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The map label for this gene is pgi [H]

Identifier: 91213546

GI number: 91213546

Start: 4486298

End: 4487953

Strand: Direct

Name: pgi [H]

Synonym: UTI89_C4593

Alternate gene names: 91213546

Gene position: 4486298-4487953 (Clockwise)

Preceding gene: 91213543

Following gene: 91213548

Centisome position: 88.56

GC content: 51.39

Gene sequence:

>1656_bases
TTGCTAATGAAAAACATCAATCCAACGCAGACCGCTGCCTGGCAGGCACTACAGAAACACTTCGATGAAATGAAAGACGT
TACGATCGCCGATCTTTTTGCTAAAGACGGCGATCGTTTTTCTAAGTTCTCCGCAACCTTCGACGATCAGATGCTGGTGG
ATTACTCCAAAAACCGCATCACTGAAGAGACGCTGGCGAAATTACAAGATCTGGCGAAAGAGTGCGATCTGGCGGGCGCG
ATTAAGTCGATGTTCTCTGGCGAGAAGATCAACCGCACTGAAAACCGCGCCGTACTGCACGTAGCGCTGCGTAACCGTAG
CAATACCCCGATTCTGGTTGATGGCAAAGATGTTATGCCGGAAGTCAACGCAGTGCTGGAGAAGATGAAAACCTTCTCGG
AAGCGATTATTTCCGGTGAGTGGAAAGGCTATACCGGCAAGGCAATCACTGACGTAGTGAACATCGGGATCGGCGGTTCT
GACCTCGGCCCGTACATGGTGACTGAAGCACTGCGTCCATACAAAAACCACCTGAACATGCACTTTGTTTCTAACGTCGA
TGGGACTCACATCGCGGAAGTGCTGAAAAAAGTAAACCCGGAAACCACGCTGTTCCTGGTAGCATCTAAAACCTTCACCA
CTCAGGAAACCATGACCAACGCCCATAGCGCGCGTGACTGGTTCCTGAAAGCGGCAGGTGATGAGAAACACGTTGCGAAA
CACTTCGCTGCGCTCTCAACCAACGCCAAAGCCGTTGGCGAGTTTGGTATTGATACTGCCAACATGTTCGAATTCTGGGA
CTGGGTCGGCGGTCGTTACTCTTTGTGGTCAGCGATTGGCCTGTCGATTGTTCTCTCCATCGGCTTTGATAACTTCGTTG
AACTGCTTTCTGGCGCACACGCGATGGACAAGCATTTCTCCACCACGCCTGCCGAGAAAAACCTGCCTGTACTGCTGGCG
CTGATTGGCATCTGGTACAACAATTTCTTTGGCGCGGAAACTGAAGCGATTCTGCCGTATGACCAGTATATGCACCGTTT
CGCGGCGTACTTCCAGCAGGGCAATATGGAATCCAACGGTAAGTATGTTGACCGTAACGGTAAGGTTGTGGATTACCAGA
CTGGCCCGATTATCTGGGGTGAACCTGGCACGAACGGTCAGCACGCGTTCTATCAGCTGATCCACCAGGGAACCAAAATG
GTACCGTGCGATTTCATCGCTCCGGCTATCACCCATAACCCGCTCTCTGATCATCACCAGAAACTGCTGTCTAACTTCTT
TGCTCAGACCGAAGCGCTGGCGTTTGGTAAATCCCGCGAAGTGGTTGAGCAGGAATATCGCGATCAGGGTAAAGATCCGG
CAACGCTTGACTACGTGGTGCCGTTCAAAGTGTTCGAAGGTAACCGCCCGACCAACTCCATCCTGCTGCGTGAAATCACT
CCGTTCAGCCTGGGTGCGTTGATTGCGCTGTATGAGCACAAAATCTTTACTCAGGGCGTGATCCTGAACATCTTCACCTT
CGACCAGTGGGGCGTGGAGCTGGGTAAACAACTGGCGAACCGTATTCTGCCAGAGCTGAAAGATGATAAAGAAATCAGCA
GCCACGATAGCTCGACCAATGGTCTGATTAACCGCTATAAAGCGTGGCGCGGTTAA

