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The map label for this gene is nadR [C]

Identifier: 91213581

GI number: 91213581

Start: 4522038

End: 4523060

Strand: Direct

Name: nadR [C]

Synonym: UTI89_C4628

Alternate gene names: 91213581

Gene position: 4522038-4523060 (Clockwise)

Preceding gene: 91213580

Following gene: 162138312

Centisome position: 89.27

GC content: 51.22

Gene sequence:

>1023_bases
ATGGCGCAAAGAGTTGCAAACATCATGAAGCCTTTTGCAACGGGCCTGGTGGTTGGTAAATTCGCGCCTTTGCATTGTGG
TCATGAAAAGTTGATCAATACCGCACTGGCGCAATGTGAAGAACTGTTCATCATCAGTTATTCCGTGCCGGAAATGCCTG
ACTGTGAACCTGAAAAGCGCCTGACGTGGCTGCAAGTGCGCTTCCCGCAAGCGACGATTTTGGTACTGACGCCAGAGCTT
GTTGCGCGTTATAACTTACCTGCCATACCGCATAACGATGCCGACATCCACCGTCATTATGTGGCGACGCTGTGCCTGCA
GATATTACGCTGTCGTCCACATGCTGTATTTACTGCAGAAGACTATGGCGATGGCTTTGCTAACGTGCTGGCGCGGCGTT
TTGCCCAACCCGTTGAACACGTTCGAATGGCGCGCCCAGTTGGCGATGAAGCGCCTTCGGGAACGCTTATTCGTTCCGAT
GTTCACCGCTATCGCTACATGTTGGCGAATGATGTTTATTACAGTTTCGTTCGCCGTATCTGTCTGCTTGGTGGCGAATC
TACCGGTAAAAGCACGCTTTCAAAAGCGCTGGCGGATGGGCTTGATACGGTGTATGTCGCTGAATTTGGCCGCGACTATT
GGGAAGAAAAAAACGGAATCTTAACCGCGGATGATTTGTTGCATATCGCCTGCGAACAGGTACGCCGGGAACAACAAGCA
GAAGCTAATCACTATCTTATATGTGACACGTCGCCACTCACGACCTTGTTCTATGCCCTTGATCAATATGGTCATGCTCC
GCAAGAACTTCATCAACTGGCGGAGCGGGAATACTCTCTGGTGGTGCTTTGCGGCGCAGAATTTCCCTTCGTGCAGGATG
GCACCCGGCAAGGAGAGGTATTTCGCGCACGGCAACAGGTGTGGTATGAACAGGAATTATCGCGCAGGAATATTCCTTAT
CTTTCTGTTTCGGGTTCGCTGCAAGAGCGACTGGGGCAAATTCTACATCGCCTTCCCGACTGA

Upstream 100 bases:

>100_bases
TGAATACCCTGGCAGTGCCACTGTATATGACGCGCGGTTTAAACCTGACCGCTGGCTTATATTTCCTGTTCTGGATTAAC
GCCTGGCATGGTTTGTATCA

Downstream 100 bases:

>100_bases
CTTTGAACATCCACTCGATCTTCGTCTACTTCCGGTTTATTGTGTTTTAACCACCTGCCCGTAAACCTGGAGAACCATCG
CGTGTTTCAAAAAGTTGACG

Product: NadR transcriptional repressor / NMN adenylyltransferase

Products: NAD; pyrophosphate [C]

Alternate protein names: Nicotinamide-Nucleotide Adenylyltransferase; NADR-Like Protein; Transcriptional Regulatory Protein NADR; ATPase/Kinase Involved In NAD Metabolism-Like Protein; NAD Metabolism ATPase/Kinase; Transcriptional Regulatory Protein; Cytidylyltransferase; ATPase/Kinase Involved In NAD Metabolism; NADR-Like Transcriptional Regulator; Cytidyltransferase-Related; Transcriptional Regulator; Transcriptional Regulator NADR; Transcription Regulator NADR; Cytidyltransferase-Related Domain-Containing Protein; ATPase/Kinase NadR; NADR Family Transcriptional Regulator; Nicotinamide-Nucleotide Adenylyltransferase NADR; NAD Metabolism Atpase/Kinase-Like Protein; Cytidyltransferase-Like Protein

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MAQRVANIMKPFATGLVVGKFAPLHCGHEKLINTALAQCEELFIISYSVPEMPDCEPEKRLTWLQVRFPQATILVLTPEL
VARYNLPAIPHNDADIHRHYVATLCLQILRCRPHAVFTAEDYGDGFANVLARRFAQPVEHVRMARPVGDEAPSGTLIRSD
VHRYRYMLANDVYYSFVRRICLLGGESTGKSTLSKALADGLDTVYVAEFGRDYWEEKNGILTADDLLHIACEQVRREQQA
EANHYLICDTSPLTTLFYALDQYGHAPQELHQLAEREYSLVVLCGAEFPFVQDGTRQGEVFRARQQVWYEQELSRRNIPY
LSVSGSLQERLGQILHRLPD

Sequences:

>Translated_340_residues
MAQRVANIMKPFATGLVVGKFAPLHCGHEKLINTALAQCEELFIISYSVPEMPDCEPEKRLTWLQVRFPQATILVLTPEL
VARYNLPAIPHNDADIHRHYVATLCLQILRCRPHAVFTAEDYGDGFANVLARRFAQPVEHVRMARPVGDEAPSGTLIRSD
VHRYRYMLANDVYYSFVRRICLLGGESTGKSTLSKALADGLDTVYVAEFGRDYWEEKNGILTADDLLHIACEQVRREQQA
EANHYLICDTSPLTTLFYALDQYGHAPQELHQLAEREYSLVVLCGAEFPFVQDGTRQGEVFRARQQVWYEQELSRRNIPY
LSVSGSLQERLGQILHRLPD
>Mature_339_residues
AQRVANIMKPFATGLVVGKFAPLHCGHEKLINTALAQCEELFIISYSVPEMPDCEPEKRLTWLQVRFPQATILVLTPELV
ARYNLPAIPHNDADIHRHYVATLCLQILRCRPHAVFTAEDYGDGFANVLARRFAQPVEHVRMARPVGDEAPSGTLIRSDV
HRYRYMLANDVYYSFVRRICLLGGESTGKSTLSKALADGLDTVYVAEFGRDYWEEKNGILTADDLLHIACEQVRREQQAE
ANHYLICDTSPLTTLFYALDQYGHAPQELHQLAEREYSLVVLCGAEFPFVQDGTRQGEVFRARQQVWYEQELSRRNIPYL
SVSGSLQERLGQILHRLPD

Specific function: NADr Is Bifunctional; It Interacts With Pnuc At Low Internal NAD Levels, Permitting Transport Of Nmn Intact Into The Cell. As NAD Levels Increase Within The Cell, The Affinity Of NADr For The Operator Regions Of NADa, NADb, And Pncb Increases, Repressing

COG id: COG3172

COG function: function code H; Predicted ATPase/kinase involved in NAD metabolism

Gene ontology:

Cell location: May Loosely Associate With The Membrane Through Its Interaction With The Membrane-Bound Pnuc [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87082440, Length=340, Percent_Identity=28.5294117647059, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 38690; Mature: 38558

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQRVANIMKPFATGLVVGKFAPLHCGHEKLINTALAQCEELFIISYSVPEMPDCEPEKR
CHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHC
LTWLQVRFPQATILVLTPELVARYNLPAIPHNDADIHRHYVATLCLQILRCRPHAVFTAE
CEEEEEECCCEEEEEECHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEC
DYGDGFANVLARRFAQPVEHVRMARPVGDEAPSGTLIRSDVHRYRYMLANDVYYSFVRRI
HHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
CLLGGESTGKSTLSKALADGLDTVYVAEFGRDYWEEKNGILTADDLLHIACEQVRREQQA
HHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHH
EANHYLICDTSPLTTLFYALDQYGHAPQELHQLAEREYSLVVLCGAEFPFVQDGTRQGEV
CCCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHH
FRARQQVWYEQELSRRNIPYLSVSGSLQERLGQILHRLPD
HHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AQRVANIMKPFATGLVVGKFAPLHCGHEKLINTALAQCEELFIISYSVPEMPDCEPEKR
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHC
LTWLQVRFPQATILVLTPELVARYNLPAIPHNDADIHRHYVATLCLQILRCRPHAVFTAE
CEEEEEECCCEEEEEECHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEC
DYGDGFANVLARRFAQPVEHVRMARPVGDEAPSGTLIRSDVHRYRYMLANDVYYSFVRRI
HHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
CLLGGESTGKSTLSKALADGLDTVYVAEFGRDYWEEKNGILTADDLLHIACEQVRREQQA
HHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHH
EANHYLICDTSPLTTLFYALDQYGHAPQELHQLAEREYSLVVLCGAEFPFVQDGTRQGEV
CCCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHH
FRARQQVWYEQELSRRNIPYLSVSGSLQERLGQILHRLPD
HHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: nicotinamide nucleotide; ATP [C]

Specific reaction: nicotinamide nucleotide + ATP = NAD + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA