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The map label for this gene is yidY [H]

Identifier: 91213235

GI number: 91213235

Start: 4153183

End: 4154358

Strand: Direct

Name: yidY [H]

Synonym: UTI89_C4263

Alternate gene names: 91213235

Gene position: 4153183-4154358 (Clockwise)

Preceding gene: 91213234

Following gene: 91213236

Centisome position: 81.99

GC content: 53.4

Gene sequence:

>1176_bases
ATGTCCCGCTTTTTGATTTGTAGTTTTGCCCTGGTTTTACTTTATCCCGCAGGGATTGATATGTACCTCGTTGGTTTACC
GCGCATCGCCGCCGATCTCAATGCCAGCGAAGCGCAGTTGCATATTGCGTTCTCCGTTTATCTGGCGGGGATGGCGGCTG
CGATGTTATTTGCCGGTAAAGTGGCCGATCGTTCAGGGAGAAAGCCTGTCGCCATACCCGGCGCGGCGCTATTTATTATC
GCCTCGGTGTTCTGTTCACTGGCTGAAACCAGCGCGTTATTTCTTGCAGGGCGATTTCTACAGGGACTGGGCGCGGGCTG
TTGTTACGTAGTGGCGTTCGCCATTTTGCGCGACACGCTGGATGATCGACGTCGGGCTAAAGTGCTGTCGTTACTCAACG
GCATTACCTGCATCATTCCGGTGTTAGCGCCGGTGCTCGGACACCTGATTATGCTTAAATTCCCTTGGCAGAGTCTGTTC
TGGACGATGGCAACGATGGGCATCGCGTTACTGATGTTGTCTTTGTTTATTTTAAAAGAAACGCGCCCTGCGGCCCCCAC
AACTTCGGACAAACCACGAGAAAATAGCGAGTCACTGCTTAATCGGTTTTTCCTCAGCCGTGTTGTTATCACCACCCTCA
GCGTTTCGGTGATCCTCACCTTCGTCAACACGTCGCCAGTATTGCTGATGGAAATCATGGGTTTTGAGCGCGGAGAATAC
GCCACCATTATGGCGTTGACCGCTGGCGTCAGCATGACCGTTTCATTCTCCACGCCGTTTGCGCTGGGAATTTTTAAGCC
ACGTACGTTGATGATCACCTCACAGGTGTTATTCCTGGCGGCGGGGATCACCCTTGCCGTTTCACCTTCCCATGCGGTTT
CGCTGTTTGGTATCACGCTGATTTGCGCCGGTTTCTCGGTAGGTTTTGGTGTGGCGATGAGTCAGGCGTTAGGGCCGTTT
TCATTACGCGCGGGCGTAGCCAGCTCGACCTTAGGTATTGCGCAAGTTTGCGGTTCGTCACTGTGGATTTGGCTGGCGGC
GGTGGTTGGTATCGGCGCATGGAATATGCTGATCGGGATTCTGATTGCCTGTAGCATAGTGAGCCTGTTGCTGATTATGT
TCGTCGCGCCTGGACGCCCCGTTGCCGCTCATGAAGAAATCCATCACCACGCTTGA

Upstream 100 bases:

>100_bases
CTTGCCTGTCAGGAAATCACTTATGTCCAAATGGCAACTCGCCTGATTCTCCTTCACCACGTATGCTTTGCGTCACCTTA
CTATCAGGACGCTTTAGCCC

Downstream 100 bases:

>100_bases
TCTCAATCTGCTGCTCTGTCTGCAACTGCTGATGCAGGAGCGCAGCGTGACCAAAGCGGCGAAGCGGATGAACGTGACCC
CTTCGGCGGTGAGTAAGTCG

Product: multidrug efflux system protein MdtL

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MSRFLICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFII
ASVFCSLAETSALFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLF
WTMATMGIALLMLSLFILKETRPAAPTTSDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEY
ATIMALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALGPF
SLRAGVASSTLGIAQVCGSSLWIWLAAVVGIGAWNMLIGILIACSIVSLLLIMFVAPGRPVAAHEEIHHHA

Sequences:

>Translated_391_residues
MSRFLICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFII
ASVFCSLAETSALFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLF
WTMATMGIALLMLSLFILKETRPAAPTTSDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEY
ATIMALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALGPF
SLRAGVASSTLGIAQVCGSSLWIWLAAVVGIGAWNMLIGILIACSIVSLLLIMFVAPGRPVAAHEEIHHHA
>Mature_390_residues
SRFLICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKVADRSGRKPVAIPGAALFIIA
SVFCSLAETSALFLAGRFLQGLGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFW
TMATMGIALLMLSLFILKETRPAAPTTSDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEYA
TIMALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITLICAGFSVGFGVAMSQALGPFS
LRAGVASSTLGIAQVCGSSLWIWLAAVVGIGAWNMLIGILIACSIVSLLLIMFVAPGRPVAAHEEIHHHA

Specific function: Confers resistance to chloramphenicol [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790146, Length=391, Percent_Identity=98.4654731457801, Blast_Score=763, Evalue=0.0,
Organism=Escherichia coli, GI1788509, Length=226, Percent_Identity=30.9734513274336, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI48994889, Length=242, Percent_Identity=30.5785123966942, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1790794, Length=227, Percent_Identity=27.7533039647577, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87082312, Length=345, Percent_Identity=27.2463768115942, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787065, Length=233, Percent_Identity=24.4635193133047, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI87081738, Length=140, Percent_Identity=35.7142857142857, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41534; Mature: 41403

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFLICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGK
CCCHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCCCHHHEEHHHHHHHHHHHHHHHHHHH
VADRSGRKPVAIPGAALFIIASVFCSLAETSALFLAGRFLQGLGAGCCYVVAFAILRDTL
HHCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
DDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWTMATMGIALLMLSLFILKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHC
TRPAAPTTSDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCH
ATIMALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITL
HEEEEECCCCEEEEEECCCEEEECCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHH
ICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAVVGIGAWNMLIGI
HHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHH
LIACSIVSLLLIMFVAPGRPVAAHEEIHHHA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHCCC
>Mature Secondary Structure 
SRFLICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGK
CCHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCCCHHHEEHHHHHHHHHHHHHHHHHHH
VADRSGRKPVAIPGAALFIIASVFCSLAETSALFLAGRFLQGLGAGCCYVVAFAILRDTL
HHCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
DDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFWTMATMGIALLMLSLFILKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHC
TRPAAPTTSDKPRENSESLLNRFFLSRVVITTLSVSVILTFVNTSPVLLMEIMGFERGEY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCH
ATIMALTAGVSMTVSFSTPFALGIFKPRTLMITSQVLFLAAGITLAVSPSHAVSLFGITL
HEEEEECCCCEEEEEECCCEEEECCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHH
ICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAVVGIGAWNMLIGI
HHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHH
LIACSIVSLLLIMFVAPGRPVAAHEEIHHHA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA