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The map label for this gene is trxA [H]

Identifier: 91213301

GI number: 91213301

Start: 4225650

End: 4226084

Strand: Direct

Name: trxA [H]

Synonym: UTI89_C4335

Alternate gene names: 91213301

Gene position: 4225650-4226084 (Clockwise)

Preceding gene: 91213298

Following gene: 91213303

Centisome position: 83.42

GC content: 48.51

Gene sequence:

>435_bases
TTGCTTTACGAAAGCGTATCCGGTGAAATAAAGTCAACCTTTAGTTGGTTAATGTTACACCAACAACGAAACCAACACGC
CAGGCTTATTCCTGTGGAGTTATATATGAGCGATAAAATTATTCACCTGACTGACGACAGTTTTGACACGGATGTACTCA
AAGCGGACGGGGCGATCCTCGTCGATTTCTGGGCAGAGTGGTGCGGTCCGTGCAAAATGATCGCCCCGATTCTGGATGAA
ATCGCTGACGAATATCAGGGCAAACTGACCGTTGCAAAACTGAACATCGATCAAAACCCTGGCACTGCGCCGAAATATGG
CATCCGTGGTATCCCGACTCTGCTGCTGTTCAAAAACGGTGAAGTGGCGGCAACCAAAGTGGGCGCACTGTCTAAAGGTC
AGTTGAAAGAGTTCCTCGACGCTAACCTGGCGTAA

Upstream 100 bases:

>100_bases
TTCAAGGGCTTCTACAACCTTCGGATGCAGGGCGAAGTCGGAAAACTTCTGTTCTGTTAAATGTGTTTTGCTCATAGTGT
GGTAGAATATCAGCTTACTA

Downstream 100 bases:

>100_bases
GGGAATTTCATGTTCGGGTGCCCCGTCGCTAAAAACTGGACGCCCGGCGTGAGTCATGCTAACTTAGTGTTGACTTCGTA
TTAAACATACCTTATTAAGT

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MLYESVSGEIKSTFSWLMLHQQRNQHARLIPVELYMSDKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPILDE
IADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFKNGEVAATKVGALSKGQLKEFLDANLA

Sequences:

>Translated_144_residues
MLYESVSGEIKSTFSWLMLHQQRNQHARLIPVELYMSDKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPILDE
IADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFKNGEVAATKVGALSKGQLKEFLDANLA
>Mature_144_residues
MLYESVSGEIKSTFSWLMLHQQRNQHARLIPVELYMSDKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPILDE
IADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFKNGEVAATKVGALSKGQLKEFLDANLA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=38.0434782608696, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI5031973, Length=100, Percent_Identity=36, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI21361657, Length=91, Percent_Identity=38.4615384615385, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI224493972, Length=103, Percent_Identity=32.0388349514563, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI42794771, Length=103, Percent_Identity=32.0388349514563, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI87082331, Length=109, Percent_Identity=100, Blast_Score=224, Evalue=2e-60,
Organism=Escherichia coli, GI1788936, Length=105, Percent_Identity=38.0952380952381, Blast_Score=91, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI212646193, Length=99, Percent_Identity=39.3939393939394, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71998175, Length=95, Percent_Identity=41.0526315789474, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115532380, Length=118, Percent_Identity=34.7457627118644, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115532378, Length=109, Percent_Identity=35.7798165137615, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17544108, Length=109, Percent_Identity=35.7798165137615, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115532254, Length=130, Percent_Identity=29.2307692307692, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=100, Percent_Identity=32, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17556044, Length=86, Percent_Identity=34.8837209302326, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17554386, Length=88, Percent_Identity=36.3636363636364, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115532252, Length=113, Percent_Identity=30.0884955752212, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17507705, Length=75, Percent_Identity=38.6666666666667, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=73, Percent_Identity=35.6164383561644, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=63, Percent_Identity=39.6825396825397, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=110, Percent_Identity=30.9090909090909, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=99, Percent_Identity=40.4040404040404, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=96, Percent_Identity=34.375, Blast_Score=72, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=90, Percent_Identity=31.1111111111111, Blast_Score=62, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=41.25, Blast_Score=82, Evalue=8e-17,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24664269, Length=87, Percent_Identity=36.7816091954023, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI19921434, Length=88, Percent_Identity=39.7727272727273, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17648013, Length=97, Percent_Identity=37.1134020618557, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583090, Length=97, Percent_Identity=37.1134020618557, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=27.9569892473118, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 15995; Mature: 15995

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYESVSGEIKSTFSWLMLHQQRNQHARLIPVELYMSDKIIHLTDDSFDTDVLKADGAIL
CCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCEEEEEECCCCCCCEECCCCCEE
VDFWAEWCGPCKMIAPILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFKNG
EEEHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCEEEEEECC
EVAATKVGALSKGQLKEFLDANLA
CEEEEECCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MLYESVSGEIKSTFSWLMLHQQRNQHARLIPVELYMSDKIIHLTDDSFDTDVLKADGAIL
CCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCEEEEEECCCCCCCEECCCCCEE
VDFWAEWCGPCKMIAPILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFKNG
EEEHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCEEEEEECC
EVAATKVGALSKGQLKEFLDANLA
CEEEEECCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]