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The map label for this gene is cycA [H]

Identifier: 91213766

GI number: 91213766

Start: 4711410

End: 4712822

Strand: Direct

Name: cycA [H]

Synonym: UTI89_C4817

Alternate gene names: 91213766

Gene position: 4711410-4712822 (Clockwise)

Preceding gene: 162138300

Following gene: 91213770

Centisome position: 93.01

GC content: 51.8

Gene sequence:

>1413_bases
ATGGTAGATCAGGTAAAAGTCGTTGCCGATGATCAGGCTCCGGCTGAACAGTCGCTACGGCGCAATCTCACAAACCGACA
TATTCAGCTTATTGCCATTGGCGGTGCCATTGGTACAGGGCTGTTTATGGGGTCCGGCAAAACGATTAGCCTTGCCGGGC
CGTCGATCATTTTCGTTTATATGATCATCGGTTTTATGCTCTTTTTCGTGATGCGGGCAATGGGGGAATTGCTGCTTTCG
AATCTGGAATACAAATCTTTTAGTGACTTCGCTTCCGATTTACTCGGGCCGTGGGCAGGATATTTCACCGGCTGGACTTA
CTGGTTCTGCTGGGTTGTAACCGGTATGGCAGACGTGGTTGCCATTACCGCCTATGCGCAATTCTGGTTCCCTGGGCTTT
CTGACTGGGTTGCTTCGTTATCCGTGATCATTCTGTTACTGGTTCTAAACCTCGCCACGGTAAAAATGTTCGGTGAGATG
GAGTTCTGGTTTGCGATGATCAAAATCGTCGCCATCGTGTCGCTGATTGTTGTCGGCCTGGTCATGGTGGCGATGCACTT
TCAGTCACCGACCGGTGTGGAAGCATCATTTGCACATTTGTGGAATGACGGCGGCTGGTTCCCGAAAGGCTTAAGCGGCT
TCTTTGCCGGATTCCAGATAGCGGTTTTTGCTTTCGTGGGGATTGAGCTGGTAGGTACAACAGCTGCGGAAACCAAAGAT
CCGGAGAAATCACTGCCACGCGCGATTAACTCCATTCCGATCCGTATCATTATGTTCTACGTCTTCTCGCTGATTGTGAT
TATGTCCGTGACGCCGTGGAGTTCGGTAGTCCCGGAGAAAAGCCCGTTCGTTGAACTGTTTGTGTTGGTAGGTTTGCCTG
CGGCTGCCAGCGTGATCAACTTTGTGGTGCTGACCTCTGCGGCGTCTTCCGCTAACAGCGGTGTCTTCTCTACCAGCCGT
ATGCTGTTTGGCCTGGCCCAGGAAGGTGTGGCACCGAAAGCGTTCGCTAAACTCTCTAAGCGCGCAGTACCCGCGAAAGG
GCTGACCTTCTCTTGTATCTGTCTGCTCGGCGGCGTGGTGATGTTGTATGTGAATCCCAGCGTGATTGGCGCGTTCACGA
TGATTACAACCGTTTCCGCGATTCTGTTTATGTTTGTCTGGACGATTATCCTTTGCTCGTACCTGGTGTATCGCAAACAG
CGTCCTCATCTGCATGAGAAGTCGATCTACAAGATGCCACTCGGCAAGCTGATGTGCTGGGTATGTATGGCGTTCTTTGT
GTTTGTTCTGGTGTTGTTGACACTGGAAGATGACACCCGCCAGGCGCTGCTGGTTACCCCGCTGTGGTTTATCGCGCTGG
GGCTGGGCTGGCTGTTTATTGGTAAGAAGCGGGCTGCTGAACTGCGGAAATAA

Upstream 100 bases:

>100_bases
TACCTAATATCGATGAGTCCCGATACAGATTCGTCGTATCATAGACTGACTAAAGGCCGTAGAGCCTGAACAACACAGAC
AGGTACAGGAAGAAAAAAAC

Downstream 100 bases:

>100_bases
CCGCATTATCATGCTGGATGGCGCAATGCCATCCAGCTTTTAGATCACTCACCCGCCAGCGCGCGCGGGAATAGTACATT
GTTTTCCAGACTGATGTGCT

Product: D-alanine/D-serine/glycine permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MVDQVKVVADDQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPGLSDWVASLSVIILLLVLNLATVKMFGEM
EFWFAMIKIVAIVSLIVVGLVMVAMHFQSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPIRIIMFYVFSLIVIMSVTPWSSVVPEKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQ
RPHLHEKSIYKMPLGKLMCWVCMAFFVFVLVLLTLEDDTRQALLVTPLWFIALGLGWLFIGKKRAAELRK

Sequences:

