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The map label for this gene is ilvR [H]

Identifier: 91782201

GI number: 91782201

Start: 925442

End: 926428

Strand: Direct

Name: ilvR [H]

Synonym: Bxe_A3633

Alternate gene names: 91782201

Gene position: 925442-926428 (Clockwise)

Preceding gene: 91782198

Following gene: 91782202

Centisome position: 18.9

GC content: 69.91

Gene sequence:

>987_bases
ATGCTGCCAGCCATCCCTGACCTGCGCCAGTTGCGCTATTTCGTCACCGTCGCCGAAGAAAAGCACTTCGGCCGCGCCGC
CGTGCGCCTTTCGATGACGCAGCCGCCGCTCTCGCAAGCCATTCGGGCGCTGGAGGAGACGCTCGGCGTCGCGCTGTTCG
CGCGCACCAAGCGCTCGGTCGAGCTGACGCCGGTGGGCGCCGATCTGTTGCCGGAGGTGCAGCGTCTGCTGGCGAGCGCC
GAAGGGCTGCGGCCGCTCGCGCAGAGCCTCGCGCGCGGCGAGGCGGGCGTGCTGTCGCTGGCTTTTGTTTCGACGGCGGA
CTATGGCCTGCTGCCGCTGTTGCTGCGCGATTTCGGCGTGCGCCATCCGCGCGTGCGGCTGGAGTTGACCGAAGCCACCA
GCGACGTGCAGGTGGACGAACTGGTGGCCGGGCGCATCGACGCGGGCCTCGTGATCGCGCCGCTGCCGTCGCGCCATGCC
GCGCAGTTGTCGTGGTTGCCCATCGCGCGCGAACCGCTGGTGATCGCCATGTCGACGGAGATGGCGGCGCGCGTGGCGAG
CGCTAGCGGCAGCCGCGGCGACCCGGGCGCGGAATGGCTCGACACGCCGATCAGCCTGCGCGATGTCGCCGACGCACCGC
TCGTGATCTTCCCAAGACGTCTGGCGCCAGGCTTTTATGACATCATTATGGATTGCTACGGCGTGGCGGGCCTCGCGCCG
CGGATCGGCCAGGAAGCGATCCAGATGCAGACGATCGTGAGCCTCGTGTCGGCCGGCATGGGTGTCGCACTGGTGCCGCA
ATCGTTGCGTAATCTGCGCCGCACCGGCGTGGTGTACCGGCCGCTGTCCGAGTCGGTGCCCGCCATCGAGACGGGGCTGG
TCTGGCGCACGGCGGAGGTGAGCCCGGTGCTGGCGGGCTTCATCGAGATCGTGCGCTCGCATGCCGCGACCGTCGAGGCG
CCGCTATCCGCCGCGCCGCGCGTTTAG

Upstream 100 bases:

>100_bases
CGTTCAGTGTAGTTCCGGCGCGCCGCGCAAGGATGCGGTTTTGCAATGAGCGTGTCCAGTATATTATTCGTGCTTCATTA
GGTCGCAAAACGTATTACCC

Downstream 100 bases:

>100_bases
AAGCGTTCTCGCGAACGCATCGGCGCGAGGAGCGTCCAACGCATGCACCACAGGGTGCGGGCAGCGCCGCCCACTATTAC
AAAACCCGGAAAACCCGCTT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Isoleucine biosynthesis transcriptional activator [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MLPAIPDLRQLRYFVTVAEEKHFGRAAVRLSMTQPPLSQAIRALEETLGVALFARTKRSVELTPVGADLLPEVQRLLASA
EGLRPLAQSLARGEAGVLSLAFVSTADYGLLPLLLRDFGVRHPRVRLELTEATSDVQVDELVAGRIDAGLVIAPLPSRHA
AQLSWLPIAREPLVIAMSTEMAARVASASGSRGDPGAEWLDTPISLRDVADAPLVIFPRRLAPGFYDIIMDCYGVAGLAP
RIGQEAIQMQTIVSLVSAGMGVALVPQSLRNLRRTGVVYRPLSESVPAIETGLVWRTAEVSPVLAGFIEIVRSHAATVEA
PLSAAPRV

Sequences:

>Translated_328_residues
MLPAIPDLRQLRYFVTVAEEKHFGRAAVRLSMTQPPLSQAIRALEETLGVALFARTKRSVELTPVGADLLPEVQRLLASA
EGLRPLAQSLARGEAGVLSLAFVSTADYGLLPLLLRDFGVRHPRVRLELTEATSDVQVDELVAGRIDAGLVIAPLPSRHA
AQLSWLPIAREPLVIAMSTEMAARVASASGSRGDPGAEWLDTPISLRDVADAPLVIFPRRLAPGFYDIIMDCYGVAGLAP
RIGQEAIQMQTIVSLVSAGMGVALVPQSLRNLRRTGVVYRPLSESVPAIETGLVWRTAEVSPVLAGFIEIVRSHAATVEA
PLSAAPRV
>Mature_328_residues
MLPAIPDLRQLRYFVTVAEEKHFGRAAVRLSMTQPPLSQAIRALEETLGVALFARTKRSVELTPVGADLLPEVQRLLASA
EGLRPLAQSLARGEAGVLSLAFVSTADYGLLPLLLRDFGVRHPRVRLELTEATSDVQVDELVAGRIDAGLVIAPLPSRHA
AQLSWLPIAREPLVIAMSTEMAARVASASGSRGDPGAEWLDTPISLRDVADAPLVIFPRRLAPGFYDIIMDCYGVAGLAP
RIGQEAIQMQTIVSLVSAGMGVALVPQSLRNLRRTGVVYRPLSESVPAIETGLVWRTAEVSPVLAGFIEIVRSHAATVEA
PLSAAPRV

Specific function: Positively regulates the expression of the ilvD gene while negatively autoregulating its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=307, Percent_Identity=36.1563517915309, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1788887, Length=315, Percent_Identity=31.7460317460317, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI2367136, Length=304, Percent_Identity=32.5657894736842, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1790399, Length=297, Percent_Identity=28.956228956229, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1787806, Length=311, Percent_Identity=26.3665594855305, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI145693105, Length=170, Percent_Identity=29.4117647058824, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI157672245, Length=254, Percent_Identity=30.3149606299213, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790208, Length=148, Percent_Identity=34.4594594594595, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788748, Length=259, Percent_Identity=27.027027027027, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787589, Length=137, Percent_Identity=37.2262773722628, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787530, Length=264, Percent_Identity=25.3787878787879, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081904, Length=146, Percent_Identity=30.8219178082192, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787601, Length=145, Percent_Identity=29.6551724137931, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788297, Length=267, Percent_Identity=23.5955056179775, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35146; Mature: 35146

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPAIPDLRQLRYFVTVAEEKHFGRAAVRLSMTQPPLSQAIRALEETLGVALFARTKRSV
CCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCE
ELTPVGADLLPEVQRLLASAEGLRPLAQSLARGEAGVLSLAFVSTADYGLLPLLLRDFGV
EEECCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCC
RHPRVRLELTEATSDVQVDELVAGRIDAGLVIAPLPSRHAAQLSWLPIAREPLVIAMSTE
CCCEEEEEEECCCCCCCHHHHHHCCCCCCEEEECCCCCCCCEEEECCCCCCCEEEEECHH
MAARVASASGSRGDPGAEWLDTPISLRDVADAPLVIFPRRLAPGFYDIIMDCYGVAGLAP
HHHHHHHCCCCCCCCCHHHHCCCCCHHHHCCCCEEEECHHHCCHHHHHHHHHHHHHCCCH
RIGQEAIQMQTIVSLVSAGMGVALVPQSLRNLRRTGVVYRPLSESVPAIETGLVWRTAEV
HHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCEEEECCCCCCCCHHHCCEEEECCC
SPVLAGFIEIVRSHAATVEAPLSAAPRV
CHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MLPAIPDLRQLRYFVTVAEEKHFGRAAVRLSMTQPPLSQAIRALEETLGVALFARTKRSV
CCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCE
ELTPVGADLLPEVQRLLASAEGLRPLAQSLARGEAGVLSLAFVSTADYGLLPLLLRDFGV
EEECCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCC
RHPRVRLELTEATSDVQVDELVAGRIDAGLVIAPLPSRHAAQLSWLPIAREPLVIAMSTE
CCCEEEEEEECCCCCCCHHHHHHCCCCCCEEEECCCCCCCCEEEECCCCCCCEEEEECHH
MAARVASASGSRGDPGAEWLDTPISLRDVADAPLVIFPRRLAPGFYDIIMDCYGVAGLAP
HHHHHHHCCCCCCCCCHHHHCCCCCHHHHCCCCEEEECHHHCCHHHHHHHHHHHHHCCCH
RIGQEAIQMQTIVSLVSAGMGVALVPQSLRNLRRTGVVYRPLSESVPAIETGLVWRTAEV
HHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCEEEECCCCCCCCHHHCCEEEECCC
SPVLAGFIEIVRSHAATVEAPLSAAPRV
CHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8113165; 11259647 [H]