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The map label for this gene is ldh [H]

Identifier: 91213590

GI number: 91213590

Start: 4533539

End: 4534750

Strand: Direct

Name: ldh [H]

Synonym: UTI89_C4637

Alternate gene names: 91213590

Gene position: 4533539-4534750 (Clockwise)

Preceding gene: 91213589

Following gene: 91213593

Centisome position: 89.49

GC content: 52.15

Gene sequence:

>1212_bases
GTGTATGGGTACGGATACCTTCACGCCACGCCAGTTTACCCGTGTGGGACTGTACCTGACGGTAATCGGCTACCTGTTGT
TGCTACTGTTTGCCGCCACCTGGTGGAAAATTTTAGGTCTAATGTGAGGAAACCAACGATGTCATTACAAATTGCTGTTG
AAAAAGTGCGTTGGTTAGCTGCCGGGCTGCTGGAACTTAATGGCTGTGATGCCGATATCGCTCAGGATGTGGCGGAACAT
ATGATTGAAGCGGAACGTTATGGCTTTGCCAGCCACGGCGTCACGCTGCTACCGAAATATCTGGAAAATATCGCTCGTGG
CGATGTAACCGCGAATGCCCGCCCGGAATGCTTAACAAGTGAAGGTAATTTACAACGTTTTCATGCCCACAATGGCTTTG
GTCAACACGCCGGAAAAGTGGCGGTAAATGCTGCCATCGAACAAGCAAAACACCGCGGTTTTTGCCTGTTAACGTTGTGC
CATGCGCATCATTTAGGGCGTATGGGGCATTACGGGCAAATGGTTGCTGATCAAGGCCTGGCGATGCTGGCCATGAGTAA
CGTCACCGGGCGTCCGGCACTGGTCGCCCCGTGGGGCGGTGCGGAACCGCGTATGACCACTAACCCTTTCTGCTTTGCCT
GGCCGTTCAGTGATGGGCGTCCGCCGATTCTGGTTGATTTTGCCACCAGTAGCATGGCGCTAAATAAAGCACGGGTAATG
TCGTCCACCGGGAAGCAGGCCGCGCCGGGACAATTGATCGATGCACAGGGGAATCCAAGCAATGATCCTGGGGTGTTATT
CAGCAATCCTCCAGGGGCGTTACTGCCATTTGGTGAGCATAAAGGATTTGGCCTGGCACTGATGATTGAAATGATGGCGG
GGATCTTATCTGGTGGTGACACGATCGCCGAAGATCATCAGACGGATGGATCTGCGCATAATCATCTTTTTGCGTTGATT
ATCGATCCTGATCAATTCACCGATCTGGCAGGGGAGAAAGGGCAGTTCTTTGCGGATTATCTGTTAGCTACGCAGCCTCA
ACCTGGCGGCAATCCGGTGATTTACCCCGGTATGCCAGAAGCTGCCAACCGGGAACGCAATGCGAAGATGATTACGATCC
CGGTATCATTCTGGTCCTGGATAGTTGAACATTACGCCCGCAAAGGTATCGATTTGGGGTTACATCCTCAGGAATCAGCA
TTAGCTGGATGA

Upstream 100 bases:

>100_bases
CGCCAGAACTCGGCGTTAACCCGGTCGGCATGACCATTCTGCTCGCCTTCAGTGTCAGTTTTGGCTTCATCCTGCCGATT
AACGCGCCACAAAATATGGT

Downstream 100 bases:

>100_bases
TTCTGGTCGATAAACTTGCGGTTGAATCTGATGTTTGTTGAGTTTGTCATATAAAGTCTTGCGCGGCAGCTGTAATAGCC
GCGCTGTCAAACTGACTTGG

Product: putative lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MYGYGYLHATPVYPCGTVPDGNRLPVVATVCRHLVENFRSNVRKPTMSLQIAVEKVRWLAAGLLELNGCDADIAQDVAEH
MIEAERYGFASHGVTLLPKYLENIARGDVTANARPECLTSEGNLQRFHAHNGFGQHAGKVAVNAAIEQAKHRGFCLLTLC
HAHHLGRMGHYGQMVADQGLAMLAMSNVTGRPALVAPWGGAEPRMTTNPFCFAWPFSDGRPPILVDFATSSMALNKARVM
SSTGKQAAPGQLIDAQGNPSNDPGVLFSNPPGALLPFGEHKGFGLALMIEMMAGILSGGDTIAEDHQTDGSAHNHLFALI
IDPDQFTDLAGEKGQFFADYLLATQPQPGGNPVIYPGMPEAANRERNAKMITIPVSFWSWIVEHYARKGIDLGLHPQESA
LAG

Sequences:

