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The map label for this gene is pepA [H]

Identifier: 91782196

GI number: 91782196

Start: 920004

End: 921530

Strand: Direct

Name: pepA [H]

Synonym: Bxe_A3638

Alternate gene names: 91782196

Gene position: 920004-921530 (Clockwise)

Preceding gene: 91782192

Following gene: 91782197

Centisome position: 18.79

GC content: 65.16

Gene sequence:

>1527_bases
ATGGACTTTAGCATAAAAGCCTGTGATTGGACCAAAGGCTCGTCAAACGGTTTCCTGACTGGAAAATCCGATTGCATCGT
AATCGGTGTGTTCGAGTCGCAAACCCTCTCGGGCGCGGCTCTCGAGATCGACGCGGCCACCAAGGGCCTGTTGACCCGCA
TCATCAAGGCCGGCGACATGGACGGCAAGGCCGGCACCACGCTGTTCCTGCACGAAGTGTCGGGTATCGGCGCTTCCCGC
GTGCTGCTGGTCGGCCTCGGCAAGCAGGACGCTTTCAACCAGAAAGCCTACGGCGACGCCGCACGGGCCGCCTGGCGCGC
ACTGCTGTCCACCAAGATCGTCCAGGTCACCTTCACGCTGGCGCAACTGCCGATCCTCGAGCGTTCGGCGGATTGGGCGG
TGCGCGCCGCGATCCTCGCGCTGCGCGAGCTGACCTACAAGTTCACGCAGATGAAGAGCAAGCCGGACACGTCGGCGCGT
GCGTTGAAGCGCATCGTCTTCAGCGTCAACACGGGCGACGAGAAGGCCGCCAAGCTGGCCGCGAAGCAGGGCGCGGCGCT
CGCCAACGGCATGGACCTCACGCGCGACCTCGGCAACCTGCCGAGCAACGTCTGCACGCCAACCTACCTCGCCAACACGG
CGAAGAAGCTCGCCAAAGACTGGAAGCTGAAGGTCGAAGTGCTGGGCGAAAAGCAGTGTGAAGCGCTCAAGATGGGCTCG
TTCCTGTCGGTCACGGCCGGTTCGGTCGAACCGGCGCAGTTCATCGTGCTGCAATACCAGGGCGGCGCCGCGAAGGCCGC
GCCGGTGGTGCTGGTCGGCAAGGGCGTGACGTTCGACACGGGCGGCATCTCGCTCAAGCCGGGCGAAGGCATGGACGAGA
TGAAATACGACATGTGCGGCGCCGGTTCGGTGCTGGGCACGTTGCGCGCCGTCGCGGAAATGGGCTTGAAAATCAACGTG
GTGGGCATCATTCCGGCGGTGGAGAACATGCCGTCGGCTACGGCCACCAAGCCGGGCGACATCGTCACCAGCATGAAGGG
CCTGACGATCGAAGTGCTGAACACGGACGCCGAAGGCCGGCTGATCCTGTGCGACGCGCTCACCTATGCGGAGCGCTTCA
AGCCGGCCGCGGTGATCGACATCGCCACGCTCACGGGTGCCTGCATCATTGCGCTCGGCCACCACAACAGCGGCCTGTTC
TCCAAAGACGACGCGCTGGCGGGCGAGTTGCTCGACGCATCGCGTGAAGCGTCGGACCCGGCCTGGCGCATGCCGCTCGA
CGACGAGTATCAGGATCAGCTCAAGTCGAACTTCGCGGATCTGGCCAACATCGGCGGCCGTCCGGCGGGCAGCGTGACGG
CGGCGTGCTTCCTGTCGCGCTTCACGGAGGCTTACCCGTGGGCGCATCTGGACATCGCGGGTACGGCGTGGAAGAGCGGT
GCGGCGAAGGGGGCAACGGGCCGTCCGGTGCCGTTGCTCGCGCAGTTCCTGATCGATAGGGCCGCCGACGGTCGCGCCAC
GCAATGA

Upstream 100 bases:

>100_bases
GGTTGCTTCCCGTCACACCTCCGGTGCAGCCGCCGCGGGAAAAATAGCGGATAATTGCGGCTTTCATCCTAAGCCCAGAT
TTTATCCGAGGACAAGCGCG

Downstream 100 bases:

>100_bases
CGCAATGCAGTAAAGATGCAGGCCCGGCCGCGCAAGCAGTCGCCGGGCGGAGCCGCCGATGACGAGAATCGACTTTCACT
CGAACGTCGGCGATTCGCTG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MDFSIKACDWTKGSSNGFLTGKSDCIVIGVFESQTLSGAALEIDAATKGLLTRIIKAGDMDGKAGTTLFLHEVSGIGASR
VLLVGLGKQDAFNQKAYGDAARAAWRALLSTKIVQVTFTLAQLPILERSADWAVRAAILALRELTYKFTQMKSKPDTSAR
ALKRIVFSVNTGDEKAAKLAAKQGAALANGMDLTRDLGNLPSNVCTPTYLANTAKKLAKDWKLKVEVLGEKQCEALKMGS
FLSVTAGSVEPAQFIVLQYQGGAAKAAPVVLVGKGVTFDTGGISLKPGEGMDEMKYDMCGAGSVLGTLRAVAEMGLKINV
VGIIPAVENMPSATATKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDIATLTGACIIALGHHNSGLF
SKDDALAGELLDASREASDPAWRMPLDDEYQDQLKSNFADLANIGGRPAGSVTAACFLSRFTEAYPWAHLDIAGTAWKSG
AAKGATGRPVPLLAQFLIDRAADGRATQ

Sequences:

>Translated_508_residues
MDFSIKACDWTKGSSNGFLTGKSDCIVIGVFESQTLSGAALEIDAATKGLLTRIIKAGDMDGKAGTTLFLHEVSGIGASR
VLLVGLGKQDAFNQKAYGDAARAAWRALLSTKIVQVTFTLAQLPILERSADWAVRAAILALRELTYKFTQMKSKPDTSAR
ALKRIVFSVNTGDEKAAKLAAKQGAALANGMDLTRDLGNLPSNVCTPTYLANTAKKLAKDWKLKVEVLGEKQCEALKMGS
FLSVTAGSVEPAQFIVLQYQGGAAKAAPVVLVGKGVTFDTGGISLKPGEGMDEMKYDMCGAGSVLGTLRAVAEMGLKINV
VGIIPAVENMPSATATKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDIATLTGACIIALGHHNSGLF
SKDDALAGELLDASREASDPAWRMPLDDEYQDQLKSNFADLANIGGRPAGSVTAACFLSRFTEAYPWAHLDIAGTAWKSG
AAKGATGRPVPLLAQFLIDRAADGRATQ
>Mature_508_residues
MDFSIKACDWTKGSSNGFLTGKSDCIVIGVFESQTLSGAALEIDAATKGLLTRIIKAGDMDGKAGTTLFLHEVSGIGASR
VLLVGLGKQDAFNQKAYGDAARAAWRALLSTKIVQVTFTLAQLPILERSADWAVRAAILALRELTYKFTQMKSKPDTSAR
ALKRIVFSVNTGDEKAAKLAAKQGAALANGMDLTRDLGNLPSNVCTPTYLANTAKKLAKDWKLKVEVLGEKQCEALKMGS
FLSVTAGSVEPAQFIVLQYQGGAAKAAPVVLVGKGVTFDTGGISLKPGEGMDEMKYDMCGAGSVLGTLRAVAEMGLKINV
VGIIPAVENMPSATATKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDIATLTGACIIALGHHNSGLF
SKDDALAGELLDASREASDPAWRMPLDDEYQDQLKSNFADLANIGGRPAGSVTAACFLSRFTEAYPWAHLDIAGTAWKSG
AAKGATGRPVPLLAQFLIDRAADGRATQ

