BacMap

Definition	Burkholderia xenovorans LB400 chromosome 1, complete sequence.
Accession	NC_007951
Length	4,895,836

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The map label for this gene is fabG2 [H]

Identifier: 91782271

GI number: 91782271

Start: 998295

End: 999053

Strand: Direct

Name: fabG2 [H]

Synonym: Bxe_A3563

Alternate gene names: 91782271

Gene position: 998295-999053 (Clockwise)

Preceding gene: 91782269

Following gene: 91782272

Centisome position: 20.39

GC content: 61.92

Gene sequence:

>759_bases
ATGAGACTTGAAGGCAAGGTGGCGATCATCACCGGTGCGGCAACCGGTATCGGCAACGCGATCGCGCGGGCGTATGTGGC
CGAAGGTGCGAAGGTCGTGATTGCAGACCTGAAGGGGGCGGAGGCAGCGGCATCTGAACTTGGCGCGGGTATTGCGCTAG
GTATTTACGCCAACGTCGCCGATCCGGACAGCACCAGGCAGATGGCTGCTGCTGCTGTCGAGCGGTTTGGCAAGATCGAC
GTGCTGGTCAACAATGCCGGCATTTTCACGGGCCTCAGCGGTGTTCCGATGGAAGGCATCACGGTCGAGGACTGGGACAA
ACTCTACGCTGTCAATGTCAAGGGTCCGTGGCTTTGCACGAGCGCAGTCTCGGCGGCGATGCGTGAGGGCGGTGGCGGCA
AGATCATCAACATCGCCTCGGTCATCGCGCACGTCGGCGTGCCCTTCATGCTGCACTACGTCTCGAGCAAGGGTGCCGTG
GCAGCCATGACCCGCGCAATGGCGCGGGAGTTTGCTGCCACCAAGGCGGGAATTACGGTCAACGCGATCTCTCCCGGCTA
TACCCATTCTGCAAACGCAGTGGCCAATACCCAGCAGCACGAGCAGTTCGAAGGCGTCGCCGCACAGATGCGCACGATCG
GGCGGCCGCAGGTGCCCGAGGACATTGCCGGCGCAGCACTCTGGCTCGCGAGCGACGAAGCGTCCTACGTCAACGGGCAG
AACATCATTGTGGACGGTGGCATTTTCATGAGCCTCTGA

Upstream 100 bases:

>100_bases
CGTATCACATATCCTTGGTTCAGCATTTCGCAATGCACAAACAGACCGTACAGTCTGTTTGTTTAAAAGAATTCCAACTG
ATCTTAACTGGAGCGAGACG

Downstream 100 bases:

>100_bases
AAGCCTGCCGGACGTTTCGCCAGTGAGAACCATTGCGGAGTCAAACCCATGAATGCAAATCCGAAACACGTCGCGGATCC
GACCAGGCTTCGTAATCAGA

Product: p-cumic alcohol dehydrogenase (CymB)

Products: L-sorbose; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MRLEGKVAIITGAATGIGNAIARAYVAEGAKVVIADLKGAEAAASELGAGIALGIYANVADPDSTRQMAAAAVERFGKID
VLVNNAGIFTGLSGVPMEGITVEDWDKLYAVNVKGPWLCTSAVSAAMREGGGGKIINIASVIAHVGVPFMLHYVSSKGAV
AAMTRAMAREFAATKAGITVNAISPGYTHSANAVANTQQHEQFEGVAAQMRTIGRPQVPEDIAGAALWLASDEASYVNGQ
NIIVDGGIFMSL

Sequences:

>Translated_252_residues
MRLEGKVAIITGAATGIGNAIARAYVAEGAKVVIADLKGAEAAASELGAGIALGIYANVADPDSTRQMAAAAVERFGKID
VLVNNAGIFTGLSGVPMEGITVEDWDKLYAVNVKGPWLCTSAVSAAMREGGGGKIINIASVIAHVGVPFMLHYVSSKGAV
AAMTRAMAREFAATKAGITVNAISPGYTHSANAVANTQQHEQFEGVAAQMRTIGRPQVPEDIAGAALWLASDEASYVNGQ
NIIVDGGIFMSL
>Mature_252_residues
MRLEGKVAIITGAATGIGNAIARAYVAEGAKVVIADLKGAEAAASELGAGIALGIYANVADPDSTRQMAAAAVERFGKID
VLVNNAGIFTGLSGVPMEGITVEDWDKLYAVNVKGPWLCTSAVSAAMREGGGGKIINIASVIAHVGVPFMLHYVSSKGAV
AAMTRAMAREFAATKAGITVNAISPGYTHSANAVANTQQHEQFEGVAAQMRTIGRPQVPEDIAGAALWLASDEASYVNGQ
NIIVDGGIFMSL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI19923817, Length=257, Percent_Identity=34.6303501945525, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=34.9397590361446, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI5031737, Length=257, Percent_Identity=34.2412451361868, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI15277342, Length=265, Percent_Identity=32.8301886792453, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI66933014, Length=250, Percent_Identity=34.4, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI59889578, Length=230, Percent_Identity=32.1739130434783, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI31542939, Length=201, Percent_Identity=31.8407960199005, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI40254992, Length=249, Percent_Identity=29.718875502008, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI126723750, Length=252, Percent_Identity=30.1587301587302, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI33667109, Length=188, Percent_Identity=36.7021276595745, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI10190704, Length=262, Percent_Identity=29.0076335877863, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI109715829, Length=247, Percent_Identity=28.7449392712551, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4758504, Length=260, Percent_Identity=32.6923076923077, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI126723191, Length=197, Percent_Identity=33.502538071066, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4504505, Length=262, Percent_Identity=28.2442748091603, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI20149619, Length=239, Percent_Identity=33.8912133891213, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI142976729, Length=192, Percent_Identity=28.6458333333333, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI210032110, Length=196, Percent_Identity=28.0612244897959, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI224922801, Length=178, Percent_Identity=32.0224719101124, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI83715985, Length=260, Percent_Identity=31.9230769230769, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI4503301, Length=253, Percent_Identity=28.8537549407115, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI186928839, Length=208, Percent_Identity=30.2884615384615, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI225579078, Length=268, Percent_Identity=28.3582089552239, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI7705925, Length=248, Percent_Identity=26.2096774193548, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI40254986, Length=198, Percent_Identity=31.3131313131313, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI7706318, Length=203, Percent_Identity=29.064039408867, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI166795268, Length=208, Percent_Identity=28.3653846153846, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=252, Percent_Identity=35.7142857142857, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=36.8627450980392, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1789208, Length=252, Percent_Identity=36.5079365079365, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1788459, Length=256, Percent_Identity=33.203125, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1790717, Length=257, Percent_Identity=35.408560311284, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI87082160, Length=250, Percent_Identity=32.4, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI2367365, Length=246, Percent_Identity=33.739837398374, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1787905, Length=255, Percent_Identity=36.8627450980392, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1786812, Length=254, Percent_Identity=31.8897637795276, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI2367175, Length=250, Percent_Identity=31.2, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1789378, Length=255, Percent_Identity=29.0196078431373, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1789057, Length=261, Percent_Identity=27.9693486590038, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1787820, Length=239, Percent_Identity=27.1966527196653, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787526, Length=244, Percent_Identity=22.5409836065574, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=256, Percent_Identity=37.109375, Blast_Score=130, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=29.5880149812734, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25147288, Length=255, Percent_Identity=32.156862745098, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17560332, Length=274, Percent_Identity=31.3868613138686, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17538480, Length=274, Percent_Identity=32.1167883211679, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17555706, Length=251, Percent_Identity=30.6772908366534, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17531453, Length=262, Percent_Identity=30.9160305343511, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71994604, Length=254, Percent_Identity=30.7086614173228, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17562904, Length=265, Percent_Identity=32.4528301886792, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17551412, Length=273, Percent_Identity=31.5018315018315, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17536025, Length=256, Percent_Identity=31.25, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17560676, Length=253, Percent_Identity=28.8537549407115, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71994600, Length=252, Percent_Identity=29.7619047619048, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17563726, Length=261, Percent_Identity=29.5019157088123, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI193204405, Length=268, Percent_Identity=31.3432835820896, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17560150, Length=264, Percent_Identity=29.1666666666667, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17560220, Length=272, Percent_Identity=30.5147058823529, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562906, Length=264, Percent_Identity=29.9242424242424, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI72000259, Length=264, Percent_Identity=30.6818181818182, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17562990, Length=262, Percent_Identity=29.7709923664122, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17562908, Length=265, Percent_Identity=29.0566037735849, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17568967, Length=195, Percent_Identity=32.3076923076923, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17536651, Length=256, Percent_Identity=28.515625, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17559104, Length=270, Percent_Identity=29.2592592592593, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=280, Percent_Identity=27.8571428571429, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17538182, Length=261, Percent_Identity=32.183908045977, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538486, Length=266, Percent_Identity=28.1954887218045, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17565030, Length=274, Percent_Identity=29.5620437956204, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193203117, Length=251, Percent_Identity=25.8964143426295, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI193203115, Length=249, Percent_Identity=26.1044176706827, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=194, Percent_Identity=27.8350515463918, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561272, Length=255, Percent_Identity=30.9803921568627, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71982365, Length=197, Percent_Identity=28.4263959390863, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=245, Percent_Identity=28.1632653061224, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17508651, Length=257, Percent_Identity=26.8482490272374, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=195, Percent_Identity=29.2307692307692, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17558628, Length=194, Percent_Identity=29.8969072164948, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=198, Percent_Identity=31.3131313131313, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324126, Length=268, Percent_Identity=26.865671641791, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323882, Length=264, Percent_Identity=24.2424242424242, Blast_Score=62, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=35.6862745098039, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21355319, Length=252, Percent_Identity=30.5555555555556, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24644339, Length=256, Percent_Identity=31.640625, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI28571526, Length=255, Percent_Identity=32.156862745098, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=30.8300395256917, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI23397609, Length=261, Percent_Identity=33.3333333333333, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI18859837, Length=195, Percent_Identity=31.2820512820513, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24644337, Length=199, Percent_Identity=30.1507537688442, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17737361, Length=264, Percent_Identity=29.9242424242424, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641232, Length=198, Percent_Identity=29.2929292929293, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24643142, Length=249, Percent_Identity=26.5060240963855, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357673, Length=198, Percent_Identity=29.7979797979798, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24647946, Length=208, Percent_Identity=29.8076923076923, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116007236, Length=198, Percent_Identity=28.7878787878788, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45553409, Length=207, Percent_Identity=29.951690821256, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24647948, Length=207, Percent_Identity=29.951690821256, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648693, Length=203, Percent_Identity=33.0049261083744, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21355889, Length=203, Percent_Identity=33.0049261083744, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24663911, Length=242, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI281364892, Length=172, Percent_Identity=28.4883720930233, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281364494, Length=203, Percent_Identity=33.0049261083744, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21358495, Length=197, Percent_Identity=27.9187817258883, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.14

