853513, Blast_Score=498, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI71982997, Length=671, Percent_Identity=43.070044709389, Blast_Score=497, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17569507, Length=662, Percent_Identity=24.6223564954683, Blast_Score=148, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI71994694, Length=558, Percent_Identity=24.7311827956989, Blast_Score=90, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71994703, Length=558, Percent_Identity=24.7311827956989, Blast_Score=90, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71994690, Length=558, Percent_Identity=24.7311827956989, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=656, Percent_Identity=23.6280487804878, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17558820, Length=549, Percent_Identity=23.4972677595628, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17559526, Length=571, Percent_Identity=23.9929947460595, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323182, Length=643, Percent_Identity=48.3670295489891, Blast_Score=570, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6319264, Length=664, Percent_Identity=47.1385542168675, Blast_Score=559, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6319699, Length=554, Percent_Identity=22.9241877256318, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24667955, Length=673, Percent_Identity=46.2109955423477, Blast_Score=584, Evalue=1e-167,
Organism=Drosophila melanogaster, GI62472339, Length=566, Percent_Identity=49.469964664311, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24667959, Length=529, Percent_Identity=49.1493383742911, Blast_Score=502, Evalue=1e-142,
Organism=Drosophila melanogaster, GI21355225, Length=665, Percent_Identity=35.4887218045113, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI21355181, Length=524, Percent_Identity=25, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19922652, Length=545, Percent_Identity=25.1376146788991, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24581924, Length=578, Percent_Identity=25.9515570934256, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24656500, Length=369, Percent_Identity=27.9132791327913, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72255; Mature: 72124

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIESVLQERRVFPPSAETVAAATISGMDAYRALAAEAERDYEGFWGRLARETLSWNTP
CHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
FTKVLDESKAPFYTWFEDGRLNASYNSIDRHVEAGNGARVAIIFEADDGTVTNVTYQDLL
HHHHHHCCCCCEEEEECCCCCCCCHHHHHHHEECCCCCEEEEEEECCCCCEEECCHHHHH
QRVSRFANALKKRGVKKGDRVVIYMPMSIEGIVAMQACARIGATHSVVFGGFSSKSLNER
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHH
LVDVGAVALITSDEQMRGGKALPLKNIADEALAMGGCEAVRSVIVFQRTGGKIAWNADRD
HHHCCEEEEEECCHHHCCCCCCCHHHHHHHHHHHCCHHHHHHEEEEEECCCEEEECCCCH
LWMHELTQAEPDQCAPEWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFD
HHHHHHHCCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCCEECCCCEEEEEEEEEEEEEC
WKPTDVFWCTADIGWITGHSYITYGPLTLGGTQVVFEGVPTYPNAGRFWDMIARHKVSLF
CCCCEEEEEECCCCEEECCCEEEECCEEECCCEEEEECCCCCCCCCHHHHHHHHCEEEEE
YTAPTAIRSLIKAADADAKVHPKSYDLSTLRIIGTVGEPINPEAWVWYYENVGGSHCPIV
EECHHHHHHHHHHCCCCCEECCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCEE
DTWWQTETGGHMITPLPGATPLVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPW
ECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCC
PSMLRNVWGDPDRYRKSYFPEELGGKLYLAGDGAVRDKETGYFTIMGRIDDVLNVSGHRL
HHHHHHHCCCHHHHHHHCCCHHHCCEEEEECCCCCCCCCCCEEEEEECHHHHHCCCCCEE
GTMEIESALVSNPLVAEAAVVGRPDATTGEAVCAFVVLKRSRPEGEEAVKLANELRNWVG
EHHHHHHHHHCCCCHHHHEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
KEIGPIAKPKDIRFGENLPKTRSGKIMRRLLRSLAKGEEITQDVSTLENPAILDQLGESL
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHCCCC
>Mature Secondary Structure 
SAIESVLQERRVFPPSAETVAAATISGMDAYRALAAEAERDYEGFWGRLARETLSWNTP
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
FTKVLDESKAPFYTWFEDGRLNASYNSIDRHVEAGNGARVAIIFEADDGTVTNVTYQDLL
HHHHHHCCCCCEEEEECCCCCCCCHHHHHHHEECCCCCEEEEEEECCCCCEEECCHHHHH
QRVSRFANALKKRGVKKGDRVVIYMPMSIEGIVAMQACARIGATHSVVFGGFSSKSLNER
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHH
LVDVGAVALITSDEQMRGGKALPLKNIADEALAMGGCEAVRSVIVFQRTGGKIAWNADRD
HHHCCEEEEEECCHHHCCCCCCCHHHHHHHHHHHCCHHHHHHEEEEEECCCEEEECCCCH
LWMHELTQAEPDQCAPEWVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAAQTMKWTFD
HHHHHHHCCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCCEECCCCEEEEEEEEEEEEEC
WKPTDVFWCTADIGWITGHSYITYGPLTLGGTQVVFEGVPTYPNAGRFWDMIARHKVSLF
CCCCEEEEEECCCCEEECCCEEEECCEEECCCEEEEECCCCCCCCCHHHHHHHHCEEEEE
YTAPTAIRSLIKAADADAKVHPKSYDLSTLRIIGTVGEPINPEAWVWYYENVGGSHCPIV
EECHHHHHHHHHHCCCCCEECCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCEE
DTWWQTETGGHMITPLPGATPLVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPW
ECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCC
PSMLRNVWGDPDRYRKSYFPEELGGKLYLAGDGAVRDKETGYFTIMGRIDDVLNVSGHRL
HHHHHHHCCCHHHHHHHCCCHHHCCEEEEECCCCCCCCCCCEEEEEECHHHHHCCCCCEE
GTMEIESALVSNPLVAEAAVVGRPDATTGEAVCAFVVLKRSRPEGEEAVKLANELRNWVG
EHHHHHHHHHCCCCHHHHEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
KEIGPIAKPKDIRFGENLPKTRSGKIMRRLLRSLAKGEEITQDVSTLENPAILDQLGESL
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA