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The map label for this gene is hslU [H]

Identifier: 91781465

GI number: 91781465

Start: 99064

End: 100410

Strand: Reverse

Name: hslU [H]

Synonym: Bxe_A4381

Alternate gene names: 91781465

Gene position: 100410-99064 (Counterclockwise)

Preceding gene: 91781466

Following gene: 91781462

Centisome position: 2.05

GC content: 60.95

Gene sequence:

>1347_bases
ATGAGCACCATGACCCCTGCCGAGATCGTCTCGGAACTCGACAAACACATCATCGGCCAAGGCCGCGCGAAGAAAGCGGT
GGCCGTCGCGTTGCGCAACCGCTGGCGTCGCCAGCAGGTCGAAGAGCCGCTGCGTCAGGAAATCACGCCGAAGAACATTC
TGATGATCGGACCGACCGGCGTCGGCAAGACCGAAATCGCGCGGCGTCTGGCAAAACTCGCGGACGCGCCGTTCATCAAG
ATCGAAGCCACCAAGTTCACCGAAGTCGGCTACGTAGGCCGCGACGTGGACAGCATCGTGCGCGATCTGATCGAAATCTC
GGTCAAGCAGACGCGTGAAACGGAGATGCGCAAGGTGCGAACCAAGGCCGAAGATCAGGCCGAAGACCGCATCCTCGACA
TTCTGCTGCCGAGCGCGCGCCCGGTCGGCTTCGGCGCGAGTTCTGGCGCCGCTGATACCGTGGACGAAGGCAGCACCACG
CGCCAGACCTTCCGCAAGCGTCTGCGCGAAGGCCTGCTCGACGACAAGGAAGTCGAGCTCGACGTGGAACAGCCGCAAGT
CGGCATGGACATCATGGGGCCGCCCGGCATGGAAGACATGACCGAGCAGATCCGTTCGATGTTCGCGAACATCGGCGGCG
GCAAGAAAACACGCCGCAAGATGAAGGTGAAGGAAGCGCTAAAAGCACTCACCGACGAAGAAGCCGCCAGGATGCTGAAC
GACGAAGAGGTGAAAACCAAGGCGGTGCAGAACGTCGAGCAGAACGGCATTGTGTTTCTCGACGAAATCGACAAGATCGC
CTCGCGCAACGAAGCCGGCGGCGGCGAAGTCTCCCGTCAGGGTGTGCAGCGCGATCTGCTGCCGCTGGTCGAAGGCACCA
CGATCAACACCAAGTACGGCATGGTGAAGACCGATCACATTCTGTTCATTGCCAGCGGCGCATTTCACCTCGCCAAGCCG
AGCGATCTGATTCCGGAGCTGCAAGGCCGCTTTCCGATTCGCGTCGAACTGGACTCGCTGTCGGTGAACGATTTCGAATC
GATCCTGGTGTCTACGGATGCGAGCCTCGTCAAGCAATACCAGGCATTGCTCGCCACCGAAGACGTGCATCTCGAATTCG
CCGACGACGGCATTCGGCGCCTCGCCGAAATCGCGTACGCGGTCAACGAGAAAACCGAGAACATCGGCGCGCGCCGCCTG
TACACGGTGATCGAAAAGCTGCTCGAGGAAGTCTCGTTCGCGGCCGGCAACCACTCGGGCCGCACGGTGCAGATCGACGC
GGCCTATGTCGATCGCGCACTGAACGAAGTGGCGGAAGACGAAGATCTGTCGCGTTACGTGCTGTGA

Upstream 100 bases:

>100_bases
GCCCCGCGAAATCGTGGAGAAGTCGCTGGAGATTGCCGGCGACATGTGCATCTACACGAACCACAACCGCGTTATCGAGA
CGATCGAGTAAGGACCCACG

Downstream 100 bases:

>100_bases
TATCGGCGCGGAGAATGCCTCAGGCGGTGATATGTTCATCACCGCTTGTGACAGATCTGATCTGATGTGATCCGCATAAA
AAACGGGCTGCCTTTACCAA

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSTMTPAEIVSELDKHIIGQGRAKKAVAVALRNRWRRQQVEEPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIK
IEATKFTEVGYVGRDVDSIVRDLIEISVKQTRETEMRKVRTKAEDQAEDRILDILLPSARPVGFGASSGAADTVDEGSTT
RQTFRKRLREGLLDDKEVELDVEQPQVGMDIMGPPGMEDMTEQIRSMFANIGGGKKTRRKMKVKEALKALTDEEAARMLN
DEEVKTKAVQNVEQNGIVFLDEIDKIASRNEAGGGEVSRQGVQRDLLPLVEGTTINTKYGMVKTDHILFIASGAFHLAKP
SDLIPELQGRFPIRVELDSLSVNDFESILVSTDASLVKQYQALLATEDVHLEFADDGIRRLAEIAYAVNEKTENIGARRL
YTVIEKLLEEVSFAAGNHSGRTVQIDAAYVDRALNEVAEDEDLSRYVL

