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The map label for this gene is zwf [H]

Identifier: 91782379

GI number: 91782379

Start: 1116632

End: 1118095

Strand: Reverse

Name: zwf [H]

Synonym: Bxe_A3452

Alternate gene names: 91782379

Gene position: 1118095-1116632 (Counterclockwise)

Preceding gene: 91782384

Following gene: 91782378

Centisome position: 22.84

GC content: 63.32

Gene sequence:

>1464_bases
ATGCAAACCGATTCAAGCTTCACCTTCGTTCTCTTCGGCGGCACCGGCGATCTGTCGATGCGCAAGATCCTGCCGGCACT
GTTTGAAGCACATCGCGCAGGCGGCATGCTGGCCGACAGCGGCAAGATCGTCGCGGTGGCCCGGCACGCGGCGGATCGCA
GCGAGTATTTGCAGCGGGTGAACGAGCACGTCAAACCGCATGTGTCGAAGAACGGTGTGGACGAAGCGGCATGGGCGAGC
TTTCTGAAGCGCATCGAGTTCGTGAAGATCGACCTCGGCAACCCGGACGACTTCGCCCTTCTGCGCGACGCCATTCAGGA
CCTGCCCGGCATCCGCGTGTTCTATCTGGCCACCGGCCCGTCGCTGTTCGTGCCGATCTGCCACGCGCTCGCCTCGGTGG
GATTGAATGCGAACGCCCGCATCGTGCTGGAAAAGCCGCTCGGCTACGACCTCAAGTCGTCCAACGCAATTAATGATGCG
GTCGGCGAAATCTTCGCCGAAGAGCAGATCTACCGCATCGACCACTACCTCGGCAAAGAACCGGTGCAGAACCTGCTGGC
GCTGCGCTTCGGCAATGCGCTGTTCGAGCCGCTGTGGCGCCGCGAGTGGGTCGAAAGCATTCAGATCACGATCGCCGAAG
AACTCGGCGTGGAAGCGCGCGGCGACTTCTACGACAATACCGGCGCGCTGCGCGACATGGTGCAGAACCATTTGCTGCAG
TTGCTTTCCATCGTCGCGATGGAGCCGCCGCATTCCATGGATTCGGATTCGGTGCGTGACGAAAAGCTGCGCGTGCTGCG
TGCGCTCAAGCCTGTCGATTCGCGCGATATCGGCAAGGTGGCCGTGCGCGGCCAGTATCATTCGGGAGTGATTCGCGGCA
CTTCCGTGCCGGCGTATGCAACGGAGCCTGGCGTCAGGCCAGACAGCACGACCGAGACTTTCGTCGCGCTGAAGGTCGAG
ATCGAAAACTGGCGCTGGGCCGGCGTGCCGTTTTTCCTGCGCACCGGCAAGCGGCTGGCCGATCGCGTCGCCGAGATCGT
GGTGAACTTTCGCGCCGTGCCGCATTCGGCGCTGGGCGCCTCCGCGCTGCGCGCCGGCGCGAATCGCCTGGTGATCCGCC
TGCAGCCGAACGAGACCATTCGCCTCTACTGTCTCGCGAAGCAGCCCGGCGAAGGCATGAATCTCGCCAGCGTCCACCTC
GACCTCGCGTTCGACCAGTTCTTCCGCGAAGGGCAAATGGAAGCGTATCAGCGTCTGCTGCTCGACGTGATCAACGGCCG
CCTCGCGCTGTTCGTGCGGCGCGACGAGCAGGAAGCCGCATGGCGCTGGGTCGAACCGATCCTGAACGAATGGAAGGCGT
CGAACAAGCCGCCCAAGCCGTATGCTTCGGGCACATGGGGACCGGCCGCATCGAGTGCGATGCTGGCGCAGCACGGCACC
TGCTGGCTCGAAGAAGAGAATTGA

Upstream 100 bases:

>100_bases
ATTGTAGTTAAACTACAATTCAGTGTCAAAAAAAATTTTATCGGACTACGGTCGCGCTGCCCCTCACTTTCCGCGGCCCC
AGGACAATCGACGGAGACTC

Downstream 100 bases:

>100_bases
ATCGCGGCGCCACGTCGTATTCCGCGGAACACGGCGTGGCGCCTGTAAGACCCACCGACGAACTGAACGGAATGGCGCCG
GTATCACGAGGGCGCCTGCA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MQTDSSFTFVLFGGTGDLSMRKILPALFEAHRAGGMLADSGKIVAVARHAADRSEYLQRVNEHVKPHVSKNGVDEAAWAS
FLKRIEFVKIDLGNPDDFALLRDAIQDLPGIRVFYLATGPSLFVPICHALASVGLNANARIVLEKPLGYDLKSSNAINDA
VGEIFAEEQIYRIDHYLGKEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHLLQ
LLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDSRDIGKVAVRGQYHSGVIRGTSVPAYATEPGVRPDSTTETFVALKVE
IENWRWAGVPFFLRTGKRLADRVAEIVVNFRAVPHSALGASALRAGANRLVIRLQPNETIRLYCLAKQPGEGMNLASVHL
DLAFDQFFREGQMEAYQRLLLDVINGRLALFVRRDEQEAAWRWVEPILNEWKASNKPPKPYASGTWGPAASSAMLAQHGT
CWLEEEN

Sequences:

