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The map label for this gene is dxs [H]

Identifier: 89898506

GI number: 89898506

Start: 804780

End: 806714

Strand: Direct

Name: dxs [H]

Synonym: CF0699

Alternate gene names: 89898506

Gene position: 804780-806714 (Clockwise)

Preceding gene: 89898505

Following gene: 89898512

Centisome position: 69.01

GC content: 39.22

Gene sequence:

>1935_bases
ATGACTTCCCAAGTTTCTTCTATTTTAAGTCGAATTTCTTCCCCTACAGATTTAAAAAATCTTTCTCTTGCTGAGCTTTC
TCTTCTTGCTGAGCAGATGCGTCATAAAATTATTTCTGTTCTTACCAATACTGGAGGGCATTTAGCTTCTAACTTAGGCA
TCATAGAAGTAACTATAGCTTTGCATTATGTTTTTTCCTCTACTGAGGATAAGTTTATTTTTGATGTCGGCCATCAAGCC
TATCCGCATAAATTACTCACGGGACGAAATACTGAGGAGTTTGATCGGATTCGCCACGATGGGGGTCTGAGTGGGTTCAC
CTCACCCTCGGAAAGCATGCACGATCTATTTTTTTCTGGTCATGCAGGTAATGCCCTATCTTTAGCCTTGGGGATGGCTA
AAGCTACTGAGGATTCTAGAACTCACATTCTTCCCATCCTTGGTGACGCAGCTTTTTCCTGTGGATTAACTTTAGAAGCT
TTGAATAATATCAGCTCGAATCTATCTAAATTTATTGTTATTTTAAATGACAATAACATGTCGATTTCGCAAAACGTTGG
CGTCATGTCTAAGAATTTGTCGCGATGGATTCACCATCCCAAATTCAGTTTATTTTCTCGAAAGATAGAAAAATGGCTAA
CCAAGATCCCACGTTATGGCAATGGTATATCTAAGCGTTCTCATAAGCTATCTACCTGCTTAAAATCTTTATTTTGTCCG
ATTCCTATTTTTGAGCAGTTTAACTTGGCCTATATGGGTCCTGTAGATGGTCACAATATAAAAAGGCTTATCTCTGTATT
TCAAACTGCGCGAGATTTACCATTTCCAGTTCTTATTCATATTTGCACAACTAAAGGTAAGGGTTTGGAAATCGCTCAAG
AAAACCCAGAAAAATATCATGGGGTGACAGCGAATTTTAACTCTTCTGAAAAAAATAAATTACTTCCAACTATTAAGCCT
CAGCTCACTTACCCGGATGTTTTCGGACAAACAGTGTGCAAACTTGGAGAAACTTCTCCGAATTTACATATTGTTACTCC
TGCGATGTCCTTAGGATCTCGCTTAGAAGCATTTAAAGAAAAATTTCCTAAGCGTTTCATAGATGTGGGGATTGCCGAGG
GACATGCTGTGACTTTTTCAGCGGGCATTGCCAAAGCTAAATCTCCTGTTATTTGTTCCATCTACTCGACATTCTTACAT
CGTGCTTTAGACAATGTTTTCCACGATGTATGTTTACAAGGTCTCCCTGTAATCTTAGCGATAGATCGTGCAGGTTTAGC
CTATGGGGACGGCTGCAGTCATCATGGCATTTACGATATAAGTTTTCTTCGTGCCATGCCTAATATGATTATTTGCCAGC
CGAGAAGCGCGATTGTTTTACAGCAGTTACTTCAATCGTCTCTACAATGGAACATGCCTTCGGCGATTCGTTATCCTAAT
ATTGCTGCGATTCAAAGAGATCCTATTGCTACGGATGTGAATATGCACAGAGATCCGGGATTAGGAGAAATCCTCAGTCA
GGGAGAGGATATTTTGATCATAGGTTTGGGTCATATGTGTAATACTGCGCTATCTATCAAACTGCAGTTGCTCACCCATG
GGATTTCTGCAACTGTGGTAGATCCTGTATTTATCAAACCTTTTGATAACAATCTATTTAGCATTCTATTAATGCATCAT
TCTAAAGTCATTATTATAGAAGAGCACTCTATTCGGGGTGGGTTAGCTTCAGAATTCAATGATTTTTTAGCTACGTACGG
CTTTAAAGTTGATGTCTTACACTTCGGCATTCCTGATGCGTTCTTTTCTCATGGGGACAAAGAAAGCTTATTAAAAAGAG
TGGGCTTGGATACTGAAAGCATGGTTAAACGTATTCTCACACACTTTAATTTCCGGACAAAAACCTCCCCATCTAACAAG
TTAAGCATTGTTTAA

Upstream 100 bases:

>100_bases
ATCAACAATGTTACATTCTTTCTGTGCAATCTAATGGAACCATTTTAAAGGATGCCTTAGATCAGCCTGTTTTACAAACA
TTTGCGATGACTATAAGACT

Downstream 100 bases:

>100_bases
CACTGTTAGATTCAGATGTGTTCTTTAAGCCCCTCTATTACCCTATTACAGACGCTACAAATGTAGTTTTCCTACAACAG
CGGCTAAAAGGTGATAAATA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 644; Mature: 643

Protein sequence:

>644_residues
MTSQVSSILSRISSPTDLKNLSLAELSLLAEQMRHKIISVLTNTGGHLASNLGIIEVTIALHYVFSSTEDKFIFDVGHQA
YPHKLLTGRNTEEFDRIRHDGGLSGFTSPSESMHDLFFSGHAGNALSLALGMAKATEDSRTHILPILGDAAFSCGLTLEA
LNNISSNLSKFIVILNDNNMSISQNVGVMSKNLSRWIHHPKFSLFSRKIEKWLTKIPRYGNGISKRSHKLSTCLKSLFCP
IPIFEQFNLAYMGPVDGHNIKRLISVFQTARDLPFPVLIHICTTKGKGLEIAQENPEKYHGVTANFNSSEKNKLLPTIKP
QLTYPDVFGQTVCKLGETSPNLHIVTPAMSLGSRLEAFKEKFPKRFIDVGIAEGHAVTFSAGIAKAKSPVICSIYSTFLH
RALDNVFHDVCLQGLPVILAIDRAGLAYGDGCSHHGIYDISFLRAMPNMIICQPRSAIVLQQLLQSSLQWNMPSAIRYPN
IAAIQRDPIATDVNMHRDPGLGEILSQGEDILIIGLGHMCNTALSIKLQLLTHGISATVVDPVFIKPFDNNLFSILLMHH
SKVIIIEEHSIRGGLASEFNDFLATYGFKVDVLHFGIPDAFFSHGDKESLLKRVGLDTESMVKRILTHFNFRTKTSPSNK
LSIV

Sequences:

>Translated_644_residues
MTSQVSSILSRISSPTDLKNLSLAELSLLAEQMRHKIISVLTNTGGHLASNLGIIEVTIALHYVFSSTEDKFIFDVGHQA
YPHKLLTGRNTEEFDRIRHDGGLSGFTSPSESMHDLFFSGHAGNALSLALGMAKATEDSRTHILPILGDAAFSCGLTLEA
LNNISSNLSKFIVILNDNNMSISQNVGVMSKNLSRWIHHPKFSLFSRKIEKWLTKIPRYGNGISKRSHKLSTCLKSLFCP
IPIFEQFNLAYMGPVDGHNIKRLISVFQTARDLPFPVLIHICTTKGKGLEIAQENPEKYHGVTANFNSSEKNKLLPTIKP
QLTYPDVFGQTVCKLGETSPNLHIVTPAMSLGSRLEAFKEKFPKRFIDVGIAEGHAVTFSAGIAKAKSPVICSIYSTFLH
RALDNVFHDVCLQGLPVILAIDRAGLAYGDGCSHHGIYDISFLRAMPNMIICQPRSAIVLQQLLQSSLQWNMPSAIRYPN
IAAIQRDPIATDVNMHRDPGLGEILSQGEDILIIGLGHMCNTALSIKLQLLTHGISATVVDPVFIKPFDNNLFSILLMHH
SKVIIIEEHSIRGGLASEFNDFLATYGFKVDVLHFGIPDAFFSHGDKESLLKRVGLDTESMVKRILTHFNFRTKTSPSNK
LSIV
>Mature_643_residues
TSQVSSILSRISSPTDLKNLSLAELSLLAEQMRHKIISVLTNTGGHLASNLGIIEVTIALHYVFSSTEDKFIFDVGHQAY
PHKLLTGRNTEEFDRIRHDGGLSGFTSPSESMHDLFFSGHAGNALSLALGMAKATEDSRTHILPILGDAAFSCGLTLEAL
NNISSNLSKFIVILNDNNMSISQNVGVMSKNLSRWIHHPKFSLFSRKIEKWLTKIPRYGNGISKRSHKLSTCLKSLFCPI
PIFEQFNLAYMGPVDGHNIKRLISVFQTARDLPFPVLIHICTTKGKGLEIAQENPEKYHGVTANFNSSEKNKLLPTIKPQ
LTYPDVFGQTVCKLGETSPNLHIVTPAMSLGSRLEAFKEKFPKRFIDVGIAEGHAVTFSAGIAKAKSPVICSIYSTFLHR
ALDNVFHDVCLQGLPVILAIDRAGLAYGDGCSHHGIYDISFLRAMPNMIICQPRSAIVLQQLLQSSLQWNMPSAIRYPNI
AAIQRDPIATDVNMHRDPGLGEILSQGEDILIIGLGHMCNTALSIKLQLLTHGISATVVDPVFIKPFDNNLFSILLMHHS
KVIIIEEHSIRGGLASEFNDFLATYGFKVDVLHFGIPDAFFSHGDKESLLKRVGLDTESMVKRILTHFNFRTKTSPSNKL
SIV

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=668, Percent_Identity=22.3053892215569, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI4507521, Length=668, Percent_Identity=22.3053892215569, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI133778974, Length=420, Percent_Identity=21.9047619047619, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1786622, Length=624, Percent_Identity=36.2179487179487, Blast_Score=404, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24666278, Length=608, Percent_Identity=22.3684210526316, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45551847, Length=620, Percent_Identity=22.5806451612903, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45550715, Length=620, Percent_Identity=22.5806451612903, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24645119, Length=576, Percent_Identity=22.3958333333333, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 71097; Mature: 70966

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQVSSILSRISSPTDLKNLSLAELSLLAEQMRHKIISVLTNTGGHLASNLGIIEVTIA
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEH
LHYVFSSTEDKFIFDVGHQAYPHKLLTGRNTEEFDRIRHDGGLSGFTSPSESMHDLFFSG
HHHHHCCCCCCEEEECCCCCCCCHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCC
HAGNALSLALGMAKATEDSRTHILPILGDAAFSCGLTLEALNNISSNLSKFIVILNDNNM
CCCCHHHHHHHHHHCCCCCCCEEEEEECCHHHHCCCHHHHHHHHHCCCEEEEEEECCCCC
SISQNVGVMSKNLSRWIHHPKFSLFSRKIEKWLTKIPRYGNGISKRSHKLSTCLKSLFCP
EECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC
IPIFEQFNLAYMGPVDGHNIKRLISVFQTARDLPFPVLIHICTTKGKGLEIAQENPEKYH
CCCHHCCCEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEECCCCHHHC
GVTANFNSSEKNKLLPTIKPQLTYPDVFGQTVCKLGETSPNLHIVTPAMSLGSRLEAFKE
CEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHH
KFPKRFIDVGIAEGHAVTFSAGIAKAKSPVICSIYSTFLHRALDNVFHDVCLQGLPVILA
HCCHHHHHCCCCCCCEEEEECCHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
IDRAGLAYGDGCSHHGIYDISFLRAMPNMIICQPRSAIVLQQLLQSSLQWNMPSAIRYPN
EECCCCCCCCCCCCCCEEHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCC
IAAIQRDPIATDVNMHRDPGLGEILSQGEDILIIGLGHMCNTALSIKLQLLTHGISATVV
EEEEECCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCHHHCHHHHEEEEEHHCCCCCEEE
DPVFIKPFDNNLFSILLMHHSKVIIIEEHSIRGGLASEFNDFLATYGFKVDVLHFGIPDA
CCEEEEECCCCHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEECCCHH
FFSHGDKESLLKRVGLDTESMVKRILTHFNFRTKTSPSNKLSIV
HHCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCEECC
>Mature Secondary Structure 
TSQVSSILSRISSPTDLKNLSLAELSLLAEQMRHKIISVLTNTGGHLASNLGIIEVTIA
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEH
LHYVFSSTEDKFIFDVGHQAYPHKLLTGRNTEEFDRIRHDGGLSGFTSPSESMHDLFFSG
HHHHHCCCCCCEEEECCCCCCCCHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCC
HAGNALSLALGMAKATEDSRTHILPILGDAAFSCGLTLEALNNISSNLSKFIVILNDNNM
CCCCHHHHHHHHHHCCCCCCCEEEEEECCHHHHCCCHHHHHHHHHCCCEEEEEEECCCCC
SISQNVGVMSKNLSRWIHHPKFSLFSRKIEKWLTKIPRYGNGISKRSHKLSTCLKSLFCP
EECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC
IPIFEQFNLAYMGPVDGHNIKRLISVFQTARDLPFPVLIHICTTKGKGLEIAQENPEKYH
CCCHHCCCEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEECCCCHHHC
GVTANFNSSEKNKLLPTIKPQLTYPDVFGQTVCKLGETSPNLHIVTPAMSLGSRLEAFKE
CEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHH
KFPKRFIDVGIAEGHAVTFSAGIAKAKSPVICSIYSTFLHRALDNVFHDVCLQGLPVILA
HCCHHHHHCCCCCCCEEEEECCHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
IDRAGLAYGDGCSHHGIYDISFLRAMPNMIICQPRSAIVLQQLLQSSLQWNMPSAIRYPN
EECCCCCCCCCCCCCCEEHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCC
IAAIQRDPIATDVNMHRDPGLGEILSQGEDILIIGLGHMCNTALSIKLQLLTHGISATVV
EEEEECCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCHHHCHHHHEEEEEHHCCCCCEEE
DPVFIKPFDNNLFSILLMHHSKVIIIEEHSIRGGLASEFNDFLATYGFKVDVLHFGIPDA
CCEEEEECCCCHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEECCCHH
FFSHGDKESLLKRVGLDTESMVKRILTHFNFRTKTSPSNKLSIV
HHCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]