>Translated_470_residues
MVDQVKVVADDQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPGLSDWVASLSVIILLLVLNLATVKMFGEM
EFWFAMIKIVAIVSLIVVGLVMVAMHFQSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPIRIIMFYVFSLIVIMSVTPWSSVVPEKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQ
RPHLHEKSIYKMPLGKLMCWVCMAFFVFVLVLLTLEDDTRQALLVTPLWFIALGLGWLFIGKKRAAELRK
>Mature_470_residues
MVDQVKVVADDQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPGLSDWVASLSVIILLLVLNLATVKMFGEM
EFWFAMIKIVAIVSLIVVGLVMVAMHFQSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPIRIIMFYVFSLIVIMSVTPWSSVVPEKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQ
RPHLHEKSIYKMPLGKLMCWVCMAFFVFVLVLLTLEDDTRQALLVTPLWFIALGLGWLFIGKKRAAELRK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=367, Percent_Identity=22.0708446866485, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI181337167, Length=340, Percent_Identity=21.7647058823529, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI258645169, Length=363, Percent_Identity=22.038567493113, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI115648063, Length=369, Percent_Identity=25.2032520325203, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI115648022, Length=369, Percent_Identity=25.2032520325203, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI114326544, Length=363, Percent_Identity=21.763085399449, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI114326550, Length=363, Percent_Identity=21.763085399449, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1790653, Length=470, Percent_Identity=98.7234042553192, Blast_Score=935, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=461, Percent_Identity=40.5639913232104, Blast_Score=350, Evalue=9e-98,
Organism=Escherichia coli, GI1786602, Length=454, Percent_Identity=41.4096916299559, Blast_Score=338, Evalue=5e-94,
Organism=Escherichia coli, GI1786789, Length=453, Percent_Identity=38.1898454746137, Blast_Score=335, Evalue=4e-93,
Organism=Escherichia coli, GI48994972, Length=462, Percent_Identity=38.5281385281385, Blast_Score=322, Evalue=3e-89,
Organism=Escherichia coli, GI87081915, Length=459, Percent_Identity=37.4727668845316, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI87081708, Length=465, Percent_Identity=32.9032258064516, Blast_Score=241, Evalue=7e-65,
Organism=Escherichia coli, GI1788480, Length=458, Percent_Identity=33.1877729257642, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1789017, Length=447, Percent_Identity=30.6487695749441, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI2367353, Length=399, Percent_Identity=24.3107769423559, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87082023, Length=351, Percent_Identity=21.0826210826211, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=362, Percent_Identity=25.1381215469613, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17531343, Length=449, Percent_Identity=22.271714922049, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=461, Percent_Identity=32.5379609544469, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6324924, Length=426, Percent_Identity=31.2206572769953, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6320772, Length=447, Percent_Identity=29.7539149888143, Blast_Score=184, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6324990, Length=416, Percent_Identity=30.7692307692308, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322892, Length=421, Percent_Identity=29.9287410926366, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324059, Length=459, Percent_Identity=28.9760348583878, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324553, Length=399, Percent_Identity=28.5714285714286, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6321629, Length=430, Percent_Identity=27.906976744186, Blast_Score=151, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6320717, Length=414, Percent_Identity=26.0869565217391, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6319543, Length=443, Percent_Identity=27.5395033860045, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320251, Length=402, Percent_Identity=26.6169154228856, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6321053, Length=410, Percent_Identity=26.8292682926829, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319824, Length=408, Percent_Identity=25.4901960784314, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6319542, Length=400, Percent_Identity=25.25, Blast_Score=143, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6319608, Length=417, Percent_Identity=26.1390887290168, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322967, Length=422, Percent_Identity=28.6729857819905, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324981, Length=419, Percent_Identity=27.9236276849642, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320364, Length=488, Percent_Identity=24.3852459016393, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24666159, Length=359, Percent_Identity=21.1699164345404, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221512776, Length=359, Percent_Identity=21.1699164345404, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51660; Mature: 51660

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDQVKVVADDQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVY
CCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHH
MIIGFMLFFVMRAMGELLLSNLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITAYAQFWFPGLSDWVASLSVIILLLVLNLATVKMFGEMEFWFAMIKIVAIVSLIVVGL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMVAMHFQSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
HHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PEKSLPRAINSIPIRIIMFYVFSLIVIMSVTPWSSVVPEKSPFVELFVLVGLPAAASVIN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHCCCHHHHHHH
FVVLTSAASSANSGVFSTSRMLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVV
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQRPHLHEKSIYKMPLGKLMCW
HHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHH
VCMAFFVFVLVLLTLEDDTRQALLVTPLWFIALGLGWLFIGKKRAAELRK
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure
MVDQVKVVADDQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVY
CCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHH
MIIGFMLFFVMRAMGELLLSNLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITAYAQFWFPGLSDWVASLSVIILLLVLNLATVKMFGEMEFWFAMIKIVAIVSLIVVGL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMVAMHFQSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
HHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PEKSLPRAINSIPIRIIMFYVFSLIVIMSVTPWSSVVPEKSPFVELFVLVGLPAAASVIN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHCCCHHHHHHH
FVVLTSAASSANSGVFSTSRMLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVV
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQRPHLHEKSIYKMPLGKLMCW
HHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHH
VCMAFFVFVLVLLTLEDDTRQALLVTPLWFIALGLGWLFIGKKRAAELRK
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]