Sequences:

>Translated_448_residues
MSTMTPAEIVSELDKHIIGQGRAKKAVAVALRNRWRRQQVEEPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIK
IEATKFTEVGYVGRDVDSIVRDLIEISVKQTRETEMRKVRTKAEDQAEDRILDILLPSARPVGFGASSGAADTVDEGSTT
RQTFRKRLREGLLDDKEVELDVEQPQVGMDIMGPPGMEDMTEQIRSMFANIGGGKKTRRKMKVKEALKALTDEEAARMLN
DEEVKTKAVQNVEQNGIVFLDEIDKIASRNEAGGGEVSRQGVQRDLLPLVEGTTINTKYGMVKTDHILFIASGAFHLAKP
SDLIPELQGRFPIRVELDSLSVNDFESILVSTDASLVKQYQALLATEDVHLEFADDGIRRLAEIAYAVNEKTENIGARRL
YTVIEKLLEEVSFAAGNHSGRTVQIDAAYVDRALNEVAEDEDLSRYVL
>Mature_447_residues
STMTPAEIVSELDKHIIGQGRAKKAVAVALRNRWRRQQVEEPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIKI
EATKFTEVGYVGRDVDSIVRDLIEISVKQTRETEMRKVRTKAEDQAEDRILDILLPSARPVGFGASSGAADTVDEGSTTR
QTFRKRLREGLLDDKEVELDVEQPQVGMDIMGPPGMEDMTEQIRSMFANIGGGKKTRRKMKVKEALKALTDEEAARMLND
EEVKTKAVQNVEQNGIVFLDEIDKIASRNEAGGGEVSRQGVQRDLLPLVEGTTINTKYGMVKTDHILFIASGAFHLAKPS
DLIPELQGRFPIRVELDSLSVNDFESILVSTDASLVKQYQALLATEDVHLEFADDGIRRLAEIAYAVNEKTENIGARRLY
TVIEKLLEEVSFAAGNHSGRTVQIDAAYVDRALNEVAEDEDLSRYVL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=448, Percent_Identity=63.1696428571429, Blast_Score=589, Evalue=1e-169,
Organism=Escherichia coli, GI1786642, Length=108, Percent_Identity=46.2962962962963, Blast_Score=94, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24648291, Length=279, Percent_Identity=30.1075268817204, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24648289, Length=279, Percent_Identity=30.1075268817204, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 49772; Mature: 49641

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTMTPAEIVSELDKHIIGQGRAKKAVAVALRNRWRRQQVEEPLRQEITPKNILMIGPTG
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
VGKTEIARRLAKLADAPFIKIEATKFTEVGYVGRDVDSIVRDLIEISVKQTRETEMRKVR
CCHHHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TKAEDQAEDRILDILLPSARPVGFGASSGAADTVDEGSTTRQTFRKRLREGLLDDKEVEL
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEE
DVEQPQVGMDIMGPPGMEDMTEQIRSMFANIGGGKKTRRKMKVKEALKALTDEEAARMLN
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
DEEVKTKAVQNVEQNGIVFLDEIDKIASRNEAGGGEVSRQGVQRDLLPLVEGTTINTKYG
HHHHHHHHHHHHHCCCEEEEHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCC
MVKTDHILFIASGAFHLAKPSDLIPELQGRFPIRVELDSLSVNDFESILVSTDASLVKQY
CEEECEEEEEECCCCCCCCCHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCHHHHHHH
QALLATEDVHLEFADDGIRRLAEIAYAVNEKTENIGARRLYTVIEKLLEEVSFAAGNHSG
HHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RTVQIDAAYVDRALNEVAEDEDLSRYVL
CEEEEEHHHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure 
STMTPAEIVSELDKHIIGQGRAKKAVAVALRNRWRRQQVEEPLRQEITPKNILMIGPTG
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
VGKTEIARRLAKLADAPFIKIEATKFTEVGYVGRDVDSIVRDLIEISVKQTRETEMRKVR
CCHHHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TKAEDQAEDRILDILLPSARPVGFGASSGAADTVDEGSTTRQTFRKRLREGLLDDKEVEL
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEE
DVEQPQVGMDIMGPPGMEDMTEQIRSMFANIGGGKKTRRKMKVKEALKALTDEEAARMLN
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
DEEVKTKAVQNVEQNGIVFLDEIDKIASRNEAGGGEVSRQGVQRDLLPLVEGTTINTKYG
HHHHHHHHHHHHHCCCEEEEHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCC
MVKTDHILFIASGAFHLAKPSDLIPELQGRFPIRVELDSLSVNDFESILVSTDASLVKQY
CEEECEEEEEECCCCCCCCCHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCHHHHHHH
QALLATEDVHLEFADDGIRRLAEIAYAVNEKTENIGARRLYTVIEKLLEEVSFAAGNHSG
HHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RTVQIDAAYVDRALNEVAEDEDLSRYVL
CEEEEEHHHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA