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The map label for this gene is fucA [C]

Identifier: 91781542

GI number: 91781542

Start: 183753

End: 184541

Strand: Reverse

Name: fucA [C]

Synonym: Bxe_A4303

Alternate gene names: 91781542

Gene position: 184541-183753 (Counterclockwise)

Preceding gene: 91781544

Following gene: 91781541

Centisome position: 3.77

GC content: 62.74

Gene sequence:

>789_bases
ATGGCAGACACTCTCACTACTTCAAAAAGCGAACTAGTGGCAACCGCAGAGCGGCAGATGCAGACCGCCTTGCCCGAACT
CGTATGGGCGACTCGCGAGAAGCTCGCACTGACCTGCCGGATTCTGTTCGAGCAGGGCCACGATTCCGGGCTCGCCGGGC
AGATCACCGCCCGCACCGACGAGCCGGACACTTACTACACACAGCGTTTCGGCCTGGGCTTCGACGAGATCACGGCGTCG
AACCTCGTCCACGTGAATCAGGATTTGAAGCTCGTCTCCGGCGAGGGCATGCCGAATCCGGCGAACCGCTTTCACACGTG
GATCTATCGGGCGCGACCGGATGTGAACTGCATCATCCACACGCACCCGCTGCATGTCGCCGCGCTGTCGATGCTGGAAA
CGCCGCTCGTCGTCTCGCACATGGATCTGTGCCCGCTCCATGACGATTGCGCGTTTCTCGAACAATGGCCAGGCGTTCCG
GTCGGCAACGAAGAAGGCGAAATCATCTCGGCGGCGCTCGGCGGGAAGCGCGCGATCCTGCTTTCGCATCATGGCCAACT
GGTCACCGGCAGCACGATCGAAGAGGCCTGCACGCTCGCGCTCCTGATTGAGCGCGCCGCGCAAATGCAATTGCTCGCAA
TGGCGGCCGGCGACGTGAAGCCCATTCCCGCCGAACTCGGCCGGGAAGCACACGACTGGATTTCCACACCCAAACGCAAT
CAGGCGACGTTCGCCTACTTCGCCCGCCGCGCGCTGCGCAGTCCGATGCACCGCGATTGTCTCGCCTGA

Upstream 100 bases:

>100_bases
TTCTAAGATGGAATCCACGTCGTCGCATCGACGCGTGGCTGGAGCCGGATTCGGCGCCTTCGCCACTTCCACCCAGGATC
CTCTTCGATTGGGATTGCAC

Downstream 100 bases:

>100_bases
CGCCTCTTACCTATCGATCCAAGGAGCTGCATCCCTATGAAAAGCACAGAATTTCGCGGCATCATTTCGTACCCCGTAAC
ACCGTTCGATCTGCACGACG

Product: class II aldolase/adducin domain protein

Products: Dihydroxyacetone phosphate; L-Lactaldehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MADTLTTSKSELVATAERQMQTALPELVWATREKLALTCRILFEQGHDSGLAGQITARTDEPDTYYTQRFGLGFDEITAS
NLVHVNQDLKLVSGEGMPNPANRFHTWIYRARPDVNCIIHTHPLHVAALSMLETPLVVSHMDLCPLHDDCAFLEQWPGVP
VGNEEGEIISAALGGKRAILLSHHGQLVTGSTIEEACTLALLIERAAQMQLLAMAAGDVKPIPAELGREAHDWISTPKRN
QATFAYFARRALRSPMHRDCLA

Sequences:

>Translated_262_residues
MADTLTTSKSELVATAERQMQTALPELVWATREKLALTCRILFEQGHDSGLAGQITARTDEPDTYYTQRFGLGFDEITAS
NLVHVNQDLKLVSGEGMPNPANRFHTWIYRARPDVNCIIHTHPLHVAALSMLETPLVVSHMDLCPLHDDCAFLEQWPGVP
VGNEEGEIISAALGGKRAILLSHHGQLVTGSTIEEACTLALLIERAAQMQLLAMAAGDVKPIPAELGREAHDWISTPKRN
QATFAYFARRALRSPMHRDCLA
>Mature_261_residues
ADTLTTSKSELVATAERQMQTALPELVWATREKLALTCRILFEQGHDSGLAGQITARTDEPDTYYTQRFGLGFDEITASN
LVHVNQDLKLVSGEGMPNPANRFHTWIYRARPDVNCIIHTHPLHVAALSMLETPLVVSHMDLCPLHDDCAFLEQWPGVPV
GNEEGEIISAALGGKRAILLSHHGQLVTGSTIEEACTLALLIERAAQMQLLAMAAGDVKPIPAELGREAHDWISTPKRNQ
ATFAYFARRALRSPMHRDCLA

