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The map label for this gene is glpK2 [H]

Identifier: 91212977

GI number: 91212977

Start: 3888627

End: 3890135

Strand: Direct

Name: glpK2 [H]

Synonym: UTI89_C4003

Alternate gene names: 91212977

Gene position: 3888627-3890135 (Clockwise)

Preceding gene: 91212976

Following gene: 91212978

Centisome position: 76.76

GC content: 53.94

Gene sequence:

>1509_bases
ATGCCTGATAACAGCGCAGCTATCGTTATCGATATTGGCACCACCAATTGCAAAGTCACCTGCTTTTCCTGCCTGGACGC
AACGACGTTGGGCGCGCATAAATTCGTGACGGCAAAACAGATCTCCCCACAGGGCAATGTCGATTTCGATATCGACGCCC
TCTGGCAGGAGGTCCGCCAGGCGATAGCGCAACTGAACGCCGCTTCGCCGCTGCCAGTCAGGCGGATCAGCATTGCCAGT
TTTGGCGAGTCAGGGGTGTTTCTTGACAAACATGGCGAGATTCTGACGCCAATGCTGGCATGGTATGACCGTCGCGGTGA
AGAGTATCTGGCAACGCTTAGCGAGGCAGACAGTGCGGCACTTTATGACATTTGCGGGTTACCACTGCACAGCAATTACT
CTGCCTTCAAAATGCGTTGGTTGCTGGAGCATTATCCGCTGCGCAATCGTCGCGGCCTGCGCTGGCTACATGCACCGGAA
GTGCTGCTCTGGCGGCTGACTGGCGAACAGCGAACGGATATCACCTTAGCCAGCCGTACACTGTGTCTGGACGTGCGCAA
AGGCGAATGGTCAGCGAAAGCGGCGGCGTTGTTACACGTTCCCTGTTCAGCATTTGCGCCATTGTTGCAGCCAGGTGAGC
ACGCCGGATGGGTCAGTGAGTCGCTCTGCAAAACGCTTGGGTTCTCGCAATCGGTCAGCGTGACGCTGGCCGGACATGAC
CATATGGTGGGTGCGCGGGCGTTGCAGATGATGCCGGGCGATATCCTTAACTCGACGGGCACCACGGAAGGCATTCTGCA
ACTGGATACACAACCGACGCTGGATGAACAGGCCAAACGTGACAAGCTGGCAAACGGCTGTTACTCGCTTGCCAACCAGT
TCACCCTGTTTGCTTCTCTGCCCGTGGGCGGTTTCGCGCTGGAGTGGCTGCGTAACACGTTCCGGCTAACCGATGAGGAG
ATCGCCGTGTCGCTCAATCGTGGGTATGCGGATTACCTGGCGGGGAACTGGTCGCTCGATGACATTCCCGTTTTTATTCC
GCATCTTCGCGGTTCGGGTTCGCCCTATAAAAATCGCCATACCCGAGGATTATTTTATGGGCTTGGCGATACGTTAAATA
TCGATATGTTAATTGCCAGCGTCTCACTGGGATTAACCATGGAATTTGCCAACTGCTTCGCCTGTTTTAATGTGCCCGGC
ACCAGCGCGTTAAAAGTGATAGGTCCGGCAACCCATAATCCCCTTTGGCTGCAATTAAAGGCGGATATTTTACAGCGTCC
GGTTGAAGCAATTGCATTTAACGAGGCGGTTTCTGTCGGAGCATTATTAACCGCCGCACCGGATATTCCACCGCCGCAAG
TCACCATAGCCCAACGTTTGTTACCGAATCGGGCGAGATACCATCAATTACAGCGTTATCAGCACAAATGGAAAAGCTGG
TATCAGTTGAAATTACAGCAAGAAGGCGTGATGCCATTACATCATCGGGAGGAGCACTATGTTGAGTAA

Upstream 100 bases:

>100_bases
CTGCTGGAAATCTTCAACGGCAATCTCATCGCCATTGGTCTGGTGCCGGTTATCGCCCTGGTACTGTATGGTATTTTCCG
AATGACGCGGAGCACGGTTT

Downstream 100 bases:

>100_bases
AACCGTGGAAGTCAGAAACAGTACTGGCCTGCATGCACGTCCGGCGGCCTGTCTGGCGAAAGCCGCCAAAAAATATAGCT
GTAAAGTGACGCTGCACTAT

Product: putative xylulose kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase 2; Glycerokinase 2; GK 2 [H]

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MPDNSAAIVIDIGTTNCKVTCFSCLDATTLGAHKFVTAKQISPQGNVDFDIDALWQEVRQAIAQLNAASPLPVRRISIAS
FGESGVFLDKHGEILTPMLAWYDRRGEEYLATLSEADSAALYDICGLPLHSNYSAFKMRWLLEHYPLRNRRGLRWLHAPE
VLLWRLTGEQRTDITLASRTLCLDVRKGEWSAKAAALLHVPCSAFAPLLQPGEHAGWVSESLCKTLGFSQSVSVTLAGHD
HMVGARALQMMPGDILNSTGTTEGILQLDTQPTLDEQAKRDKLANGCYSLANQFTLFASLPVGGFALEWLRNTFRLTDEE
IAVSLNRGYADYLAGNWSLDDIPVFIPHLRGSGSPYKNRHTRGLFYGLGDTLNIDMLIASVSLGLTMEFANCFACFNVPG
TSALKVIGPATHNPLWLQLKADILQRPVEAIAFNEAVSVGALLTAAPDIPPPQVTIAQRLLPNRARYHQLQRYQHKWKSW
YQLKLQQEGVMPLHHREEHYVE

Sequences:

>Translated_502_residues
MPDNSAAIVIDIGTTNCKVTCFSCLDATTLGAHKFVTAKQISPQGNVDFDIDALWQEVRQAIAQLNAASPLPVRRISIAS
FGESGVFLDKHGEILTPMLAWYDRRGEEYLATLSEADSAALYDICGLPLHSNYSAFKMRWLLEHYPLRNRRGLRWLHAPE
VLLWRLTGEQRTDITLASRTLCLDVRKGEWSAKAAALLHVPCSAFAPLLQPGEHAGWVSESLCKTLGFSQSVSVTLAGHD
HMVGARALQMMPGDILNSTGTTEGILQLDTQPTLDEQAKRDKLANGCYSLANQFTLFASLPVGGFALEWLRNTFRLTDEE
IAVSLNRGYADYLAGNWSLDDIPVFIPHLRGSGSPYKNRHTRGLFYGLGDTLNIDMLIASVSLGLTMEFANCFACFNVPG
TSALKVIGPATHNPLWLQLKADILQRPVEAIAFNEAVSVGALLTAAPDIPPPQVTIAQRLLPNRARYHQLQRYQHKWKSW
YQLKLQQEGVMPLHHREEHYVE
>Mature_501_residues
PDNSAAIVIDIGTTNCKVTCFSCLDATTLGAHKFVTAKQISPQGNVDFDIDALWQEVRQAIAQLNAASPLPVRRISIASF
GESGVFLDKHGEILTPMLAWYDRRGEEYLATLSEADSAALYDICGLPLHSNYSAFKMRWLLEHYPLRNRRGLRWLHAPEV
LLWRLTGEQRTDITLASRTLCLDVRKGEWSAKAAALLHVPCSAFAPLLQPGEHAGWVSESLCKTLGFSQSVSVTLAGHDH
MVGARALQMMPGDILNSTGTTEGILQLDTQPTLDEQAKRDKLANGCYSLANQFTLFASLPVGGFALEWLRNTFRLTDEEI
AVSLNRGYADYLAGNWSLDDIPVFIPHLRGSGSPYKNRHTRGLFYGLGDTLNIDMLIASVSLGLTMEFANCFACFNVPGT
SALKVIGPATHNPLWLQLKADILQRPVEAIAFNEAVSVGALLTAAPDIPPPQVTIAQRLLPNRARYHQLQRYQHKWKSWY
QLKLQQEGVMPLHHREEHYVE

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI42794763, Length=456, Percent_Identity=24.780701754386, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI41393575, Length=451, Percent_Identity=24.1685144124169, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI4504007, Length=453, Percent_Identity=24.5033112582781, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI189409120, Length=453, Percent_Identity=24.5033112582781, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1789168, Length=462, Percent_Identity=26.1904761904762, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1789987, Length=490, Percent_Identity=22.8571428571429, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790361, Length=463, Percent_Identity=22.2462203023758, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17535599, Length=446, Percent_Identity=23.542600896861, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI17864214, Length=534, Percent_Identity=23.4082397003745, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24654573, Length=460, Percent_Identity=24.1304347826087, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19922058, Length=407, Percent_Identity=21.8673218673219, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 55712; Mature: 55581

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDNSAAIVIDIGTTNCKVTCFSCLDATTLGAHKFVTAKQISPQGNVDFDIDALWQEVRQ
CCCCCEEEEEEECCCCCEEEEEEHHCCHHCCCHHEEEEEECCCCCCCCCCHHHHHHHHHH
AIAQLNAASPLPVRRISIASFGESGVFLDKHGEILTPMLAWYDRRGEEYLATLSEADSAA
HHHHCCCCCCCCEEEEEEECCCCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHCCCCHH
LYDICGLPLHSNYSAFKMRWLLEHYPLRNRRGLRWLHAPEVLLWRLTGEQRTDITLASRT
HHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCEEEEEECCCCCCCEEEEEEE
LCLDVRKGEWSAKAAALLHVPCSAFAPLLQPGEHAGWVSESLCKTLGFSQSVSVTLAGHD
EEEEECCCCCCCCEEEEEECCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCC
HMVGARALQMMPGDILNSTGTTEGILQLDTQPTLDEQAKRDKLANGCYSLANQFTLFASL
CHHHHHHHHHCCCHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCEEEEEEC
PVGGFALEWLRNTFRLTDEEIAVSLNRGYADYLAGNWSLDDIPVFIPHLRGSGSPYKNRH
CCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHCCCCCCCCCCEEEECCCCCCCCCCCCC
TRGLFYGLGDTLNIDMLIASVSLGLTMEFANCFACFNVPGTSALKVIGPATHNPLWLQLK
CCEEEEECCCCCCHHEEEEHHHHCEEEEHHCEEEEECCCCCCEEEEECCCCCCCEEEEEE
ADILQRPVEAIAFNEAVSVGALLTAAPDIPPPQVTIAQRLLPNRARYHQLQRYQHKWKSW
HHHHHCCHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHH
YQLKLQQEGVMPLHHREEHYVE
EEEEEECCCCCCCCCCHHHCCC
>Mature Secondary Structure 
PDNSAAIVIDIGTTNCKVTCFSCLDATTLGAHKFVTAKQISPQGNVDFDIDALWQEVRQ
CCCCEEEEEEECCCCCEEEEEEHHCCHHCCCHHEEEEEECCCCCCCCCCHHHHHHHHHH
AIAQLNAASPLPVRRISIASFGESGVFLDKHGEILTPMLAWYDRRGEEYLATLSEADSAA
HHHHCCCCCCCCEEEEEEECCCCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHCCCCHH
LYDICGLPLHSNYSAFKMRWLLEHYPLRNRRGLRWLHAPEVLLWRLTGEQRTDITLASRT
HHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCEEEEEECCCCCCCEEEEEEE
LCLDVRKGEWSAKAAALLHVPCSAFAPLLQPGEHAGWVSESLCKTLGFSQSVSVTLAGHD
EEEEECCCCCCCCEEEEEECCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCC
HMVGARALQMMPGDILNSTGTTEGILQLDTQPTLDEQAKRDKLANGCYSLANQFTLFASL
CHHHHHHHHHCCCHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCEEEEEEC
PVGGFALEWLRNTFRLTDEEIAVSLNRGYADYLAGNWSLDDIPVFIPHLRGSGSPYKNRH
CCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHCCCCCCCCCCEEEECCCCCCCCCCCCC
TRGLFYGLGDTLNIDMLIASVSLGLTMEFANCFACFNVPGTSALKVIGPATHNPLWLQLK
CCEEEEECCCCCCHHEEEEHHHHCEEEEHHCEEEEECCCCCCEEEEECCCCCCCEEEEEE
ADILQRPVEAIAFNEAVSVGALLTAAPDIPPPQVTIAQRLLPNRARYHQLQRYQHKWKSW
HHHHHCCHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHH
YQLKLQQEGVMPLHHREEHYVE
EEEEEECCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]