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The map label for this gene is fimA

Identifier: 91213959

GI number: 91213959

Start: 4907857

End: 4908411

Strand: Direct

Name: fimA

Synonym: UTI89_C5011

Alternate gene names: 91213959

Gene position: 4907857-4908411 (Clockwise)

Preceding gene: 91213958

Following gene: 91213960

Centisome position: 96.88

GC content: 50.45

Gene sequence:

>555_bases
ATGAAAATTAAAACTCTGGCAATTGTTGTTCTGTCGGCTCTGTCCCTGAGTTCTACAGCGGCTCTGGCTGATACTACACC
CACGACGGTAAATGGTGGGACCGTTCACTTTAAAGGGGAAGTTGTTAACGCCGCTTGCGCAGTTGATGCAGGCTCTGTTG
ATCAAACCGTTCAGTTAGGACAGGTTCGTACCGCCACTTTGAAGCAGGCTGGAGCAACCAGCTCTGCTGTCGGTTTTAAC
ATTCAGCTGAATGATTGCGATACCACTGTTGCCACAAAAGCCGCTGTTGCCTTCTTGGGGACGGCGATTGACAGTACTCA
TCCTAAAGTCCTGGCTCTACAGAGTTCAGCTGCGGGTAGCGCAACAAACGTTGGCGTGCAGATTCTGGACAGAACAGGTA
ATGAGCTGACGCTGGACGGTGCGACATTTAGTGCAGAAACAACCCTGAATAACGGTACTAACACCATTCCGTTCCAGGCG
CGTTATTTTGCAACCGGTGCTGCAACCCCAGGTGCTGCTAATGCGGATGCGACCTTCAAGGTTCAGTATCAATAA

Upstream 100 bases:

>100_bases
AAAACTGTGCAGTGTTGGCAGTCAAACTCGTTGACAAAACAAAGTGTACAGAACGACTGCCCATGTCGATTTAGAAATAG
TTTTTTTAAAGGAAAGCAGC

Downstream 100 bases:

>100_bases
CCTACCCAGGTTCAGGGACGTCATTACGGGCAGGGATGCCCACCCTTGTGCGATAAAAATAACGATGAAAAGGAAGAGAT
TATTTCTGTTAGCGTCGTTG

Product: type 1 fimbriae major subunit FimA

Products: NA

Alternate protein names: Type-1A pilin

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MKIKTLAIVVLSALSLSSTAALADTTPTTVNGGTVHFKGEVVNAACAVDAGSVDQTVQLGQVRTATLKQAGATSSAVGFN
IQLNDCDTTVATKAAVAFLGTAIDSTHPKVLALQSSAAGSATNVGVQILDRTGNELTLDGATFSAETTLNNGTNTIPFQA
RYFATGAATPGAANADATFKVQYQ

Sequences:

>Translated_184_residues
MKIKTLAIVVLSALSLSSTAALADTTPTTVNGGTVHFKGEVVNAACAVDAGSVDQTVQLGQVRTATLKQAGATSSAVGFN
IQLNDCDTTVATKAAVAFLGTAIDSTHPKVLALQSSAAGSATNVGVQILDRTGNELTLDGATFSAETTLNNGTNTIPFQA
RYFATGAATPGAANADATFKVQYQ
>Mature_184_residues
MKIKTLAIVVLSALSLSSTAALADTTPTTVNGGTVHFKGEVVNAACAVDAGSVDQTVQLGQVRTATLKQAGATSSAVGFN
IQLNDCDTTVATKAAVAFLGTAIDSTHPKVLALQSSAAGSATNVGVQILDRTGNELTLDGATFSAETTLNNGTNTIPFQA
RYFATGAATPGAANADATFKVQYQ

Specific function: Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs

COG id: NA

COG function: NA

Gene ontology:

Cell location: Fimbrium

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fimbrial protein family

Homologues:

Organism=Escherichia coli, GI1790769, Length=184, Percent_Identity=90.7608695652174, Blast_Score=272, Evalue=9e-75,
Organism=Escherichia coli, GI87081753, Length=157, Percent_Identity=50.9554140127389, Blast_Score=124, Evalue=3e-30,
Organism=Escherichia coli, GI87082421, Length=186, Percent_Identity=35.4838709677419, Blast_Score=97, Evalue=5e-22,
Organism=Escherichia coli, GI87081804, Length=156, Percent_Identity=36.5384615384615, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1789422, Length=161, Percent_Identity=36.6459627329193, Blast_Score=70, Evalue=7e-14,
Organism=Escherichia coli, GI1790773, Length=154, Percent_Identity=35.0649350649351, Blast_Score=67, Evalue=5e-13,
Organism=Escherichia coli, GI1786938, Length=161, Percent_Identity=29.8136645962733, Blast_Score=67, Evalue=6e-13,
Organism=Escherichia coli, GI1786746, Length=151, Percent_Identity=31.7880794701987, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1787174, Length=191, Percent_Identity=32.9842931937173, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FIMA1_ECOLX (Q47223)

Other databases:

- EMBL:   Z37500
- EMBL:   AF286465
- EMBL:   AF490877
- EMBL:   FN643152
- PIR:   S53065
- ProteinModelPortal:   Q47223
- SMR:   Q47223
- GO:   GO:0009289
- InterPro:   IPR008966
- InterPro:   IPR000259
- InterPro:   IPR014779
- Gene3D:   G3DSA:2.60.40.1090

Pfam domain/function: PF00419 Fimbrial; SSF49401 Adhes_bact

EC number: NA

Molecular weight: Translated: 18553; Mature: 18553

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKTLAIVVLSALSLSSTAALADTTPTTVNGGTVHFKGEVVNAACAVDAGSVDQTVQLG
CCCHHHHHHHHHHHCCCCCEEECCCCCCEECCCEEEEECEEEEEEEEECCCCCCCEEECC
QVRTATLKQAGATSSAVGFNIQLNDCDTTVATKAAVAFLGTAIDSTHPKVLALQSSAAGS
CEEEEHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
ATNVGVQILDRTGNELTLDGATFSAETTLNNGTNTIPFQARYFATGAATPGAANADATFK
CCCCEEEEEECCCCEEEECCCEEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCEEEE
VQYQ
EEEC
>Mature Secondary Structure
MKIKTLAIVVLSALSLSSTAALADTTPTTVNGGTVHFKGEVVNAACAVDAGSVDQTVQLG
CCCHHHHHHHHHHHCCCCCEEECCCCCCEECCCEEEEECEEEEEEEEECCCCCCCEEECC
QVRTATLKQAGATSSAVGFNIQLNDCDTTVATKAAVAFLGTAIDSTHPKVLALQSSAAGS
CEEEEHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
ATNVGVQILDRTGNELTLDGATFSAETTLNNGTNTIPFQARYFATGAATPGAANADATFK
CCCCEEEEEECCCCEEEECCCEEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCEEEE
VQYQ
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8636962; 11251843; 12657207