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The map label for this gene is serS

Identifier: 91782396

GI number: 91782396

Start: 1136950

End: 1138245

Strand: Direct

Name: serS

Synonym: Bxe_A3435

Alternate gene names: 91782396

Gene position: 1136950-1138245 (Clockwise)

Preceding gene: 91782395

Following gene: 91782397

Centisome position: 23.22

GC content: 62.35

Gene sequence:

>1296_bases
ATGCTCGACATTCAGTTGCTGCGCAAAGACCTCGACGGCGTCGCCAAACGCCTCGCCGACCGCGGCTATACCCTCGACGT
GGCGGCCTTCACCGCGCTCGAAGCGGAACGCCGCGATACCCAGACCCGTACCGAAGAGATGCAGGCGCGCCGCAACAGTC
TGTCGAAACAGATCGGCGCGCTGAAAGGCAAGGGCGAGGACACCTCGGCGGTGATGGCTGAAGTGAGTGGTATCGGCGAC
GAGATGAAGGCGTCGGCGGCCAGGCTCGACGAGATCCAGAAGCGTTTGTCGGACCTGCTGCTCGGCGTGCCGAACCTGCC
GCACGAAAGCGTGCCGTTGGGCAAGGACGAAACCGAAAACGTGGAAGTGCGCCGCTGGGGCACGCCGCGCCAGTTCGAAT
TCGAGGTGAAGGATCATGTGGATGTCGGCGCGCCGCTCGGGCTCGACTTCGAGACCGGCGCGAAGCTCTCGGGCGCGCGC
TTCACCATGCTGCGCGGCCAGATTGCGCGGTTGCATCGCGCGCTGGCGCAGTTCATGATCGACACGCACACGCAGCACCA
CGGCTATACGGAGATCTACACGCCGTACATCGTGAATCCGGAGATTCTGTACGGCACCGGCCAACTGCCGAAGTTCGCCG
ACGATATGTTCCGCGTCGAGAAGGGCGGTGACGAAAATACGGTCACGCAATATCTGATTTCCACGTCGGAAATTTCACTG
ACGAACACGGTGCGCGACAGCATTCTCGAAGCGGACGCGCTGCCGATCAAGCTGACCGCGCATTCGCCGTGCTTTCGCTC
GGAAGCGGGCTCGTATGGCCGCGACACGCGTGGCCTCATCCGGCAGCATCAGTTCGACAAGGTCGAGATGGTGCAGATCG
TCGCGCCGGAGACTTCGTACGACGCGCTGGAACAGATGGTCGGCCACGCGGAGACGATTCTGCAGAAGCTGGAACTGCCG
TACCGCGTGATTACGCTGTGCACGGGCGACATGGGCTTTTCCGCAGCCAAGACGTACGACCTGGAAGTGTGGGTGCCGGC
GCAGAATACGTATCGCGAAATTTCGAGCTGTTCGAATACCGAGTCGTTCCAGGCTCGCCGCATGCAGGCGCGTTATCGCA
ATGCGCAGGGCAAGCCGGAGCTGGTGCATACGCTGAATGGGTCGGGTCTGGCCGTCGGTCGCACGCTCGTGGCGGTACTG
GAAAATTTCCAGAACGCCGATGGTTCGGTCACTGTGCCGGTGGCGTTGCGTCCGTACCTTGGCGGTTTGGAACGGCTGGA
ATTACCGGCTGCCTGA

Upstream 100 bases:

>100_bases
CCCGGTCGGCTTTGCGCACACGCTGACCATCTAACGCACCGGCCGCCCGCGCCGGTGCGCTAAAATCCCATCTTCATACA
ACGAACATCCGCCCCATTCC

Downstream 100 bases:

>100_bases
TTTGAGCACGGCGGGTTGCCGTGAACGGTTGCCAGGTGGTCGCCGAGCCTCTTTGAAAAATTTTTGACGAGGGGCTTGGA
AATCGAATTCAGCTGTTCTA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFTALEAERRDTQTRTEEMQARRNSLSKQIGALKGKGEDTSAVMAEVSGIGD
EMKASAARLDEIQKRLSDLLLGVPNLPHESVPLGKDETENVEVRRWGTPRQFEFEVKDHVDVGAPLGLDFETGAKLSGAR
FTMLRGQIARLHRALAQFMIDTHTQHHGYTEIYTPYIVNPEILYGTGQLPKFADDMFRVEKGGDENTVTQYLISTSEISL
TNTVRDSILEADALPIKLTAHSPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQIVAPETSYDALEQMVGHAETILQKLELP
YRVITLCTGDMGFSAAKTYDLEVWVPAQNTYREISSCSNTESFQARRMQARYRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENFQNADGSVTVPVALRPYLGGLERLELPAA

Sequences:

>Translated_431_residues
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFTALEAERRDTQTRTEEMQARRNSLSKQIGALKGKGEDTSAVMAEVSGIGD
EMKASAARLDEIQKRLSDLLLGVPNLPHESVPLGKDETENVEVRRWGTPRQFEFEVKDHVDVGAPLGLDFETGAKLSGAR
FTMLRGQIARLHRALAQFMIDTHTQHHGYTEIYTPYIVNPEILYGTGQLPKFADDMFRVEKGGDENTVTQYLISTSEISL
TNTVRDSILEADALPIKLTAHSPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQIVAPETSYDALEQMVGHAETILQKLELP
YRVITLCTGDMGFSAAKTYDLEVWVPAQNTYREISSCSNTESFQARRMQARYRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENFQNADGSVTVPVALRPYLGGLERLELPAA
>Mature_431_residues
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFTALEAERRDTQTRTEEMQARRNSLSKQIGALKGKGEDTSAVMAEVSGIGD
EMKASAARLDEIQKRLSDLLLGVPNLPHESVPLGKDETENVEVRRWGTPRQFEFEVKDHVDVGAPLGLDFETGAKLSGAR
FTMLRGQIARLHRALAQFMIDTHTQHHGYTEIYTPYIVNPEILYGTGQLPKFADDMFRVEKGGDENTVTQYLISTSEISL
TNTVRDSILEADALPIKLTAHSPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQIVAPETSYDALEQMVGHAETILQKLELP
YRVITLCTGDMGFSAAKTYDLEVWVPAQNTYREISSCSNTESFQARRMQARYRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENFQNADGSVTVPVALRPYLGGLERLELPAA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=476, Percent_Identity=33.6134453781513, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI8923421, Length=414, Percent_Identity=28.5024154589372, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI225579074, Length=325, Percent_Identity=31.3846153846154, Blast_Score=166, Evalue=3e-41,
Organism=Escherichia coli, GI1787120, Length=427, Percent_Identity=62.5292740046838, Blast_Score=553, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI17539260, Length=344, Percent_Identity=35.1744186046512, Blast_Score=224, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI17542084, Length=334, Percent_Identity=31.1377245508982, Blast_Score=151, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6320226, Length=444, Percent_Identity=31.981981981982, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6321799, Length=384, Percent_Identity=30.9895833333333, Blast_Score=193, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24581334, Length=481, Percent_Identity=31.6008316008316, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI17737985, Length=340, Percent_Identity=31.1764705882353, Blast_Score=151, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_BURXL (Q143D9)

Other databases:

- EMBL:   CP000270
- RefSeq:   YP_557602.1
- ProteinModelPortal:   Q143D9
- SMR:   Q143D9
- GeneID:   4002312
- GenomeReviews:   CP000270_GR
- KEGG:   bxe:Bxe_A3435
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47830; Mature: 47830

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 289-289 BINDING 388-388

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFTALEAERRDTQTRTEEMQARRNSLSKQIGA
CCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGKGEDTSAVMAEVSGIGDEMKASAARLDEIQKRLSDLLLGVPNLPHESVPLGKDETEN
CCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRWGTPRQFEFEVKDHVDVGAPLGLDFETGAKLSGARFTMLRGQIARLHRALAQFMI
EEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
DTHTQHHGYTEIYTPYIVNPEILYGTGQLPKFADDMFRVEKGGDENTVTQYLISTSEISL
HHCCCCCCCCEECCCEEECCEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCEEH
TNTVRDSILEADALPIKLTAHSPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQIVAPETSY
HHHHHHHHHHCCCCEEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCH
DALEQMVGHAETILQKLELPYRVITLCTGDMGFSAAKTYDLEVWVPAQNTYREISSCSNT
HHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHHCCCC
ESFQARRMQARYRNAQGKPELVHTLNGSGLAVGRTLVAVLENFQNADGSVTVPVALRPYL
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECHHH
GGLERLELPAA
CCHHHHCCCCC
>Mature Secondary Structure
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFTALEAERRDTQTRTEEMQARRNSLSKQIGA
CCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGKGEDTSAVMAEVSGIGDEMKASAARLDEIQKRLSDLLLGVPNLPHESVPLGKDETEN
CCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRWGTPRQFEFEVKDHVDVGAPLGLDFETGAKLSGARFTMLRGQIARLHRALAQFMI
EEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
DTHTQHHGYTEIYTPYIVNPEILYGTGQLPKFADDMFRVEKGGDENTVTQYLISTSEISL
HHCCCCCCCCEECCCEEECCEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCEEH
TNTVRDSILEADALPIKLTAHSPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQIVAPETSY
HHHHHHHHHHCCCCEEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCH
DALEQMVGHAETILQKLELPYRVITLCTGDMGFSAAKTYDLEVWVPAQNTYREISSCSNT
HHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHHCCCC
ESFQARRMQARYRNAQGKPELVHTLNGSGLAVGRTLVAVLENFQNADGSVTVPVALRPYL
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECHHH
GGLERLELPAA
CCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA