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The map label for this gene is ntpA [H]

Identifier: 91781803

GI number: 91781803

Start: 465983

End: 466561

Strand: Direct

Name: ntpA [H]

Synonym: Bxe_A4042

Alternate gene names: 91781803

Gene position: 465983-466561 (Clockwise)

Preceding gene: 91781802

Following gene: 91781804

Centisome position: 9.52

GC content: 61.83

Gene sequence:

>579_bases
ATGCAACCGCGTTCGACCGCTTGTCGAACACTCGCCGACATGTACCGCGCACGCGTTGCGCCCAGTTTTTACGCCATGCC
GAAACCGCCGAAGATTCCGCAATCCGTACTCGTCATCATCCATACGCCCGCGCTCGACGTACTGCTGATCGAGCGTGCTG
ATCACGCCGGTTTCTGGCAGTCGGTCACGGGTTCCAAAGATCGACTCGATGAGCCGCTCGTCGAGACGGCGGCGCGTGAA
GTCGCCGAAGAGACCGGCATCGTGGTGGGTGGCGCGCGGGTGCCGCAGAGCGCGTTGTTCGACTGGCAATATTCGATCGA
ATACGAGATCTATCCGGAGTTCCGGCACCGCTACGCCGAAGGCGTGATCCATAACACCGAACACTGGTTCAGCCTGCAGG
TGCCGGAGCAGCTTGAAGTCACGCTGGCGCCGCGCGAGCACACCGCATTCATATGGCTGCCGTATGAAGAGGCGGCATCG
CGCTGCTTTTCGTCGTCGAATGCCGATGCGATCCTGCAGTTGCCGAGGCGGTTGAGTGGGCGTGCCGTGGTTGGGCAATC
CGGGGAGCGTAACCGGTGA

Upstream 100 bases:

>100_bases
CGTAATGGCATAAGCGGAACGAGTGCTGTCTGAAAACGACAGCGGGCAGCAACCGGAAAAGGCGCGTCATGCGCCTTTTT
CGTTTTTTGCGTTACAGTCG

Downstream 100 bases:

>100_bases
GCGTCGGCGGCGCGCGCCGTTTCGCCCGACTGCGGCAATCGCTGCTCGGCCGCCGCTATTGGCAACGCTATCGGTTCACC
AGCGGCAACGACGTCAAGCT

Product: dATP pyrophosphohydrolase

Products: dAMP; pyrophosphate [C]

Alternate protein names: dATP pyrophosphohydrolase [H]

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MQPRSTACRTLADMYRARVAPSFYAMPKPPKIPQSVLVIIHTPALDVLLIERADHAGFWQSVTGSKDRLDEPLVETAARE
VAEETGIVVGGARVPQSALFDWQYSIEYEIYPEFRHRYAEGVIHNTEHWFSLQVPEQLEVTLAPREHTAFIWLPYEEAAS
RCFSSSNADAILQLPRRLSGRAVVGQSGERNR

Sequences:

>Translated_192_residues
MQPRSTACRTLADMYRARVAPSFYAMPKPPKIPQSVLVIIHTPALDVLLIERADHAGFWQSVTGSKDRLDEPLVETAARE
VAEETGIVVGGARVPQSALFDWQYSIEYEIYPEFRHRYAEGVIHNTEHWFSLQVPEQLEVTLAPREHTAFIWLPYEEAAS
RCFSSSNADAILQLPRRLSGRAVVGQSGERNR
>Mature_192_residues
MQPRSTACRTLADMYRARVAPSFYAMPKPPKIPQSVLVIIHTPALDVLLIERADHAGFWQSVTGSKDRLDEPLVETAARE
VAEETGIVVGGARVPQSALFDWQYSIEYEIYPEFRHRYAEGVIHNTEHWFSLQVPEQLEVTLAPREHTAFIWLPYEEAAS
RCFSSSNADAILQLPRRLSGRAVVGQSGERNR

Specific function: Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788172, Length=148, Percent_Identity=41.8918918918919, Blast_Score=95, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003564
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 21705; Mature: 21705

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPRSTACRTLADMYRARVAPSFYAMPKPPKIPQSVLVIIHTPALDVLLIERADHAGFWQ
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEEECCCCCCCHH
SVTGSKDRLDEPLVETAAREVAEETGIVVGGARVPQSALFDWQYSIEYEIYPEFRHRYAE
CCCCCHHHCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHCCEEEEEEEEECHHHHHHHHH
GVIHNTEHWFSLQVPEQLEVTLAPREHTAFIWLPYEEAASRCFSSSNADAILQLPRRLSG
CCEECCCCEEEEECCCCEEEEECCCCCEEEEEEEHHHHHHHHHCCCCCHHHHHHHHHCCC
RAVVGQSGERNR
CEEECCCCCCCC
>Mature Secondary Structure
MQPRSTACRTLADMYRARVAPSFYAMPKPPKIPQSVLVIIHTPALDVLLIERADHAGFWQ
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEEECCCCCCCHH
SVTGSKDRLDEPLVETAAREVAEETGIVVGGARVPQSALFDWQYSIEYEIYPEFRHRYAE
CCCCCHHHCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHCCEEEEEEEEECHHHHHHHHH
GVIHNTEHWFSLQVPEQLEVTLAPREHTAFIWLPYEEAASRCFSSSNADAILQLPRRLSG
CCEECCCCEEEEECCCCEEEEECCCCCEEEEEEEHHHHHHHHHCCCCCHHHHHHHHHCCC
RAVVGQSGERNR
CEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxy-ATP; H2O [C]

Specific reaction: deoxy-ATP + H2O = dAMP + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]