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The map label for this gene is lon [H]

Identifier: 89898491

GI number: 89898491

Start: 788889

End: 791345

Strand: Direct

Name: lon [H]

Synonym: CF0684

Alternate gene names: 89898491

Gene position: 788889-791345 (Clockwise)

Preceding gene: 89898490

Following gene: 89898492

Centisome position: 67.64

GC content: 40.62

Gene sequence:

>2457_bases
GTGGACTCTACAACAAACAACGACTCTCAGATCTTGGATCCCAATCCCGAAGAAGTAGAAAAACTCTTGGATGAATCCGA
AGAAGTCGAAGAAAAATCAGATGATCGCGCTTTACCTTCCGAGTTATTTATTCTTCCACTGAACAAGCGTCCTTTTTTCC
CCGGCATGGCAGCTCCGATTCTGATAGAGTCGGGTCCCTACTACGAAGTTTTAAAACTTCTTGCCAAATCCTCCCAAAAG
TACATAGGTTTGGTTCTTACGAAAAAGGAAGATGCCGACATTTTAAAAGTGGGTTTCAACCAACTTTATCGTGTAGGGGT
GGCTGCGCGTATTTTACGTATTATGCCTATAGAAGGAGGCAGCGCACAAATATTATTAAGCATAGAAGAACGCATTAGCA
TCGTAGAGCCTCTTAAAGATAAATATCTCAAAGCACGCGTTTCTTATCACAAAGACAATAAAGAGCTCACTGAAGAGCTA
AAAGCGTATTCTATCAGTATTGTTTCTGTAATAAAGGATCTTTTAAAGCTTAACCCTCTATTTAAAGAAGAGCTGCAGAT
CTTCCTAGGCCACTCTGATTTTACCGAACCAGGAAAGCTTGCTGATTTCTCCGTAGCATTAACAACTGCTACCAGGGAAG
AGCTTCAAGAAGTTCTTGAAACAACAAACATGCATGATCGCATTGATAAGGCTTTGATTCTGCTTAAAAAAGAGCTAGAT
CTTAGCCGATTGCAAAGTAGCATCAATCAGAAAATTGAAGCAACGATCACCAAAAGCCAAAAAGAATTCTTCTTAAAAGA
ACAGCTAAAAACAATCAAAAAAGAGCTGGGACTAGAAAAAGAAGATCGAGCTATTGACCTAGAAAAATTCATGGACCGGT
TAAAAAAACGTCAGGTTCCTGATTACGCTATGGAAGTTATCCAAGATGAAATGGAAAAGCTCCAAACTCTGGAGACGTCG
TCAGCAGAGTACACTGTTTGTCGCAACTATCTCGACTGGCTAACCATTATTCCTTGGGGAATTCAAAGCAAAGAGTACCA
CGATCTTAAAAAAGCAGAAGTAATTCTTAATAAAGACCACTACGGATTGGAAGATATTAAGCAACGCATTTTGGAACTCA
TTAGCGTTGGCAAACTATCTAAAGGTCTTAAAGGAAGCATCATTTGCCTAGTAGGCCCTCCAGGAGTGGGTAAAACAAGT
ATTGGTCGTAGCATAGCAAAAGTTTTACATCGCAAATTCTTCCGTTTTTCAGTAGGCGGAATGCGTGATGAAGCTGAGAT
CAAAGGGCACCGACGCACCTATATCGGCGCAATGCCAGGGAAAATGGTACAAGCTTTGAAGCAAAGTCAAGCTATGAATC
CCGTCATTATGATTGATGAGGTTGATAAAATTGGTGCGAGTTATCATGGCGACCCCGCATCAGCTTTGTTAGAAGTTTTA
GATCCAGAACAAAATAAAGACTTTCTAGATCATTATCTAGACGTACGTGTTGATCTATCCAATGTTCTATTTATTCTCAC
AGCAAACGTATTGGATACCATCCCCGATCCCCTCTTAGATCGTATGGAGATCTTACGTCTTTCGGGTTATATTCTAGAAG
AGAAGTTGCAGATAGCAACGAAATATCTTGTTCCTCGAGCACGTAAAGAGATGGGATTAACAGCTCGTGAAATTATGTTC
CATCCTGAAGCTCTTAAGCATATGATTAACAACTATGCTCGAGAAGCTGGTGTGCGCACGTTGAACGGGAATATTAAAAA
GGTTTTAAGAAAAGTTGCTCTTAAAATAGTTAAAAATCAGGAAAAACCCAATCCAAAACCTACTCAATACAAGATTAATG
TAAGTAACCTTCAAGACTACTTAGGGAAGCCTGTTTTTTCCAGCGATCGTTTCTACGATAATACGCCTGTAGGTGTGGCT
ACTGGTTTAGCTTGGACATCATTAGGAGGCGCCACTTTATATATTGAAAGCGTCCAAGTTCCCTCCATGAAAACTGACAT
GCATCTTACAGGACAAGCTGGAGATGTTATGAAAGAATCTTCTCAAATTGCTTGGACATATTTGCACAGCGCTTTAGAAC
GCTACGCACCCGGTTACAGCTTTTTCCCAAAATCTCAGGTACATATTCATATCCCTGAGGGAGCAACGCCTAAAGACGGT
CCTTCAGCAGGTGTAACGATGGTAACATCCTTACTTTCCTTGCTTTTGGATACACCGATTTTAGAAAACCTAGGCATGAC
AGGTGAGATCACCCTAACTGGTCGAGTGTTAGGAGTGGGCGGAATCCGAGAAAAGCTCATAGCAGCTCGTCGCTCTCGTC
TTAATGTGTTAATCTTCCCTGAAGATAACCGTCGTGACTATGAAGAACTTCCTGCTTATCTCAAAAAAGGACTGAAAATT
CATTTTGTTGCACATTATGACGATGTCTTCAAAGTTGCTTTCCCACACATTAATTAA

Upstream 100 bases:

>100_bases
ATATCGAAAAGAGGATCTTTATTGTTGAAACTGCTGCCATCAATAAGCTATCAGAGCAACTTAGACAAATGTATCCGATG
ATTTTAGTATAAGGACAATA

Downstream 100 bases:

>100_bases
CCCTTACAACACAGTTTAGAGCTGGTTTATTTATAAATAAACAGCTCTATATTCTTCTTGCAAAAAAAACTGTATATTTA
CAAACGTTTCCAAAATTTCT

Product: lon/ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 818; Mature: 818

Protein sequence:

>818_residues
MDSTTNNDSQILDPNPEEVEKLLDESEEVEEKSDDRALPSELFILPLNKRPFFPGMAAPILIESGPYYEVLKLLAKSSQK
YIGLVLTKKEDADILKVGFNQLYRVGVAARILRIMPIEGGSAQILLSIEERISIVEPLKDKYLKARVSYHKDNKELTEEL
KAYSISIVSVIKDLLKLNPLFKEELQIFLGHSDFTEPGKLADFSVALTTATREELQEVLETTNMHDRIDKALILLKKELD
LSRLQSSINQKIEATITKSQKEFFLKEQLKTIKKELGLEKEDRAIDLEKFMDRLKKRQVPDYAMEVIQDEMEKLQTLETS
SAEYTVCRNYLDWLTIIPWGIQSKEYHDLKKAEVILNKDHYGLEDIKQRILELISVGKLSKGLKGSIICLVGPPGVGKTS
IGRSIAKVLHRKFFRFSVGGMRDEAEIKGHRRTYIGAMPGKMVQALKQSQAMNPVIMIDEVDKIGASYHGDPASALLEVL
DPEQNKDFLDHYLDVRVDLSNVLFILTANVLDTIPDPLLDRMEILRLSGYILEEKLQIATKYLVPRARKEMGLTAREIMF
HPEALKHMINNYAREAGVRTLNGNIKKVLRKVALKIVKNQEKPNPKPTQYKINVSNLQDYLGKPVFSSDRFYDNTPVGVA
TGLAWTSLGGATLYIESVQVPSMKTDMHLTGQAGDVMKESSQIAWTYLHSALERYAPGYSFFPKSQVHIHIPEGATPKDG
PSAGVTMVTSLLSLLLDTPILENLGMTGEITLTGRVLGVGGIREKLIAARRSRLNVLIFPEDNRRDYEELPAYLKKGLKI
HFVAHYDDVFKVAFPHIN

Sequences:

>Translated_818_residues
MDSTTNNDSQILDPNPEEVEKLLDESEEVEEKSDDRALPSELFILPLNKRPFFPGMAAPILIESGPYYEVLKLLAKSSQK
YIGLVLTKKEDADILKVGFNQLYRVGVAARILRIMPIEGGSAQILLSIEERISIVEPLKDKYLKARVSYHKDNKELTEEL
KAYSISIVSVIKDLLKLNPLFKEELQIFLGHSDFTEPGKLADFSVALTTATREELQEVLETTNMHDRIDKALILLKKELD
LSRLQSSINQKIEATITKSQKEFFLKEQLKTIKKELGLEKEDRAIDLEKFMDRLKKRQVPDYAMEVIQDEMEKLQTLETS
SAEYTVCRNYLDWLTIIPWGIQSKEYHDLKKAEVILNKDHYGLEDIKQRILELISVGKLSKGLKGSIICLVGPPGVGKTS
IGRSIAKVLHRKFFRFSVGGMRDEAEIKGHRRTYIGAMPGKMVQALKQSQAMNPVIMIDEVDKIGASYHGDPASALLEVL
DPEQNKDFLDHYLDVRVDLSNVLFILTANVLDTIPDPLLDRMEILRLSGYILEEKLQIATKYLVPRARKEMGLTAREIMF
HPEALKHMINNYAREAGVRTLNGNIKKVLRKVALKIVKNQEKPNPKPTQYKINVSNLQDYLGKPVFSSDRFYDNTPVGVA
TGLAWTSLGGATLYIESVQVPSMKTDMHLTGQAGDVMKESSQIAWTYLHSALERYAPGYSFFPKSQVHIHIPEGATPKDG
PSAGVTMVTSLLSLLLDTPILENLGMTGEITLTGRVLGVGGIREKLIAARRSRLNVLIFPEDNRRDYEELPAYLKKGLKI
HFVAHYDDVFKVAFPHIN
>Mature_818_residues
MDSTTNNDSQILDPNPEEVEKLLDESEEVEEKSDDRALPSELFILPLNKRPFFPGMAAPILIESGPYYEVLKLLAKSSQK
YIGLVLTKKEDADILKVGFNQLYRVGVAARILRIMPIEGGSAQILLSIEERISIVEPLKDKYLKARVSYHKDNKELTEEL
KAYSISIVSVIKDLLKLNPLFKEELQIFLGHSDFTEPGKLADFSVALTTATREELQEVLETTNMHDRIDKALILLKKELD
LSRLQSSINQKIEATITKSQKEFFLKEQLKTIKKELGLEKEDRAIDLEKFMDRLKKRQVPDYAMEVIQDEMEKLQTLETS
SAEYTVCRNYLDWLTIIPWGIQSKEYHDLKKAEVILNKDHYGLEDIKQRILELISVGKLSKGLKGSIICLVGPPGVGKTS
IGRSIAKVLHRKFFRFSVGGMRDEAEIKGHRRTYIGAMPGKMVQALKQSQAMNPVIMIDEVDKIGASYHGDPASALLEVL
DPEQNKDFLDHYLDVRVDLSNVLFILTANVLDTIPDPLLDRMEILRLSGYILEEKLQIATKYLVPRARKEMGLTAREIMF
HPEALKHMINNYAREAGVRTLNGNIKKVLRKVALKIVKNQEKPNPKPTQYKINVSNLQDYLGKPVFSSDRFYDNTPVGVA
TGLAWTSLGGATLYIESVQVPSMKTDMHLTGQAGDVMKESSQIAWTYLHSALERYAPGYSFFPKSQVHIHIPEGATPKDG
PSAGVTMVTSLLSLLLDTPILENLGMTGEITLTGRVLGVGGIREKLIAARRSRLNVLIFPEDNRRDYEELPAYLKKGLKI
HFVAHYDDVFKVAFPHIN

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=834, Percent_Identity=45.2038369304556, Blast_Score=727, Evalue=0.0,
Organism=Homo sapiens, GI31377667, Length=842, Percent_Identity=34.2042755344418, Blast_Score=455, Evalue=1e-128,
Organism=Escherichia coli, GI1786643, Length=776, Percent_Identity=40.2061855670103, Blast_Score=558, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI17505831, Length=695, Percent_Identity=47.6258992805755, Blast_Score=645, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17556486, Length=631, Percent_Identity=33.4389857369255, Blast_Score=383, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6319449, Length=719, Percent_Identity=48.5396383866481, Blast_Score=686, Evalue=0.0,
Organism=Drosophila melanogaster, GI221513036, Length=670, Percent_Identity=52.5373134328358, Blast_Score=714, Evalue=0.0,
Organism=Drosophila melanogaster, GI24666867, Length=670, Percent_Identity=52.5373134328358, Blast_Score=714, Evalue=0.0,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 92382; Mature: 92382

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSTTNNDSQILDPNPEEVEKLLDESEEVEEKSDDRALPSELFILPLNKRPFFPGMAAPI
CCCCCCCCCEECCCCHHHHHHHHCCHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCE
LIESGPYYEVLKLLAKSSQKYIGLVLTKKEDADILKVGFNQLYRVGVAARILRIMPIEGG
EECCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SAQILLSIEERISIVEPLKDKYLKARVSYHKDNKELTEELKAYSISIVSVIKDLLKLNPL
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
FKEELQIFLGHSDFTEPGKLADFSVALTTATREELQEVLETTNMHDRIDKALILLKKELD
HHHHHHEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
LSRLQSSINQKIEATITKSQKEFFLKEQLKTIKKELGLEKEDRAIDLEKFMDRLKKRQVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCC
DYAMEVIQDEMEKLQTLETSSAEYTVCRNYLDWLTIIPWGIQSKEYHDLKKAEVILNKDH
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEEECCCC
YGLEDIKQRILELISVGKLSKGLKGSIICLVGPPGVGKTSIGRSIAKVLHRKFFRFSVGG
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
MRDEAEIKGHRRTYIGAMPGKMVQALKQSQAMNPVIMIDEVDKIGASYHGDPASALLEVL
CCCHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECHHHHCCCCCCCHHHHHHHHH
DPEQNKDFLDHYLDVRVDLSNVLFILTANVLDTIPDPLLDRMEILRLSGYILEEKLQIAT
CCCCCHHHHHHHHHHEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
KYLVPRARKEMGLTAREIMFHPEALKHMINNYAREAGVRTLNGNIKKVLRKVALKIVKNQ
HHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHHHHHHHCC
EKPNPKPTQYKINVSNLQDYLGKPVFSSDRFYDNTPVGVATGLAWTSLGGATLYIESVQV
CCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCCCCHHHHCHHHHCCCCEEEEEEEEEC
PSMKTDMHLTGQAGDVMKESSQIAWTYLHSALERYAPGYSFFPKSQVHIHIPEGATPKDG
CCCCCCEEECCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCC
PSAGVTMVTSLLSLLLDTPILENLGMTGEITLTGRVLGVGGIREKLIAARRSRLNVLIFP
CCCHHHHHHHHHHHHHCCHHHHHCCCCEEEEEEEEEEECCHHHHHHHHHHHHCCEEEEEC
EDNRRDYEELPAYLKKGLKIHFVAHYDDVFKVAFPHIN
CCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHCCCCC
>Mature Secondary Structure
MDSTTNNDSQILDPNPEEVEKLLDESEEVEEKSDDRALPSELFILPLNKRPFFPGMAAPI
CCCCCCCCCEECCCCHHHHHHHHCCHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCE
LIESGPYYEVLKLLAKSSQKYIGLVLTKKEDADILKVGFNQLYRVGVAARILRIMPIEGG
EECCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SAQILLSIEERISIVEPLKDKYLKARVSYHKDNKELTEELKAYSISIVSVIKDLLKLNPL
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
FKEELQIFLGHSDFTEPGKLADFSVALTTATREELQEVLETTNMHDRIDKALILLKKELD
HHHHHHEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
LSRLQSSINQKIEATITKSQKEFFLKEQLKTIKKELGLEKEDRAIDLEKFMDRLKKRQVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCC
DYAMEVIQDEMEKLQTLETSSAEYTVCRNYLDWLTIIPWGIQSKEYHDLKKAEVILNKDH
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEEECCCC
YGLEDIKQRILELISVGKLSKGLKGSIICLVGPPGVGKTSIGRSIAKVLHRKFFRFSVGG
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
MRDEAEIKGHRRTYIGAMPGKMVQALKQSQAMNPVIMIDEVDKIGASYHGDPASALLEVL
CCCHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECHHHHCCCCCCCHHHHHHHHH
DPEQNKDFLDHYLDVRVDLSNVLFILTANVLDTIPDPLLDRMEILRLSGYILEEKLQIAT
CCCCCHHHHHHHHHHEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
KYLVPRARKEMGLTAREIMFHPEALKHMINNYAREAGVRTLNGNIKKVLRKVALKIVKNQ
HHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHHHHHHHCC
EKPNPKPTQYKINVSNLQDYLGKPVFSSDRFYDNTPVGVATGLAWTSLGGATLYIESVQV
CCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCCCCHHHHCHHHHCCCCEEEEEEEEEC
PSMKTDMHLTGQAGDVMKESSQIAWTYLHSALERYAPGYSFFPKSQVHIHIPEGATPKDG
CCCCCCEEECCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCC
PSAGVTMVTSLLSLLLDTPILENLGMTGEITLTGRVLGVGGIREKLIAARRSRLNVLIFP
CCCHHHHHHHHHHHHHCCHHHHHCCCCEEEEEEEEEEECCHHHHHHHHHHHHCCEEEEEC
EDNRRDYEELPAYLKKGLKIHFVAHYDDVFKVAFPHIN
CCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]