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The map label for this gene is folK [H]

Identifier: 91781889

GI number: 91781889

Start: 572294

End: 572842

Strand: Reverse

Name: folK [H]

Synonym: Bxe_A3956

Alternate gene names: 91781889

Gene position: 572842-572294 (Counterclockwise)

Preceding gene: 91781890

Following gene: 91781888

Centisome position: 11.7

GC content: 61.38

Gene sequence:

>549_bases
ATGACGGTTGCTTATCTCGGCCTCGGCGCGAATCTCGGGGACGCGCGCCAGACCCTGAAAGACGCGGTGGTGTGCCTCGC
ACAACAGCACACCATCACCGTGCTCGCCAAGTCGAGCCTGTATCGCACTGCCCCGATCGACGCGGGCGGTGACGATTATT
TCAACTGCGTCGTGAAGGTCGATACGACGCTCCCCGTGCGGCATCTGCTTGCGCTATGCCACAAGATCGAACATCAGTTC
GGCCGCGAACGGCCGTTTCGCAACGCGCCGCGCACGCTCGACCTGGACATCCTGCTATTCGGCGATCAATCGATCGACGA
AGCCGATCTGATCGTGCCGCATCCTCGCCTGATCGAACGCGCTTTTGCGCTCGTGCCGCTCGTCGAGATCGACTCCGCCT
TGATCATTCCGCAACACGGCCGCGCCGAGGCGCTGCTCAGCAAGGTGAGCGATCAACGCATCGAGAAGGTGAAAGGACCT
TGCCAGTGTCCTATGCTCAACGCGTTGACCGTCGGTGAAGACAAAACCGGCAAGGGCCGCTGCGAATGA

Upstream 100 bases:

>100_bases
AGCCGAACGCACAGCCGACGAAGCAGGCCATGACGGCCCGCGCGAAGACTGACACAGCGTTCGCTGAAGCCGTCGAACGA
CAGTTGCAGGAAGTTATGCC

Downstream 100 bases:

>100_bases
ATTCATCGCCGCTCACCGTCACGGCGCCGCAGCTGCGGCCGCCGTTCGGCTATCTCGCGATCGAAGGCCCGATCGGCGTC
GGCAAGACGTCGCTCGCACG

Product: 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 182; Mature: 181

Protein sequence:

>182_residues
MTVAYLGLGANLGDARQTLKDAVVCLAQQHTITVLAKSSLYRTAPIDAGGDDYFNCVVKVDTTLPVRHLLALCHKIEHQF
GRERPFRNAPRTLDLDILLFGDQSIDEADLIVPHPRLIERAFALVPLVEIDSALIIPQHGRAEALLSKVSDQRIEKVKGP
CQCPMLNALTVGEDKTGKGRCE

Sequences:

>Translated_182_residues
MTVAYLGLGANLGDARQTLKDAVVCLAQQHTITVLAKSSLYRTAPIDAGGDDYFNCVVKVDTTLPVRHLLALCHKIEHQF
GRERPFRNAPRTLDLDILLFGDQSIDEADLIVPHPRLIERAFALVPLVEIDSALIIPQHGRAEALLSKVSDQRIEKVKGP
CQCPMLNALTVGEDKTGKGRCE
>Mature_181_residues
TVAYLGLGANLGDARQTLKDAVVCLAQQHTITVLAKSSLYRTAPIDAGGDDYFNCVVKVDTTLPVRHLLALCHKIEHQFG
RERPFRNAPRTLDLDILLFGDQSIDEADLIVPHPRLIERAFALVPLVEIDSALIIPQHGRAEALLSKVSDQRIEKVKGPC
QCPMLNALTVGEDKTGKGRCE

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=139, Percent_Identity=41.0071942446043, Blast_Score=97, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6324073, Length=143, Percent_Identity=37.7622377622378, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19976; Mature: 19845

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVAYLGLGANLGDARQTLKDAVVCLAQQHTITVLAKSSLYRTAPIDAGGDDYFNCVVKV
CEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEECCCCCCCCCEEEEEEEE
DTTLPVRHLLALCHKIEHQFGRERPFRNAPRTLDLDILLFGDQSIDEADLIVPHPRLIER
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCEECCCHHHHHH
AFALVPLVEIDSALIIPQHGRAEALLSKVSDQRIEKVKGPCQCPMLNALTVGEDKTGKGR
HHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCC
CE
CC
>Mature Secondary Structure 
TVAYLGLGANLGDARQTLKDAVVCLAQQHTITVLAKSSLYRTAPIDAGGDDYFNCVVKV
EEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEECCCCCCCCCEEEEEEEE
DTTLPVRHLLALCHKIEHQFGRERPFRNAPRTLDLDILLFGDQSIDEADLIVPHPRLIER
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCEECCCHHHHHH
AFALVPLVEIDSALIIPQHGRAEALLSKVSDQRIEKVKGPCQCPMLNALTVGEDKTGKGR
HHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCC
CE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 2123867 [H]