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The map label for this gene is yicE [H]

Identifier: 91213172

GI number: 91213172

Start: 4087333

End: 4088733

Strand: Direct

Name: yicE [H]

Synonym: UTI89_C4199

Alternate gene names: 91213172

Gene position: 4087333-4088733 (Clockwise)

Preceding gene: 162138336

Following gene: 91213173

Centisome position: 80.69

GC content: 54.68

Gene sequence:

>1401_bases
TTGTTTTCGATGTCTGTTTCCACCCTCGAGTCAGAAAATGCGCAACCGGTTGCGCAGACTCAAAACAGCGAACTGATTTA
CCGTCTTGAAGATCGTCCGCCGCTTCCTCAAACCCTGTTTGCCGCCTGTCAGCATTTGCTGGCGATGTTCGTTGCGGTGA
TCACGCCAGCGCTATTAATCTGCCAGGCGCTGGGTTTACCGGCACAAGACACGCAACACATTATTAGTATGTCGCTGTTT
GCCTCCGGTGTGGCATCGATTATTCAAATTAAGGCCTGGGGTCCGGTTGGCTCCGGGTTGTTGTCTATTCAGGGCACCAG
CTTCAACTTTGTTGCTCCGCTGATTATGGGCGGCACAGCGCTGAAGACCGGTGGTGCTGATGTTCCTACCATGATGGCAG
CTTTGTTCGGCACGTTGATGCTGGCAAGTTGTACCGAGATGGTGATCTCCCGCGTTCTGCATCTGGCGCGCCGCATTATT
ACGCCGCTGGTTTCTGGCGTTGTGGTGATGATTATCGGCCTGTCGCTAATTCAGGTTGGGCTGACCTCCATTGGCGGCGG
TTACGCAGCCATGAGCGATAACACCTTCGGCGCACCGAAAAATCTGCTGCTGGCAGGCGTGGTCTTAGCCTTAATTATCC
TGCTTAACCGTCAACGTAACCCTTACTTACGCGTGGCCTCACTGGTGATTGCGATGGCGGCCGGATATGCGCTGGCGTGG
TTTATGGGCATGTTGCCAGAAAGCAACGAACCGATGACACAAGAACTGATTATGGTGCCAACGCCGCTCTATTACGGTCT
TGGCATTGAATGGAGTCTGCTGCTGCCGCTGATGCTGGTCTTTATGATCACTTCGCTGGAAACCATTGGCGATATCACGG
CGACCTCTGACGTTTCCGAACAGCCAGTGTCCGGTCCGCTGTACATGAAACGCCTGAAAGGCGGCGTACTGGCAAACGGC
CTGAACTCGTTTGTCTCGGCGGTATTTAATACCTTCCCGAACTCCTGCTTCGGGCAGAACAACGGGGTGATCCAGTTAAC
CGGTGTTGCCAGCCGCTATGTCGGTTTTGTCGTCGCGCTGATGTTGATCGTGCTGGGTCTGTTCCCGGCAGTGAGCGGTT
TTGTACAACACATTCCAGAACCGGTTCTGGGCGGCGCAACGCTTGTAATGTTTGGCACCATCGCCGCCTCCGGTGTGCGT
ATCGTTTCTCGTGAGCCGCTGAACCGCCGGGCGATTCTGATTATCGCGCTGTCGCTGGCGGTCGGTCTGGGCGTGTCTCA
GCAGCCGCTGATTTTGCAGTTTGCCCCTGAATGGCTGAAAAACCTACTCTCCTCCGGGATTGCCGCGGGCGGTATTACTG
CCATCGTGCTGAATCTGATTTTCCCACCAGAAAAACAGTAA

Upstream 100 bases:

>100_bases
AAAAAGTACATTTATCTCATTTAAATATTTAGATGAGGATGTGGCAAACGTTTGCTTTTCTCTTTCGGTCAGCTAAAATG
CCCGCTTTGCTACCACGGGA

Downstream 100 bases:

>100_bases
TTCACTGGCGGCGGTAAGATAATTACCGCCGCAGTCTCACCTCTTTCACCATTCCCGCCTTGAGGATTGCGCGTAAATCG
TGCATAACTCCCTTATGTGC

Product: putative transport protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MFSMSVSTLESENAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSLF
ASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKTGGADVPTMMAALFGTLMLASCTEMVISRVLHLARRII
TPLVSGVVVMIIGLSLIQVGLTSIGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAW
FMGMLPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLANG
LNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVR
IVSREPLNRRAILIIALSLAVGLGVSQQPLILQFAPEWLKNLLSSGIAAGGITAIVLNLIFPPEKQ

Sequences:

>Translated_466_residues
MFSMSVSTLESENAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSLF
ASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKTGGADVPTMMAALFGTLMLASCTEMVISRVLHLARRII
TPLVSGVVVMIIGLSLIQVGLTSIGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAW
FMGMLPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLANG
LNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVR
IVSREPLNRRAILIIALSLAVGLGVSQQPLILQFAPEWLKNLLSSGIAAGGITAIVLNLIFPPEKQ
>Mature_466_residues
MFSMSVSTLESENAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSLF
ASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKTGGADVPTMMAALFGTLMLASCTEMVISRVLHLARRII
TPLVSGVVVMIIGLSLIQVGLTSIGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAW
FMGMLPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLANG
LNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVR
IVSREPLNRRAILIIALSLAVGLGVSQQPLILQFAPEWLKNLLSSGIAAGGITAIVLNLIFPPEKQ

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=516, Percent_Identity=23.062015503876, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI40316845, Length=516, Percent_Identity=23.062015503876, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1790087, Length=463, Percent_Identity=100, Blast_Score=915, Evalue=0.0,
Organism=Escherichia coli, GI87082178, Length=444, Percent_Identity=45.045045045045, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI87082181, Length=460, Percent_Identity=28.695652173913, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI1788843, Length=444, Percent_Identity=25.6756756756757, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081818, Length=405, Percent_Identity=24.4444444444444, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17558856, Length=481, Percent_Identity=24.5322245322245, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 49234; Mature: 49234

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSMSVSTLESENAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLI
CCCCCHHHHHCCCCCCHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
CQALGLPAQDTQHIISMSLFASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEECCCCHHHHHHHHCCCC
LKTGGADVPTMMAALFGTLMLASCTEMVISRVLHLARRIITPLVSGVVVMIIGLSLIQVG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTSIGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAW
HHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
FMGMLPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSE
HHHHCCCCCCCHHHHHEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
QPVSGPLYMKRLKGGVLANGLNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVAL
CCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHH
MLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVSREPLNRRAILIIALSLA
HHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHH
VGLGVSQQPLILQFAPEWLKNLLSSGIAAGGITAIVLNLIFPPEKQ
HHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFSMSVSTLESENAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLI
CCCCCHHHHHCCCCCCHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
CQALGLPAQDTQHIISMSLFASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEECCCCHHHHHHHHCCCC
LKTGGADVPTMMAALFGTLMLASCTEMVISRVLHLARRIITPLVSGVVVMIIGLSLIQVG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTSIGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAW
HHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
FMGMLPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSE
HHHHCCCCCCCHHHHHEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
QPVSGPLYMKRLKGGVLANGLNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVAL
CCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHH
MLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVSREPLNRRAILIIALSLA
HHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHH
VGLGVSQQPLILQFAPEWLKNLLSSGIAAGGITAIVLNLIFPPEKQ
HHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]