>Translated_487_residues
MQTDSSFTFVLFGGTGDLSMRKILPALFEAHRAGGMLADSGKIVAVARHAADRSEYLQRVNEHVKPHVSKNGVDEAAWAS
FLKRIEFVKIDLGNPDDFALLRDAIQDLPGIRVFYLATGPSLFVPICHALASVGLNANARIVLEKPLGYDLKSSNAINDA
VGEIFAEEQIYRIDHYLGKEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHLLQ
LLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDSRDIGKVAVRGQYHSGVIRGTSVPAYATEPGVRPDSTTETFVALKVE
IENWRWAGVPFFLRTGKRLADRVAEIVVNFRAVPHSALGASALRAGANRLVIRLQPNETIRLYCLAKQPGEGMNLASVHL
DLAFDQFFREGQMEAYQRLLLDVINGRLALFVRRDEQEAAWRWVEPILNEWKASNKPPKPYASGTWGPAASSAMLAQHGT
CWLEEEN
>Mature_487_residues
MQTDSSFTFVLFGGTGDLSMRKILPALFEAHRAGGMLADSGKIVAVARHAADRSEYLQRVNEHVKPHVSKNGVDEAAWAS
FLKRIEFVKIDLGNPDDFALLRDAIQDLPGIRVFYLATGPSLFVPICHALASVGLNANARIVLEKPLGYDLKSSNAINDA
VGEIFAEEQIYRIDHYLGKEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHLLQ
LLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDSRDIGKVAVRGQYHSGVIRGTSVPAYATEPGVRPDSTTETFVALKVE
IENWRWAGVPFFLRTGKRLADRVAEIVVNFRAVPHSALGASALRAGANRLVIRLQPNETIRLYCLAKQPGEGMNLASVHL
DLAFDQFFREGQMEAYQRLLLDVINGRLALFVRRDEQEAAWRWVEPILNEWKASNKPPKPYASGTWGPAASSAMLAQHGT
CWLEEEN

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=489, Percent_Identity=35.5828220858896, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI109389365, Length=489, Percent_Identity=35.5828220858896, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI52145310, Length=503, Percent_Identity=28.0318091451292, Blast_Score=156, Evalue=4e-38,
Organism=Escherichia coli, GI1788158, Length=489, Percent_Identity=44.7852760736196, Blast_Score=439, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17538218, Length=492, Percent_Identity=35.5691056910569, Blast_Score=318, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6324088, Length=489, Percent_Identity=36.40081799591, Blast_Score=295, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24643350, Length=471, Percent_Identity=36.5180467091295, Blast_Score=300, Evalue=2e-81,
Organism=Drosophila melanogaster, GI24643352, Length=474, Percent_Identity=36.2869198312236, Blast_Score=299, Evalue=4e-81,
Organism=Drosophila melanogaster, GI221513548, Length=483, Percent_Identity=29.399585921325, Blast_Score=202, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54275; Mature: 54275

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTDSSFTFVLFGGTGDLSMRKILPALFEAHRAGGMLADSGKIVAVARHAADRSEYLQRV
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEECCCCEEEEEHHHCCHHHHHHHH
NEHVKPHVSKNGVDEAAWASFLKRIEFVKIDLGNPDDFALLRDAIQDLPGIRVFYLATGP
HHHCCCCCCCCCCCHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCC
SLFVPICHALASVGLNANARIVLEKPLGYDLKSSNAINDAVGEIFAEEQIYRIDHYLGKE
HHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHH
PVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHLLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
LLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDSRDIGKVAVRGQYHSGVIRGTSVPAYA
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEECCCCCCCC
TEPGVRPDSTTETFVALKVEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRAVPHSALGA
CCCCCCCCCCCCEEEEEEEEECCEEECCCHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHH
SALRAGANRLVIRLQPNETIRLYCLAKQPGEGMNLASVHLDLAFDQFFREGQMEAYQRLL
HHHHCCCCEEEEEECCCCEEEEEEEECCCCCCCCEEEEEEHHHHHHHHHCCHHHHHHHHH
LDVINGRLALFVRRDEQEAAWRWVEPILNEWKASNKPPKPYASGTWGPAASSAMLAQHGT
HHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCC
CWLEEEN
EEEECCC
>Mature Secondary Structure
MQTDSSFTFVLFGGTGDLSMRKILPALFEAHRAGGMLADSGKIVAVARHAADRSEYLQRV
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEECCCCEEEEEHHHCCHHHHHHHH
NEHVKPHVSKNGVDEAAWASFLKRIEFVKIDLGNPDDFALLRDAIQDLPGIRVFYLATGP
HHHCCCCCCCCCCCHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCC
SLFVPICHALASVGLNANARIVLEKPLGYDLKSSNAINDAVGEIFAEEQIYRIDHYLGKE
HHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHH
PVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHLLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
LLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDSRDIGKVAVRGQYHSGVIRGTSVPAYA
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEECCCCCCCC
TEPGVRPDSTTETFVALKVEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRAVPHSALGA
CCCCCCCCCCCCEEEEEEEEECCEEECCCHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHH
SALRAGANRLVIRLQPNETIRLYCLAKQPGEGMNLASVHLDLAFDQFFREGQMEAYQRLL
HHHHCCCCEEEEEECCCCEEEEEEEECCCCCCCCEEEEEEHHHHHHHHHCCHHHHHHHHH
LDVINGRLALFVRRDEQEAAWRWVEPILNEWKASNKPPKPYASGTWGPAASSAMLAQHGT
HHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCC
CWLEEEN
EEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]