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=524, Percent_Identity=36.8320610687023, Blast_Score=265, Evalue=8e-71,
Organism=Homo sapiens, GI47155554, Length=333, Percent_Identity=31.5315315315315, Blast_Score=117, Evalue=4e-26,
Organism=Escherichia coli, GI1790710, Length=505, Percent_Identity=50.0990099009901, Blast_Score=516, Evalue=1e-147,
Organism=Escherichia coli, GI87082123, Length=320, Percent_Identity=42.8125, Blast_Score=200, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17556903, Length=303, Percent_Identity=35.3135313531353, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17565172, Length=445, Percent_Identity=25.8426966292135, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355725, Length=334, Percent_Identity=36.8263473053892, Blast_Score=205, Evalue=7e-53,
Organism=Drosophila melanogaster, GI24661038, Length=334, Percent_Identity=37.125748502994, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI20129969, Length=500, Percent_Identity=30.6, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI161077148, Length=502, Percent_Identity=30.8764940239044, Blast_Score=194, Evalue=9e-50,
Organism=Drosophila melanogaster, GI20130057, Length=502, Percent_Identity=30.8764940239044, Blast_Score=194, Evalue=9e-50,
Organism=Drosophila melanogaster, GI24662227, Length=329, Percent_Identity=35.258358662614, Blast_Score=189, Evalue=6e-48,
Organism=Drosophila melanogaster, GI21355645, Length=506, Percent_Identity=28.8537549407115, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24662223, Length=506, Percent_Identity=28.8537549407115, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI19922386, Length=529, Percent_Identity=27.9773156899811, Blast_Score=168, Evalue=8e-42,
Organism=Drosophila melanogaster, GI20129963, Length=502, Percent_Identity=27.8884462151394, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI221379063, Length=310, Percent_Identity=30.9677419354839, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI221379062, Length=310, Percent_Identity=30.9677419354839, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI21357381, Length=310, Percent_Identity=30.9677419354839, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24646701, Length=429, Percent_Identity=26.1072261072261, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24646703, Length=429, Percent_Identity=26.1072261072261, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21358201, Length=429, Percent_Identity=26.1072261072261, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53468; Mature: 53468

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSIKACDWTKGSSNGFLTGKSDCIVIGVFESQTLSGAALEIDAATKGLLTRIIKAGDM
CCCCEEECCCCCCCCCCEEECCCCEEEEEEECCCCCCCCEEEECHHHHHHHHHHHHCCCC
DGKAGTTLFLHEVSGIGASRVLLVGLGKQDAFNQKAYGDAARAAWRALLSTKIVQVTFTL
CCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHHHHEEEHH
AQLPILERSADWAVRAAILALRELTYKFTQMKSKPDTSARALKRIVFSVNTGDEKAAKLA
HHCCHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEECCCCHHHHHHH
AKQGAALANGMDLTRDLGNLPSNVCTPTYLANTAKKLAKDWKLKVEVLGEKQCEALKMGS
HHCCCHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHCCC
FLSVTAGSVEPAQFIVLQYQGGAAKAAPVVLVGKGVTFDTGGISLKPGEGMDEMKYDMCG
EEEEECCCCCCEEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHCC
AGSVLGTLRAVAEMGLKINVVGIIPAVENMPSATATKPGDIVTSMKGLTIEVLNTDAEGR
CHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCC
LILCDALTYAERFKPAAVIDIATLTGACIIALGHHNSGLFSKDDALAGELLDASREASDP
EEEEEHHHHHHHCCCCEEEEHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCC
AWRMPLDDEYQDQLKSNFADLANIGGRPAGSVTAACFLSRFTEAYPWAHLDIAGTAWKSG
CEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCC
AAKGATGRPVPLLAQFLIDRAADGRATQ
CCCCCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDFSIKACDWTKGSSNGFLTGKSDCIVIGVFESQTLSGAALEIDAATKGLLTRIIKAGDM
CCCCEEECCCCCCCCCCEEECCCCEEEEEEECCCCCCCCEEEECHHHHHHHHHHHHCCCC
DGKAGTTLFLHEVSGIGASRVLLVGLGKQDAFNQKAYGDAARAAWRALLSTKIVQVTFTL
CCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHHHHEEEHH
AQLPILERSADWAVRAAILALRELTYKFTQMKSKPDTSARALKRIVFSVNTGDEKAAKLA
HHCCHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEECCCCHHHHHHH
AKQGAALANGMDLTRDLGNLPSNVCTPTYLANTAKKLAKDWKLKVEVLGEKQCEALKMGS
HHCCCHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHCCC
FLSVTAGSVEPAQFIVLQYQGGAAKAAPVVLVGKGVTFDTGGISLKPGEGMDEMKYDMCG
EEEEECCCCCCEEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHCC
AGSVLGTLRAVAEMGLKINVVGIIPAVENMPSATATKPGDIVTSMKGLTIEVLNTDAEGR
CHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCC
LILCDALTYAERFKPAAVIDIATLTGACIIALGHHNSGLFSKDDALAGELLDASREASDP
EEEEEHHHHHHHCCCCEEEEHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCC
AWRMPLDDEYQDQLKSNFADLANIGGRPAGSVTAACFLSRFTEAYPWAHLDIAGTAWKSG
CEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCC
AAKGATGRPVPLLAQFLIDRAADGRATQ
CCCCCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA