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The map label for this gene is ubiE

Identifier: 89898585

GI number: 89898585

Start: 921328

End: 922020

Strand: Direct

Name: ubiE

Synonym: CF0778

Alternate gene names: 89898585

Gene position: 921328-922020 (Clockwise)

Preceding gene: 89898584

Following gene: 89898590

Centisome position: 79.0

GC content: 41.56

Gene sequence:

>693_bases
ATGCCACCATCTATCAACGAGCCTAATCTTCAGGAGATGTTTGATTCCTTAGCTCCTAAATACGATAGGATAAACTCTAT
CCTATCTCTAGGCATGCATCATTTATGGAATCGTACGTTTGCAAGAATGTTAGGAAAGTCCGAGCATCTTCTAGATCTTT
GTTCAGGAACAGGGAAAGTTGCCTATAGGTATATCCGTGATTATCCTGGATCAAAGGCTACTCTGGTAGACTTCTCTGAA
AAAATGCTGCTTGCGGCTCAACAGCGCTATCCTGATGCACCTTTTACTTTTATAGAGGGGGATATTGTTCAGCTGCCCAT
AGATGAAGAATCGCAAACTCTAGCTTCAATGTCCTATGGATTAAGAAATCTCTCCAATCCTAAGCAAGCTCTTGAGGAAA
TCCATCGTATTTTACAACACAACGGATGCTTAGGCATCTTAGAACTCACCTCACCCTCTCGCAAGCATCCCCTCTATCTC
GCCCATCGACTATATCTAAACTTCTTAGTGCCTTGGCTGGGGAGACTATGTTCTAAAAATAAGCAAGCCTATACATATCT
AGCCGAGAGCATTAAGAAACTCCCGAGCGATGACTATCTAGAACAACTATTCCAAAACGCGAAGTTCCAAGTAAGCAAAA
AAAGGAAATTAGCCTTTGGATCAGCTACAATCTGGATACTGAAGAAAATCTAA

Upstream 100 bases:

>100_bases
TCTCAGCTTCCCCAAGATCTTATTCAGGAGTACTACTCTCTATGCCGTTATCGTCTAAGAGAAGAAGACTATGCAGGACT
TGAGAAATTCCGAGAATATT

Downstream 100 bases:

>100_bases
ACCTTATGAAGACTTTTTGCGACCGCGTTTAGCAGGAGCCTTACTCTTAGGCGCAGGCTTTTCATCCTCGCTATCGTCAT
CATCCCCAAAGAAATCTCCC

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MPPSINEPNLQEMFDSLAPKYDRINSILSLGMHHLWNRTFARMLGKSEHLLDLCSGTGKVAYRYIRDYPGSKATLVDFSE
KMLLAAQQRYPDAPFTFIEGDIVQLPIDEESQTLASMSYGLRNLSNPKQALEEIHRILQHNGCLGILELTSPSRKHPLYL
AHRLYLNFLVPWLGRLCSKNKQAYTYLAESIKKLPSDDYLEQLFQNAKFQVSKKRKLAFGSATIWILKKI

Sequences:

>Translated_230_residues
MPPSINEPNLQEMFDSLAPKYDRINSILSLGMHHLWNRTFARMLGKSEHLLDLCSGTGKVAYRYIRDYPGSKATLVDFSE
KMLLAAQQRYPDAPFTFIEGDIVQLPIDEESQTLASMSYGLRNLSNPKQALEEIHRILQHNGCLGILELTSPSRKHPLYL
AHRLYLNFLVPWLGRLCSKNKQAYTYLAESIKKLPSDDYLEQLFQNAKFQVSKKRKLAFGSATIWILKKI
>Mature_229_residues
PPSINEPNLQEMFDSLAPKYDRINSILSLGMHHLWNRTFARMLGKSEHLLDLCSGTGKVAYRYIRDYPGSKATLVDFSEK
MLLAAQQRYPDAPFTFIEGDIVQLPIDEESQTLASMSYGLRNLSNPKQALEEIHRILQHNGCLGILELTSPSRKHPLYLA
HRLYLNFLVPWLGRLCSKNKQAYTYLAESIKKLPSDDYLEQLFQNAKFQVSKKRKLAFGSATIWILKKI

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2)

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family

Homologues:

Organism=Homo sapiens, GI116063536, Length=258, Percent_Identity=25.968992248062, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI48994983, Length=208, Percent_Identity=30.2884615384615, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17557039, Length=227, Percent_Identity=29.0748898678414, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323526, Length=245, Percent_Identity=25.7142857142857, Blast_Score=93, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24641702, Length=241, Percent_Identity=29.045643153527, Blast_Score=111, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIE_CHLFF (Q253I8)

Other databases:

- EMBL:   AP006861
- RefSeq:   YP_515695.1
- ProteinModelPortal:   Q253I8
- SMR:   Q253I8
- STRING:   Q253I8
- GeneID:   3958578
- GenomeReviews:   AP006861_GR
- KEGG:   cfe:CF0778
- eggNOG:   COG2226
- HOGENOM:   HBG559580
- OMA:   GGAISKN
- ProtClustDB:   PRK00216
- BioCyc:   CFEL264202:CF0778-MONOMER
- HAMAP:   MF_01813
- InterPro:   IPR004033
- PANTHER:   PTHR10108:SF24
- TIGRFAMs:   TIGR01934

Pfam domain/function: PF01209 Ubie_methyltran

EC number: 2.1.1.-

Molecular weight: Translated: 26404; Mature: 26273

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS01183 UBIE_1; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPSINEPNLQEMFDSLAPKYDRINSILSLGMHHLWNRTFARMLGKSEHLLDLCSGTGKV
CCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHH
AYRYIRDYPGSKATLVDFSEKMLLAAQQRYPDAPFTFIEGDIVQLPIDEESQTLASMSYG
HHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCCCCCEEECCCEEEECCCCHHHHHHHHHHH
LRNLSNPKQALEEIHRILQHNGCLGILELTSPSRKHPLYLAHRLYLNFLVPWLGRLCSKN
HHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
KQAYTYLAESIKKLPSDDYLEQLFQNAKFQVSKKRKLAFGSATIWILKKI
CHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure 
PPSINEPNLQEMFDSLAPKYDRINSILSLGMHHLWNRTFARMLGKSEHLLDLCSGTGKV
CCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHH
AYRYIRDYPGSKATLVDFSEKMLLAAQQRYPDAPFTFIEGDIVQLPIDEESQTLASMSYG
HHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCCCCCEEECCCEEEECCCCHHHHHHHHHHH
LRNLSNPKQALEEIHRILQHNGCLGILELTSPSRKHPLYLAHRLYLNFLVPWLGRLCSKN
HHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
KQAYTYLAESIKKLPSDDYLEQLFQNAKFQVSKKRKLAFGSATIWILKKI
CHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA