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The map label for this gene is mmsB [H]

Identifier: 91782259

GI number: 91782259

Start: 984685

End: 985578

Strand: Direct

Name: mmsB [H]

Synonym: Bxe_A3575

Alternate gene names: 91782259

Gene position: 984685-985578 (Clockwise)

Preceding gene: 91782258

Following gene: 91782260

Centisome position: 20.11

GC content: 60.63

Gene sequence:

>894_bases
ATGAAAATCGGATTTATCGGCCTGGGCAACATGGGTGCTCCCATGGCGCTCAATCTGCTGAAGGCTGGACATGAGCTCAA
GGTCTTTGACCTGAATGGCCGGGCGGTACAACTGCTTGTCGACGCGGGTGCAAAAGGGGCAGCTTCCCCCAGAGCGTTGG
CGAGCGACGTGGAGCTCGTGATCACCATGCTGCCAGCAGCGGCGCATGTACGGGGCGTGCTGACCGGAAGCGAAGGCGTA
TTCTCGGGCATCGGTGATGGAGTCACGATCGTGGACTCCAGCACGATTGATCCCGCCAGTGTCAGGGAATTTGCAGCGCT
GGCAACGGAGCACAAATGTGTGCTCGTGGATGCGCCAGTGTCGGGTGGTACCGGTGGCGCGTCGGCGGGAACGCTGACCT
TCATGGTCGGAGGTAGCGAGGAGGCATACGCGCGGGTGAAACCGGTGCTTTCCACCATGGGCAGGAACATTGTCCACTGC
GGCGATACCGGAACGGGACAGGTCGCCAAGATCTGCAATAACCTGGTGCTCGGTATCACGATGGCGGGGGTCGCAGAAGC
GATGGCACTGGGCGACGCCCTCGGTATCGATGCGAAGGTGCTGGGGGGAATCATGAATACGTCGACCGGGCGCTCGTGGA
GTTCGGACACGTATAACCCGTTTCCCGGTGTGATCGACACAGCGCCATCGTCGCGTGGCTATACAGGGGGGTTCGGTACC
GATCTGATGCTGAAGGATCTTGGTCTGGCGACCGAGGCAGCAAAAAGTGCGAAGCAGCCGGTGTTCATGGGAGCACTCGC
GCAGCAGCTCTATCAGGCAATGAGTAGCCGCGGGGACGGCAAACTGGACTTCTCCGCGGTAATCCGGCTGTACCAGCAGG
GTGAGATCGCGTAA

Upstream 100 bases:

>100_bases
CGCGCGCTGGTTCGACGATGCGACCGTCAACGATGGTGTGAACACGACGATCAGCCTGCGCTGACCCGCCAGCCAGGTAA
TGCGCAGGTGAGGAGAGGAT

Downstream 100 bases:

>100_bases
AGCGCGTACAGAATCAGGGATCTAAAGATGGATGAGTTCTATACCGACGACCAGCGGATGATCCGCGATGCGGCGCGTGA
CCTCTCGACAGGACGTCTGG

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MKIGFIGLGNMGAPMALNLLKAGHELKVFDLNGRAVQLLVDAGAKGAASPRALASDVELVITMLPAAAHVRGVLTGSEGV
FSGIGDGVTIVDSSTIDPASVREFAALATEHKCVLVDAPVSGGTGGASAGTLTFMVGGSEEAYARVKPVLSTMGRNIVHC
GDTGTGQVAKICNNLVLGITMAGVAEAMALGDALGIDAKVLGGIMNTSTGRSWSSDTYNPFPGVIDTAPSSRGYTGGFGT
DLMLKDLGLATEAAKSAKQPVFMGALAQQLYQAMSSRGDGKLDFSAVIRLYQQGEIA

Sequences:

>Translated_297_residues
MKIGFIGLGNMGAPMALNLLKAGHELKVFDLNGRAVQLLVDAGAKGAASPRALASDVELVITMLPAAAHVRGVLTGSEGV
FSGIGDGVTIVDSSTIDPASVREFAALATEHKCVLVDAPVSGGTGGASAGTLTFMVGGSEEAYARVKPVLSTMGRNIVHC
GDTGTGQVAKICNNLVLGITMAGVAEAMALGDALGIDAKVLGGIMNTSTGRSWSSDTYNPFPGVIDTAPSSRGYTGGFGT
DLMLKDLGLATEAAKSAKQPVFMGALAQQLYQAMSSRGDGKLDFSAVIRLYQQGEIA
>Mature_297_residues
MKIGFIGLGNMGAPMALNLLKAGHELKVFDLNGRAVQLLVDAGAKGAASPRALASDVELVITMLPAAAHVRGVLTGSEGV
FSGIGDGVTIVDSSTIDPASVREFAALATEHKCVLVDAPVSGGTGGASAGTLTFMVGGSEEAYARVKPVLSTMGRNIVHC
GDTGTGQVAKICNNLVLGITMAGVAEAMALGDALGIDAKVLGGIMNTSTGRSWSSDTYNPFPGVIDTAPSSRGYTGGFGT
DLMLKDLGLATEAAKSAKQPVFMGALAQQLYQAMSSRGDGKLDFSAVIRLYQQGEIA

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=293, Percent_Identity=49.4880546075085, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI40556376, Length=294, Percent_Identity=27.2108843537415, Blast_Score=108, Evalue=8e-24,
Organism=Escherichia coli, GI1790315, Length=293, Percent_Identity=36.518771331058, Blast_Score=167, Evalue=6e-43,
Organism=Escherichia coli, GI145693186, Length=293, Percent_Identity=33.7883959044369, Blast_Score=167, Evalue=9e-43,
Organism=Escherichia coli, GI1786719, Length=298, Percent_Identity=34.5637583892617, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1789092, Length=294, Percent_Identity=33.6734693877551, Blast_Score=125, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17557316, Length=292, Percent_Identity=49.3150684931507, Blast_Score=263, Evalue=7e-71,
Organism=Drosophila melanogaster, GI24655230, Length=296, Percent_Identity=46.6216216216216, Blast_Score=264, Evalue=7e-71,
Organism=Drosophila melanogaster, GI19922568, Length=296, Percent_Identity=46.6216216216216, Blast_Score=264, Evalue=7e-71,
Organism=Drosophila melanogaster, GI28574115, Length=296, Percent_Identity=21.6216216216216, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24655240, Length=63, Percent_Identity=55.5555555555556, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 30181; Mature: 30181

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGFIGLGNMGAPMALNLLKAGHELKVFDLNGRAVQLLVDAGAKGAASPRALASDVELV
CEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHH
ITMLPAAAHVRGVLTGSEGVFSGIGDGVTIVDSSTIDPASVREFAALATEHKCVLVDAPV
HHHHHHHHHHEEEEECCCCCHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCC
SGGTGGASAGTLTFMVGGSEEAYARVKPVLSTMGRNIVHCGDTGTGQVAKICNNLVLGIT
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHH
MAGVAEAMALGDALGIDAKVLGGIMNTSTGRSWSSDTYNPFPGVIDTAPSSRGYTGGFGT
HHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCC
DLMLKDLGLATEAAKSAKQPVFMGALAQQLYQAMSSRGDGKLDFSAVIRLYQQGEIA
HHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MKIGFIGLGNMGAPMALNLLKAGHELKVFDLNGRAVQLLVDAGAKGAASPRALASDVELV
CEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHH
ITMLPAAAHVRGVLTGSEGVFSGIGDGVTIVDSSTIDPASVREFAALATEHKCVLVDAPV
HHHHHHHHHHEEEEECCCCCHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCC
SGGTGGASAGTLTFMVGGSEEAYARVKPVLSTMGRNIVHCGDTGTGQVAKICNNLVLGIT
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHH
MAGVAEAMALGDALGIDAKVLGGIMNTSTGRSWSSDTYNPFPGVIDTAPSSRGYTGGFGT
HHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCC
DLMLKDLGLATEAAKSAKQPVFMGALAQQLYQAMSSRGDGKLDFSAVIRLYQQGEIA
HHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]