Click here to switch to the map view.

The map label for this gene is lldP [H]

Identifier: 91213117

GI number: 91213117

Start: 4039241

End: 4040917

Strand: Direct

Name: lldP [H]

Synonym: UTI89_C4144

Alternate gene names: 91213117

Gene position: 4039241-4040917 (Clockwise)

Preceding gene: 91213116

Following gene: 91213118

Centisome position: 79.74

GC content: 54.98

Gene sequence:

>1677_bases
GTGGACTGCAGGAGACCTGCAATGAATCTCTGGCAACAAAACTACGATCCCGCCGGGAATATCTGGCTTTCCAGCCTGAT
AGCATCGCTTCCCATCCTGTTTTTCTTCTTTGCGCTGATTAAGCTCAAACTGAAAGGATACGTCGCCGCCTCATGGACGG
TGGCAATCGCCCTTGCCGTGGCTTTGCTGTTCTATAAAATGCCGGTCGCTAACGCGCTGGCCTCGGTGGTTTATGGCTTC
TTCTACGGGTTGTGGCCCATCGCGTGGATCATTATTGCAGCGGTGTTCGTCTATAAGATCTCGGTGAAAACCGGGCAGTT
TGACATCATCCGCTCGTCTATTCTTTCGATAACCCCTGACCAGCGCCTGCAAATGCTGATCGTCGGTTTCTGTTTCGGCG
CTTTCCTTGAAGGAGCCGCAGGCTTTGGCGCACCGGTAGCAATTACCGCCGCATTGCTGGTCGGTCTGGGCTTTAAACCA
CTGTACGCCGCCGGGCTGTGCCTGATTGTTAACACCGCGCCAGTGGCATTTGGTGCGATGGGTATTCCGATTCTGGTCGC
CGGGCAGGTAACAGGCATCGACAGCTTTGAGATTGGTCAGATGGTGGGGCGTCAGCTGCCGTTTATGACCATTATCGTGC
TGTTCTGGATCATGGCGATTATGGACGGCTGGCGCGGTATCAAAGAGACGTGGCCTGCGGTCGTGGTTGCGGGCGGGTCG
TTTGCCATTGCTCAATACCTCAGCTCTAACTTTATTGGGCCGGAACTGCCAGACATTATCTCTTCGCTGGTATCGCTGCT
CTGTCTGACACTGTTCCTCAAACGCTGGCAACCAGTGCGCGTATTCCGCTTCGGTGACTTAGGGGCGTCACAGGTTGATA
TGACGCTGGCTCACACAGGTTACACGGCAGGTCAGGTGCTGCGCGCCTGGACACCGTTCCTGTTCCTGACCGCCACCGTA
ACGCTGTGGAGTATCCCGCCGTTTAAAGCCCTGTTCGCTTCAGGCGGTGCGCTGTATGAGTGGGTGATCAACATTCCGGT
GCCGTACCTCGATAAACTGGTTGCCCGTATGCCGCCAGTGGTCAGCGAAGCGACAGCGTATGCCGCCGTGTTTAAGTTTG
ACTGGTTCTCTGCCACTGGCACCGCCATTCTGTTTGCTGCCCTGCTCTCGATTGTCTGGCTGAAGATGAAACCATCTGAC
GCTATCAGCACCTTCGGCAGCACGCTGAAAGAACTGGCTCTGCCCATCTACTCCATCGGTATGGTGCTGGCATTCGCCTT
TATCTCGAACTATTCAGGACTGTCATCAACACTGGCGCTGGCACTGGCGCACACCGGTCATGCATTCACCTTCTTCTCGC
CGTTCCTCGGCTGGCTTGGGGTATTCCTGACCGGGTCGGATACGTCATCTAATGCTTTGTTTGCCGCTTTGCAGGCTACC
GCCGCACAACAAATTGGCGTTTCTGACCTGTTGCTGGTTGCAGCCAACACCACCGGTGGTGTCACCGGCAAAATGATCTC
TCCGCAATCTATCGCTATCGCCTGTGCGGCGGTAGGTCTGGTGGGCAAAGAGTCTGATTTGTTCCGCTTTACTGTCAAAC
ACAGCCTGATCTTCACCTGTATGGTGGGCGTGATCACCACGCTTCAGGCCTATGTCTTAACGTGGATGATTCCTTAA

Upstream 100 bases:

>100_bases
AACTATCCATTGTCATTATCCCTACACAACACAATTGGCAGTGCCACTTTTACACAACGTGTGACAAGGAGATGAGCAAC
AGACTCATTACACGGCGTGT

Downstream 100 bases:

>100_bases
TGATTGTTTTACCCAGACGCCTGTCAGACGAGGTTGCCGATCGTGTGCGGGCGCTGATTGATGAAAAAAACCTGGAAGCG
GGCATGAAGTTGCCCGCTGA

Product: L-lactate permease

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MDCRRPAMNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYVAASWTVAIALAVALLFYKMPVANALASVVYGF
FYGLWPIAWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLIVGFCFGAFLEGAAGFGAPVAITAALLVGLGFKP
LYAAGLCLIVNTAPVAFGAMGIPILVAGQVTGIDSFEIGQMVGRQLPFMTIIVLFWIMAIMDGWRGIKETWPAVVVAGGS
FAIAQYLSSNFIGPELPDIISSLVSLLCLTLFLKRWQPVRVFRFGDLGASQVDMTLAHTGYTAGQVLRAWTPFLFLTATV
TLWSIPPFKALFASGGALYEWVINIPVPYLDKLVARMPPVVSEATAYAAVFKFDWFSATGTAILFAALLSIVWLKMKPSD
AISTFGSTLKELALPIYSIGMVLAFAFISNYSGLSSTLALALAHTGHAFTFFSPFLGWLGVFLTGSDTSSNALFAALQAT
AAQQIGVSDLLLVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTCMVGVITTLQAYVLTWMIP

Sequences:

>Translated_558_residues
MDCRRPAMNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYVAASWTVAIALAVALLFYKMPVANALASVVYGF
FYGLWPIAWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLIVGFCFGAFLEGAAGFGAPVAITAALLVGLGFKP
LYAAGLCLIVNTAPVAFGAMGIPILVAGQVTGIDSFEIGQMVGRQLPFMTIIVLFWIMAIMDGWRGIKETWPAVVVAGGS
FAIAQYLSSNFIGPELPDIISSLVSLLCLTLFLKRWQPVRVFRFGDLGASQVDMTLAHTGYTAGQVLRAWTPFLFLTATV
TLWSIPPFKALFASGGALYEWVINIPVPYLDKLVARMPPVVSEATAYAAVFKFDWFSATGTAILFAALLSIVWLKMKPSD
AISTFGSTLKELALPIYSIGMVLAFAFISNYSGLSSTLALALAHTGHAFTFFSPFLGWLGVFLTGSDTSSNALFAALQAT
AAQQIGVSDLLLVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTCMVGVITTLQAYVLTWMIP
>Mature_558_residues
MDCRRPAMNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYVAASWTVAIALAVALLFYKMPVANALASVVYGF
FYGLWPIAWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLIVGFCFGAFLEGAAGFGAPVAITAALLVGLGFKP
LYAAGLCLIVNTAPVAFGAMGIPILVAGQVTGIDSFEIGQMVGRQLPFMTIIVLFWIMAIMDGWRGIKETWPAVVVAGGS
FAIAQYLSSNFIGPELPDIISSLVSLLCLTLFLKRWQPVRVFRFGDLGASQVDMTLAHTGYTAGQVLRAWTPFLFLTATV
TLWSIPPFKALFASGGALYEWVINIPVPYLDKLVARMPPVVSEATAYAAVFKFDWFSATGTAILFAALLSIVWLKMKPSD
AISTFGSTLKELALPIYSIGMVLAFAFISNYSGLSSTLALALAHTGHAFTFFSPFLGWLGVFLTGSDTSSNALFAALQAT
AAQQIGVSDLLLVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTCMVGVITTLQAYVLTWMIP

Specific function: Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=551, Percent_Identity=99.8185117967332, Blast_Score=1086, Evalue=0.0,
Organism=Escherichia coli, GI1789347, Length=558, Percent_Identity=63.0824372759857, Blast_Score=685, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 60017; Mature: 60017

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDCRRPAMNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYVAASWTVAIALAV
CCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLFYKMPVANALASVVYGFFYGLWPIAWIIIAAVFVYKISVKTGQFDIIRSSILSITPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCH
QRLQMLIVGFCFGAFLEGAAGFGAPVAITAALLVGLGFKPLYAAGLCLIVNTAPVAFGAM
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHCCEEEEEECCCHHHCCC
GIPILVAGQVTGIDSFEIGQMVGRQLPFMTIIVLFWIMAIMDGWRGIKETWPAVVVAGGS
CCCEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCCEEEEECCH
FAIAQYLSSNFIGPELPDIISSLVSLLCLTLFLKRWQPVRVFRFGDLGASQVDMTLAHTG
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHEEEHHCCC
YTAGQVLRAWTPFLFLTATVTLWSIPPFKALFASGGALYEWVINIPVPYLDKLVARMPPV
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEHEECCCHHHHHHHHHHCCCH
VSEATAYAAVFKFDWFSATGTAILFAALLSIVWLKMKPSDAISTFGSTLKELALPIYSIG
HHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
MVLAFAFISNYSGLSSTLALALAHTGHAFTFFSPFLGWLGVFLTGSDTSSNALFAALQAT
HHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHH
AAQQIGVSDLLLVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTC
HHHHCCCHHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHH
MVGVITTLQAYVLTWMIP
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDCRRPAMNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYVAASWTVAIALAV
CCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLFYKMPVANALASVVYGFFYGLWPIAWIIIAAVFVYKISVKTGQFDIIRSSILSITPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCH
QRLQMLIVGFCFGAFLEGAAGFGAPVAITAALLVGLGFKPLYAAGLCLIVNTAPVAFGAM
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHCCEEEEEECCCHHHCCC
GIPILVAGQVTGIDSFEIGQMVGRQLPFMTIIVLFWIMAIMDGWRGIKETWPAVVVAGGS
CCCEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCCEEEEECCH
FAIAQYLSSNFIGPELPDIISSLVSLLCLTLFLKRWQPVRVFRFGDLGASQVDMTLAHTG
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHEEEHHCCC
YTAGQVLRAWTPFLFLTATVTLWSIPPFKALFASGGALYEWVINIPVPYLDKLVARMPPV
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEHEECCCHHHHHHHHHHCCCH
VSEATAYAAVFKFDWFSATGTAILFAALLSIVWLKMKPSDAISTFGSTLKELALPIYSIG
HHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
MVLAFAFISNYSGLSSTLALALAHTGHAFTFFSPFLGWLGVFLTGSDTSSNALFAALQAT
HHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHH
AAQQIGVSDLLLVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTC
HHHHCCCHHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHH
MVGVITTLQAYVLTWMIP
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]