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The map label for this gene is yeiA [H]

Identifier: 91211433

GI number: 91211433

Start: 2376469

End: 2377710

Strand: Direct

Name: yeiA [H]

Synonym: UTI89_C2420

Alternate gene names: 91211433

Gene position: 2376469-2377710 (Clockwise)

Preceding gene: 91211432

Following gene: 91211438

Centisome position: 46.91

GC content: 50.16

Gene sequence:

>1242_bases
TTGCTCATGTTAACGAAAGATCTTTCGATTACTTTTTGCGGCGTGAAGTTTCCCAACCCGTTCTGCCTTTCTTCTTCGCC
GGTAGGCAACTGCTATGAGATGTGCGCCAAAGCCTACGACACAGGTTGGGGCGGCGTGGTGTTTAAAACGATCGGTTTTT
TTATCGCCAACGAAGTCTCGCCGCGTTTTGATCATCTGGTGAAAGAAGATACCGGTTTTATCGGCTTCAAAAATATGGAG
CAGATTGCTGAACATCCGTTGGAAGAGAATCTGGCCGCCCTGCGTCGGCTGAAAGAAGATTACCCGGACAAAGTATTGAT
CGCTTCAATCATGGGCGAAAATGAGCAGCAATGGGAAGAGCTGGCGCGTCTGGTGCAAGAAGCTGGCGCGGATATGATCG
AGTGTAACTTCTCCTGTCCGCAAATGACTTCTCATGCGATGGGTAGCGATGTCGGGCAAAGCCCGGAGCTGGTAGAAAAA
TATTGTCGGGCAGTAAAACGTGGTTCCACGCTGCCAATGCTGGCGAAGATGACGCCGAATATTGGTGATATGTGCGAAGT
GGCGCTGGCGGCGAAGCGCGGCGGCGCAGATGGCATTGCGGCGATTAACACCGTTAAATCCATCACCAATATCGATCTTA
ATCAGAAAATTGGTATGCCGATCGTTAACGGTAAATCGAGTATTTCCGGATATTCCGGTAAAGCGGTAAAACCGATCGCC
CTACGCTTTATTCAGCAAATGCGCACCCATCCAGAACTGCGCGATTTCCCGATCAGCGGTATCGGCGGCATTGAAACCTG
GGAAGATGCGGCGGAGTTTTTATTGCTCGGCGCAGCGACGTTGCAGGTGACCACCGGCATTATGCAGTACGGGTATCGGA
TAGTGGAAGATATGGCAAGCGGGTTGTCGCATTATCTCGCCGATCAAGGGTTTGATTCGTTGCAGGAGATGGTGGGTCTG
GCGAATCACAATATTGTCCCGGCGGAAGATTTAGACCGCAGTTATATTGTCTATCCCCATATCAATCTTGATAAATGTGT
TGGCTGTGGACGCTGTTATATTTCCTGTTACGACGGCGGTCACCAGGCGATGGAATGGAGCGAGAAAACCCGCACACCGC
ATTGTAATACCGAGAAATGCGTGGGTTGTCTGCTTTGTGGTCATGTCTGCCCGGTAGGTTGTATTGATCTTGGGGAAGTG
AAGTTTAAGAAAGGCGAGAAAGAACACCCGGTAACGTTGTAA

Upstream 100 bases:

>100_bases
TTGCTGCTGGCGATATTGTTGAGGGTGACAAAACCGTGGTCTATGCAGTGAAAACCGGGAAAGAAGCCGCCGGGGCGATT
CATCACTATTTAGAGGGAGC

Downstream 100 bases:

>100_bases
AACCAGCGACGCATCCGGCATTTAGTTCCTGTCGCCGGATGCGGCGTGAACGCCTTACCCGGCATACAAAACAATATAAA
TCAGTATGTTGTGCTCATTG

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MLMLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGFIGFKNME
QIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEK
YCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA
LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGL
ANHNIVPAEDLDRSYIVYPHINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIDLGEV
KFKKGEKEHPVTL

Sequences:

>Translated_413_residues
MLMLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGFIGFKNME
QIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEK
YCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA
LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGL
ANHNIVPAEDLDRSYIVYPHINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIDLGEV
KFKKGEKEHPVTL
>Mature_413_residues
MLMLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGFIGFKNME
QIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEK
YCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA
LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGL
ANHNIVPAEDLDRSYIVYPHINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIDLGEV
KFKKGEKEHPVTL

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=328, Percent_Identity=35.9756097560976, Blast_Score=196, Evalue=3e-50,
Organism=Escherichia coli, GI87082059, Length=411, Percent_Identity=99.2700729927007, Blast_Score=851, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984108, Length=475, Percent_Identity=33.6842105263158, Blast_Score=245, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6322633, Length=240, Percent_Identity=27.9166666666667, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24640763, Length=315, Percent_Identity=38.7301587301587, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI18858217, Length=315, Percent_Identity=38.7301587301587, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI281361352, Length=337, Percent_Identity=24.3323442136499, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17137316, Length=337, Percent_Identity=24.3323442136499, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 45304; Mature: 45304

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
8.5 %Cys+Met (Translated Protein)
4.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
8.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVS
CEEEEECCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
PRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE
HHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCEEHHHHHCCCHHHHHH
LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN
HHHHHHHCCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCC
IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCHHHHH
LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLSHYLADQGFDSLQEMVGLANHNIVPAEDLDRSYIVYPHINLDKCVGCGRCYISCYDGG
HHHHHHHHCCHHHHHHHHHHHCCCCCCHHHCCCCEEEEECCCHHHHCCCCEEEEEEECCC
HQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIDLGEVKFKKGEKEHPVTL
CHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCC
>Mature Secondary Structure
MLMLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVS
CEEEEECCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
PRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE
HHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCEEHHHHHCCCHHHHHH
LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN
HHHHHHHCCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCC
IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCHHHHH
LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLSHYLADQGFDSLQEMVGLANHNIVPAEDLDRSYIVYPHINLDKCVGCGRCYISCYDGG
HHHHHHHHCCHHHHHHHHHHHCCCCCCHHHCCCCEEEEECCCHHHHCCCCEEEEEEECCC
HQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIDLGEVKFKKGEKEHPVTL
CHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]