Molecular weight: Translated: 25831; Mature: 25831

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLEGKVAIITGAATGIGNAIARAYVAEGAKVVIADLKGAEAAASELGAGIALGIYANVA
CCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCEEEEEEEECC
DPDSTRQMAAAAVERFGKIDVLVNNAGIFTGLSGVPMEGITVEDWDKLYAVNVKGPWLCT
CCCHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCEECCCCEEEEEECCCCCHHH
SAVSAAMREGGGGKIINIASVIAHVGVPFMLHYVSSKGAVAAMTRAMAREFAATKAGITV
HHHHHHHHCCCCCCEEHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEE
NAISPGYTHSANAVANTQQHEQFEGVAAQMRTIGRPQVPEDIAGAALWLASDEASYVNGQ
EECCCCCCCCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHCCEEEEEECCCCCEECCC
NIIVDGGIFMSL
EEEEECCEEECC
>Mature Secondary Structure
MRLEGKVAIITGAATGIGNAIARAYVAEGAKVVIADLKGAEAAASELGAGIALGIYANVA
CCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCEEEEEEEECC
DPDSTRQMAAAAVERFGKIDVLVNNAGIFTGLSGVPMEGITVEDWDKLYAVNVKGPWLCT
CCCHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCEECCCCEEEEEECCCCCHHH
SAVSAAMREGGGGKIINIASVIAHVGVPFMLHYVSSKGAVAAMTRAMAREFAATKAGITV
HHHHHHHHCCCCCCEEHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEE
NAISPGYTHSANAVANTQQHEQFEGVAAQMRTIGRPQVPEDIAGAALWLASDEASYVNGQ
EECCCCCCCCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHCCEEEEEECCCCCEECCC
NIIVDGGIFMSL
EEEEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-iditol; NAD+

Specific reaction: L-iditol + NAD+ = L-sorbose + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]