Upstream 100 bases:

>100_bases
TTTACACTCAACATTACGCTAACGGCACTAAAACCATCACATTTTTCTGTGACTGGCGCTACAATCTTCCAAAGTCACAA
TTCTCAAAATCAGAAGAGTA

Downstream 100 bases:

>100_bases
TCATTGTCGATATGTAGGCCGGATAAGGCGTTCACGCCGCATCCGGCAACCGATGCCTGATGCGACGCGGTCGCGTCTTA
TCAGGCCTACAGGTCGATGC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MLMKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFDDQMLVDYSKNRITEETLAKLQDLAKECDLAGA
IKSMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGS
DLGPYMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAK
HFAALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAMDKHFSTTPAEKNLPVLLA
LIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGKVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKM
VPCDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREIT
PFSLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGLINRYKAWRG

Sequences:

>Translated_551_residues
MLMKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFDDQMLVDYSKNRITEETLAKLQDLAKECDLAGA
IKSMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGS
DLGPYMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAK
HFAALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAMDKHFSTTPAEKNLPVLLA
LIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGKVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKM
VPCDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREIT
PFSLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGLINRYKAWRG
>Mature_551_residues
MLMKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFDDQMLVDYSKNRITEETLAKLQDLAKECDLAGA
IKSMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGS
DLGPYMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAK
HFAALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAMDKHFSTTPAEKNLPVLLA
LIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGKVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKM
VPCDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREIT
PFSLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGLINRYKAWRG

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=549, Percent_Identity=64.8451730418944, Blast_Score=739, Evalue=0.0,
Organism=Homo sapiens, GI296080693, Length=549, Percent_Identity=60.8378870673953, Blast_Score=679, Evalue=0.0,
Organism=Escherichia coli, GI1790457, Length=549, Percent_Identity=99.8178506375228, Blast_Score=1142, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=546, Percent_Identity=64.4688644688645, Blast_Score=723, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996703, Length=541, Percent_Identity=64.8798521256932, Blast_Score=723, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319673, Length=549, Percent_Identity=59.3806921675774, Blast_Score=655, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651916, Length=549, Percent_Identity=65.9380692167577, Blast_Score=735, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651914, Length=549, Percent_Identity=65.9380692167577, Blast_Score=735, Evalue=0.0,
Organism=Drosophila melanogaster, GI17737445, Length=549, Percent_Identity=65.9380692167577, Blast_Score=735, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 61789; Mature: 61789

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFDDQMLVDYSKNRI
CCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHCCCCCCHHHCCHHHCC
TEETLAKLQDLAKECDLAGAIKSMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMP
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCEEECCHHHHH
EVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNM
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCE
HFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAK
EEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCHHHHHH
HFAALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAH
HHHHHCCCCHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCH
AMDKHFSTTPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNG
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCC
KYVDRNGKVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQ
EEECCCCCEEEEECCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHH
KLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREIT
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCEEEECCC
PFSLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTN
CHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCH
GLINRYKAWRG
HHHHHHHHCCC
>Mature Secondary Structure
MLMKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFDDQMLVDYSKNRI
CCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHCCCCCCHHHCCHHHCC
TEETLAKLQDLAKECDLAGAIKSMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMP
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCEEECCHHHHH
EVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNM
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCE
HFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAK
EEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCHHHHHH
HFAALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAH
HHHHHCCCCHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCH
AMDKHFSTTPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNG
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCC
KYVDRNGKVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQ
EEECCCCCEEEEECCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHH
KLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREIT
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCEEEECCC
PFSLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTN
CHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCH
GLINRYKAWRG
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA