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The map label for this gene is tlyC1 [C]

Identifier: 89898412

GI number: 89898412

Start: 708732

End: 709967

Strand: Direct

Name: tlyC1 [C]

Synonym: CF0605

Alternate gene names: 89898412

Gene position: 708732-709967 (Clockwise)

Preceding gene: 89898411

Following gene: 89898413

Centisome position: 60.77

GC content: 36.57

Gene sequence:

>1236_bases
ATGATTTCTACTCTACTGATCTTTTTAATCATTTGTTTCACTTTGTGTTCTGGTTTTGTTTCATTATCACAGATAGCACT
TTTCTCTCTGCCTACATCTTTAATTTCTCATTATAAGCGCTCTAGGCATAAAAAACAGCAGTTAGTAGCCTCGTTACTTT
CTCATCCTCACCATTTATTAATCACGCTTATCTTTCTTGATATTGGATTAAATATTGGAATACAAAACTGTGTTGCTATA
CTTGTTGGAGATAAGGCTTCGTGGTTAATCATTGTCGGTTTCCCTTTAGCTCTTACACTTATTCTTTGTGAAATTTTACC
TAAGGCAGTAGCTTTACCTTATAACACACAAATAGCCTCTTTTGTCGCGCCTCTCATTTTAGTATTTACGAAAGTCCTTC
GACCGCTACTTTACTGGGCAATTAGCGGGATTAACTATGTTGTTCAATGGATTCTTTCATCTCAGAAAACAGATATTATC
CAACCTCAAGAATTGAAAGAAGTTTTACAAAGCTGTAAGGACTTCGGAGTTGTCAACCAGGAAGAAAGTCGTTTGTTGTA
TGGTTATTTATCGCTTAGCGACTGTAGTGTTAAAGAACGTATGAAACCCCGTCAGGACGTATTGTTCTACGACATTCAAA
CTCCTCTTGACAATCTCTATGATTTATTTTCTAGGCAACACTGCTCTCGAGTTCCTGTATGCAATGATAATTTACAAAAT
TTACTAGGAATCTGTACTGCGAAGGCTTTGCTACTTTATGGCAAACCTTTACAATCCTCAGAAGATCTTTTACCCTTATT
GAATAAACCTTATTACATGCCCGAGACAATATCCGCAAAAACAGCCTTATGCCATCTTGCAGCTGAAGATGAAACTCTGG
GTATGATTATTGATGAGTATGGGTCCATTGAGGGATTGATTACCCAAGAAGATCTTTTTGAAATTGTTTCTGGAGAAATC
ATAGATCAACGAAGTGAAAAAGTTCTTTATACAATGTCAGGGAAAGATGTTATTATTGCAGCAGGAACTTTAGAGCTAAG
TGATCTTAGTGAGATTTTTAATATTAATCTTCCTACCTATACCAATAGTGCAACTTTAGGAGGATGGCTAACGGAACAAA
TGGAATCTATTCCAATCACAGGAACAAAGCTCATGTGGAAGAATCTTATGTTTCAAGTTTTAGATGCGGCTCCCAATCGC
ATACGCCGAGTCTATATAAGGAAAATGCATGACTGA

Upstream 100 bases:

>100_bases
ATCTGCTTTGATTCGTAGGCTGGGTTTAATTCCTAAGGGTTATACTAAGGTGTGTTTCTCTCCGGTTATAGAATCGAAGA
GCACAGATTGAGACAAGAGC

Downstream 100 bases:

>100_bases
TTCTCCTTTCTTTTGGCTTGGGGTTAATTTTCTATGTATTGTCCTTCAGGGATTTTATTCTATGATGGAAATGGCATGCG
TTTCTTTTAACCGCGTACGT

Product: hemolysin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MISTLLIFLIICFTLCSGFVSLSQIALFSLPTSLISHYKRSRHKKQQLVASLLSHPHHLLITLIFLDIGLNIGIQNCVAI
LVGDKASWLIIVGFPLALTLILCEILPKAVALPYNTQIASFVAPLILVFTKVLRPLLYWAISGINYVVQWILSSQKTDII
QPQELKEVLQSCKDFGVVNQEESRLLYGYLSLSDCSVKERMKPRQDVLFYDIQTPLDNLYDLFSRQHCSRVPVCNDNLQN
LLGICTAKALLLYGKPLQSSEDLLPLLNKPYYMPETISAKTALCHLAAEDETLGMIIDEYGSIEGLITQEDLFEIVSGEI
IDQRSEKVLYTMSGKDVIIAAGTLELSDLSEIFNINLPTYTNSATLGGWLTEQMESIPITGTKLMWKNLMFQVLDAAPNR
IRRVYIRKMHD

Sequences:

>Translated_411_residues
MISTLLIFLIICFTLCSGFVSLSQIALFSLPTSLISHYKRSRHKKQQLVASLLSHPHHLLITLIFLDIGLNIGIQNCVAI
LVGDKASWLIIVGFPLALTLILCEILPKAVALPYNTQIASFVAPLILVFTKVLRPLLYWAISGINYVVQWILSSQKTDII
QPQELKEVLQSCKDFGVVNQEESRLLYGYLSLSDCSVKERMKPRQDVLFYDIQTPLDNLYDLFSRQHCSRVPVCNDNLQN
LLGICTAKALLLYGKPLQSSEDLLPLLNKPYYMPETISAKTALCHLAAEDETLGMIIDEYGSIEGLITQEDLFEIVSGEI
IDQRSEKVLYTMSGKDVIIAAGTLELSDLSEIFNINLPTYTNSATLGGWLTEQMESIPITGTKLMWKNLMFQVLDAAPNR
IRRVYIRKMHD
>Mature_411_residues
MISTLLIFLIICFTLCSGFVSLSQIALFSLPTSLISHYKRSRHKKQQLVASLLSHPHHLLITLIFLDIGLNIGIQNCVAI
LVGDKASWLIIVGFPLALTLILCEILPKAVALPYNTQIASFVAPLILVFTKVLRPLLYWAISGINYVVQWILSSQKTDII
QPQELKEVLQSCKDFGVVNQEESRLLYGYLSLSDCSVKERMKPRQDVLFYDIQTPLDNLYDLFSRQHCSRVPVCNDNLQN
LLGICTAKALLLYGKPLQSSEDLLPLLNKPYYMPETISAKTALCHLAAEDETLGMIIDEYGSIEGLITQEDLFEIVSGEI
IDQRSEKVLYTMSGKDVIIAAGTLELSDLSEIFNINLPTYTNSATLGGWLTEQMESIPITGTKLMWKNLMFQVLDAAPNR
IRRVYIRKMHD

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=284, Percent_Identity=26.7605633802817, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI145693175, Length=404, Percent_Identity=23.2673267326733, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082033, Length=269, Percent_Identity=26.7657992565056, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1790664, Length=433, Percent_Identity=21.4780600461894, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786879, Length=252, Percent_Identity=21.8253968253968, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788119, Length=237, Percent_Identity=26.1603375527426, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 46215; Mature: 46215

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISTLLIFLIICFTLCSGFVSLSQIALFSLPTSLISHYKRSRHKKQQLVASLLSHPHHLL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
ITLIFLDIGLNIGIQNCVAILVGDKASWLIIVGFPLALTLILCEILPKAVALPYNTQIAS
HHHHHHHHCCCCCCCCEEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCHHHHH
FVAPLILVFTKVLRPLLYWAISGINYVVQWILSSQKTDIIQPQELKEVLQSCKDFGVVNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCC
EESRLLYGYLSLSDCSVKERMKPRQDVLFYDIQTPLDNLYDLFSRQHCSRVPVCNDNLQN
CCCEEEEEEEECCCCCHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHH
LLGICTAKALLLYGKPLQSSEDLLPLLNKPYYMPETISAKTALCHLAAEDETLGMIIDEY
HHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHC
GSIEGLITQEDLFEIVSGEIIDQRSEKVLYTMSGKDVIIAAGTLELSDLSEIFNINLPTY
CCCCCEECHHHHHHHHHCHHHCCCCCEEEEEECCCEEEEEECCEEHHHHHHHHCCCCCCC
TNSATLGGWLTEQMESIPITGTKLMWKNLMFQVLDAAPNRIRRVYIRKMHD
CCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MISTLLIFLIICFTLCSGFVSLSQIALFSLPTSLISHYKRSRHKKQQLVASLLSHPHHLL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
ITLIFLDIGLNIGIQNCVAILVGDKASWLIIVGFPLALTLILCEILPKAVALPYNTQIAS
HHHHHHHHCCCCCCCCEEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCHHHHH
FVAPLILVFTKVLRPLLYWAISGINYVVQWILSSQKTDIIQPQELKEVLQSCKDFGVVNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCC
EESRLLYGYLSLSDCSVKERMKPRQDVLFYDIQTPLDNLYDLFSRQHCSRVPVCNDNLQN
CCCEEEEEEEECCCCCHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHH
LLGICTAKALLLYGKPLQSSEDLLPLLNKPYYMPETISAKTALCHLAAEDETLGMIIDEY
HHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHC
GSIEGLITQEDLFEIVSGEIIDQRSEKVLYTMSGKDVIIAAGTLELSDLSEIFNINLPTY
CCCCCEECHHHHHHHHHCHHHCCCCCEEEEEECCCEEEEEECCEEHHHHHHHHCCCCCCC
TNSATLGGWLTEQMESIPITGTKLMWKNLMFQVLDAAPNRIRRVYIRKMHD
CCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]