Click here to switch to the map view.

The map label for this gene is panF [H]

Identifier: 91212689

GI number: 91212689

Start: 3625557

End: 3627014

Strand: Direct

Name: panF [H]

Synonym: UTI89_C3700

Alternate gene names: 91212689

Gene position: 3625557-3627014 (Clockwise)

Preceding gene: 91212688

Following gene: 91212690

Centisome position: 71.57

GC content: 54.53

Gene sequence:

>1458_bases
ATGACGATGCAGCTTGAAGTGATTCTACCGCTGGTCGCCTATCTGGTGGTGGTGTTCGGTATCTCTGTTTATGCGATGCG
TAAACGGAGCACTGGCACCTTCCTTAATGAGTATTTCCTCGGCAGCCGCTCTATGGGCGGTATTGTGCTGGCGATGACGC
TCACCGCGACCTATATCAGTGCCAGTTCGTTTATCGGCGGGCCTGGAGCTGCTTATAAATACGGCCTGGGCTGGGTATTG
CTAGCGATGATTCAGCTTCCTGCAGTCTGGCTTTCGCTCGGTATTCTCGGCAAGAAGTTCGCAATTCTTGCGCGCCGCTA
CAATGCGGTGACGCTGAACGATATGCTGTTTGCCCGCTACCAGAGTCGTCTTCTGGTATGGCTGGCGAGTTTGAGTTTGC
TGGTTGCGTTCGTTGGTGCGATGACCGTGCAGTTTATCGGCGGTGCGCGCCTGCTGGAAACCGCGGCGGGTATTCCTTAT
GAAACCGGGCTGCTGATTTTCGGTATCAGCATTGCGTTGTATACCGCCTTTGGCGGCTTTCGCGCCAGCGTGCTGAACGA
CACCATGCAAGGGCTGGTGATGCTGATTGGCACCGTTGTGCTGCTTATTGGCGTGGTACATGCCGCAGGTGGTTTAAGTA
ATGCGGTAGACACGCTGCAAACCATCGATCCGCAACTGGTTACGCCACAAGGCGCTGACGATATTCTGTCGCCTGCCTTT
ATGACGTCGTTCTGGGTACTGGTGTGCTTTGGCGTTATAGGCCTGCCGCATACTGCGGTGCGCTGTATCTCTTATAAAGA
CAGCAAAGCCGTACATCGGGGGATCATTATCGGTACGATTGTAGTCGCAATCCTGATGTTCGGTATGCATCTGGCCGGAG
CGTTAGGTCGGGCGGTGATCCCCGATCTCACCGTACCGGATCTGGTGATCCCGACGTTAATGGTAAAAGTGCTGCCACCG
TTTGCCGCCGGGATCTTCCTGGCTGCACCGATGGCTGCGATCATGTCGACAATTAACGCCCAACTGCTGCAAAGTTCCGC
TACGATCATTAAAGATCTCTATCTGAATATCCGTCCGGATCAAATGCAAAACGAGACGCGTCTGAAGCGGATGTCGGCGG
TGATCACGTTGGTTCTCGGTGCGTTGCTGCTGCTTGCCGCCTGGAAGCCGCCAGAAATGATCATCTGGCTGAATTTGCTG
GCCTTCGGTGGGCTGGAAGCCGTTTTCCTGTGGCCGCTGGTGCTGGGTCTTTACTGGGAACGTGCCAACGCCAAAGGCGC
GCTAAGTGCGATGATCGTTGGCGGCGTGCTGTATGCCGTACTCGCGAAGCTGAATATTCAGTACCTGGGCTTCCACCCTA
TCGTGCCCTCGTTACTACTAAGTTTGCTGGCTTTCCTGGTCGGAAACCGTTTCGGTACATCCGTCCCGCAAGCTACCGTT
TTGACTACTGATAAATAA

Upstream 100 bases:

>100_bases
CCGCGCTGGTTTGAGATGGCCTGCATCCTGACGCCGCTGCTGTTTATTGGACTGTGCTGGGCGATGGTGAAATTTATCTA
TCGCGATATCCCGCTGGAGG

Downstream 100 bases:

>100_bases
AGAGTTTTGCCATGCCTTGGATCCAACTGAAACTGAACACTACCGGCGCGAACGCGGAAGATCTTAGCGATGCGCTGATG
GAAGCGGGTGCCGTTTCTAT

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MTMQLEVILPLVAYLVVVFGISVYAMRKRSTGTFLNEYFLGSRSMGGIVLAMTLTATYISASSFIGGPGAAYKYGLGWVL
LAMIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFVGAMTVQFIGGARLLETAAGIPY
ETGLLIFGISIALYTAFGGFRASVLNDTMQGLVMLIGTVVLLIGVVHAAGGLSNAVDTLQTIDPQLVTPQGADDILSPAF
MTSFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVIPDLTVPDLVIPTLMVKVLPP
FAAGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNIRPDQMQNETRLKRMSAVITLVLGALLLLAAWKPPEMIIWLNLL
AFGGLEAVFLWPLVLGLYWERANAKGALSAMIVGGVLYAVLAKLNIQYLGFHPIVPSLLLSLLAFLVGNRFGTSVPQATV
LTTDK

Sequences:

>Translated_485_residues
MTMQLEVILPLVAYLVVVFGISVYAMRKRSTGTFLNEYFLGSRSMGGIVLAMTLTATYISASSFIGGPGAAYKYGLGWVL
LAMIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFVGAMTVQFIGGARLLETAAGIPY
ETGLLIFGISIALYTAFGGFRASVLNDTMQGLVMLIGTVVLLIGVVHAAGGLSNAVDTLQTIDPQLVTPQGADDILSPAF
MTSFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVIPDLTVPDLVIPTLMVKVLPP
FAAGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNIRPDQMQNETRLKRMSAVITLVLGALLLLAAWKPPEMIIWLNLL
AFGGLEAVFLWPLVLGLYWERANAKGALSAMIVGGVLYAVLAKLNIQYLGFHPIVPSLLLSLLAFLVGNRFGTSVPQATV
LTTDK
>Mature_484_residues
TMQLEVILPLVAYLVVVFGISVYAMRKRSTGTFLNEYFLGSRSMGGIVLAMTLTATYISASSFIGGPGAAYKYGLGWVLL
AMIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFVGAMTVQFIGGARLLETAAGIPYE
TGLLIFGISIALYTAFGGFRASVLNDTMQGLVMLIGTVVLLIGVVHAAGGLSNAVDTLQTIDPQLVTPQGADDILSPAFM
TSFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVIPDLTVPDLVIPTLMVKVLPPF
AAGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNIRPDQMQNETRLKRMSAVITLVLGALLLLAAWKPPEMIIWLNLLA
FGGLEAVFLWPLVLGLYWERANAKGALSAMIVGGVLYAVLAKLNIQYLGFHPIVPSLLLSLLAFLVGNRFGTSVPQATVL
TTDK

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=473, Percent_Identity=27.906976744186, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI14140236, Length=478, Percent_Identity=23.8493723849372, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI4507033, Length=407, Percent_Identity=26.5356265356265, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI4507031, Length=479, Percent_Identity=24.6346555323591, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI110835708, Length=490, Percent_Identity=23.6734693877551, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4507035, Length=367, Percent_Identity=24.5231607629428, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI157671931, Length=359, Percent_Identity=21.1699164345404, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI87082237, Length=483, Percent_Identity=99.5859213250518, Blast_Score=947, Evalue=0.0,
Organism=Escherichia coli, GI1787251, Length=484, Percent_Identity=27.0661157024793, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1790113, Length=472, Percent_Identity=23.5169491525424, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790503, Length=446, Percent_Identity=21.9730941704036, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24651739, Length=453, Percent_Identity=21.8543046357616, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51964; Mature: 51833

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMQLEVILPLVAYLVVVFGISVYAMRKRSTGTFLNEYFLGSRSMGGIVLAMTLTATYIS
CCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCEEHHHHHHHHHHH
ASSFIGGPGAAYKYGLGWVLLAMIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARY
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHH
QSRLLVWLASLSLLVAFVGAMTVQFIGGARLLETAAGIPYETGLLIFGISIALYTAFGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCH
RASVLNDTMQGLVMLIGTVVLLIGVVHAAGGLSNAVDTLQTIDPQLVTPQGADDILSPAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEECCCCCHHHHHHHH
MTSFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVI
HHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PDLTVPDLVIPTLMVKVLPPFAAGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNIRPD
CCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
QMQNETRLKRMSAVITLVLGALLLLAAWKPPEMIIWLNLLAFGGLEAVFLWPLVLGLYWE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
RANAKGALSAMIVGGVLYAVLAKLNIQYLGFHPIVPSLLLSLLAFLVGNRFGTSVPQATV
CCCCCHHHHHHHHHHHHHHHHHHCCHHEECCHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
LTTDK
EECCC
>Mature Secondary Structure 
TMQLEVILPLVAYLVVVFGISVYAMRKRSTGTFLNEYFLGSRSMGGIVLAMTLTATYIS
CEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCEEHHHHHHHHHHH
ASSFIGGPGAAYKYGLGWVLLAMIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARY
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHH
QSRLLVWLASLSLLVAFVGAMTVQFIGGARLLETAAGIPYETGLLIFGISIALYTAFGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCH
RASVLNDTMQGLVMLIGTVVLLIGVVHAAGGLSNAVDTLQTIDPQLVTPQGADDILSPAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEECCCCCHHHHHHHH
MTSFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVI
HHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PDLTVPDLVIPTLMVKVLPPFAAGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNIRPD
CCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
QMQNETRLKRMSAVITLVLGALLLLAAWKPPEMIIWLNLLAFGGLEAVFLWPLVLGLYWE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
RANAKGALSAMIVGGVLYAVLAKLNIQYLGFHPIVPSLLLSLLAFLVGNRFGTSVPQATV
CCCCCHHHHHHHHHHHHHHHHHHCCHHEECCHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
LTTDK
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]