>Translated_403_residues
MYGYGYLHATPVYPCGTVPDGNRLPVVATVCRHLVENFRSNVRKPTMSLQIAVEKVRWLAAGLLELNGCDADIAQDVAEH
MIEAERYGFASHGVTLLPKYLENIARGDVTANARPECLTSEGNLQRFHAHNGFGQHAGKVAVNAAIEQAKHRGFCLLTLC
HAHHLGRMGHYGQMVADQGLAMLAMSNVTGRPALVAPWGGAEPRMTTNPFCFAWPFSDGRPPILVDFATSSMALNKARVM
SSTGKQAAPGQLIDAQGNPSNDPGVLFSNPPGALLPFGEHKGFGLALMIEMMAGILSGGDTIAEDHQTDGSAHNHLFALI
IDPDQFTDLAGEKGQFFADYLLATQPQPGGNPVIYPGMPEAANRERNAKMITIPVSFWSWIVEHYARKGIDLGLHPQESA
LAG
>Mature_403_residues
MYGYGYLHATPVYPCGTVPDGNRLPVVATVCRHLVENFRSNVRKPTMSLQIAVEKVRWLAAGLLELNGCDADIAQDVAEH
MIEAERYGFASHGVTLLPKYLENIARGDVTANARPECLTSEGNLQRFHAHNGFGQHAGKVAVNAAIEQAKHRGFCLLTLC
HAHHLGRMGHYGQMVADQGLAMLAMSNVTGRPALVAPWGGAEPRMTTNPFCFAWPFSDGRPPILVDFATSSMALNKARVM
SSTGKQAAPGQLIDAQGNPSNDPGVLFSNPPGALLPFGEHKGFGLALMIEMMAGILSGGDTIAEDHQTDGSAHNHLFALI
IDPDQFTDLAGEKGQFFADYLLATQPQPGGNPVIYPGMPEAANRERNAKMITIPVSFWSWIVEHYARKGIDLGLHPQESA
LAG

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=327, Percent_Identity=33.9449541284404, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1790000, Length=340, Percent_Identity=28.2352941176471, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1786727, Length=348, Percent_Identity=27.2988505747126, Blast_Score=105, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17507179, Length=325, Percent_Identity=27.3846153846154, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17536633, Length=319, Percent_Identity=22.884012539185, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24667904, Length=298, Percent_Identity=26.510067114094, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24667908, Length=298, Percent_Identity=26.510067114094, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI45553211, Length=298, Percent_Identity=26.510067114094, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24667912, Length=298, Percent_Identity=26.510067114094, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24658010, Length=367, Percent_Identity=22.0708446866485, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 43424; Mature: 43424

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGYGYLHATPVYPCGTVPDGNRLPVVATVCRHLVENFRSNVRKPTMSLQIAVEKVRWLA
CCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AGLLELNGCDADIAQDVAEHMIEAERYGFASHGVTLLPKYLENIARGDVTANARPECLTS
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHCCCCCCCCCCCEECC
EGNLQRFHAHNGFGQHAGKVAVNAAIEQAKHRGFCLLTLCHAHHLGRMGHYGQMVADQGL
CCCEEEEECCCCCCHHCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHCCCCHHHHHHHCCE
AMLAMSNVTGRPALVAPWGGAEPRMTTNPFCFAWPFSDGRPPILVDFATSSMALNKARVM
EEEEECCCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHH
SSTGKQAAPGQLIDAQGNPSNDPGVLFSNPPGALLPFGEHKGFGLALMIEMMAGILSGGD
HCCCCCCCCCCEEECCCCCCCCCCEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCC
TIAEDHQTDGSAHNHLFALIIDPDQFTDLAGEKGQFFADYLLATQPQPGGNPVIYPGMPE
CHHCCCCCCCCCCCEEEEEEECCHHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEECCCCC
AANRERNAKMITIPVSFWSWIVEHYARKGIDLGLHPQESALAG
CCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCHHHCCC
>Mature Secondary Structure
MYGYGYLHATPVYPCGTVPDGNRLPVVATVCRHLVENFRSNVRKPTMSLQIAVEKVRWLA
CCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AGLLELNGCDADIAQDVAEHMIEAERYGFASHGVTLLPKYLENIARGDVTANARPECLTS
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHCCCCCCCCCCCEECC
EGNLQRFHAHNGFGQHAGKVAVNAAIEQAKHRGFCLLTLCHAHHLGRMGHYGQMVADQGL
CCCEEEEECCCCCCHHCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHCCCCHHHHHHHCCE
AMLAMSNVTGRPALVAPWGGAEPRMTTNPFCFAWPFSDGRPPILVDFATSSMALNKARVM
EEEEECCCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHH
SSTGKQAAPGQLIDAQGNPSNDPGVLFSNPPGALLPFGEHKGFGLALMIEMMAGILSGGD
HCCCCCCCCCCEEECCCCCCCCCCEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCC
TIAEDHQTDGSAHNHLFALIIDPDQFTDLAGEKGQFFADYLLATQPQPGGNPVIYPGMPE
CHHCCCCCCCCCCCEEEEEEECCHHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEECCCCC
AANRERNAKMITIPVSFWSWIVEHYARKGIDLGLHPQESALAG
CCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8405966 [H]