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The map label for this gene is aqpZ [H]

Identifier: 91781777

GI number: 91781777

Start: 434127

End: 434873

Strand: Direct

Name: aqpZ [H]

Synonym: Bxe_A4068

Alternate gene names: 91781777

Gene position: 434127-434873 (Clockwise)

Preceding gene: 91781776

Following gene: 91781778

Centisome position: 8.87

GC content: 62.78

Gene sequence:

>747_bases
ATGGTGGCGTTAGGTAAGCGGTTGTTGGTCGAGAGTGCGGGCACGGCGTGGCTGGTTTTCATCGGTTGCGGGAGCATCGT
GTTGAACGTCGGTGCGATCCAGCAGGCGGGCGGCGTGCTGGAAGCGGCGTTGGCATTCGGCCTCGCTCTCGCTACAGCCA
GCTACTGCGTGGGCAGCCTGTCCGGCGGTCACTTCAATCCCGCCGTCACCGTGGGCTTTACCGTCGCGCAACGTTTTCCG
GTCAGGGATCTGCTCCCCTACATTGCCTCGCAGATTTTCGGCGCGATCGTTGCCGCAGCACTACTTCTTTATGTGGCGGG
CGGCCGTCCCGGCTTTGACCTGCACGCTACCGAGTTCGCGGCGAATGGTTTCGGCGACCATTCTCCGGCTGACTATCAAA
TGCATTCGGCGCTGGCAATCGAGTTCGTGCTGTCCTTCTGCTTTGTCATGGCAACCCTCGTGATCTCCCGCCGGCATGAC
ATGGAGCCGATTGCGCCGCTCGTGGCCGGCGCCTGCCTCGTGCTCGTCTATCTGGTGTCGATTCCGGTTACCAACGGCTC
GGTCAATCCTGCCCGCTCCACCGCCCAGGCGCTGTTCGTCGGCGATTGGGCGCTGGATCAGCTCTGGCTGTTCTGGGCCG
CGCCTCTATCGGGCGGCGTTATTGCCGGCGCTCTGTTTTCGTTTCTGCACGGCAAGCCTGACAACCATACTGCTGCGCTC
GCCGAGGGGCGAGGCGAAGTTGTCTGA

Upstream 100 bases:

>100_bases
TTCGTCGCACTGAGCAATGCCCGAGCCGAGAGAATTCAGGCAGATGTCTTATGGCAATCGTGCAATGCCGTCTGCCCCGT
AGACAGAAACAGGAGGCGGC

Downstream 100 bases:

>100_bases
GTATTGCCGGGTGCCATTGTCGTGTCTTCCGTCAATTTTCCGCCGGACGTTGCAATGAGGCGCGCGCTTGAACGCGTGCG
GCTCTGTCTGCTCGCATGGT

Product: Aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MVALGKRLLVESAGTAWLVFIGCGSIVLNVGAIQQAGGVLEAALAFGLALATASYCVGSLSGGHFNPAVTVGFTVAQRFP
VRDLLPYIASQIFGAIVAAALLLYVAGGRPGFDLHATEFAANGFGDHSPADYQMHSALAIEFVLSFCFVMATLVISRRHD
MEPIAPLVAGACLVLVYLVSIPVTNGSVNPARSTAQALFVGDWALDQLWLFWAAPLSGGVIAGALFSFLHGKPDNHTAAL
AEGRGEVV

Sequences:

>Translated_248_residues
MVALGKRLLVESAGTAWLVFIGCGSIVLNVGAIQQAGGVLEAALAFGLALATASYCVGSLSGGHFNPAVTVGFTVAQRFP
VRDLLPYIASQIFGAIVAAALLLYVAGGRPGFDLHATEFAANGFGDHSPADYQMHSALAIEFVLSFCFVMATLVISRRHD
MEPIAPLVAGACLVLVYLVSIPVTNGSVNPARSTAQALFVGDWALDQLWLFWAAPLSGGVIAGALFSFLHGKPDNHTAAL
AEGRGEVV
>Mature_248_residues
MVALGKRLLVESAGTAWLVFIGCGSIVLNVGAIQQAGGVLEAALAFGLALATASYCVGSLSGGHFNPAVTVGFTVAQRFP
VRDLLPYIASQIFGAIVAAALLLYVAGGRPGFDLHATEFAANGFGDHSPADYQMHSALAIEFVLSFCFVMATLVISRRHD
MEPIAPLVAGACLVLVYLVSIPVTNGSVNPARSTAQALFVGDWALDQLWLFWAAPLSGGVIAGALFSFLHGKPDNHTAAL
AEGRGEVV

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI37694062, Length=234, Percent_Identity=31.1965811965812, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI4755125, Length=189, Percent_Identity=32.2751322751323, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4502181, Length=189, Percent_Identity=32.2751322751323, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI4502179, Length=233, Percent_Identity=32.618025751073, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI6912506, Length=231, Percent_Identity=31.6017316017316, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI45446752, Length=205, Percent_Identity=31.219512195122, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI4502183, Length=230, Percent_Identity=31.304347826087, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI86792455, Length=237, Percent_Identity=31.6455696202532, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI157266307, Length=262, Percent_Identity=29.3893129770992, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1787101, Length=207, Percent_Identity=50.7246376811594, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI1790362, Length=214, Percent_Identity=29.4392523364486, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71993722, Length=240, Percent_Identity=28.3333333333333, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17558372, Length=219, Percent_Identity=27.3972602739726, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24652747, Length=236, Percent_Identity=32.2033898305085, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45551084, Length=236, Percent_Identity=32.2033898305085, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24652751, Length=240, Percent_Identity=34.1666666666667, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922038, Length=240, Percent_Identity=34.1666666666667, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136672, Length=235, Percent_Identity=28.936170212766, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24762346, Length=221, Percent_Identity=31.6742081447964, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24762348, Length=221, Percent_Identity=31.6742081447964, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20130305, Length=221, Percent_Identity=31.6742081447964, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24762344, Length=221, Percent_Identity=31.6742081447964, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550503, Length=229, Percent_Identity=27.0742358078603, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24762342, Length=222, Percent_Identity=27.4774774774775, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 25741; Mature: 25741

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVALGKRLLVESAGTAWLVFIGCGSIVLNVGAIQQAGGVLEAALAFGLALATASYCVGSL
CCCCCHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SGGHFNPAVTVGFTVAQRFPVRDLLPYIASQIFGAIVAAALLLYVAGGRPGFDLHATEFA
CCCCCCCCEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
ANGFGDHSPADYQMHSALAIEFVLSFCFVMATLVISRRHDMEPIAPLVAGACLVLVYLVS
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
IPVTNGSVNPARSTAQALFVGDWALDQLWLFWAAPLSGGVIAGALFSFLHGKPDNHTAAL
HCCCCCCCCCHHHHHHHHEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHH
AEGRGEVV
HCCCCCCC
>Mature Secondary Structure
MVALGKRLLVESAGTAWLVFIGCGSIVLNVGAIQQAGGVLEAALAFGLALATASYCVGSL
CCCCCHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SGGHFNPAVTVGFTVAQRFPVRDLLPYIASQIFGAIVAAALLLYVAGGRPGFDLHATEFA
CCCCCCCCEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
ANGFGDHSPADYQMHSALAIEFVLSFCFVMATLVISRRHDMEPIAPLVAGACLVLVYLVS
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
IPVTNGSVNPARSTAQALFVGDWALDQLWLFWAAPLSGGVIAGALFSFLHGKPDNHTAAL
HCCCCCCCCCHHHHHHHHEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHH
AEGRGEVV
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]