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The map label for this gene is pcaK [H]

Identifier: 91782303

GI number: 91782303

Start: 1032615

End: 1034009

Strand: Direct

Name: pcaK [H]

Synonym: Bxe_A3530

Alternate gene names: 91782303

Gene position: 1032615-1034009 (Clockwise)

Preceding gene: 91782302

Following gene: 91782304

Centisome position: 21.09

GC content: 64.95

Gene sequence:

>1395_bases
ATGACGGAGACGACATCAGTTGCCAACGTAATCGACGCACGACCCATAGGGTGGCTGCAGCTCGTGATTGCGGCGGTCGG
CGCGCTCGCGCTGCTTTGCGAGGGTTTCGATCTGCAGATCATTTCCTATGTGATGCCGCGGATCGTTCAGGAATGGGGCA
TAGAGCGGGCAAGGCAGGGCACGATCCTGTCGGCGGGTTACGGCGGCATGTTGATCGGCTTCCTCGCGCTCGCGCCGCTT
GCTTCGAGGATCGGCGCGAAGCGGCTTGCGGTTTACTGCCTGCTGGCGATGGGTGTGCTTAACCTCGGGACGTTGTTCGC
CACCGGCGGGTGGATGCTCATCGCCTTTCGAGTCGCCGTCGGACTGACGCTCGGTGGAGTCGTTCCCCCGACGCTAGCGC
TCGTCGCCGAATTCTTTCCCACGCGTCATCGTTCGGCGCTCATCGCGATGCTGTATCTGGGGACGACGAGCGGCATCATG
ATCGCTGGCGTCGTCGCATGGTTGACGTTGGCGCGCTACGGCTGGCGCGGCGCAATGGTGGTCGGCGGCGTGATGCCGAT
CGTTGCGGCGATCGCGGTCCGGCTGGTCTGGTTCGAATCGCCGGTCTGGCTGCTCTCCCGCGGCGCAGCGGGAGCAGCGC
GCGTGAGCGTGATGCTGGAACGGCTGTATCCGCGCATGCCGTCGAGCAACCCGGTCGCGGCGGCCGAAGCTTCGACGCCG
GATGCGGGCAGCGTCGTGCATCTCTTCACTGAACGGCGCCTTGTGGGCACGCTGATGCTGTGGCTGGGATTGAGCTGCAA
CGCGGTCGTCTATTTCTTCGCGCTTAGCTGGATACCGCTGATTCTCGTCGGGATCGGCGCGACCCAGCAGAACGCGATTC
TTGCGTCCACGCTGGCCAACCTCGGCGGTATTGCCGCAATCGTGACCGGTTTTCTGATGGACCGGTACGGCAGGTCGCGC
GTCGTCATCGGCTATTTCTTTGCAGGCGCTGCGTTCGTTCTGCTCGTGGGCGCGATGCTGTCTCCGACCGTGATGGTGAT
CGCGCCGACGGCGTTCTGCCTCGGGTATTGCGTCAGCGGTTTGCAGAAGGGCGTGTCGGCGTTGGCGATCGAATTCTATC
CGTCCGCGCTGCGATCGGCTGGCGTCGGTTGGGTGCTCGGCGTCGGCCGCAGCGGCGCGATTCTCGGGCCGATGGTGCCC
GGGCTGCTGATGCAGGCCGGCTGGCCGCCGGCGCATGTTTTTTATCTGATGTCAGTACCGCTGGTGCTCGGAGGCGCAGG
CATTGCGCTGATGCAGGCATGGTACCGGCCGCGTACGTCGCGGGACCACGCGCTGCTGCATGCGGTTGCGCCGGTACACG
ACGATTACCCGGGGACGAAAGTGCGGACGCGCTAG

Upstream 100 bases:

>100_bases
TTCATGGTGGGCGCGACGATCGATGTGAACGGCGGCCTGTATATGCGGTAGGCGGCATAGCGGTGCAGGCGGCGAACAGA
TACAACAACGAGGAGACGCC

Downstream 100 bases:

>100_bases
CGTCGGGCGCTTTCGCCACTCGCTTTTTTTGAAGCTACGAAAAGGAAGAGGAATGACGGATCTTGCAGACCTGACTTGCG
TTGGCCCCGGTACGCCGATG

Product: major facilitator superfamily transporter 4- hydroxybenzoate transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MTETTSVANVIDARPIGWLQLVIAAVGALALLCEGFDLQIISYVMPRIVQEWGIERARQGTILSAGYGGMLIGFLALAPL
ASRIGAKRLAVYCLLAMGVLNLGTLFATGGWMLIAFRVAVGLTLGGVVPPTLALVAEFFPTRHRSALIAMLYLGTTSGIM
IAGVVAWLTLARYGWRGAMVVGGVMPIVAAIAVRLVWFESPVWLLSRGAAGAARVSVMLERLYPRMPSSNPVAAAEASTP
DAGSVVHLFTERRLVGTLMLWLGLSCNAVVYFFALSWIPLILVGIGATQQNAILASTLANLGGIAAIVTGFLMDRYGRSR
VVIGYFFAGAAFVLLVGAMLSPTVMVIAPTAFCLGYCVSGLQKGVSALAIEFYPSALRSAGVGWVLGVGRSGAILGPMVP
GLLMQAGWPPAHVFYLMSVPLVLGGAGIALMQAWYRPRTSRDHALLHAVAPVHDDYPGTKVRTR

Sequences:

>Translated_464_residues
MTETTSVANVIDARPIGWLQLVIAAVGALALLCEGFDLQIISYVMPRIVQEWGIERARQGTILSAGYGGMLIGFLALAPL
ASRIGAKRLAVYCLLAMGVLNLGTLFATGGWMLIAFRVAVGLTLGGVVPPTLALVAEFFPTRHRSALIAMLYLGTTSGIM
IAGVVAWLTLARYGWRGAMVVGGVMPIVAAIAVRLVWFESPVWLLSRGAAGAARVSVMLERLYPRMPSSNPVAAAEASTP
DAGSVVHLFTERRLVGTLMLWLGLSCNAVVYFFALSWIPLILVGIGATQQNAILASTLANLGGIAAIVTGFLMDRYGRSR
VVIGYFFAGAAFVLLVGAMLSPTVMVIAPTAFCLGYCVSGLQKGVSALAIEFYPSALRSAGVGWVLGVGRSGAILGPMVP
GLLMQAGWPPAHVFYLMSVPLVLGGAGIALMQAWYRPRTSRDHALLHAVAPVHDDYPGTKVRTR
>Mature_463_residues
TETTSVANVIDARPIGWLQLVIAAVGALALLCEGFDLQIISYVMPRIVQEWGIERARQGTILSAGYGGMLIGFLALAPLA
SRIGAKRLAVYCLLAMGVLNLGTLFATGGWMLIAFRVAVGLTLGGVVPPTLALVAEFFPTRHRSALIAMLYLGTTSGIMI
AGVVAWLTLARYGWRGAMVVGGVMPIVAAIAVRLVWFESPVWLLSRGAAGAARVSVMLERLYPRMPSSNPVAAAEASTPD
AGSVVHLFTERRLVGTLMLWLGLSCNAVVYFFALSWIPLILVGIGATQQNAILASTLANLGGIAAIVTGFLMDRYGRSRV
VIGYFFAGAAFVLLVGAMLSPTVMVIAPTAFCLGYCVSGLQKGVSALAIEFYPSALRSAGVGWVLGVGRSGAILGPMVPG
LLMQAGWPPAHVFYLMSVPLVLGGAGIALMQAWYRPRTSRDHALLHAVAPVHDDYPGTKVRTR

Specific function: Could Be A Transporter For 3-Phenylpropionate (Hydrocinnamic Acid). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=438, Percent_Identity=23.2876712328767, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI87081723, Length=377, Percent_Identity=27.5862068965517, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI87082159, Length=402, Percent_Identity=24.6268656716418, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786229, Length=370, Percent_Identity=23.7837837837838, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082231, Length=478, Percent_Identity=23.8493723849372, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788068, Length=437, Percent_Identity=23.3409610983982, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=425, Percent_Identity=21.6470588235294, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19922874, Length=421, Percent_Identity=22.5653206650831, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48997; Mature: 48866

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TETTSVANVIDARPIGWLQLVIAAVGALALLCEGFDLQIISYVMPRIVQEWGIERARQG
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHHHCC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HHHCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8063101 [H]