Specific function: Fucose metabolism; third step. [C]

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family [H]

Homologues:

Organism=Homo sapiens, GI29826325, Length=194, Percent_Identity=30.9278350515464, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI29826323, Length=194, Percent_Identity=30.9278350515464, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI29826321, Length=194, Percent_Identity=31.4432989690722, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI29826319, Length=194, Percent_Identity=31.4432989690722, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI9943848, Length=161, Percent_Identity=33.5403726708075, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI9951927, Length=161, Percent_Identity=33.5403726708075, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI62912453, Length=161, Percent_Identity=33.5403726708075, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1789164, Length=199, Percent_Identity=29.6482412060301, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71989560, Length=207, Percent_Identity=34.2995169082126, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71989550, Length=207, Percent_Identity=34.2995169082126, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71989544, Length=207, Percent_Identity=34.2995169082126, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71989541, Length=207, Percent_Identity=34.2995169082126, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71989555, Length=207, Percent_Identity=34.2995169082126, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115533216, Length=202, Percent_Identity=26.7326732673267, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI115533218, Length=202, Percent_Identity=26.7326732673267, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI281363755, Length=192, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI281363751, Length=192, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24655690, Length=192, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24655685, Length=192, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI281363763, Length=191, Percent_Identity=32.9842931937173, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI281363757, Length=191, Percent_Identity=32.9842931937173, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI17136738, Length=191, Percent_Identity=32.9842931937173, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI281363761, Length=192, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281363759, Length=192, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281363753, Length=192, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: 4.1.2.17 [C]

Molecular weight: Translated: 28867; Mature: 28736

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTLTTSKSELVATAERQMQTALPELVWATREKLALTCRILFEQGHDSGLAGQITARTD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEEECCC
EPDTYYTQRFGLGFDEITASNLVHVNQDLKLVSGEGMPNPANRFHTWIYRARPDVNCIIH
CCCHHHHHHHCCCHHHHHHCCEEEECCCEEEEECCCCCCHHHHHHEEEEECCCCCEEEEE
THPLHVAALSMLETPLVVSHMDLCPLHDDCAFLEQWPGVPVGNEEGEIISAALGGKRAIL
ECCHHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEECCCCEEEE
LSHHGQLVTGSTIEEACTLALLIERAAQMQLLAMAAGDVKPIPAELGREAHDWISTPKRN
EECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHCCCCCC
QATFAYFARRALRSPMHRDCLA
CHHHHHHHHHHHHCCHHHHHCC
>Mature Secondary Structure 
ADTLTTSKSELVATAERQMQTALPELVWATREKLALTCRILFEQGHDSGLAGQITARTD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEEECCC
EPDTYYTQRFGLGFDEITASNLVHVNQDLKLVSGEGMPNPANRFHTWIYRARPDVNCIIH
CCCHHHHHHHCCCHHHHHHCCEEEECCCEEEEECCCCCCHHHHHHEEEEECCCCCEEEEE
THPLHVAALSMLETPLVVSHMDLCPLHDDCAFLEQWPGVPVGNEEGEIISAALGGKRAIL
ECCHHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEECCCCEEEE
LSHHGQLVTGSTIEEACTLALLIERAAQMQLLAMAAGDVKPIPAELGREAHDWISTPKRN
EECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHCCCCCC
QATFAYFARRALRSPMHRDCLA
CHHHHHHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+; Co2+; Mg2+; Mn2+; Zn2+ [C]

Kcat value (1/min): 19.3 [C]

Specific activity: 21.0

Km value (mM): 0.7 {L-fuculose} [C]

Substrates: L-Fuculose 1-phosphate [C]

Specific reaction: L-Fuculose 1-phosphate <==> Dihydroxyacetone phosphate + L-Lactaldehyde [C]

General reaction: Elimination of an aldehyde C-C bond; Cleavage [C]

Inhibitor: EDTA; Phosphoglycolohydroxamate [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]